Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionion channel regulator activity

ANO9 PRKCZ KCNMB3 SRI

3.67e-04162424GO:0099106
GeneOntologyMolecularFunctionchannel regulator activity

ANO9 PRKCZ KCNMB3 SRI

4.81e-04174424GO:0016247
GeneOntologyMolecularFunctiondiacylglycerol-dependent serine/threonine kinase activity

PRKCA PRKCZ

5.09e-0416422GO:0004697
GeneOntologyMolecularFunctiontransporter regulator activity

ANO9 PRKCZ KCNMB3 SRI

5.14e-04177424GO:0141108
GeneOntologyMolecularFunctionprotein serine kinase activity

ROCK2 STK11 PRKCA FAM20C PRKCZ

9.45e-04363425GO:0106310
GeneOntologyBiologicalProcessregulation of angiotensin-activated signaling pathway

ROCK2 PRKCA

2.54e-054432GO:0110061
GeneOntologyBiologicalProcesspositive regulation of vesicle transport along microtubule

TRIM46 STK11

4.23e-055432GO:1901610
GeneOntologyBiologicalProcessregulation of vesicle transport along microtubule

TRIM46 STK11

6.33e-056432GO:1901608
GeneOntologyBiologicalProcessvesicle transport along microtubule

TRIM46 STK11 PRKCZ

1.64e-0451433GO:0047496
GeneOntologyBiologicalProcessmicrotubule-based transport

TRIM46 STK11 PRKCZ ANK3 DNAH5

1.76e-04253435GO:0099111
GeneOntologyBiologicalProcessregulation of circadian rhythm

ROCK2 NR1D1 PPP1CA PPP1CC

1.78e-04135434GO:0042752
GeneOntologyBiologicalProcessprotein dephosphorylation

ROCK2 STK11 PDP2 PPP1CA PPP1CC

1.85e-04256435GO:0006470
GeneOntologyBiologicalProcessprotein localization to axon

TRIM46 ANK3

2.31e-0411432GO:0099612
GeneOntologyBiologicalProcessmicrotubule bundle formation

TRIM46 CLXN TRIM36 DNAH5

2.34e-04145434GO:0001578
GeneOntologyBiologicalProcessregulation of organelle transport along microtubule

TRIM46 STK11

2.77e-0412432GO:1902513
GeneOntologyCellularComponentPTW/PP1 phosphatase complex

PPP1CA PPP1CC

8.62e-057432GO:0072357
MousePhenoabnormal circulating mineral level

CUL3 FNIP1 FAM20C NAA35 SLC38A10 SLC46A3 PRKCZ SGSM1 AGAP9 DNAH5 C16orf89

5.24e-059823911MP:0006357
MousePhenodental pulp necrosis

FAM20C CTSV

7.54e-055392MP:0013251
MousePhenoabnormal circulating iron level

FNIP1 SLC38A10 SLC46A3 PRKCZ SGSM1

1.03e-04170395MP:0004152
MousePhenoabnormal mineral level

CUL3 FNIP1 FAM20C NAA35 SLC38A10 SLC46A3 PRKCZ SGSM1 AGAP9 DNAH5 C16orf89

1.10e-0410663911MP:0000192
MousePhenoincreased circulating iron level

FNIP1 SLC38A10 PRKCZ SGSM1

1.16e-0491394MP:0008810
MousePhenoabnormal mineral homeostasis

CUL3 FNIP1 FAM20C NAA35 SLC38A10 SLC46A3 PRKCZ SGSM1 AGAP9 DNAH5 C16orf89

1.20e-0410763911MP:0005636
MousePhenoincreased circulating mineral level

CUL3 FNIP1 NAA35 SLC38A10 PRKCZ SGSM1 AGAP9 DNAH5

2.77e-04626398MP:0014547
MousePhenoabnormal iron level

FNIP1 SLC38A10 SLC46A3 PRKCZ SGSM1

3.29e-04218395MP:0001770
MousePhenoabnormal iron homeostasis

FNIP1 SLC38A10 SLC46A3 PRKCZ SGSM1

3.66e-04223395MP:0005637
MousePhenoincreased iron level

FNIP1 SLC38A10 PRKCZ SGSM1

3.82e-04124394MP:0014541
MousePhenoabnormal ion homeostasis

CUL3 FNIP1 FAM20C NAA35 SLC38A10 SLC46A3 PRKCZ SGSM1 AGAP9 DNAH5 C16orf89

3.95e-0412323911MP:0001765
MousePhenoincreased mineral level

CUL3 FNIP1 NAA35 SLC38A10 PRKCZ SGSM1 AGAP9 DNAH5

4.30e-04668398MP:0014535
DomainSTPPase_N

PPP1CA PPP1CC

1.48e-053422PF16891
DomainSTPPase_N

PPP1CA PPP1CC

1.48e-053422IPR031675
DomainPkinase_C

ROCK2 PRKCA PRKCZ

7.79e-0537423IPR017892
DomainPkinase_C

ROCK2 PRKCA PRKCZ

1.14e-0442423PF00433
DomainAGC-kinase_C

ROCK2 PRKCA PRKCZ

2.70e-0456423IPR000961
DomainAGC_KINASE_CTER

ROCK2 PRKCA PRKCZ

2.70e-0456423PS51285
DomainS_TK_X

ROCK2 PRKCA PRKCZ

2.70e-0456423SM00133
DomainC1_1

ROCK2 PRKCA PRKCZ

2.84e-0457423PF00130
DomainCOS_domain

TRIM46 TRIM36

3.21e-0412422IPR017903
DomainCOS

TRIM46 TRIM36

3.21e-0412422PS51262
DomainSer/Thr-sp_prot-phosphatase

PPP1CA PPP1CC

3.79e-0413422IPR006186
DomainSER_THR_PHOSPHATASE

PPP1CA PPP1CC

3.79e-0413422PS00125
DomainPP2Ac

PPP1CA PPP1CC

3.79e-0413422SM00156
DomainZF_DAG_PE_1

ROCK2 PRKCA PRKCZ

4.00e-0464423PS00479
DomainZF_DAG_PE_2

ROCK2 PRKCA PRKCZ

4.00e-0464423PS50081
DomainC1

ROCK2 PRKCA PRKCZ

4.19e-0465423SM00109
DomainPE/DAG-bd

ROCK2 PRKCA PRKCZ

4.38e-0466423IPR002219
DomainAa_trans

SLC38A10 TMEM104

6.57e-0417422PF01490
DomainAA_transpt_TM

SLC38A10 TMEM104

6.57e-0417422IPR013057
DomainDAG/PE-bd

PRKCA PRKCZ

1.01e-0321422IPR020454
DomainCalcineurin-like_PHP_ApaH

PPP1CA PPP1CC

1.80e-0328422IPR004843
DomainMetallophos

PPP1CA PPP1CC

1.80e-0328422PF00149
DomainMetallo-depent_PP-like

PPP1CA PPP1CC

2.06e-0330422IPR029052
Domain-

PPP1CA PPP1CC

2.06e-03304223.60.21.10
DomainZnf-RING_LisH

TRIM46 TRIM36

2.65e-0334422IPR027370
Domainzf-RING_UBOX

TRIM46 TRIM36

2.65e-0334422PF13445
DomainEF-hand_1

CLXN CIB3 SRI

4.81e-03152423PF00036
DomainEFh

CLXN CIB3 SRI

5.36e-03158423SM00054
Domainfn3

TRIM46 COL14A1 TRIM36

5.74e-03162423PF00041
DomainEF_Hand_1_Ca_BS

CLXN CIB3 SRI

7.10e-03175423IPR018247
DomainFN3

TRIM46 COL14A1 TRIM36

8.27e-03185423SM00060
DomainSer/Thr_kinase_AS

ROCK2 STK11 PRKCA PRKCZ

8.29e-03357424IPR008271
DomainS_TKc

ROCK2 STK11 PRKCA PRKCZ

8.45e-03359424SM00220
DomainPROTEIN_KINASE_ST

ROCK2 STK11 PRKCA PRKCZ

8.70e-03362424PS00108
DomainFN3

TRIM46 COL14A1 TRIM36

1.01e-02199423PS50853
DomainProtein_kinase_ATP_BS

ROCK2 STK11 PRKCA PRKCZ

1.02e-02379424IPR017441
DomainPkinase

ROCK2 STK11 PRKCA PRKCZ

1.04e-02381424PF00069
DomainBBOX

TRIM46 TRIM36

1.05e-0269422SM00336
DomainEF_HAND_1

CLXN CIB3 SRI

1.08e-02204423PS00018
Domain-

TRIM46 TRIM36

1.11e-02714224.10.45.10
Domainzf-B_box

TRIM46 TRIM36

1.14e-0272422PF00643
DomainFN3_dom

TRIM46 COL14A1 TRIM36

1.15e-02209423IPR003961
DomainConA-like_dom

TRIM46 COL14A1 TRIM36

1.30e-02219423IPR013320
DomainZF_BBOX

TRIM46 TRIM36

1.40e-0280422PS50119
DomainZnf_B-box

TRIM46 TRIM36

1.43e-0281422IPR000315
DomainEF_HAND_2

CLXN CIB3 SRI

1.50e-02231423PS50222
DomainPH_dom-like

ROCK2 ECT2L AGAP9 WDFY4

1.51e-02426424IPR011993
DomainEF_hand_dom

CLXN CIB3 SRI

1.52e-02232423IPR002048
PathwayKEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION

ROCK2 PRKCA KCNMB3 PPP1CA PPP1CC

4.01e-06115305M9387
PathwayWP_COMMON_PATHWAYS_UNDERLYING_DRUG_ADDICTION

PRKCA PPP1CA PPP1CC

8.78e-0541303M39655
PathwayKEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_MRAS_SHOC2_PP1_HOLOPHOSPHATASE

PPP1CA PPP1CC

1.22e-048302M47933
PathwayKEGG_MEDICUS_REFERENCE_CENPE_INTERACTION_WITH_NDC80_COMPLEX

PPP1CA PPP1CC

2.85e-0412302M47887
PathwayKEGG_MEDICUS_REFERENCE_DEPHOSPHORYLATION_OF_KINETOCHORE

PPP1CA PPP1CC

2.85e-0412302M47891
PathwayKEGG_LONG_TERM_POTENTIATION

PRKCA PPP1CA PPP1CC

4.32e-0470303M3115
PathwayREACTOME_CIRCADIAN_CLOCK

NR1D1 PPP1CA PPP1CC

4.32e-0470303M938
PathwayREACTOME_RESPIRATORY_SYNCYTIAL_VIRUS_RSV_GENOME_REPLICATION_TRANSCRIPTION_AND_TRANSLATION

PPP1CA PPP1CC

5.16e-0416302M48235
PathwayBIOCARTA_CCR3_PATHWAY

ROCK2 PRKCA

7.32e-0419302MM1361
PathwayREACTOME_VEGFR2_MEDIATED_CELL_PROLIFERATION

PRKCA PRKCZ

7.32e-0419302M27423
PathwayWP_KCNQ2RELATED_EPILEPSIES

PRKCA ANK3

7.32e-0419302M48320
PathwayBIOCARTA_CCR3_PATHWAY

ROCK2 PRKCA

7.32e-0419302M9152
PathwayWP_FOCAL_ADHESION

ROCK2 PRKCA PPP1CA PPP1CC

7.92e-04199304M39402
PathwayKEGG_FOCAL_ADHESION

ROCK2 PRKCA PPP1CA PPP1CC

7.92e-04199304M7253
PathwayWP_CIRCADIAN_RHYTHM_GENES

ROCK2 NR1D1 PPP1CA PPP1CC

8.22e-04201304M39605
PathwayWP_NICOTINE_EFFECT_ON_DOPAMINERGIC_NEURONS

KCNK9 PPP1CA

8.97e-0421302M39343
PathwayREACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX

PRKCZ PPP1CA PPP1CC

1.02e-0394303M1041
PathwayREACTOME_RHOBTB1_GTPASE_CYCLE

ROCK2 CUL3

1.08e-0323302M41817
PathwayWP_NRF2ARE_REGULATION

CUL3 PRKCA

1.08e-0323302M39761
PathwayREACTOME_TRIGLYCERIDE_CATABOLISM

PPP1CA PPP1CC

1.17e-0324302M10064
PathwayREACTOME_RHO_GTPASES_ACTIVATE_NADPH_OXIDASES

PRKCA PRKCZ

1.17e-0324302M27553
PathwayREACTOME_RHOBTB1_GTPASE_CYCLE

ROCK2 CUL3

1.27e-0325302MM15608
PathwayPID_INSULIN_GLUCOSE_PATHWAY

PRKCZ PPP1CC

1.38e-0326302M247
PathwayREACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING

PPP1CA PPP1CC

1.38e-0326302M628
PathwayREACTOME_SIGNALING_BY_VEGF

ROCK2 PRKCA PRKCZ

1.45e-03106303M27077
PathwayPID_RAS_PATHWAY

PRKCA PRKCZ

1.84e-0330302M269
PathwayKEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION

ROCK2 PRKCA CLDN15

1.87e-03116303M2164
PathwayREACTOME_RESPIRATORY_SYNCYTIAL_VIRUS_INFECTION_PATHWAY

MED18 PPP1CA PPP1CC

2.07e-03120303M48233
Pubmed

TRIM46 Controls Neuronal Polarity and Axon Specification by Driving the Formation of Parallel Microtubule Arrays.

TRIM46 ANK3 TRIM36

1.47e-07943326671463
Pubmed

Large-scale proteomics and phosphoproteomics of urinary exosomes.

CUL3 STK11 PRKCA FAM20C SLC46A3 PRKCZ MYO15A TMBIM1 SRI C16orf89

3.46e-071016431019056867
Pubmed

Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.

ROCK2 CUL3 PRKCA ANK3 PPP1CA PPP1CC

6.49e-0725143627507650
Pubmed

RGS12 polarizes the GPSM2-GNAI complex to organize and elongate stereocilia in sensory hair cells.

PRKCA PRKCZ MYO15A

7.93e-071543336260679
Pubmed

In vitro evidence of the role of hemoglobin during vasospasm on the modifications of the expression of PKCalpha and zeta.

PRKCA PRKCZ

1.49e-06243217786270
Pubmed

Activation of protein kinase C zeta by peroxynitrite regulates LKB1-dependent AMP-activated protein kinase in cultured endothelial cells.

STK11 PRKCZ

1.49e-06243216407220
Pubmed

Differential activation of adenylyl cyclase by protein kinase C isoenzymes.

PRKCA PRKCZ

1.49e-0624328206971
Pubmed

Protein kinase C alpha and zeta differentially regulate death-inducing signaling complex formation in cigarette smoke extract-induced apoptosis.

PRKCA PRKCZ

1.49e-06243218354190
Pubmed

PP-1α and PP-1γ display antagonism and differential roles in tumorigenicity of lung cancer cells.

PPP1CA PPP1CC

1.49e-06243223176181
Pubmed

Replacement of Ser657 of protein kinase C-alpha by alanine leads to premature down regulation after phorbol-ester-induced translocation to the membrane.

PRKCA PRKCZ

1.49e-0624328856079
Pubmed

Rapamycin-sensitive phosphorylation of PKC on a carboxy-terminal site by an atypical PKC complex.

PRKCA PRKCZ

1.49e-06243210339425
Pubmed

Spermiogenesis is impaired in mice bearing a targeted mutation in the protein phosphatase 1cgamma gene.

PPP1CA PPP1CC

1.49e-0624329882500
Pubmed

Axonal TAU Sorting Requires the C-terminus of TAU but is Independent of ANKG and TRIM46 Enrichment at the AIS.

TRIM46 ANK3

1.49e-06243233556457
Pubmed

Mutually exclusive binding of PP1 and RNA to AKAP149 affects the mitochondrial network.

PPP1CA PPP1CC

4.48e-06343219074462
Pubmed

Isoforms of protein kinase C and their distribution in human adrenal cortex and tumors.

PRKCA PRKCZ

4.48e-06343211740573
Pubmed

1E7-03, a low MW compound targeting host protein phosphatase-1, inhibits HIV-1 transcription.

PPP1CA PPP1CC

4.48e-06343225073485
Pubmed

Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock.

PPP1CA PPP1CC

4.48e-06343221712997
Pubmed

NOM1 targets protein phosphatase I to the nucleolus.

PPP1CA PPP1CC

4.48e-06343217965019
Pubmed

Dose-dependent differential expression of protein kinase C isozymes in mouse lymphocytes after gamma irradiation in vivo and ex vivo.

PRKCA PRKCZ

4.48e-06343212643789
Pubmed

Phosphorylation of HMG-I by protein kinase C attenuates its binding affinity to the promoter regions of protein kinase C gamma and neurogranin/RC3 genes.

PRKCA PRKCZ

4.48e-06343210617144
Pubmed

The direct binding of the catalytic subunit of protein phosphatase 1 to the PKR protein kinase is necessary but not sufficient for inactivation and disruption of enzyme dimer formation.

PPP1CA PPP1CC

4.48e-06343212138106
Pubmed

Chromosomal localization of human, rat, and mouse protein phosphatase type 1 beta catalytic subunit genes (PPP1CB) by fluorescence in situ hybridization.

PPP1CA PPP1CC

4.48e-0634327857673
Pubmed

Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells.

PPP1CA PPP1CC

4.48e-06343211739654
Pubmed

Myr 8, a novel unconventional myosin expressed during brain development associates with the protein phosphatase catalytic subunits 1alpha and 1gamma1.

PPP1CA PPP1CC

4.48e-06343211588169
Pubmed

Protein kinase C alpha but not PKCzeta suppresses intestinal tumor formation in ApcMin/+ mice.

PRKCA PRKCZ

4.48e-06343216849539
Pubmed

Over-expression of protein kinase C isoforms (α, δ, θ and ζ) in squamous cervical cancer.

PRKCA PRKCZ

4.48e-06343221895402
Pubmed

Characterization of protein phosphatases in mouse oocytes.

PPP1CA PPP1CC

4.48e-0634329882488
Pubmed

Dephosphorylation of the RNA sensors RIG-I and MDA5 by the phosphatase PP1 is essential for innate immune signaling.

PPP1CA PPP1CC

8.94e-06443223499489
Pubmed

Cullin-3 regulates vascular smooth muscle function and arterial blood pressure via PPARγ and RhoA/Rho-kinase.

ROCK2 CUL3

8.94e-06443223040068
Pubmed

Nuclear targeting of protein phosphatase-1 by HIV-1 Tat protein.

PPP1CA PPP1CC

8.94e-06443216131488
Pubmed

Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1.

PPP1CA PPP1CC

8.94e-06443210194355
Pubmed

Effects of the antiandrogen flutamide on the expression of protein kinase C isoenzymes in LNCaP and PC3 human prostate cancer cells.

PRKCA PRKCZ

8.94e-06443215499829
Pubmed

Activation and substrate specificity of the human protein kinase C alpha and zeta isoenzymes.

PRKCA PRKCZ

8.94e-0644328375396
Pubmed

NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1.

PPP1CA PPP1CC

8.94e-06443210880350
Pubmed

Identification of the spermatogenic zip protein Spz1 as a putative protein phosphatase-1 (PP1) regulatory protein that specifically binds the PP1cgamma2 splice variant in mouse testis.

PPP1CA PPP1CC

8.94e-06443215226296
Pubmed

Differential dephosphorylation of the protein kinase C-zeta (PKCζ) in an integrin αIIbβ3-dependent manner in platelets.

PRKCZ PPP1CC

8.94e-06443221645497
Pubmed

Small molecules targeted to a non-catalytic "RVxF" binding site of protein phosphatase-1 inhibit HIV-1.

PPP1CA PPP1CC

8.94e-06443222768081
Pubmed

Interaction of inhibitor-2 with the catalytic subunit of type 1 protein phosphatase. Identification of a sequence analogous to the consensus type 1 protein phosphatase-binding motif.

PPP1CA PPP1CC

8.94e-06443210807923
Pubmed

Nuclear protein phosphatase-1 regulates HIV-1 transcription.

PPP1CA PPP1CC

8.94e-06443212788939
Pubmed

Expression of protein kinase C isoforms and interleukin-1beta in myofibrillar myopathy.

PRKCA PRKCZ

8.94e-06443215159477
Pubmed

Protein phosphatase 1 inhibits p53 signaling by dephosphorylating and stabilizing Mdmx.

PPP1CA PPP1CC

8.94e-06443223277204
Pubmed

The neuronal actin-binding proteins, neurabin I and neurabin II, recruit specific isoforms of protein phosphatase-1 catalytic subunits.

PPP1CA PPP1CC

8.94e-06443212016225
Pubmed

Inhibitor-2 regulates protein phosphatase-1 complexed with NimA-related kinase to induce centrosome separation.

PPP1CA PPP1CC

8.94e-06443212221103
Pubmed

Protein kinase C as a tumor suppressor.

PRKCA PRKCZ

8.94e-06443228476658
Pubmed

Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1.

PPP1CA PPP1CC

8.94e-06443212226088
Pubmed

Phosphorylation of protein phosphatase 1 by cyclin-dependent protein kinase 5 during nerve growth factor-induced PC12 cell differentiation.

PPP1CA PPP1CC

8.94e-06443217202132
Pubmed

Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cdelta.

PRKCA PRKCZ

8.94e-06443210770950
Pubmed

A vitamin D receptor-Ser/Thr phosphatase-p70 S6 kinase complex and modulation of its enzymatic activities by the ligand.

PPP1CA PPP1CC

8.94e-06443212036952
Pubmed

N-CoR controls differentiation of neural stem cells into astrocytes.

PPP1CA PPP1CC

8.94e-06443212410313
Pubmed

Synphilin-1A is a phosphoprotein phosphatase 1-interacting protein and affects PPP1 sorting to subcellular compartments.

PPP1CA PPP1CC

8.94e-06443224902662
Pubmed

APPL1 mediates adiponectin-induced LKB1 cytosolic localization through the PP2A-PKCzeta signaling pathway.

STK11 PRKCZ

8.94e-06443221835890
Pubmed

Protein kinase C isoforms have differential roles in the regulation of human sebocyte biology.

PRKCA PRKCZ

1.49e-05543222475757
Pubmed

RhoBTB1 interacts with ROCKs and inhibits invasion.

ROCK2 CUL3

1.49e-05543231431478
Pubmed

Distinct roles for the α , β and γ1 isoforms of protein phosphatase 1 in the outside-in αIIbβ3 integrin signalling-dependent functions.

PPP1CA PPP1CC

1.49e-05543223197154
Pubmed

Characterization of PDK2 activity against protein kinase B gamma.

PRKCA PRKCZ

1.49e-05543212162751
Pubmed

Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions.

PPP1CA PPP1CC

1.49e-05543219581931
Pubmed

Sds22 and Repo-Man stabilize chromosome segregation by counteracting Aurora B on anaphase kinetochores.

PPP1CA PPP1CC

1.49e-05543222801782
Pubmed

betaII protein kinase C is required for the G2/M phase transition of cell cycle.

PRKCA PRKCZ

1.49e-0554328663071
Pubmed

The heterotrimeric G protein Gβ1 interacts with the catalytic subunit of protein phosphatase 1 and modulates G protein-coupled receptor signaling in platelets.

PPP1CA PPP1CC

1.49e-05543228615442
Pubmed

Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220.

PPP1CA PPP1CC

1.49e-05543210209101
Pubmed

A PP1-PP2A phosphatase relay controls mitotic progression.

PPP1CA PPP1CC

1.49e-05543225487150
Pubmed

Protein kinase C zeta phosphorylates a subset of selective sites of the NADPH oxidase component p47phox and participates in formyl peptide-mediated neutrophil respiratory burst.

PRKCA PRKCZ

1.49e-05543211145703
Pubmed

SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1.

PPP1CA PPP1CC

1.49e-05543220424263
Pubmed

MAP2 Defines a Pre-axonal Filtering Zone to Regulate KIF1- versus KIF5-Dependent Cargo Transport in Sensory Neurons.

TRIM46 ANK3

1.49e-05543228426968
Pubmed

Cell type-specific expression of the genes for the protein kinase C family: down regulation of mRNAs for PKC alpha and nPKC epsilon upon in vitro differentiation of a mouse neuroblastoma cell line neuro 2a.

PRKCA PRKCZ

1.49e-0554322590242
Pubmed

Initiation factor 2B activity is regulated by protein phosphatase 1, which is activated by the mitogen-activated protein kinase-dependent pathway in insulin-like growth factor 1-stimulated neuronal cells.

PPP1CA PPP1CC

1.49e-05543212624094
Pubmed

The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity.

PPP1CA PPP1CC

1.49e-05543212016208
Pubmed

Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle.

PPP1CA PPP1CC

1.49e-05543211551964
Pubmed

The interaction of PP1 with BRCA1 and analysis of their expression in breast tumors.

PPP1CA PPP1CC

1.49e-05543217511879
Pubmed

The nuclear envelope protein, LAP1B, is a novel protein phosphatase 1 substrate.

PPP1CA PPP1CC

1.49e-05543224116158
Pubmed

The pleckstrin homology domain of Bruton tyrosine kinase interacts with protein kinase C.

PRKCA PRKCZ

1.49e-0554327522330
Pubmed

Differential expression of protein kinase C isoforms in coronary arteries of diabetic mice lacking the G-protein Gα11.

PRKCA PRKCZ

2.23e-05643221190563
Pubmed

Protein kinase C-theta is specifically localized on centrosomes and kinetochores in mitotic cells.

PRKCA PRKCZ

2.23e-0564329854032
Pubmed

Regulation of the tumour suppressor Fbw7α by PKC-dependent phosphorylation and cancer-associated mutations.

PRKCA PRKCZ

2.23e-05643220815813
Pubmed

Isoform-specific contribution of protein kinase C to prion processing.

PRKCA PRKCZ

2.23e-05643218722532
Pubmed

Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase.

PRKCA PRKCZ

2.23e-05643217893151
Pubmed

Interaction of Bruton's tyrosine kinase and protein kinase Ctheta in platelets. Cross-talk between tyrosine and serine/threonine kinases.

PRKCA PRKCZ

2.23e-05643211788586
Pubmed

Molecular mechanisms underlying the interaction of protein phosphatase-1c with ASPP proteins.

PPP1CA PPP1CC

2.23e-05643223088536
Pubmed

SIPP1, a novel pre-mRNA splicing factor and interactor of protein phosphatase-1.

PPP1CA PPP1CC

2.23e-05643214640981
Pubmed

Protein kinase C [micro] is regulated by the multifunctional chaperon protein p32.

PRKCA PRKCZ

2.23e-05643210831594
Pubmed

Expression and activity of protein kinase C isoenzymes during normal and abnormal murine palate development.

PRKCA PRKCZ

2.23e-05643210879655
Pubmed

The use of fluorescent phorbol esters in studies of protein kinase C-membrane interactions.

PRKCA PRKCZ

2.23e-05643212093536
Pubmed

An immunohistochemical study of protein kinase C distribution in fetal mouse vertebral column.

PRKCA PRKCZ

2.23e-0564327985811
Pubmed

Subclassification of the RBCC/TRIM superfamily reveals a novel motif necessary for microtubule binding.

TRIM46 TRIM36

2.23e-05643216434393
Pubmed

Dissociation of SHP-1 from spinophilin during platelet activation exposes an inhibitory binding site for protein phosphatase-1 (PP1).

PPP1CA PPP1CC

2.23e-05643225785436
Pubmed

Inhibitory member of the apoptosis-stimulating proteins of the p53 family (iASPP) interacts with protein phosphatase 1 via a noncanonical binding motif.

PPP1CA PPP1CC

2.23e-05643221998301
Pubmed

Platelet P-selectin expression: requirement for protein kinase C, but not protein tyrosine kinase or phosphoinositide 3-kinase.

PRKCA PRKCZ

2.23e-05643212783114
Pubmed

Protein phosphatase 1 regulates the phosphorylation state of the polarity scaffold Par-3.

PPP1CA PPP1CC

2.23e-05643218641122
Pubmed

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.

CUL3 PRKCA AGAP9 ANK3 PPP1CA

2.49e-0528143528706196
Pubmed

Protein kinase C isoforms differentially phosphorylate human choline acetyltransferase regulating its catalytic activity.

PRKCA PRKCZ

3.12e-05743215381704
Pubmed

PKC-alpha regulates cardiac contractility and propensity toward heart failure.

PRKCA PPP1CA

3.12e-05743214966518
Pubmed

The myristoylated alanine-rich C-kinase substrate (MARCKS) is sequentially phosphorylated by conventional, novel and atypical isotypes of protein kinase C.

PRKCA PRKCZ

3.12e-0574327588787
Pubmed

A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta.

PPP1CA PPP1CC

3.12e-05743212147701
Pubmed

Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complex.

PPP1CA PPP1CC

3.12e-05743210637318
Pubmed

Functional association of cytokine-induced SH2 protein and protein kinase C in activated T cells.

PRKCA PRKCZ

3.12e-05743212618484
Pubmed

Polycystin-1 binds Par3/aPKC and controls convergent extension during renal tubular morphogenesis.

PRKCA PRKCZ

3.12e-05743224153433
Pubmed

Phosphorylation of p47phox sites by PKC alpha, beta II, delta, and zeta: effect on binding to p22phox and on NADPH oxidase activation.

PRKCA PRKCZ

3.12e-05743212056906
Pubmed

Inhibitor-2 prevents protein phosphatase 1-induced cardiac hypertrophy and mortality.

PPP1CA PPP1CC

3.12e-05743218689497
Pubmed

SARP, a new alternatively spliced protein phosphatase 1 and DNA interacting protein.

PPP1CA PPP1CC

3.12e-05743217123353
Pubmed

Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases.

PRKCA PRKCZ

3.12e-05743212391145
InteractionAKAP9 interactions

CUL3 STK11 PRKCA FNIP1 CLXN PPP1CA

6.13e-06221426int:AKAP9
InteractionKCTD20 interactions

CUL3 PPP1CA PPP1CC

1.09e-0521423int:KCTD20
InteractionBTBD10 interactions

CUL3 PPP1CA PPP1CC

1.26e-0522423int:BTBD10
InteractionPPP1R2C interactions

PPP1CA PPP1CC

2.54e-054422int:PPP1R2C
InteractionCSRNP2 interactions

PPP1CA PPP1CC

4.22e-055422int:CSRNP2
InteractionPPP1R14B interactions

ROCK2 PPP1CA PPP1CC

4.81e-0534423int:PPP1R14B
InteractionPRKCH interactions

PRKCA PRKCZ ZBTB8OS

5.26e-0535423int:PRKCH
InteractionSFRP5 interactions

PPP1CA PPP1CC

6.33e-056422int:SFRP5
InteractionAKAP11 interactions

CUL3 PRKCA PPP1CA PPP1CC

6.44e-05104424int:AKAP11
InteractionSHANK3 interactions

ROCK2 CUL3 PRKCA MYO15A ANK3 NR1D1 PPP1CC

6.71e-05496427int:SHANK3
InteractionPPP1R15A interactions

CUL3 PPP1CA PPP1CC

7.88e-0540423int:PPP1R15A
InteractionAKAP13 interactions

ROCK2 CUL3 PRKCA PPP1CC

9.85e-05116424int:AKAP13
InteractionC12orf57 interactions

PPP1CA PPP1CC SRI

1.12e-0445423int:C12orf57
InteractionRORC interactions

CUL3 PPP1CA PPP1CC

1.12e-0445423int:RORC
InteractionCCNE1 interactions

CUL3 STK11 TRIM36 PPP1CA

1.16e-04121424int:CCNE1
InteractionCD2BP2 interactions

CUL3 SNRNP27 NAA35 PPP1CA PPP1CC

1.16e-04232425int:CD2BP2
GeneFamilyProtein phosphatase catalytic subunits|EF-hand domain containing

PPP1CA PPP1CC

2.49e-0413332693
GeneFamilyEF-hand domain containing

CLXN EFCAB10 CIB3 SRI

6.51e-04219334863
ToppCell10x5'-Lung-Lymphocytic_T_CD4-Tnaive/CM_CD4|Lung / Manually curated celltypes from each tissue

PRKCA ECT2L ANK3 EFCAB10 DNAH5

4.90e-0716243591cc14aec8d580cf97a1929bc1acb00fcbcdb57a
ToppCell10x5'v1-week_12-13-Myeloid_DC-DC-DC1|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

ANO9 SLC46A3 TRIM36 WDFY4 CTSV

6.04e-07169435319511ea57bbd72c2d95e8516d093689df67a912
ToppCelldistal-2-Epithelial|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CLXN ANK3 EFCAB10 DNAH5 C16orf89

1.39e-062004352fc1e95706f212bf18ecdf6eb5b3182ac98c9b52
ToppCellMild/Remission-B_intermediate-14|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

TRIM46 ECT2L SGSM1 AFG1L

8.48e-061344345bd1e3fa6278facd9e949e9e5e244e700190126b
ToppCellMild/Remission-B_intermediate-14|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

TRIM46 ECT2L SGSM1 AFG1L

1.04e-0514143469e32125a0e8f0c8561e5e7a93607f368f09546f
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CLXN EFCAB10 DNAH5 CTSV

1.88e-05164434e4d4c59aebe5cacd4ecdb907facd044dc82a831d
ToppCelldroplet-Lung-nan-3m-Myeloid-myeloid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC46A3 MYO15A TRIM36 WDFY4

1.88e-05164434a67dd181eba275c191f4d0cab13df30eaa3ad913
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL14A1 ANO9 CLDN15 C16orf89

2.02e-05167434d50311b1f66f143bae4c4cf50e2e9b13c85d6920
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL14A1 ANO9 CLDN15 C16orf89

2.02e-05167434351f8de1fbdf742ac74f9099b254d515ab539bb2
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL14A1 ANO9 CLDN15 C16orf89

2.02e-05167434c042d6cdddd0e1ddef1e3ac6f4fe23151127b0f2
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL14A1 ANO9 CLDN15 C16orf89

2.02e-051674347abc785e688a384672d7fb5a62d32538fe7e5a51
ToppCellfacs-Lung-EPCAM-3m-Epithelial-club_cell_of_bronchiole|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRKCZ MYO15A EFCAB10 DNAH5

2.16e-0517043482ccba6ec53f6ca0d19949a1277434c565af2983
ToppCellfacs-Lung-EPCAM-3m-Epithelial-Club_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRKCZ MYO15A EFCAB10 DNAH5

2.16e-05170434ab19ea729ed8c8361c870e79893d1a95a1e487fa
ToppCelldroplet-Fat-BAT+GAT+MAT-30m-Epithelial-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLXN MYO15A EFCAB10 DNAH5

2.59e-051784348b7df6ab8709d9ab9dff97677cc4561aec2745bc
ToppCelldroplet-Fat-BAT+GAT+MAT-30m-Epithelial|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLXN MYO15A EFCAB10 DNAH5

2.59e-0517843458857bb8c13e0e1c6d9f5c1258f00fff62063d68
ToppCelldroplet-Fat-BAT+GAT+MAT-30m-Epithelial-epithelial_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLXN MYO15A EFCAB10 DNAH5

2.59e-05178434b0baf5667e3301898b3e45e974b8a8530af6a338
ToppCell368C-Epithelial_cells-Epithelial-F_(Ciliated)-|368C / Donor, Lineage, Cell class and subclass (all cells)

ECT2L CLXN EFCAB10 DNAH5

2.77e-051814345a4574f1bfd0b4ca78da7effda43420857e17296
ToppCell368C-Epithelial_cells-Epithelial-F_(Ciliated)|368C / Donor, Lineage, Cell class and subclass (all cells)

ECT2L CLXN EFCAB10 DNAH5

2.77e-05181434a4e891603645f694687e68e585744ddc1a3c8697
ToppCell367C-Epithelial_cells-Epithelial-F_(Ciliated)-|367C / Donor, Lineage, Cell class and subclass (all cells)

ECT2L CLXN EFCAB10 DNAH5

2.89e-05183434b1336eac5adbffade4cef3e0ce3de75a781ae365
ToppCell367C-Epithelial_cells-Epithelial-F_(Ciliated)|367C / Donor, Lineage, Cell class and subclass (all cells)

ECT2L CLXN EFCAB10 DNAH5

2.89e-05183434cc57dcb59c68d68a546dc108dd9e009b2aab8da5
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CLXN EFCAB10 DNAH5 SRI

2.95e-051844342df903924df9cb71039159416bcbe6a6614e21fe
ToppCellCiliated_cells-B-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

ECT2L CLXN EFCAB10 DNAH5

3.01e-05185434f012c243343e1d1956db19b34d062e9b13de2b2a
ToppCell15-Airway-Epithelial-Multiciliated_cell|Airway / Age, Tissue, Lineage and Cell class

ECT2L CLXN EFCAB10 DNAH5

3.01e-051854340998b6bf44287eebbf39249fff23fc3689e44c4e
ToppCellNS-critical-d_16-33-Epithelial-Ciliated|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ECT2L CLXN EFCAB10 DNAH5

3.08e-0518643476033438426d8f9c72cd6691a7baf92104c9f03d
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ECT2L CLXN EFCAB10 DNAH5

3.14e-05187434e61992de4f98eeea08b43213850769d923f8db48
ToppCelldroplet-Lung-LUNG-1m-Epithelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLXN ANK3 EFCAB10 DNAH5

3.14e-051874346288da8cdd450c58df00ebcfcc118f01fab7e610
ToppCellCiliated_cells-B-Donor_07|World / lung cells shred on cell class, cell subclass, sample id

ECT2L CLXN EFCAB10 DNAH5

3.21e-05188434606907c865bd2f11bb6474932716550f7723d858
ToppCell(7)_Epithelial-F_(Ciliated)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

ECT2L CLXN EFCAB10 DNAH5

3.21e-051884349a8b9f745eed9f129b6c582f48fbbaaacbebb4b3
ToppCellPND07-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ECT2L CLXN EFCAB10 DNAH5

3.27e-05189434057d7a03fdbe779122b203619a6f947f49b84d28
ToppCelldroplet-Lung-1m-Epithelial|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CLXN ANK3 EFCAB10 DNAH5

3.27e-0518943472ecd5a10e419bac475e22f5b602e7f008835ce9
ToppCellPND07-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ECT2L CLXN EFCAB10 DNAH5

3.27e-051894349f57a131902d23494bf389baf6e6e2d99f88b2c8
ToppCellPND07-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ECT2L CLXN EFCAB10 DNAH5

3.27e-05189434e443b02502edaefa94567a9e8af5756e8e11ff30
ToppCellCiliated_cells-B|World / lung cells shred on cell class, cell subclass, sample id

ECT2L CLXN EFCAB10 DNAH5

3.34e-051904347031fbedc13be1a00f6333ad6d51849c3739c2e6
ToppCellASK428-Epithelial-Ciliated|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq

ECT2L CLXN EFCAB10 DNAH5

3.41e-051914340c4b926a28bc94f3cf4d68a911c0a189f6ff505e
ToppCellBAL-Mild-Epithelial-Epithelial-Ciliated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ECT2L CLXN EFCAB10 DNAH5

3.41e-051914342a8e6d560907e71e9f6e190ca0667da804e25641
ToppCellBAL-Mild-Epithelial-Epithelial-Ciliated|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

ECT2L CLXN EFCAB10 DNAH5

3.41e-051914342d36e08c5629cf73b6dd02cd173cafb52e8a3a7d
ToppCellHealthy_Control-Epithelial-Epithelial|Healthy_Control / Condition, Lineage, Cell class and cell subclass

CLXN EFCAB10 DNAH5 C16orf89

3.41e-0519143415b9386b26caaa7d15f704c4a18881e1ce918a21
ToppCellBAL-Mild-Epithelial-Epithelial-Ciliated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ECT2L CLXN EFCAB10 DNAH5

3.41e-0519143446c9d4d10c66c0fae1fa351924091b69ea2f38d4
ToppCellHealthy_Control-Epithelial-Epithelial-|Healthy_Control / Condition, Lineage, Cell class and cell subclass

CLXN EFCAB10 DNAH5 C16orf89

3.41e-0519143428caedb2e448e0c7f494100d714fa7cdcf150691
ToppCellMild_COVID-19-Epithelial-Ciliated|Mild_COVID-19 / Disease group,lineage and cell class (2021.01.30)

ECT2L CLXN EFCAB10 DNAH5

3.41e-05191434995e76bbf07674d95b8ef09e078cf6410af27a09
ToppCellHealthy_Control-Epithelial|Healthy_Control / Condition, Lineage, Cell class and cell subclass

CLXN EFCAB10 DNAH5 C16orf89

3.41e-05191434fdcdadbfc9ccae175abe4de8c7428ac4f6a67fde
ToppCellBAL-Mild-Epithelial-Epithelial-Ciliated|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ECT2L CLXN EFCAB10 DNAH5

3.41e-05191434a37f20172b85566b9039254a89680e37fd503fd5
ToppCellBronchial_Biopsy-Epithelial-Ciliated_1|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X

ECT2L CLXN EFCAB10 DNAH5

3.48e-05192434be592e661367affced9ebe80849b466e6adb3a34
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ECT2L CLXN EFCAB10 DNAH5

3.48e-051924341b6cac8156e608061e1405e36e18d185b6fa8f6f
ToppCellASK428-Epithelial-Ciliated|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq

ECT2L CLXN EFCAB10 DNAH5

3.48e-05192434356ebddd03aec341b79890977edb8ff0804999a1
ToppCellBronchial_Biopsy-Epithelial-Ciliated_1|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

ECT2L CLXN EFCAB10 DNAH5

3.55e-051934340b62a6ddd7c42efd9f39781971d1438501e1fa8d
ToppCellASK452-Epithelial-Ciliated|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq

ECT2L CLXN EFCAB10 DNAH5

3.55e-05193434c0d10075862ac878aa05fc49c8b73e470783bf16
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.3|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ECT2L CLXN EFCAB10 DNAH5

3.55e-05193434e1b76102f812c433195d1e8811fdd3293a7bc22e
ToppCellASK440-Epithelial-Ciliated|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq

ECT2L CLXN EFCAB10 DNAH5

3.55e-05193434a0baa8be6f590b2031fede22be588715ae458e93
ToppCellASK452-Epithelial-Ciliated|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq

ECT2L CLXN EFCAB10 DNAH5

3.63e-051944345aeb44657ab6f61b1abf98af28d3397d8e44c1aa
ToppCellNS-critical-d_07-13-Epithelial-Ciliated|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ECT2L CLXN EFCAB10 DNAH5

3.63e-051944341ae8a10e508e672e6677f0e3c986ac30d05adeb3
ToppCellCOVID-19-Epithelial-Ciliated_cells|COVID-19 / Condition, Lineage and Cell class

ECT2L CLXN EFCAB10 DNAH5

3.63e-0519443443be5fbd51dd58839cb03ca3ddd05a458e1ddb74
ToppCellIPF-Multiplet-Multiplet|IPF / Disease state, Lineage and Cell class

ECT2L CLXN ANK3 DNAH5

3.70e-05195434fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCellnormal_Lung-Epithelial_cells-Ciliated|Epithelial_cells / Location, Cell class and cell subclass

CLXN EFCAB10 DNAH5 SRI

3.70e-05195434a3e2999fdd4c3575add6e28ecfd1d6606a61f992
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ECT2L CLXN EFCAB10 DNAH5

3.70e-0519543493b1559382a12cfb158aa5fac7386e38b4f87989
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ECT2L CLXN EFCAB10 DNAH5

3.70e-051954342d19148df56e99f66b596af2d7f9d0f10f9a9087
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ECT2L CLXN EFCAB10 DNAH5

3.70e-05195434cd6cfe3ef150a4a4575e04fc8a8213cdceefa1c4
ToppCellIPF-Multiplet|IPF / Disease state, Lineage and Cell class

ECT2L CLXN ANK3 DNAH5

3.70e-05195434eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ECT2L CLXN EFCAB10 DNAH5

3.70e-051954340e763f36786515698b593e5c93f6a56619c1242d
ToppCellIPF-Multiplet-Multiplet|World / Disease state, Lineage and Cell class

ECT2L CLXN ANK3 DNAH5

3.70e-0519543421dbdc803c6947024dc2416e9e21c2ef0af9bc31
ToppCellmoderate-Epithelial-Ciliated|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

ECT2L CLXN EFCAB10 DNAH5

3.70e-051954343486eae5fdb062a75a907b896c9d7b396d2aa195
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ECT2L CLXN EFCAB10 DNAH5

3.70e-05195434e22ca35bea06aa95ff2cc771632969f5e7229ffc
ToppCellmoderate-Epithelial-Ciliated|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

ECT2L CLXN EFCAB10 DNAH5

3.70e-05195434e80f5cdf0b18066b3e6c2f5452e58f101c67932c
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ECT2L CLXN EFCAB10 DNAH5

3.70e-051954349651ee03738226ee10e901f8b9ec6a417eb9c301
ToppCellBL-critical-LOC-Epithelial-Ciliated|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ECT2L CLXN EFCAB10 DNAH5

3.70e-0519543407a6bcef6af93ed87df455dee624037cb75e011a
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ECT2L CLXN EFCAB10 DNAH5

3.70e-05195434581b04220587e1d5198b1abd6965965ace7803e7
ToppCellControl-Epithelial|Control / Disease state, Lineage and Cell class

PRKCZ ANK3 DNAH5 C16orf89

3.70e-051954341798c3b89b1b5ff4f5777d2b9f52dc81cdad28fa
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ECT2L CLXN EFCAB10 DNAH5

3.70e-0519543443f0c257e4bb5c627afbdfc695c1199c672842d3
ToppCellBAL-Severe-Epithelial-Epithelial-Ciliated|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

ECT2L CLXN EFCAB10 DNAH5

3.77e-05196434ca56311edc6788e032e7635fa69b1e07035202b5
ToppCellSevere_COVID-19-Epithelial-Ciliated|Severe_COVID-19 / Disease group,lineage and cell class (2021.01.30)

ECT2L CLXN EFCAB10 DNAH5

3.77e-051964341cdef976a754c90d18b6149d367bd64e6e99b0a9
ToppCellcritical-Epithelial-Ciliated|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

ECT2L CLXN EFCAB10 DNAH5

3.77e-0519643427b855c6e1ae44f16db998cf0e81bd686b9cee7e
ToppCellNS-control-d_0-4-Epithelial-Ciliated|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ECT2L CLXN EFCAB10 DNAH5

3.77e-05196434d46ab80554dd3c1cc81e1938ea2acfd5e85c6d2a
ToppCellIPF-Epithelial|IPF / Disease state, Lineage and Cell class

ECT2L CLXN ANK3 DNAH5

3.77e-0519643487d9881cfec461a5d89b688a83749b618c519485
ToppCellBAL-Severe-Epithelial-Epithelial-Ciliated|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ECT2L CLXN EFCAB10 DNAH5

3.77e-05196434686a5a0ddb00929842c1c98445c59edfcc9a8a04
ToppCellBAL-Severe-Epithelial-Epithelial-Ciliated-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ECT2L CLXN EFCAB10 DNAH5

3.77e-0519643469f5081e06d84ec1d9695762df801a9d0df1984b
ToppCellBAL-Severe-Epithelial-Epithelial-Ciliated-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ECT2L CLXN EFCAB10 DNAH5

3.77e-0519643467aefc480714e4b8c9ae53c036efdc07ec6f94af
ToppCellPSB-critical-LOC-Epithelial-Ciliated|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ECT2L CLXN EFCAB10 DNAH5

3.85e-051974346865f4831eb23794fb88a8649d48d497bbae3f44
ToppCellNS-critical-d_16-33-Epithelial-Ciliated-diff|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CLXN EFCAB10 DNAH5 SRI

3.85e-05197434009dc732c43bfdc0d5a662b2c7d1a7a86b0d1d24
ToppCellcontrol-Epithelial-Ciliated|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

ECT2L CLXN EFCAB10 DNAH5

3.85e-05197434d4e963c1f82996371bf3d63578ee9fce8e00c5a8
ToppCellcontrol-Epithelial-Ciliated|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

ECT2L CLXN EFCAB10 DNAH5

3.85e-05197434e453d085182364ca347cbcc9dc995c62c3353016
ToppCellLPS_only-Epithelial_airway-airway_epithelial|LPS_only / Treatment groups by lineage, cell group, cell type

EFCAB10 DNAH5 CTSV C16orf89

3.93e-05198434e035380578c01b0243bfef29ca9b50cc17cce771
ToppCellLPS_only-Epithelial_airway|LPS_only / Treatment groups by lineage, cell group, cell type

EFCAB10 DNAH5 CTSV C16orf89

3.93e-05198434ba090210392e001a3f7bdf09371b3f0e0c8c7ef3
ToppCellcritical-Epithelial-Ciliated|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

ECT2L CLXN EFCAB10 DNAH5

3.93e-05198434ee2c8385c0bf4ea9f5c9517b52cf131af3fbdd40
ToppCellproximal-Epithelial-Ciliated|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ECT2L CLXN EFCAB10 DNAH5

4.00e-051994349700f06e51ddca85e482b4f9bd4a79bfcd3cfb76
ToppCellmedial-Epithelial-Ciliated-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ECT2L CLXN EFCAB10 DNAH5

4.00e-05199434526002f16bbf61cf086278d45a401cc0b0b757a8
ToppCelldistal-Epithelial-Ciliated-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ECT2L CLXN EFCAB10 DNAH5

4.00e-051994342de1fe124737a6cca4b3805ab3056f9d9d7c16c7
ToppCellproximal-3-Epithelial-Ciliated|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ECT2L CLXN EFCAB10 DNAH5

4.00e-051994341188afad6fd5f01f9aeba225f611f38b237dd2c9
ToppCelldistal-3-Epithelial-Ciliated|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ECT2L CLXN EFCAB10 DNAH5

4.00e-051994347e5f29f4ec1fea92f2c0064eea151d2d474ef904
ToppCellmedial-Epithelial-Ciliated|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ECT2L CLXN EFCAB10 DNAH5

4.00e-05199434a2daa42b100c422dc8c04fb7d2ebf54293eef574
ToppCelldistal-Epithelial-Ciliated|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ECT2L CLXN EFCAB10 DNAH5

4.00e-0519943418ca031cfe702afb9bf94e03c0f3680c38e7599e
ToppCellproximal-Epithelial-Ciliated-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ECT2L CLXN EFCAB10 DNAH5

4.00e-051994342e8ace105c4e2405baa06d953e52888b54e2d055
ToppCelldistal-2-Epithelial-Ciliated|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ECT2L CLXN EFCAB10 DNAH5

4.00e-0519943497b66b82c76c7bc1fcd7da7b94dd2aa2d4d70a60
ToppCellmedial-2-Epithelial-Ciliated|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ECT2L CLXN EFCAB10 DNAH5

4.00e-05199434c02f04a5aa79ee0cf427f6e94b93ceab38ebbcd7
ToppCellBiopsy_Control_(H.)-Epithelial-Ciliated|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

ECT2L CLXN EFCAB10 DNAH5

4.08e-052004349ae434c78e08adf95da49c85616e3ca72d1227bf
ToppCellBronchial-10x5prime-Epithelial-Epi_airway_ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ECT2L CLXN EFCAB10 DNAH5

4.08e-0520043452aef65f01b06cd98056f17977efe525aee6eb6f
ToppCellParenchyma_COVID-19-Epithelial-TX|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

CLXN ANK3 DNAH5 C16orf89

4.08e-05200434d5426cd318a8f90c0bd8f9804351ab230fafc995
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_ciliated-Ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ECT2L CLXN EFCAB10 DNAH5

4.08e-0520043412bc7d95c4166d12487081a76d210b7abe5991b0
ToppCellLPS_IL1RA_TNF-Epithelial_airway-airway_epithelial-Ciliated|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ECT2L EFCAB10 CIB3 DNAH5

4.08e-0520043496701a4d57753f5ec0dd5c7550054bbcc946bc5f
ToppCellBronchial-10x5prime-Epithelial-Epi_airway_ciliated-Ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ECT2L CLXN EFCAB10 DNAH5

4.08e-0520043455c148238d5c80c1faa3428a917ae8075be2c145
ToppCellmedial-2-Epithelial|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CLXN ANK3 DNAH5 C16orf89

4.08e-052004340079041c3e654c1ef77c492bdb2f31ce8f4b507b
Drugtautomycin

ROCK2 STK11 PRKCA PRKCZ PPP1CA PPP1CC

8.89e-08118436CID000440646
Diseasehyperthyroidism (biomarker_via_orthology)

STK11 NR1D1 CTSV

9.21e-0628433DOID:7998 (biomarker_via_orthology)
DiseaseOpitz GBBB syndrome (implicated_via_orthology)

TRIM46 TRIM36

3.10e-056432DOID:0080697 (implicated_via_orthology)
Diseasepsychotic symptoms

STK11 ANK3 WDFY4

1.74e-0474433EFO_0005940
DiseaseCardiac Hypertrophy

ROCK2 PRKCA PRKCZ

2.36e-0482433C1383860
DiseaseCardiomegaly

ROCK2 PRKCA PRKCZ

2.36e-0482433C0018800
Diseasecongestive heart failure (biomarker_via_orthology)

PRKCA PPP1CC SRI

5.15e-04107433DOID:6000 (biomarker_via_orthology)
Diseasesmoking cessation

CUL3 MED18 PRKCZ ANK3

1.27e-03325434EFO_0004319
Diseasesusceptibility to bacterial meningitis measurement

ANK3 DNAH5

2.63e-0352432EFO_0008411
DiseaseMetastatic melanoma

ROCK2 STK11

2.83e-0354432C0278883
DiseaseNonorganic psychosis

PRKCA ANK3

4.57e-0369432C0349204
DiseaseBipolar Disorder

PRKCZ ANK3 NR1D1 AFG1L

5.06e-03477434C0005586
DiseaseIGF-1 measurement

PRKCA CCDC47 PPP1CA AFG1L

5.48e-03488434EFO_0004627
DiseaseAntihypertensive use measurement

PDP2 MED18 TRIM36

6.78e-03265433EFO_0009927

Protein segments in the cluster

PeptideGeneStartEntry
CAMAMFGYMTDTGTV

ZBTB8OS

56

Q8IWT0
ESMGSEDMLFMLYTS

ACSS1

281

Q9NUB1
EDMLFMLYTSGSTGM

ACSS1

286

Q9NUB1
FMENIMFCGMGGFSD

C16orf89

251

Q6UX73
LMLIDASFGFEMEMF

AGAP9

46

Q5VTM2
GDMTNEEFRQMMGCF

CTSV

81

O60911
GDVGTGKTMVMDMFY

AFG1L

136

Q8WV93
ISGRMIGQFMFDTMG

ECT2L

486

Q008S8
PVNTFSLFDEFMEMM

ANO9

531

A1A5B4
MENMVTVGFFSCMGT

KCNK9

156

Q9NPC2
FTFAMGFMTGTISSM

TMBIM1

171

Q969X1
ATDMFLAVMRFMGDA

MYO15A

3071

Q9UKN7
GEVTDGMMDTKMVHF

CCDC47

306

Q96A33
SENLTDFLMEMGFRM

MED18

111

Q9BUE0
FDNAGAMMSVDETLM

PPP1CA

276

P62136
MGMGDLLSAMFDFSE

NR1D1

511

P20393
MEMGLSIEEALMYSF

PDP2

221

Q9P2J9
MFEMMDSSGRGTISF

EFCAB10

71

A6NFE3
ILDVMDMTIFDFLMG

FAM20C

441

Q8IXL6
DLAGFKMMEMFGLVE

COL14A1

1226

Q05707
EMMFGSVAMSYKGST

FNIP1

131

Q8TF40
EGMFRDMSISNTTMD

CUL3

471

Q13618
MEMSGLSFSEMEGCR

C3orf38

1

Q5JPI3
GKMFEMTRSGAIDMS

ANK3

3606

Q12955
MSMAVETFGFFMATV

CLDN15

1

P56746
DRAVMLGFAMMGFSV

KCNMB3

56

Q9NPA1
EMLRVGFMMSVAVGF

SLC38A10

271

Q9HBR0
IRGAGMDMVFFADAM

DNAH5

2921

Q8TE73
MSESGEMSEFGYIME

TRIM36

1

Q9NQ86
MAEGEDMQTFTSIMD

TRIM46

1

Q7Z4K8
DFGMCKEHMMDGVTT

PRKCA

481

P17252
IEMMKLMGFASFDST

SNRNP27

101

Q8WVK2
GIFTTMTGMAMTAFA

SLC46A3

331

Q7Z3Q1
MFTEGELMSVGMDTF

STK11

11

Q15831
FLDMFSVMSEMAPRD

CIB3

91

Q96Q77
FGMTDDMIMDRVFRG

CLXN

61

Q9HAE3
CAGMFKTMVAFDMDG

NAA35

586

Q5VZE5
ITDRVEMGQMASMFF

TMEM104

126

Q8NE00
EMGQMASMFFNKVGV

TMEM104

131

Q8NE00
MELFHMTSGGDAAMF

WDFY4

1926

Q6ZS81
ADFGTCMKMDETGMV

ROCK2

231

O75116
SMDEFMSITGSLDMA

SGSM1

846

Q2NKQ1
FDNAGAMMSVDETLM

PPP1CC

276

P36873
MLDRDMSGTMGFNEF

SRI

81

P30626
MFEMMAGRSPFDIIT

PRKCZ

441

Q05513