Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transcription factor binding	DACT2 NCOA3 MAGEA10 MED1 PBX1 TRIP12 TP53BP1 KAT6A	1.10e-05	753	30	8	GO:0008134
GeneOntologyMolecularFunction	nuclear thyroid hormone receptor binding	NCOA3 MED1 TRIP12	1.77e-05	34	30	3	GO:0046966
GeneOntologyMolecularFunction	DNA-binding transcription factor binding	NCOA3 MAGEA10 MED1 PBX1 TRIP12 TP53BP1 KAT6A	1.96e-05	582	30	7	GO:0140297
GeneOntologyMolecularFunction	protein-macromolecule adaptor activity	NCOA3 ATG14 SPAG9 MED1 GOLGA5 CBFA2T3 RBM47 TP53BP1 KAT6A	3.44e-05	1160	30	9	GO:0030674
GeneOntologyMolecularFunction	molecular adaptor activity	NCOA3 ATG14 SPAG9 MED1 GOLGA5 CBFA2T3 RBM47 TP53BP1 KAT6A	1.16e-04	1356	30	9	GO:0060090
GeneOntologyMolecularFunction	peroxisome proliferator activated receptor binding	NCOA3 MED1	4.50e-04	21	30	2	GO:0042975
GeneOntologyMolecularFunction	transcription coregulator activity	NCOA3 MED1 CBFA2T3 TP53BP1 KAT6A	1.38e-03	562	30	5	GO:0003712
GeneOntologyMolecularFunction	histone acetyltransferase activity	NCOA3 KAT6A	2.66e-03	51	30	2	GO:0004402
GeneOntologyMolecularFunction	nuclear receptor binding	NCOA3 MED1 TRIP12	2.72e-03	187	30	3	GO:0016922
GeneOntologyMolecularFunction	nuclear estrogen receptor binding	NCOA3 MED1	2.87e-03	53	30	2	GO:0030331
GeneOntologyMolecularFunction	peptide-lysine-N-acetyltransferase activity	NCOA3 KAT6A	3.08e-03	55	30	2	GO:0061733
GeneOntologyMolecularFunction	RNA polymerase II-specific DNA-binding transcription factor binding	NCOA3 MED1 TRIP12 TP53BP1	3.34e-03	417	30	4	GO:0061629
GeneOntologyMolecularFunction	peptide N-acetyltransferase activity	NCOA3 KAT6A	3.66e-03	60	30	2	GO:0034212
GeneOntologyMolecularFunction	nuclear receptor coactivator activity	NCOA3 MED1	3.78e-03	61	30	2	GO:0030374
GeneOntologyBiologicalProcess	embryonic hemopoiesis	MED1 PBX1 KAT6A	1.34e-05	32	30	3	GO:0035162
GeneOntologyBiologicalProcess	thelarche	NCOA3 MED1	3.06e-05	6	30	2	GO:0042695
GeneOntologyBiologicalProcess	mammary gland branching involved in thelarche	NCOA3 MED1	3.06e-05	6	30	2	GO:0060744
GeneOntologyBiologicalProcess	development of secondary female sexual characteristics	NCOA3 MED1	9.14e-05	10	30	2	GO:0046543
GeneOntologyBiologicalProcess	positive regulation of cytokine-mediated signaling pathway	LSM14A MED1 RBM47	1.09e-04	64	30	3	GO:0001961
GeneOntologyBiologicalProcess	positive regulation of intracellular estrogen receptor signaling pathway	NCOA3 MED1	1.34e-04	12	30	2	GO:0033148
GeneOntologyBiologicalProcess	positive regulation of response to cytokine stimulus	LSM14A MED1 RBM47	1.48e-04	71	30	3	GO:0060760
GeneOntologyBiologicalProcess	development of secondary sexual characteristics	NCOA3 MED1	1.58e-04	13	30	2	GO:0045136
GeneOntologyBiologicalProcess	positive regulation of intracellular steroid hormone receptor signaling pathway	NCOA3 MED1	3.08e-04	18	30	2	GO:0033145
GeneOntologyBiologicalProcess	negative regulation of neuron differentiation	SPAG9 MED1 PBX1	3.40e-04	94	30	3	GO:0045665
GeneOntologyBiologicalProcess	positive regulation of keratinocyte differentiation	NCOA3 MED1	3.44e-04	19	30	2	GO:0045618
GeneOntologyBiologicalProcess	positive regulation of type I interferon-mediated signaling pathway	LSM14A RBM47	4.22e-04	21	30	2	GO:0060340
HumanPheno	Low hanging columella	TRIO TRIP12 KAT6A	2.46e-05	56	6	3	HP:0009765
HumanPheno	Anteverted ears	PBX1 KAT6A	1.05e-04	14	6	2	HP:0040080
HumanPheno	Sandal gap	TRIO TRIP12 KAT6A	1.25e-04	96	6	3	HP:0001852
HumanPheno	Abnormal columella morphology	TRIO TRIP12 KAT6A	1.28e-04	97	6	3	HP:0009929
HumanPheno	Abnormal nasal septum morphology	TRIO TRIP12 KAT6A	2.13e-04	115	6	3	HP:0000419
HumanPheno	Thin upper lip vermilion	PBX1 TRIO TRIP12 KAT6A	2.60e-04	339	6	4	HP:0000219
HumanPheno	Thin lips	PBX1 TRIO TRIP12 KAT6A	2.60e-04	339	6	4	HP:0000213
Domain	CRAL_TRIO	TRIO SEC14L5	5.49e-04	21	31	2	PF00650
Domain	-	TRIO SEC14L5	6.60e-04	23	31	2	3.40.525.10
Domain	SEC14	TRIO SEC14L5	7.81e-04	25	31	2	SM00516
Domain	CRAL_TRIO	TRIO SEC14L5	9.12e-04	27	31	2	PS50191
Domain	CRAL-TRIO_dom	TRIO SEC14L5	9.81e-04	28	31	2	IPR001251
Pubmed	NCOA3, a new fusion partner for MOZ/MYST3 in M5 acute myeloid leukemia.	NCOA3 KAT6A	7.69e-07	2	31	2	17805331
Pubmed	Extracellular vesicle-derived TP53BP1, CD34, and PBX1 from human peripheral blood serve as potential biomarkers for the assessment and prediction of vascular aging.	PBX1 TP53BP1	2.31e-06	3	31	2	38173016
Pubmed	Differential role of two VDR coactivators, DRIP205 and SRC-3, in keratinocyte proliferation and differentiation.	NCOA3 MED1	2.31e-06	3	31	2	17223341
Pubmed	Regulation of human epidermal keratinocyte differentiation by the vitamin D receptor and its coactivators DRIP205, SRC2, and SRC3.	NCOA3 MED1	2.31e-06	3	31	2	17082781
Pubmed	Ubiquitin-specific protease 4 inhibits mono-ubiquitination of the master growth factor signaling kinase PDK1.	USP4 PDPK1	2.31e-06	3	31	2	22347420
Pubmed	Regulation of the BRCA1 gene by an SRC3/53BP1 complex.	NCOA3 TP53BP1	4.61e-06	4	31	2	21914189
Pubmed	Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.	SPAG9 UBAP2 GOLGA5 PDPK1	5.94e-06	133	31	4	15144186
Pubmed	Regulation of the human cyclin C gene via multiple vitamin D3-responsive regions in its promoter.	NCOA3 MED1	7.68e-06	5	31	2	15863722
Pubmed	TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes.	TRIP12 TP53BP1	7.68e-06	5	31	2	22884692
Pubmed	Spatio-temporal activation of chromatin on the human CYP24 gene promoter in the presence of 1alpha,25-Dihydroxyvitamin D3.	NCOA3 MED1	1.15e-05	6	31	2	15919092
Pubmed	Discrete roles for peroxisome proliferator-activated receptor gamma and retinoid X receptor in recruiting nuclear receptor coactivators.	NCOA3 MED1	1.15e-05	6	31	2	11027271
Pubmed	Temporal formation of distinct thyroid hormone receptor coactivator complexes in HeLa cells.	NCOA3 MED1	1.61e-05	7	31	2	11117530
Pubmed	The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine.	NCOA3 MED1	1.61e-05	7	31	2	12709428
Pubmed	Dynamic microtubules catalyze formation of navigator-TRIO complexes to regulate neurite extension.	NAV3 TRIO	1.61e-05	7	31	2	25065758
Pubmed	ATM-phosphorylated SPOP contributes to 53BP1 exclusion from chromatin during DNA replication.	NCOA3 TP53BP1	1.61e-05	7	31	2	34144977
Pubmed	The activation function-1 domain of Nur77/NR4A1 mediates trans-activation, cell specificity, and coactivator recruitment.	NCOA3 MED1	2.15e-05	8	31	2	12082103
Pubmed	Identification of the antibiotic ionomycin as an unexpected peroxisome proliferator-activated receptor γ (PPARγ) ligand with a unique binding mode and effective glucose-lowering activity in a mouse model of diabetes.	NCOA3 MED1	2.15e-05	8	31	2	23178929
Pubmed	The Wnt Signaling Antagonist Dapper1 Accelerates Dishevelled2 Degradation via Promoting Its Ubiquitination and Aggregate-induced Autophagy.	DACT2 ATG14	2.76e-05	9	31	2	25825496
Pubmed	Enhancer activation requires trans-recruitment of a mega transcription factor complex.	NCOA3 MED1	3.44e-05	10	31	2	25303530
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	NCOA3 SPAG9 MED1 TRIP12 PDPK1 TP53BP1	5.46e-05	774	31	6	15302935
Pubmed	Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk.	NCOA3 MED1	5.96e-05	13	31	2	19255064
Pubmed	The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair.	TRIP12 TP53BP1	5.96e-05	13	31	2	29499138
Pubmed	Regulation of glucocorticoid receptor activity by 14--3-3-dependent intracellular relocalization of the corepressor RIP140.	NCOA3 MED1	5.96e-05	13	31	2	11266503
Pubmed	Multiplexed molecular interactions of nuclear receptors using fluorescent microspheres.	NCOA3 MED1	6.95e-05	14	31	2	11500849
Pubmed	JIP4 is a PLK1 binding protein that regulates p38MAPK activity in G2 phase.	SPAG9 TP53BP1	9.16e-05	16	31	2	26291670
Pubmed	Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone action.	NCOA3 MED1	9.16e-05	16	31	2	10882104
Pubmed	Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort.	NCOA3 MED1	1.04e-04	17	31	2	19183483
Pubmed	Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus.	AMY2B PBX1	1.17e-04	18	31	2	11912494
Pubmed	Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor.	MED1 TRIP12	1.17e-04	18	31	2	7776974
Pubmed	Disruption of exon-bridging interactions between the minor and major spliceosomes results in alternative splicing around minor introns.	E2F3 PDPK1	1.30e-04	19	31	2	33660780
Pubmed	T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities.	NCOA3 MED1	1.45e-04	20	31	2	11877444
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	LSM14A SPAG9 UBAP2 MED1 GOLGA5 TP53BP1	1.53e-04	934	31	6	33916271
Pubmed	Ubiquitin-specific protease 7 sustains DNA damage response and promotes cervical carcinogenesis.	TRIP12 TP53BP1	1.60e-04	21	31	2	30179224
Pubmed	Nuclear receptor-coregulator interaction profiling identifies TRIP3 as a novel peroxisome proliferator-activated receptor gamma cofactor.	NCOA3 MED1	1.60e-04	21	31	2	19596656
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	E2F3 TRIO SEC14L5 KAT6A	2.09e-04	332	31	4	37433992
Pubmed	Human transcription factor protein interaction networks.	NCOA3 E2F3 LSM14A SPAG9 UBAP2 PBX1 TP53BP1	2.15e-04	1429	31	7	35140242
Pubmed	The cooperative function of nuclear receptor coactivator 1 (NCOA1) and NCOA3 in placental development and embryo survival.	NCOA3 PDPK1	2.47e-04	26	31	2	20685850
Pubmed	Increased gene copy number of VAMP7 disrupts human male urogenital development through altered estrogen action.	NCOA3 MED1	2.86e-04	28	31	2	24880616
Pubmed	TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains.	MED1 TRIP12	3.99e-04	33	31	2	33567268
Pubmed	Downregulation of HERC5 E3 ligase attenuates the ubiquitination of CtBP1 to inhibit apoptosis in colorectal cancer cells.	UBAP2 MED1	5.02e-04	37	31	2	34147029
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	ATG14 LSM14A MED1 TRIP12 KAT6A	5.18e-04	759	31	5	35915203
Pubmed	Mutation of ARHGAP9 in patients with coronary spastic angina.	TRIO CHN2	5.30e-04	38	31	2	19911011
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	UBAP2 MED1 TRIP12 TP53BP1	6.07e-04	440	31	4	34244565
Pubmed	Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.	E2F3 TRIP12	6.47e-04	42	31	2	7584044
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	MED1 TRIO TRIP12	7.70e-04	202	31	3	33005030
Pubmed	Genetic variations strongly influence phenotypic outcome in the mouse retina.	MED1 TP53BP1	7.77e-04	46	31	2	21779340
Pubmed	A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.	MAGEA10 ATG14 RWDD3	8.03e-04	205	31	3	12040188
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	NAV3 LSM14A TRIO TP53BP1	8.07e-04	475	31	4	31040226
Pubmed	An Interaction Landscape of Ubiquitin Signaling.	USP4 LSM14A TRIP12 PDPK1	8.46e-04	481	31	4	28190767
Interaction	MEX3A interactions	E2F3 LSM14A TRIO RBM47 SEC14L5 KAT6A	1.86e-05	384	30	6	int:MEX3A
Interaction	YWHAH interactions	NCOA3 USP4 UBAP2 SNCAIP MED1 TRIO TRIP12 STARD9 PDPK1	2.13e-05	1102	30	9	int:YWHAH
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	NCOA3 KAT6A	1.41e-04	17	19	2	486
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	NAV3 NCOA3 E2F3 SPAG9 MED1 TRIO TRIP12 TP53BP1 KAT6A	4.28e-07	856	31	9	M4500
Coexpression	GSE7548_NAIVE_VS_DAY7_PCC_IMMUNIZATION_CD4_TCELL_UP	USP4 ATG14 LSM14A RWDD3 CBFA2T3	3.56e-06	200	31	5	M6836
Coexpression	DAZARD_RESPONSE_TO_UV_NHEK_DN	NAV3 NCOA3 E2F3 LSM14A KAT6A	2.53e-05	300	31	5	M8702
Coexpression	RAFFEL_VEGFA_TARGETS_UP	E2F3 PBX1	4.85e-05	9	31	2	MM920
Coexpression	RAFFEL_VEGFA_TARGETS_UP	E2F3 PBX1	4.85e-05	9	31	2	M2357
Coexpression	GSE30153_LUPUS_VS_HEALTHY_DONOR_BCELL_DN	SPAG9 CBFA2T3 PDPK1 GRK1	8.47e-05	198	31	4	M8424
Coexpression	GSE33162_HDAC3_KO_VS_HDAC3_KO_4H_LPS_STIM_MACROPHAGE_UP	GOLGA5 PDPK1 TP53BP1 KAT6A	8.81e-05	200	31	4	M9041
Coexpression	GAUCHER_PBMC_YF_VAX_STAMARIL_UNKNOWN_AGE_14DY_DN	ANAPC16 RBM47	8.87e-05	12	31	2	M41057
Coexpression	SMID_BREAST_CANCER_BASAL_DN	NAV3 NCOA3 PBX1 CBFA2T3 CHN2 RBM47	1.47e-04	699	31	6	M4960
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN	NCOA3 E2F3 TRIO TRIP12 KAT6A	2.02e-04	466	31	5	M13522
Coexpression	CHOI_ATL_CHRONIC_VS_ACUTE_DN	NCOA3 ANAPC16	2.29e-04	19	31	2	M609
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Myeloid\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	UBAP2 GOLGA5 PBX1 KAT6A	1.09e-05	200	31	4	cc8368665bc6bb7c4f39632ccff07ceaa98a7b65
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Myeloid-Megakaryocyte\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	UBAP2 GOLGA5 PBX1 KAT6A	1.09e-05	200	31	4	0d76b006d8e8b32174e65e400acd0674354b962c
Computational	Genes in the cancer module 36.	E2F3 AMY2B MED1 TRIP12	2.44e-04	162	21	4	MODULE_36
Drug	novobiocin sodium, USP; Up 200; 100uM; SKMEL5; HG-U133A	SPAG9 MED1 GOLGA5 PDPK1 TP53BP1	5.65e-06	198	30	5	632_UP
Disease	triacylglycerol 58:12 measurement	E2F3 TRIP12	6.55e-05	12	30	2	EFO_0010439
Disease	Malignant neoplasm of liver	DACT2 TRIO CHN2	4.03e-04	142	30	3	C0345904
Disease	Liver neoplasms	DACT2 TRIO CHN2	4.03e-04	142	30	3	C0023903
Disease	Non-Small Cell Lung Carcinoma	NCOA3 E2F3 TP53BP1	5.30e-04	156	30	3	C0007131
Disease	congestive heart failure (implicated_via_orthology)	MED1 GRK1	7.99e-04	41	30	2	DOID:6000 (implicated_via_orthology)
Disease	total blood protein measurement	NCOA3 USP4 CBFA2T3 RBM47	1.06e-03	449	30	4	EFO_0004536
Disease	smoking status measurement, carotid artery intima media thickness	RBM47 TRIP12	1.09e-03	48	30	2	EFO_0006527, EFO_0007117
Disease	osteoporosis	UBAP2 MUC22	2.51e-03	73	30	2	EFO_0003882
Disease	serum albumin measurement	E2F3 SPAG9 RBM47 TP53BP1	2.90e-03	592	30	4	EFO_0004535
Disease	lymphocyte count	E2F3 USP4 UBAP2 PBX1 MUC22 TRIP12	3.14e-03	1464	30	6	EFO_0004587
Disease	Neurodevelopmental Disorders	TRIO TRIP12	4.04e-03	93	30	2	C1535926

Protein segments in the cluster

Peptide	Gene	Start	Entry
MAASSSSSSAGGVSG	ANAPC16	1	Q96DE5
ASSSAGGMISSAAAS	ATG14	466	Q6ZNE5
HMSGNAVSAGTSSTC	AMY2B	116	P19961
STAAMSSDSAAGSSA	RBM47	6	A0AV96
ASLCGSMTSNSSAET	SPAG9	821	O60271
SAGSSSSFNMSNSGD	PBX1	331	P40424
TTAMASASSSATGSF	MAGEA10	351	P43363
SSAGSGTTTASMAGS	MUC22	331	E2RYF6
MNSASGSSSNGSSIN	GOLGA5	626	Q8TBA6
SSSSSSGLSFTACMS	KIAA1109	4141	Q2LD37
SGASASASSSSASMV	FAM199X	276	Q6PEV8
SCTMTVAQSSGQSTG	NAV3	596	Q8IVL0
MSCSSRASSSRAGGS	KRT24	1	Q2M2I5
SSLGSSTSSFQSMGS	LSM14A	96	Q8ND56
ASSASGSTCGSMSQT	CBFA2T3	11	O75081
STMGGSICGNSSSQS	KAT6A	1571	Q92794
MAASSNSSLSGSSVS	CHN2	1	P52757
MSDGGSCSLSTSCAS	DACT2	131	Q5SW24
ASTNSGHSDCSVSMG	E2F3	381	O00716
GISGGSSSSSKSGMC	GRK1	546	Q15835
GSMSSLESCTSGFSQ	SEC14L5	661	O43304
CTASSSSFSSSGSSM	MED1	1266	Q15648
SGSSMSSSQNQHGSS	MED1	1276	Q15648
SQFGCMQVSSSSSSH	PDPK1	381	O15530
SSTSGGVSSTSNMHG	NCOA3	661	Q9Y6Q9
ACSTGSSESSSSNMA	SNCAIP	191	Q9Y6H5
LCTSSNGSLSSGMTS	STARD9	4396	Q9P2P6
GSGSEKCTFSTSTTM	RWDD3	121	Q9Y3V2
SASSGASLSSSMNTA	UBAP2	751	Q5T6F2
ANGDSTSTCGMHSSG	USP4	261	Q13107
SSGTSLSAMHSSGSS	TP53BP1	1316	Q12888
ACTNGSGSMGSTTSV	TRIP12	946	Q14669
SGTLSKSSSSGMQSC	TRIO	1841	O75962