Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessheart contraction

CACNA1E CORIN PIK3CA TRPC1 SCN8A MC3R

3.36e-05298436GO:0060047
GeneOntologyBiologicalProcessheart process

CACNA1E CORIN PIK3CA TRPC1 SCN8A MC3R

4.12e-05309436GO:0003015
DomainRibosomal_S26e

RPS26 RPS26P11

5.42e-062442IPR000892
DomainRIBOSOMAL_S26E

RPS26 RPS26P11

5.42e-062442PS00733
DomainRibosomal_S26e

RPS26 RPS26P11

5.42e-062442PF01283
DomainIQ

ASPM MYO5A SCN8A

6.23e-0471443PF00612
DomainDSRM

DUS2 DROSHA

9.04e-0419442SM00358
DomainIQ

ASPM MYO5A SCN8A

9.16e-0481443SM00015
Domaindsrm

DUS2 DROSHA

1.00e-0320442PF00035
DomainDS_RBD

DUS2 DROSHA

1.11e-0321442PS50137
DomainIQ_motif_EF-hand-BS

ASPM MYO5A SCN8A

1.24e-0390443IPR000048
DomainIQ

ASPM MYO5A SCN8A

1.37e-0393443PS50096
Domain-

DUS2 DROSHA

1.83e-03274423.30.160.20
DomaindsRBD_dom

DUS2 DROSHA

1.97e-0328442IPR014720
Domain7TM_GPCR_Srsx

MTNR1B NPY5R MC3R

2.32e-03112443SM01381
DomainIon_trans_dom

CACNA1E TRPC1 SCN8A

2.44e-03114443IPR005821
DomainIon_trans

CACNA1E TRPC1 SCN8A

2.44e-03114443PF00520
DomainLDLR_class-A_CS

CORIN C7

4.00e-0340442IPR023415
DomainLdl_recept_a

CORIN C7

5.04e-0345442PF00057
Domain-

CORIN C7

5.26e-03464424.10.400.10
DomainLDLRA_1

CORIN C7

5.71e-0348442PS01209
DomainLDLRA_2

CORIN C7

5.95e-0349442PS50068
DomainLDrepeatLR_classA_rpt

CORIN C7

5.95e-0349442IPR002172
DomainLDLa

CORIN C7

5.95e-0349442SM00192
DomainChannel_four-helix_dom

CACNA1E SCN8A

7.97e-0357442IPR027359
Domain-

CACNA1E SCN8A

7.97e-03574421.20.120.350
DomainARM-type_fold

ASPM DOCK3 ARVCF PIK3CA

8.18e-03339444IPR016024
DomainDH_1

TRIO ARHGEF25

9.67e-0363442PS00741
Pubmed

TRPC1 inhibits the proliferation and migration of estrogen receptor-positive Breast cancer and gives a better prognosis by inhibiting the PI3K/AKT pathway.

PIK3CA TRPC1

4.91e-06345232415497
Pubmed

Transcriptome analysis of mouse stem cells and early embryos.

ASPM CHD6 PRAMEF2 PGAP1 ZNF507 GPC4

7.17e-0636345614691545
Pubmed

Assembly of high order G alpha q-effector complexes with RGS proteins.

TRIO ARHGEF25

1.63e-05545218936096
Pubmed

Cocaine-induced seizure thresholds: quantitative trait loci detection and mapping in two populations derived from the C57BL/6 and DBA/2 mouse strains.

MYO5A SCN8A

1.63e-05545210734168
Pubmed

Extensive variation between inbred mouse strains due to endogenous L1 retrotransposition.

FUT8 DROSHA

3.42e-05745218381897
Pubmed

Platelet-derived growth factor CC-mediated neuroprotection against HIV Tat involves TRPC-mediated inactivation of GSK 3beta.

PIK3CA TRPC1

8.94e-051145223077641
Pubmed

Misregulation of an Activity-Dependent Splicing Network as a Common Mechanism Underlying Autism Spectrum Disorders.

ARVCF DYNC2H1

2.47e-041845227984743
Pubmed

Centrosome-related genes, genetic variation, and risk of breast cancer.

ASPM PIK3CA CDC14A

3.18e-0410245320508983
Pubmed

Candidate gene analysis in an on-going genome-wide association study of attention-deficit hyperactivity disorder: suggestive association signals in ADRA1A.

DOCK3 SCN8A

6.06e-042845219352218
Pubmed

A common variant in DRD3 receptor is associated with autism spectrum disorder.

DOCK3 NPY5R MC3R

6.17e-0412845319058789
Pubmed

Genome-wide analysis of chromosomal alterations in patients with esophageal squamous cell carcinoma exposed to tobacco and betel quid from high-risk area in India.

TRIO DROSHA

6.96e-043045220083228
Pubmed

Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development.

ARVCF DYNC2H1

7.43e-043145225838543
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

ASPM SALL1 DYNC2H1 DROSHA ZNF507

9.49e-0458845538580884
Pubmed

Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.

CACNA1E TRPC1

1.12e-033845230786075
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

DOCK3 CHD6 TMEM168 FUT8 TRIO MYO5A DROSHA

1.23e-03128545735914814
Cytoband2q33.1

C2orf69 PGAP1

1.16e-03514522q33.1
Cytoband12q13

RPS26 SCN8A

2.24e-037145212q13
CoexpressionAtlasfacebase_RNAseq_e10.5_NeuroEpith_central_2500_K4

RNF25 ASPM DOCK3 SALL1 FUT8 MYO5A ARVCF DYNC2H1 CDC14A DTX4 PGAP1 SCN8A

8.94e-0613704212facebase_RNAseq_e10.5_NeuroEpith_central_2500_K4
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Pygm_C1ql1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SLC24A3 NPY5R SALL1 CHRNA3

2.48e-05168454f3879a8e11eaf866f37c52e67021be43f0b8784a
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SLC24A3 C7 ARHGEF25 DTX4

2.66e-05171454972fab891135bd755d5526cbc5a963200067b0a6
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SLC24A3 C7 ARHGEF25 DTX4

2.66e-051714542a77ed79c6f2e700e789c80451a70ecb31639719
ToppCellfacs-Thymus-Flowthrough-3m-Myeloid|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLHL8 MYO5A ZNF366 PGAP1

2.72e-05172454356a66cd9303470e427005cc67fdd22a2c4bf971
ToppCellfacs-Thymus-Flowthrough-3m-Myeloid-macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLHL8 MYO5A ZNF366 PGAP1

2.72e-0517245446fadeee483fdf8402df92ec98575a09c6c15b16
ToppCellfacs-Thymus-Flowthrough-3m-Myeloid-macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLHL8 MYO5A ZNF366 PGAP1

2.72e-05172454438d2e7f1897668a14d85ca70722e5d0102606dc
DiseaseAdenoid Cystic Carcinoma

ASPM SLC24A3 PIK3CA DTX4

1.38e-05100434C0010606
Diseasevisual epilepsy (implicated_via_orthology)

NPY5R C7 CHRNA3

1.67e-0534433DOID:11832 (implicated_via_orthology)
DiseaseSchizophrenia and related disorders

FUT8 ARVCF

7.42e-059432C0809983
DiseaseDiamond-Blackfan anemia (implicated_via_orthology)

RPS26 RPS26P11

9.27e-0510432DOID:1339 (implicated_via_orthology)
Diseaseepilepsy (implicated_via_orthology)

CACNA1E SLC24A3 TRIO SCN8A

9.36e-05163434DOID:1826 (implicated_via_orthology)
Diseasematrix metalloproteinase measurement

SLC24A3 DYNC2H1

1.60e-0413432EFO_0004744
Diseaseinsulin measurement

MTNR1B CACNA1E SLC24A3 CHD6

6.13e-04267434EFO_0004467
Diseasemigraine disorder, pulse pressure measurement

SLC24A3 DYNC2H1

6.59e-0426432EFO_0005763, MONDO_0005277
DiseasePolydactyly

SALL1 DYNC2H1 PIK3CA

6.68e-04117433C0152427
DiseaseBilateral Wilms Tumor

DROSHA GPC4

8.21e-0429432C2930471
DiseaseAbnormality of radial ray

RPS26 SALL1

1.06e-0333432C4228778
Diseaselysophosphatidylethanolamine 18:1 measurement

SLC24A3 NPY5R

1.13e-0334432EFO_0010368
Diseasestomach cancer (is_marker_for)

ASPM PIK3CA TRPC1

1.17e-03142433DOID:10534 (is_marker_for)
DiseaseNephroblastoma

DROSHA GPC4

1.27e-0336432C0027708
Diseaseautism spectrum disorder (implicated_via_orthology)

CHD6 ARVCF TRPC1

1.42e-03152433DOID:0060041 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
KHERRLHMYVVYCQN

ARHGEF25

241

Q86VW2
CVCIMRNLSYHVHKE

ARVCF

571

O00192
KCSRMHLHKFSCYDN

C2orf69

151

Q8N8R5
CHYIVNLRYFEMCIL

CACNA1E

1146

Q15878
MCGYCHHRRIKISNF

CHRNA3

401

P32297
CYVMKHYRFTHAEII

CDC14A

291

Q9UNH5
HGRRLYKMLCHVFYA

APBA3

321

O96018
KLSRCGHVYHIYCLV

DTX4

436

Q9Y2E6
HKCAIIIQSYYRMHV

ASPM

1971

Q8IZT6
HKVCRYCMHQHLKVA

IPPK

156

Q9H8X2
HALLKMIYCSHCRGL

GPC4

246

O75487
INRYCYICHSMAYHR

MTNR1B

136

P49286
IIRSHMKDHYIFYCE

LCN1P1

106

Q5VSP4
LVARACCEYMKLHFH

KLHL8

151

Q9P2G9
YIVIMKYNACIHQCF

SLC24A3

251

Q9HC58
YCRACGMYLKHLNRQ

PIK3CA

691

P42336
HMKCHNDVKRHLCTY

OVOL1

136

O14753
LQHMVYEYICRCLFK

DYNC2H1

3551

Q8NCM8
MYIRYIHKLCDMHLQ

DOCK3

1236

Q8IZD9
EMICRALLVYCVKHY

CHD6

1131

Q8TD26
AYVVQRTHYHGMKCL

FRMPD3

246

Q5JV73
TVCKMHVLHCQGRNY

C7

741

P10643
ANRHGHTCLMISCYK

FEM1A

146

Q9BSK4
TYLHRLSCYQHIMLF

CORIN

176

Q9Y5Q5
CYTAHFNTYLVLIMC

MC3R

276

P41968
NHYTNTKYCLCQMLR

DUS2

276

Q9NX74
CHRVLSCQSALKMHY

SALL1

711

Q9NSC2
GCQLHHVVYCFMIAY

FUT8

221

Q9BYC5
RYHQCLMHLDKLIGY

DROSHA

871

Q9NRR4
TCHQIYMHLRCYSCP

TMEM184B

61

Q9Y519
RHFKLVYCICHLLGM

NPY5R

401

Q15761
NHRKIYTHVYCQSTM

PGAP1

376

Q75T13
MKTLCKLVFSRCHHY

PRAMEF2

231

O60811
VMGYICRICHKFYHS

CIZ1

796

Q9ULV3
YQKVMCCLVHRYLTS

TRPC1

731

P48995
KLYVKLHYCVSCAIH

RPS26P11

66

Q5JNZ5
YFHCHCLARYIQHME

RNF25

156

Q96BH1
TCECVLKMFALRHYY

SCN8A

1566

Q9UQD0
MCKSLRYCFSHCLYL

TMEM168

1

Q9H0V1
EVYRHHLEQMYKLCR

TMEM201

151

Q5SNT2
SHMIHHCKTRIYQCK

ZNF507

686

Q8TCN5
HTNIRAYQCHLCYKS

ZNF366

471

Q8N895
KLYVKLHYCVSCAIH

RPS26

66

P62854
HERRLHMYIAYCQNK

TRIO

2051

O75962
HYKRSMHAIIYLQCC

MYO5A

881

Q9Y4I1