Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	AHR FOXO3 ZNF534 ZNF17 HIVEP1 BRF1 HDAC6 ZNF853 CLOCK ZNF454 TP63 ZNF212 ZNF184	1.19e-06	1271	42	13	GO:0000987
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	AHR FOXO3 ZNF534 ZNF17 HIVEP1 HDAC6 ZNF853 CLOCK ZNF454 TP63 ZNF212 ZNF184	6.24e-06	1244	42	12	GO:0000978
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	AHR FOXO3 ZNF534 ZNF17 HIVEP1 HDAC6 ZNF853 CLOCK ZNF454 TP63 ZNF212 ZNF184	3.11e-05	1459	42	12	GO:0000977
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	AHR FOXO3 ZNF534 ZNF17 HIVEP1 ZNF853 CLOCK ZNF454 TP63 ZNF212 ZNF184	1.18e-04	1412	42	11	GO:0000981
GeneOntologyMolecularFunction	chromatin binding	FOXO3 CLOCK NONO JMJD1C TP63 PHF21A PHC1 TOX3	1.31e-04	739	42	8	GO:0003682
GeneOntologyMolecularFunction	RNA polymerase III general transcription initiation factor activity	GTF3A BRF1	3.32e-04	13	42	2	GO:0000995
GeneOntologyMolecularFunction	chromatin DNA binding	FOXO3 CLOCK JMJD1C TOX3	4.12e-04	167	42	4	GO:0031490
GeneOntologyMolecularFunction	transcription factor binding	AHR FOXO3 BRF1 HDAC6 RUNX1T1 CLOCK JMJD1C	8.99e-04	753	42	7	GO:0008134
GeneOntologyMolecularFunction	nitric-oxide synthase binding	DNM3 DNM2	9.71e-04	22	42	2	GO:0050998
GeneOntologyMolecularFunction	protein serine/threonine kinase binding	DNM3 DNM2	1.16e-03	24	42	2	GO:0120283
GeneOntologyMolecularFunction	WW domain binding	TP63 DNM2	1.26e-03	25	42	2	GO:0050699
GeneOntologyMolecularFunction	beta-catenin binding	FOXO3 DLG5 HDAC6	2.05e-03	120	42	3	GO:0008013
GeneOntologyMolecularFunction	TBP-class protein binding	AHR BRF1	2.19e-03	33	42	2	GO:0017025
GeneOntologyMolecularFunction	transcription coregulator binding	AHR FOXO3 HDAC6	3.17e-03	140	42	3	GO:0001221
GeneOntologyMolecularFunction	microtubule binding	DNM3 CCDC88C HDAC6 DNM2	3.92e-03	308	42	4	GO:0008017
GeneOntologyBiologicalProcess	type 2 mitophagy	MFN2 HDAC6	8.04e-05	7	41	2	GO:0061734
GeneOntologyBiologicalProcess	regulation of cholangiocyte proliferation	PKHD1 HDAC6	1.07e-04	8	41	2	GO:1904054
GeneOntologyBiologicalProcess	protein-DNA complex organization	MED15 AHR BRF1 HDAC6 CLOCK JMJD1C TP63 PHF21A PHC1	1.22e-04	999	41	9	GO:0071824
GeneOntologyBiologicalProcess	epithelial cell morphogenesis	PKHD1 CCDC88C JMJD1C	1.26e-04	49	41	3	GO:0003382
GeneOntologyBiologicalProcess	cellular response to organic cyclic compound	AHR FOXO3 HDAC6 CLOCK TP63 DNM2 ITPR1	1.70e-04	605	41	7	GO:0071407
GeneOntologyBiologicalProcess	cholangiocyte proliferation	PKHD1 HDAC6	1.72e-04	10	41	2	GO:1990705
GeneOntologyBiologicalProcess	dendritic spine development	DNM3 MFN2 DLG5 HDAC6	1.74e-04	141	41	4	GO:0060996
GeneOntologyBiologicalProcess	epithelial cell development	PKHD1 CCDC88C CLOCK JMJD1C TP63	1.86e-04	269	41	5	GO:0002064
GeneOntologyBiologicalProcess	synaptic vesicle budding from presynaptic endocytic zone membrane	DNM3 DNM2	2.10e-04	11	41	2	GO:0016185
GeneOntologyBiologicalProcess	female sex differentiation	AHR FOXO3 MFN2 TP63	2.63e-04	157	41	4	GO:0046660
GeneOntologyBiologicalProcess	negative regulation of DNA-templated transcription	AHR FOXO3 HIVEP1 HDAC6 RUNX1T1 CLOCK NONO TP63 PHF21A PHC1	3.21e-04	1399	41	10	GO:0045892
GeneOntologyBiologicalProcess	negative regulation of RNA biosynthetic process	AHR FOXO3 HIVEP1 HDAC6 RUNX1T1 CLOCK NONO TP63 PHF21A PHC1	3.48e-04	1413	41	10	GO:1902679
GeneOntologyBiologicalProcess	response to alcohol	AHR FOXO3 HDAC6 UNC79 ZNF212	3.68e-04	312	41	5	GO:0097305
GeneOntologyBiologicalProcess	synaptic vesicle budding	DNM3 DNM2	3.98e-04	15	41	2	GO:0070142
GeneOntologyBiologicalProcess	morphogenesis of a polarized epithelium	PKHD1 DLG5 TP63	4.12e-04	73	41	3	GO:0001738
GeneOntologyBiologicalProcess	cell morphogenesis	PKHD1 AHR DNM3 CCDC88C MFN2 HDAC6 JMJD1C DNM2 ITPR1	4.61e-04	1194	41	9	GO:0000902
GeneOntologyBiologicalProcess	dendrite development	DNM3 MFN2 DLG5 HDAC6 ZNF212	5.09e-04	335	41	5	GO:0016358
GeneOntologyBiologicalProcess	cellular response to hormone stimulus	FOXO3 MFN2 HDAC6 PIK3C2A CLOCK NONO TP63	5.19e-04	727	41	7	GO:0032870
GeneOntologyBiologicalProcess	reactive oxygen species biosynthetic process	AHR FOXO3 MFN2	5.39e-04	80	41	3	GO:1903409
GeneOntologyBiologicalProcess	dendritic spine morphogenesis	DNM3 MFN2 HDAC6	5.59e-04	81	41	3	GO:0060997
GeneOntologyBiologicalProcess	regulation of Golgi organization	DNM2 PDE4DIP	5.78e-04	18	41	2	GO:1903358
GeneOntologyBiologicalProcess	response to corticosterone	FOXO3 HDAC6	5.78e-04	18	41	2	GO:0051412
GeneOntologyBiologicalProcess	cellular response to nitrogen compound	AHR FOXO3 MFN2 PIK3C2A NONO DNM2 ITPR1	6.34e-04	752	41	7	GO:1901699
GeneOntologyBiologicalProcess	sex differentiation	AHR FOXO3 MFN2 JMJD1C TP63	6.37e-04	352	41	5	GO:0007548
GeneOntologyBiologicalProcess	transcription preinitiation complex assembly	MED15 AHR BRF1	6.43e-04	85	41	3	GO:0070897
GeneOntologyBiologicalProcess	suckling behavior	UNC79 PHF21A	6.45e-04	19	41	2	GO:0001967
GeneOntologyBiologicalProcess	regulation of intracellular steroid hormone receptor signaling pathway	HDAC6 CLOCK TP63	6.88e-04	87	41	3	GO:0033143
GeneOntologyBiologicalProcess	ovarian follicle development	AHR FOXO3 MFN2	6.88e-04	87	41	3	GO:0001541
GeneOntologyBiologicalProcess	rhythmic process	AHR FOXO3 MFN2 CLOCK NONO	7.04e-04	360	41	5	GO:0048511
GeneOntologyBiologicalProcess	regulation of dendritic spine development	DNM3 MFN2 DLG5	7.84e-04	91	41	3	GO:0060998
GeneOntologyBiologicalProcess	regulation of clathrin-dependent endocytosis	BMP2K DNM2	7.90e-04	21	41	2	GO:2000369
GeneOntologyBiologicalProcess	negative regulation of intracellular signal transduction	PKHD1 MFN2 DLG5 CLOCK NONO TP63 ITPR1	8.81e-04	795	41	7	GO:1902532
GeneOntologyBiologicalProcess	reproductive structure development	AHR FOXO3 MFN2 JMJD1C TP63	9.30e-04	383	41	5	GO:0048608
GeneOntologyBiologicalProcess	response to mitochondrial depolarisation	MFN2 HDAC6	9.50e-04	23	41	2	GO:0098780
GeneOntologyBiologicalProcess	regulation of hydrogen peroxide metabolic process	MFN2 HDAC6	9.50e-04	23	41	2	GO:0010310
GeneOntologyBiologicalProcess	reproductive system development	AHR FOXO3 MFN2 JMJD1C TP63	9.86e-04	388	41	5	GO:0061458
GeneOntologyBiologicalProcess	regulation of cell size	AHR MFN2 HDAC6 DNM2	1.02e-03	225	41	4	GO:0008361
GeneOntologyBiologicalProcess	morphogenesis of a branching epithelium	PKHD1 AHR DLG5 TP63	1.21e-03	236	41	4	GO:0061138
GeneOntologyBiologicalProcess	positive regulation of reactive oxygen species biosynthetic process	FOXO3 MFN2	1.22e-03	26	41	2	GO:1903428
GeneOntologyBiologicalProcess	stem cell population maintenance	MED15 FOXO3 JMJD1C TP63	1.23e-03	237	41	4	GO:0019827
GeneOntologyBiologicalProcess	cellular response to steroid hormone stimulus	FOXO3 HDAC6 CLOCK TP63	1.27e-03	239	41	4	GO:0071383
GeneOntologyBiologicalProcess	regulation of microtubule polymerization or depolymerization	CCDC88C HDAC6 PDE4DIP	1.29e-03	108	41	3	GO:0031110
GeneOntologyBiologicalProcess	neuron apoptotic process	FOXO3 NONO TP63 ZNF212 TOX3	1.30e-03	413	41	5	GO:0051402
GeneOntologyBiologicalProcess	maintenance of cell number	MED15 FOXO3 JMJD1C TP63	1.33e-03	242	41	4	GO:0098727
GeneOntologyBiologicalProcess	intracellular receptor signaling pathway	AHR WASHC4 HDAC6 CLOCK TP63	1.34e-03	416	41	5	GO:0030522
GeneOntologyCellularComponent	nuclear protein-containing complex	MED15 AHR FOXO3 HDAC6 CLOCK NONO AMOT JMJD1C PHF21A PHC1 INIP	4.89e-05	1377	41	11	GO:0140513
MousePheno	abnormal papillary duct morphology	PKHD1 DLG5	5.06e-05	5	32	2	MP:0011331
MousePheno	bile duct inflammation	PKHD1 AHR	7.57e-05	6	32	2	MP:0003254
MousePheno	impaired wound healing	CCDC88C NONO TP63	1.18e-04	42	32	3	MP:0001792
MousePheno	abnormal rectum morphology	AHR RUNX1T1 TP63	1.26e-04	43	32	3	MP:0000492
Domain	G_DYNAMIN_dom	DNM3 MFN2 DNM2	3.78e-06	14	42	3	IPR030381
Domain	G_DYNAMIN_2	DNM3 MFN2 DNM2	3.78e-06	14	42	3	PS51718
Domain	Dynamin_SF	DNM3 MFN2 DNM2	4.72e-06	15	42	3	IPR022812
Domain	Dynamin_GTPase	DNM3 MFN2 DNM2	4.72e-06	15	42	3	IPR001401
Domain	Dynamin_N	DNM3 MFN2 DNM2	4.72e-06	15	42	3	PF00350
Domain	Dynamin_central	DNM3 DNM2	7.36e-05	6	42	2	IPR000375
Domain	Dynamin_M	DNM3 DNM2	7.36e-05	6	42	2	PF01031
Domain	Dynamin_GTPase_CS	DNM3 DNM2	7.36e-05	6	42	2	IPR019762
Domain	GED	DNM3 DNM2	7.36e-05	6	42	2	SM00302
Domain	GED_dom	DNM3 DNM2	7.36e-05	6	42	2	IPR020850
Domain	GED	DNM3 DNM2	7.36e-05	6	42	2	PF02212
Domain	GED	DNM3 DNM2	7.36e-05	6	42	2	IPR003130
Domain	GED	DNM3 DNM2	7.36e-05	6	42	2	PS51388
Domain	G_DYNAMIN_1	DNM3 DNM2	1.03e-04	7	42	2	PS00410
Domain	DYNc	DNM3 DNM2	1.03e-04	7	42	2	SM00053
Domain	-	ZNF534 ZNF17 HIVEP1 GTF3A ZNF853 ZNF454 ZNF212 ZNF184	1.16e-04	679	42	8	3.30.160.60
Domain	zf-C2H2	ZNF534 ZNF17 HIVEP1 GTF3A ZNF853 ZNF454 ZNF212 ZNF184	1.33e-04	693	42	8	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF534 ZNF17 HIVEP1 GTF3A ZNF853 ZNF454 ZNF212 ZNF184	1.34e-04	694	42	8	IPR013087
Domain	ZINC_FINGER_C2H2_2	ZNF534 ZNF17 HIVEP1 GTF3A ZNF853 ZNF454 ZNF212 ZNF184	2.86e-04	775	42	8	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF534 ZNF17 HIVEP1 GTF3A ZNF853 ZNF454 ZNF212 ZNF184	2.91e-04	777	42	8	PS00028
Domain	Znf_C2H2-like	ZNF534 ZNF17 HIVEP1 GTF3A ZNF853 ZNF454 ZNF212 ZNF184	3.42e-04	796	42	8	IPR015880
Domain	Znf_C2H2	ZNF534 ZNF17 HIVEP1 GTF3A ZNF853 ZNF454 ZNF212 ZNF184	3.69e-04	805	42	8	IPR007087
Domain	ZnF_C2H2	ZNF534 ZNF17 HIVEP1 GTF3A ZNF853 ZNF454 ZNF212 ZNF184	3.78e-04	808	42	8	SM00355
Domain	KRAB	ZNF534 ZNF17 ZNF454 ZNF212 ZNF184	1.20e-03	358	42	5	PS50805
Domain	KRAB	ZNF534 ZNF17 ZNF454 ZNF212 ZNF184	1.20e-03	358	42	5	PF01352
Domain	PAS_fold_3	AHR CLOCK	1.21e-03	23	42	2	IPR013655
Domain	PAS_3	AHR CLOCK	1.21e-03	23	42	2	PF08447
Domain	KRAB	ZNF534 ZNF17 ZNF454 ZNF212 ZNF184	1.37e-03	369	42	5	SM00349
Domain	KRAB	ZNF534 ZNF17 ZNF454 ZNF212 ZNF184	1.38e-03	370	42	5	IPR001909
Domain	PAS	AHR CLOCK	1.43e-03	25	42	2	PF00989
Domain	PAS_fold	AHR CLOCK	1.43e-03	25	42	2	IPR013767
Domain	PAC	AHR CLOCK	1.55e-03	26	42	2	SM00086
Domain	PAC	AHR CLOCK	1.55e-03	26	42	2	PS50113
Domain	PAC	AHR CLOCK	1.55e-03	26	42	2	IPR001610
Domain	PAS	AHR CLOCK	2.35e-03	32	42	2	SM00091
Domain	PAS	AHR CLOCK	2.65e-03	34	42	2	IPR000014
Domain	PAS	AHR CLOCK	2.65e-03	34	42	2	PS50112
Pubmed	Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily.	DNM3 MFN2 DNM2	9.13e-08	8	42	3	24282027
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	AHR FOXO3 HIVEP1 GTF3A CLOCK ZNF212 PHF21A PHC1 TOX3	4.23e-07	808	42	9	20412781
Pubmed	Possible Involvement of the Upregulation of ΔNp63 Expression Mediated by HER2-Activated Aryl Hydrocarbon Receptor in Mammosphere Maintenance.	AHR TP63	1.42e-06	2	42	2	36292946
Pubmed	Comprehensive Analysis of Prognostic and Genetic Signatures for General Transcription Factor III (GTF3) in Clinical Colorectal Cancer Patients Using Bioinformatics Approaches.	GTF3A BRF1	1.42e-06	2	42	2	33925358
Pubmed	New gene functions in megakaryopoiesis and platelet formation.	DNM3 MFN2 BRF1 JMJD1C	2.86e-06	81	42	4	22139419
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DLG5 WASHC4 SBF1 CLOCK AMOT ZNF212 PHF21A	3.08e-06	529	42	7	14621295
Pubmed	Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2.	SBF1 PIK3C2A NONO AMOT	3.80e-06	87	42	4	17148452
Pubmed	Genetic polymorphisms in the aryl hydrocarbon receptor-signaling pathway and sleep disturbances in middle-aged women.	AHR CLOCK	4.27e-06	3	42	2	23768840
Pubmed	Dynamin and endocytosis.	DNM3 DNM2	4.27e-06	3	42	2	12383797
Pubmed	HDAC6 maintains mitochondrial connectivity under hypoxic stress by suppressing MARCH5/MITOL dependent MFN2 degradation.	MFN2 HDAC6	4.27e-06	3	42	2	26210454
Pubmed	Hippo kinases regulate cell junctions to inhibit tumor metastasis in response to oxidative stress.	FOXO3 TP63	4.27e-06	3	42	2	31212215
Pubmed	JMJD1C is required for the survival of acute myeloid leukemia by functioning as a coactivator for key transcription factors.	RUNX1T1 JMJD1C	4.27e-06	3	42	2	26494788
Pubmed	Disruption of the coxsackievirus and adenovirus receptor-homodimeric interaction triggers lipid microdomain- and dynamin-dependent endocytosis and lysosomal targeting.	DNM3 DNM2	4.27e-06	3	42	2	24273169
Pubmed	Insulin-FOXO3 signaling modulates circadian rhythms via regulation of clock transcription.	FOXO3 CLOCK	4.27e-06	3	42	2	24856209
Pubmed	Dynamin: characteristics, mechanism of action and function.	DNM3 DNM2	4.27e-06	3	42	2	12511974
Pubmed	Developmental expression of the dynamin family of mechanoenzymes in the mouse epididymis.	DNM3 DNM2	4.27e-06	3	42	2	28395327
Pubmed	Dynamin at the actin-membrane interface.	DNM3 DNM2	4.27e-06	3	42	2	12517701
Pubmed	The Expression of Dynamin 1, 2, and 3 in Human Hepatocellular Carcinoma and Patient Prognosis.	DNM3 DNM2	4.27e-06	3	42	2	32573516
Pubmed	Assembly and isolation of intermediate steps of transcription complexes formed on the human 5S rRNA gene.	GTF3A BRF1	4.27e-06	3	42	2	12711686
Pubmed	Dynamin triple knockout cells reveal off target effects of commonly used dynamin inhibitors.	DNM3 DNM2	4.27e-06	3	42	2	24046449
Pubmed	Overlapping role of dynamin isoforms in synaptic vesicle endocytosis.	DNM3 DNM2	8.53e-06	4	42	2	21689597
Pubmed	Disruption of CLOCK-BMAL1 transcriptional activity is responsible for aryl hydrocarbon receptor-mediated regulation of Period1 gene.	AHR CLOCK	8.53e-06	4	42	2	20106950
Pubmed	Trans-infection but not infection from within endosomal compartments after cell-to-cell HIV-1 transfer to CD4+ T cells.	DNM3 DNM2	8.53e-06	4	42	2	22846998
Pubmed	TRIM11 facilitates chemoresistance in nasopharyngeal carcinoma by activating the β-catenin/ABCC9 axis via p62-selective autophagic degradation of Daple.	MED15 CCDC88C	8.53e-06	4	42	2	32382014
Pubmed	WNT-Mediated Regulation of FOXO1 Constitutes a Critical Axis Maintaining Pubertal Mammary Stem Cell Homeostasis.	FOXO3 TP63	8.53e-06	4	42	2	29103953
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	AHR BRF1 RUNX1T1 CLOCK TP63 ZNF212 ZNF184 TOX3	8.74e-06	877	42	8	20211142
Pubmed	Histone deacetylase 6 is a FoxO transcription factor-dependent effector in skeletal muscle atrophy.	FOXO3 HDAC6	1.42e-05	5	42	2	25516595
Pubmed	Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER.	DNM3 DNM2	1.42e-05	5	42	2	9722593
Pubmed	New p63 targets in keratinocytes identified by a genome-wide approach.	TP63 DNM2	1.42e-05	5	42	2	17036050
Pubmed	Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.	DNM3 ATL2 PHF21A ITPR1	1.76e-05	128	42	4	30995482
Pubmed	Molecular components required for resting and stimulated endocytosis of botulinum neurotoxins by glutamatergic and peptidergic neurons.	DNM3 DNM2	2.13e-05	6	42	2	23640057
Pubmed	Dynamin 1- and 3-Mediated Endocytosis Is Essential for the Development of a Large Central Synapse In Vivo.	DNM3 DNM2	2.13e-05	6	42	2	27251629
Pubmed	A clathrin-dynamin-dependent endocytic pathway for the uptake of HIV-1 by direct T cell-T cell transmission.	DNM3 DNM2	2.13e-05	6	42	2	18602423
Pubmed	Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors.	DNM3 ITPR1	2.13e-05	6	42	2	9808459
Pubmed	Loss of zinc-finger protein 212 leads to Purkinje cell death and locomotive abnormalities with phospholipase D3 downregulation.	CCDC88C ZNF212 ITPR1	2.40e-05	46	42	3	34815492
Pubmed	Charcot-Marie-Tooth Hereditary Neuropathy Overview	MFN2 SBF1 DNM2	2.73e-05	48	42	3	20301532
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	HIVEP1 PIK3C2A AMOT JMJD1C DNM2 PDE4DIP	2.80e-05	497	42	6	23414517
Pubmed	A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis.	DNM3 DNM2	2.98e-05	7	42	2	15252009
Pubmed	ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain.	HDAC6 RUNX1T1	3.97e-05	8	42	2	11533236
Pubmed	Major histocompatibility complex class-II molecules promote targeting of human immunodeficiency virus type 1 virions in late endosomes by enhancing internalization of nascent particles from the plasma membrane.	DNM3 DNM2	5.10e-05	9	42	2	23170932
Pubmed	Transcriptionally active heterodimer formation of an Arnt-like PAS protein, Arnt3, with HIF-1a, HLF, and clock.	AHR CLOCK	5.10e-05	9	42	2	9704006
Pubmed	A directed protein interaction network for investigating intracellular signal transduction.	FOXO3 CCDC88C HDAC6 SBF1 YAE1 JMJD1C DNM2 PDE4DIP	5.16e-05	1124	42	8	21900206
Pubmed	Expression and localisation of dynamin and syntaxin during neural development and neuromuscular synapse formation.	DNM3 DNM2	6.37e-05	10	42	2	10398046
Pubmed	Protein partners of dynamin-1 in the retina.	DNM3 DNM2	6.37e-05	10	42	2	23746204
Pubmed	PRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells.	MED15 PHF21A PHC1	6.79e-05	65	42	3	22496869
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	FOXO3 CCDC88C DLG5 HIVEP1 SBF1 PIK3C2A AMOT	7.05e-05	861	42	7	36931259
Pubmed	Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.	KYAT3 DLG5 JMJD1C	7.77e-05	68	42	3	22001757
Pubmed	Ectoderm-targeted overexpression of the glucocorticoid receptor induces hypohidrotic ectodermal dysplasia.	FOXO3 TP63	7.78e-05	11	42	2	15746257
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	MFN2 WASHC4 ATL2 BMP2K NONO AMOT JMJD1C ZNF184	8.29e-05	1203	42	8	29180619
Pubmed	Large-scale genotyping identifies 41 new loci associated with breast cancer risk.	CCDC88C TOX3 ITPR1	1.08e-04	76	42	3	23535729
Pubmed	BMI1-UBR5 axis regulates transcriptional repression at damaged chromatin.	NONO PHC1	1.10e-04	13	42	2	27647897
Pubmed	A molecular mechanism for circadian clock negative feedback.	CLOCK NONO	1.10e-04	13	42	2	21680841
Pubmed	Plk2 attachment to NSF induces homeostatic removal of GluA2 during chronic overexcitation.	DNM3 DNM2	1.28e-04	14	42	2	20802490
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	DNM3 CCDC88C MFN2 SBF1 UNC79 DNM2 PDE4DIP	1.41e-04	963	42	7	28671696
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	HIVEP1 AMOT JMJD1C PHF21A PHC1	1.44e-04	418	42	5	34709266
Pubmed	EHBP1L1, an apicobasal polarity regulator, is critical for nuclear polarization during enucleation of erythroblasts.	DNM3 DNM2	1.91e-04	17	42	2	37042948
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	FOXO3 CCDC88C HDAC6 PIK3C2A AMOT	1.95e-04	446	42	5	24255178
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	MED15 KYAT3 PIK3C2A NONO JMJD1C	2.18e-04	457	42	5	32344865
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	AHR FOXO3 WASHC4 HDAC6 BMP2K NONO YAE1	2.24e-04	1038	42	7	26673895
Pubmed	DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity.	MED15 HDAC6 PHF21A	2.37e-04	99	42	3	34161765
Pubmed	Charting the molecular network of the drug target Bcr-Abl.	DNM3 BMP2K NONO DNM2	2.98e-04	266	42	4	19380743
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	MED15 HIVEP1 JMJD1C PHF21A	3.06e-04	268	42	4	33640491
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	MED15 HIVEP1 NONO JMJD1C PHF21A DNM2 ZNF184	3.24e-04	1103	42	7	34189442
Pubmed	Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks.	CCDC88C DNM2 PDE4DIP	3.32e-04	111	42	3	22558309
Pubmed	cDNAs with long CAG trinucleotide repeats from human brain.	MED15 TOX3	3.54e-04	23	42	2	9225980
Pubmed	Insulin/IGF-1 controls epidermal morphogenesis via regulation of FoxO-mediated p63 inhibition.	FOXO3 TP63	4.20e-04	25	42	2	23906066
Pubmed	An improved smaller biotin ligase for BioID proximity labeling.	JMJD1C PHF21A TOX3	4.48e-04	123	42	3	26912792
Pubmed	The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer.	BMP2K NONO JMJD1C PHF21A	4.58e-04	298	42	4	30737378
Pubmed	Neurobeachin, a protein implicated in membrane protein traffic and autism, is required for the formation and functioning of central synapses.	DNM3 DNM2	4.90e-04	27	42	2	19723784
Pubmed	Proximity labeling reveals dynamic changes in the SQSTM1 protein network.	MED15 BMP2K PIK3C2A AMOT	6.12e-04	322	42	4	39098523
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	DNM3 GTF3A HDAC6 DNM2	6.63e-04	329	42	4	17474147
Pubmed	A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.	DNM3 JMJD1C	7.79e-04	34	42	2	19820697
Pubmed	A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects.	DNM3 JMJD1C	7.79e-04	34	42	2	24026423
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	MED15 HIVEP1 BRF1 RUNX1T1 PDE4DIP	8.01e-04	608	42	5	16713569
Pubmed	Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.	ZNF17 BRF1 PDE4DIP	8.13e-04	151	42	3	17043677
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	MED15 AMOT JMJD1C	8.29e-04	152	42	3	38360978
Pubmed	Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.	RUNX1T1 AMOT PDE4DIP	8.29e-04	152	42	3	34299191
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	MED15 FOXO3 ATL2 CLOCK AMOT PHF21A DNM2	9.45e-04	1321	42	7	27173435
Pubmed	Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions.	CLOCK NONO	1.08e-03	40	42	2	23555304
Pubmed	An Oct4-centered protein interaction network in embryonic stem cells.	MED15 JMJD1C PHC1	1.09e-03	167	42	3	20362541
Pubmed	Proteomic identification of brain proteins that interact with dynein light chain LC8.	DNM3 DNM2	1.19e-03	42	42	2	14760703
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF534 ZNF17 HIVEP1 GTF3A ZNF853 ZNF454 ZNF212 ZNF184	9.12e-06	718	28	8	28
GeneFamily	General transcription factors\|Xeroderma pigmentosum complementation groups\|DNA helicases\|ERCC excision repair associated	GTF3A BRF1	6.79e-04	25	28	2	565
GeneFamily	Ataxins\|Trinucleotide repeat containing	MED15 TOX3	6.79e-04	25	28	2	775
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	HDAC6 NONO ITPR1	2.69e-03	181	28	3	694
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	DNM3 SBF1 DNM2	3.87e-03	206	28	3	682
GeneFamily	Basic helix-loop-helix proteins	AHR CLOCK	1.25e-02	110	28	2	420
Drug	felodipine; Down 200; 10uM; MCF7; HG-U133A	AHR BRF1 WASHC4 RUNX1T1 AMOT PDE4DIP	1.67e-06	199	42	6	337_DN
Disease	Charcot-Marie-Tooth disease dominant intermediate B (implicated_via_orthology)	DNM3 DNM2	1.88e-05	5	41	2	DOID:0110197 (implicated_via_orthology)
Disease	centronuclear myopathy 1 (implicated_via_orthology)	DNM3 DNM2	1.88e-05	5	41	2	DOID:0111223 (implicated_via_orthology)
Disease	microcytic anemia (implicated_via_orthology)	DNM3 DNM2	1.88e-05	5	41	2	DOID:11252 (implicated_via_orthology)
Disease	hereditary spastic paraplegia (implicated_via_orthology)	DNM3 ATL2 DNM2	2.96e-05	43	41	3	DOID:2476 (implicated_via_orthology)
Disease	attention deficit hyperactivity disorder, substance abuse, antisocial behaviour measurement	FOXO3 HIVEP1 RUNX1T1 CCDC73 UNC79 PHF21A ZNF184	1.06e-04	801	41	7	EFO_0003888, EFO_0007052, MONDO_0002491
Disease	collagen disease (implicated_via_orthology)	DNM3 DNM2	1.23e-04	12	41	2	DOID:854 (implicated_via_orthology)
Disease	cognitive function measurement, self reported educational attainment	PKHD1 FOXO3 RUNX1T1 JMJD1C ZNF184	1.29e-04	355	41	5	EFO_0004784, EFO_0008354
Disease	developmental and epileptic encephalopathy (implicated_via_orthology)	DNM3 DNM2	1.46e-04	13	41	2	DOID:0112202 (implicated_via_orthology)
Disease	alcohol use disorder measurement	PKHD1 DNM3 RUNX1T1 ZNF184	2.21e-04	214	41	4	EFO_0009458
Disease	body surface area	PKHD1 DNM3 FOXO3 HIVEP1 GTF3A UNC79	2.46e-04	643	41	6	EFO_0022196
Disease	neurotic disorder	DNM3 HIVEP1 ZNF184	3.78e-04	101	41	3	EFO_0004257
Disease	sodium measurement	PKHD1 AHR JMJD1C	4.00e-04	103	41	3	EFO_0009282
Disease	immature platelet count	DNM3 BRF1 JMJD1C	4.35e-04	106	41	3	EFO_0803544
Disease	immature platelet fraction	DNM3 BRF1 JMJD1C	5.38e-04	114	41	3	EFO_0009187
Disease	immature platelet measurement	DNM3 BRF1 JMJD1C	6.10e-04	119	41	3	EFO_0803541
Disease	neuroimaging measurement	PKHD1 FOXO3 CCDC88C RUNX1T1 JMJD1C TP63 TOX3	6.14e-04	1069	41	7	EFO_0004346
Disease	ganglion cell inner plexiform layer thickness measurement	FOXO3 PIK3C2A	6.96e-04	28	41	2	EFO_0600005
Disease	longevity, healthspan, parental longevity	FOXO3 TOX3	7.47e-04	29	41	2	EFO_0004300, EFO_0007796, EFO_0009762
Disease	cutaneous mastocytosis	RPTN PDE4DIP	8.54e-04	31	41	2	EFO_1000886
Disease	platelet measurement	DNM3 MFN2 BRF1 JMJD1C	9.45e-04	315	41	4	EFO_0005036
Disease	cutaneous squamous cell carcinoma	AHR TP63	9.68e-04	33	41	2	EFO_1001927
Disease	oppositional defiant disorder measurement	HIVEP1 RUNX1T1	1.15e-03	36	41	2	EFO_0007679
Disease	red blood cell density measurement	PKHD1 DNM3 HIVEP1 BRF1 BMP2K JMJD1C	1.28e-03	880	41	6	EFO_0007978
Disease	Mastocytosis	RPTN PDE4DIP	1.35e-03	39	41	2	EFO_0009001
Disease	Parkinson's disease (implicated_via_orthology)	FOXO3 HDAC6 BMP2K	1.36e-03	157	41	3	DOID:14330 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
HLHLEQQQQHHQKQV	AHR	616	P35869
QQQQQQQQQHHHHHH	AMOT	376	Q4VCS5
LHLQHRHPHQQQQQQ	BMP2K	451	Q9NSY1
QQQQQQQQQQQHHHH	BMP2K	476	Q9NSY1
QHHHQQQHHQQQQQQ	NONO	21	Q15233
AGNQQNQALLHKHIN	ITPR1	1256	Q14643
KHHHICGQTLQAQQQ	RUNX1T1	546	Q06455
LALAHQQQQQLLQHQ	JMJD1C	826	Q15652
HHLLSQIQLLSQQNQ	CCDC88C	1336	Q9P219
HLQKVLNQQLTNHIR	DNM3	276	Q9UQ16
LQNNHCLGSHEHIQN	PIK3C2A	481	O00443
EVQAHNKRNLIQHNN	DLG5	826	Q8TDM6
QQQQQQQQHLIKLHH	MED15	211	Q96RN5
QQQHLIKLHHQNQQQ	MED15	216	Q96RN5
LPQQLQQMHHTQHHQ	MED15	286	Q96RN5
PLQQLQQQQQYHHHH	PHF21A	91	Q96BD5
HLQKTLNQQLTNHIR	DNM2	276	P50570
NQLAHALHQDKQLHA	MFN2	161	O95140
LHLHVQQNRAVLDHQ	SBF1	606	O95248
QQHQHLLQKQTSIQS	TP63	441	Q9H3D4
NVNISHLHLNNENSH	CCDC73	771	Q6ZRK6
QNQHEELQNVRKHIH	ATL2	271	Q8NHH9
HHQALLDVKNIAHQN	HDAC6	1191	Q9UBN7
LHQLHQLHQLHLQQQ	IER5L	111	Q5T953
QLHQLHLQQQLHQHQ	IER5L	116	Q5T953
NHLIKHLQTVQQNTI	KYAT3	296	Q6YP21
GSLVNQNLLHHQHQT	FOXO3	526	O43524
VQISAHHLHQLLQNN	PKHD1	806	P08F94
QQHIAAQQKAALQHA	INIP	61	Q9NRY2
SHHQQHQSQQQQQLS	CLOCK	816	O15516
QNSHLAQHQKIHTGQ	ZNF534	266	Q76KX8
QQQIAIHHQQQFQHR	PHC1	396	P78364
IHHQQQFQHRQSQLL	PHC1	401	P78364
HFQHHMQQHLQQQQQ	TOX3	481	O15405
RHIHHLGNQLQLNQH	BRF1	91	Q92994
HLHNNNSTLINKINN	YAE1	91	Q9NRH1
SQLQQEKHQSVHHQE	ZNF853	131	P0CG23
NNKHLNTINIRHIAN	WASHC4	811	Q2M389
QKQHLLQHQKIHQRE	ZNF212	466	Q9UDV6
NQTANLIQHQRHHIG	ZNF454	506	Q8N9F8
HQQLKIHQCQHTNEP	GTF3A	146	Q92664
QHHQHKLLAQIQQER	RPTN	656	Q6XPR3
QHEHFVPKSNQHNQQ	HIVEP1	286	P15822
QQHKNIQLQNSHIHL	HIVEP1	1081	P15822
VFNQNSHLIQHQKVH	ZNF17	646	P17021
NQNIHLTQHKRIHTG	ZNF184	596	Q99676
QLRLQAIQNHVNHHS	UNC79	2576	Q9P2D8
TQEQNIQHLNHSLSH	PDE4DIP	431	Q5VU43