Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	molecular function activator activity	SLURP1 CGB7 ARHGAP30 PDPK1 SIPA1L1 CGB3 CGB1	1.28e-04	1233	20	7	GO:0140677
GeneOntologyMolecularFunction	hormone activity	CGB7 CGB3 CGB1	3.17e-04	135	20	3	GO:0005179
GeneOntologyMolecularFunction	receptor ligand activity	SLURP1 CGB7 CGB3 CGB1	1.90e-03	547	20	4	GO:0048018
GeneOntologyMolecularFunction	signaling receptor activator activity	SLURP1 CGB7 CGB3 CGB1	1.99e-03	554	20	4	GO:0030546
GeneOntologyMolecularFunction	signaling receptor regulator activity	SLURP1 CGB7 CGB3 CGB1	2.93e-03	616	20	4	GO:0030545
GeneOntologyBiologicalProcess	luteinizing hormone signaling pathway involved in ovarian follicle development	CGB7 CGB1	8.92e-06	5	20	2	GO:0035471
GeneOntologyBiologicalProcess	luteinizing hormone signaling pathway	CGB7 CGB1	1.87e-05	7	20	2	GO:0042700
GeneOntologyCellularComponent	pituitary gonadotropin complex	CGB7 CGB3 CGB1	4.18e-08	8	20	3	GO:0061696
GeneOntologyCellularComponent	postsynaptic density	MPDZ PDPK1 SIPA1L1 CAST	7.87e-04	451	20	4	GO:0014069
GeneOntologyCellularComponent	asymmetric synapse	MPDZ PDPK1 SIPA1L1 CAST	9.70e-04	477	20	4	GO:0032279
GeneOntologyCellularComponent	postsynaptic specialization	MPDZ PDPK1 SIPA1L1 CAST	1.18e-03	503	20	4	GO:0099572
GeneOntologyCellularComponent	neuron to neuron synapse	MPDZ PDPK1 SIPA1L1 CAST	1.36e-03	523	20	4	GO:0098984
MousePheno	small vulva	CGB7 CGB1	1.39e-05	6	14	2	MP:0003527
MousePheno	small bulbourethral gland	CGB7 CGB1	1.95e-05	7	14	2	MP:0013737
MousePheno	small external male genitalia	CGB7 CGB1	2.60e-05	8	14	2	MP:0009202
MousePheno	abnormal bulbourethral gland morphology	CGB7 CGB1	6.11e-05	12	14	2	MP:0001169
MousePheno	thin endometrium	CGB7 CGB1	9.71e-05	15	14	2	MP:0008258
MousePheno	abnormal Leydig cell differentiation	CGB7 CGB1	1.11e-04	16	14	2	MP:0013602
MousePheno	small prostate gland	CGB7 CGB1	1.58e-04	19	14	2	MP:0002774
MousePheno	abnormal external female genitalia morphology	CGB7 CGB1	1.93e-04	21	14	2	MP:0003126
MousePheno	abnormal sex gland secretion	CGB7 CGB1	2.33e-04	23	14	2	MP:0002779
MousePheno	uterus hypoplasia	CGB7 CGB1	2.33e-04	23	14	2	MP:0001121
MousePheno	decreased Leydig cell number	CGB7 CGB1	3.72e-04	29	14	2	MP:0005536
MousePheno	myeloid hyperplasia	FBXO4 PPM1D	5.13e-04	34	14	2	MP:0010373
MousePheno	decreased circulating progesterone level	CGB7 CGB1	5.75e-04	36	14	2	MP:0005185
MousePheno	decreased circulating estradiol level	CGB7 CGB1	6.41e-04	38	14	2	MP:0005181
MousePheno	absent mature ovarian follicles	CGB7 CGB1	7.11e-04	40	14	2	MP:0001132
MousePheno	decreased circulating estrogen level	CGB7 CGB1	7.47e-04	41	14	2	MP:0003371
MousePheno	abnormal prostate gland size	CGB7 CGB1	7.84e-04	42	14	2	MP:0004959
MousePheno	increased fibroblast proliferation	FBXO4 SULF2	8.60e-04	44	14	2	MP:0011703
MousePheno	absent estrous cycle	CGB7 CGB1	8.60e-04	44	14	2	MP:0009009
MousePheno	ovary cyst	CGB7 CGB1	9.40e-04	46	14	2	MP:0002016
MousePheno	abnormal endometrium morphology	CGB7 CGB1	1.07e-03	49	14	2	MP:0004896
MousePheno	abnormal circulating progesterone level	CGB7 CGB1	1.11e-03	50	14	2	MP:0005184
MousePheno	abnormal circulating estradiol level	CGB7 CGB1	1.20e-03	52	14	2	MP:0005183
MousePheno	abnormal external male genitalia morphology	CGB7 CGB1	1.25e-03	53	14	2	MP:0009199
MousePheno	abnormal progesterone level	CGB7 CGB1	1.29e-03	54	14	2	MP:0011384
MousePheno	abnormal circulating estrogen level	CGB7 CGB1	1.44e-03	57	14	2	MP:0003369
MousePheno	abnormal tertiary ovarian follicle morphology	CGB7 CGB1	1.44e-03	57	14	2	MP:0009363
MousePheno	decreased circulating testosterone level	CGB7 CGB1	1.59e-03	60	14	2	MP:0002780
MousePheno	absent corpus luteum	CGB7 CGB1	1.93e-03	66	14	2	MP:0001134
MousePheno	decreased grip strength	SLURP1 MPDZ TM2D3 SIPA1L1	2.04e-03	575	14	4	MP:0010053
MousePheno	small epididymis	CGB7 CGB1	2.16e-03	70	14	2	MP:0004930
MousePheno	abnormal epididymis morphology	CGB7 PPM1D CGB1	2.19e-03	269	14	3	MP:0002631
MousePheno	abnormal startle reflex	MPDZ ZBTB24 SIPA1L1 CAST	2.26e-03	591	14	4	MP:0001486
MousePheno	abnormal prostate gland morphology	CGB7 CGB1	2.35e-03	73	14	2	MP:0001158
MousePheno	decreased mature ovarian follicle number	CGB7 CGB1	2.35e-03	73	14	2	MP:0002682
MousePheno	abnormal mature ovarian follicle morphology	CGB7 CGB1	2.68e-03	78	14	2	MP:0009364
MousePheno	abnormal Leydig cell morphology	CGB7 CGB1	2.95e-03	82	14	2	MP:0002786
MousePheno	abnormal circulating androgen level	CGB7 CGB1	3.10e-03	84	14	2	MP:0009819
MousePheno	abnormal circulating testosterone level	CGB7 CGB1	3.10e-03	84	14	2	MP:0005180
MousePheno	abnormal testis interstitial tissue morphology	CGB7 CGB1	3.24e-03	86	14	2	MP:0011416
MousePheno	abnormal testosterone level	CGB7 CGB1	3.70e-03	92	14	2	MP:0011385
MousePheno	small uterus	CGB7 CGB1	3.70e-03	92	14	2	MP:0002637
MousePheno	decreased oocyte number	CGB7 CGB1	3.94e-03	95	14	2	MP:0005431
MousePheno	abnormal oocyte number	CGB7 CGB1	4.02e-03	96	14	2	MP:0020152
Domain	Gonadotropin_bsu_CS	CGB7 CGB3 CGB1	2.10e-08	6	20	3	IPR018245
Domain	Gonadotropin_bsu	CGB7 CGB3 CGB1	3.67e-08	7	20	3	IPR001545
Domain	GLYCO_HORMONE_BETA_2	CGB7 CGB3 CGB1	3.67e-08	7	20	3	PS00689
Domain	GHB	CGB7 CGB3 CGB1	3.67e-08	7	20	3	SM00068
Domain	GLYCO_HORMONE_BETA_1	CGB7 CGB3 CGB1	3.67e-08	7	20	3	PS00261
Domain	Glyco_hormone_CN	CGB7 CGB3 CGB1	4.74e-07	15	20	3	IPR006208
Domain	Cys_knot	CGB7 CGB3 CGB1	4.74e-07	15	20	3	PF00007
Domain	-	CGB7 CGB3 CGB1	4.82e-05	67	20	3	2.10.90.10
Domain	Cystine-knot_cytokine	CGB7 CGB3 CGB1	4.82e-05	67	20	3	IPR029034
Domain	PDZ	MPDZ SIPA1L1 FRMPD3	4.37e-04	141	20	3	PF00595
Domain	PDZ	MPDZ SIPA1L1 FRMPD3	5.03e-04	148	20	3	SM00228
Domain	-	MPDZ SIPA1L1 FRMPD3	5.24e-04	150	20	3	2.30.42.10
Domain	PDZ	MPDZ SIPA1L1 FRMPD3	5.34e-04	151	20	3	PS50106
Domain	PDZ	MPDZ SIPA1L1 FRMPD3	5.44e-04	152	20	3	IPR001478
Pathway	REACTOME_MINERALOCORTICOID_BIOSYNTHESIS	CGB7 CGB1	6.93e-05	12	15	2	MM14749
Pathway	REACTOME_GLYCOPROTEIN_HORMONES	CGB7 CGB1	8.19e-05	13	15	2	MM14830
Pathway	REACTOME_REACTIONS_SPECIFIC_TO_THE_COMPLEX_N_GLYCAN_SYNTHESIS_PATHWAY	CGB7 CGB1	8.19e-05	13	15	2	MM15701
Pathway	REACTOME_PEPTIDE_HORMONE_BIOSYNTHESIS	CGB7 CGB1	1.10e-04	15	15	2	MM14832
Pathway	REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS	CGB7 CGB1	1.10e-04	15	15	2	MM14972
Pathway	REACTOME_ANDROGEN_BIOSYNTHESIS	CGB7 CGB1	1.10e-04	15	15	2	MM14739
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_THE_AP_2_TFAP2_FAMILY_OF_TRANSCRIPTION_FACTORS	CGB7 CGB1	3.38e-04	26	15	2	MM15502
Pathway	REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI	CGB7 CGB1	4.22e-04	29	15	2	MM15699
Pathway	REACTOME_METABOLISM_OF_STEROID_HORMONES	CGB7 CGB1	8.46e-04	41	15	2	MM14757
Pubmed	Isolation and characterization of the human chorionic gonadotropin beta subunit (CG beta) gene cluster: regulation of transcriptionally active CG beta gene by cyclic AMP.	CGB7 CGB3 CGB1	1.62e-09	5	20	3	2468994
Pubmed	The beta subunit of human chorionic gonadotropin is encoded by multiple genes.	CGB7 CGB3 CGB1	3.25e-09	6	20	3	6194155
Pubmed	Identification of the transcriptionally active genes of the chorionic gonadotropin beta gene cluster in vivo.	CGB7 CGB3 CGB1	3.25e-09	6	20	3	1371113
Pubmed	The human genome contains seven genes for the beta-subunit of chorionic gonadotropin but only one gene for the beta-subunit of luteinizing hormone.	CGB7 CGB3 CGB1	3.25e-09	6	20	3	6319099
Pubmed	The beta chorionic gonadotropin-beta luteinizing gene cluster maps to human chromosome 19.	CGB7 CGB3 CGB1	3.25e-09	6	20	3	6204923
Pubmed	A map of the hCG beta-LH beta gene cluster.	CGB7 CGB3 CGB1	3.25e-09	6	20	3	2422163
Pubmed	Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone.	CGB7 CGB3 CGB1	5.68e-09	7	20	3	6690982
Pubmed	Tumorigenesis and metastasis of neoplastic Kaposi's sarcoma cell line in immunodeficient mice blocked by a human pregnancy hormone.	CGB7 CGB3	3.14e-07	2	20	2	7723844
Pubmed	Site-specific N-glycosylation of human chorionic gonadotrophin--structural analysis of glycopeptides by one- and two-dimensional 1H NMR spectroscopy.	CGB7 CGB3	3.14e-07	2	20	2	1820200
Pubmed	The cDNA for the beta-subunit of human chorionic gonadotropin suggests evolution of a gene by readthrough into the 3'-untranslated region.	CGB7 CGB3	3.14e-07	2	20	2	6774259
Pubmed	Molecular cloning, characterization and expression of thyroid-stimulating hormone receptor in channel catfish.	CGB3 CGB1	9.42e-07	3	20	2	19523396
Pubmed	Novel insights into the expression of CGB1 & 2 genes by epithelial cancer cell lines secreting ectopic free hCGβ.	CGB3 CGB1	9.42e-07	3	20	2	24778026
Pubmed	Fine-scale quantification of HCG beta gene transcription in human trophoblastic and non-malignant non-trophoblastic tissues.	CGB3 CGB1	9.42e-07	3	20	2	18048458
Pubmed	Abortive expansion of the cumulus and impaired fertility in mice lacking the prostaglandin E receptor subtype EP(2).	CGB7 CGB3	9.42e-07	3	20	2	10468638
Pubmed	Role of disulfide bond formation in the folding of human chorionic gonadotropin beta subunit into an alpha beta dimer assembly-competent form.	CGB7 CGB3	9.42e-07	3	20	2	1688430
Pubmed	Chorionic gonadotropin has a recent origin within primates and an evolutionary history of selection.	CGB7 CGB3	9.42e-07	3	20	2	11861891
Pubmed	Crystal structure of human chorionic gonadotropin.	CGB7 CGB3	1.88e-06	4	20	2	8202136
Pubmed	Identification of a promoter region in the CG beta gene cluster.	CGB7 CGB3	1.88e-06	4	20	2	2452822
Pubmed	Only three of the seven human chorionic gonadotropin beta subunit genes can be expressed in the placenta.	CGB7 CGB1	1.88e-06	4	20	2	6209613
Pubmed	Luteinizing hormone induction of ovarian tumors: oligogenic differences between mouse strains dictates tumor disposition.	CGB7 CGB1	3.14e-06	5	20	2	10618427
Pubmed	Evolution of different transcriptional start sites in the human luteinizing hormone and chorionic gonadotropin beta-subunit genes.	CGB7 CGB3	3.14e-06	5	20	2	2424697
Pubmed	Androgen-responsive microRNAs in mouse Sertoli cells.	CGB7 CGB1	3.14e-06	5	20	2	22911753
Pubmed	Cloning of the mouse gonadotropin beta-subunit-encoding genes, II. Structure of the luteinizing hormone beta-subunit-encoding genes.	CGB7 CGB1	3.14e-06	5	20	2	8543188
Pubmed	Targeted disruption of luteinizing hormone beta-subunit leads to hypogonadism, defects in gonadal steroidogenesis, and infertility.	CGB7 CGB1	3.14e-06	5	20	2	15569941
Pubmed	Sulfation of LH does not affect intracellular trafficking.	CGB7 CGB1	3.14e-06	5	20	2	19647136
Pubmed	Hypogonadism caused by a single amino acid substitution in the beta subunit of luteinizing hormone.	CGB7 CGB1	3.14e-06	5	20	2	1727547
Pubmed	Expression of the beta subunit of chorionic gonadotropin in transgenic mice.	CGB7 CGB1	3.14e-06	5	20	2	7508931
Pubmed	Targeted overexpression of luteinizing hormone in transgenic mice leads to infertility, polycystic ovaries, and ovarian tumors.	CGB7 CGB1	3.14e-06	5	20	2	7877975
Pubmed	Elevated luteinizing hormone in prepubertal transgenic mice causes hyperandrogenemia, precocious puberty, and substantial ovarian pathology.	CGB7 CGB1	3.14e-06	5	20	2	9231809
Pubmed	Targeted overexpression of luteinizing hormone causes ovary-dependent functional adenomas restricted to cells of the Pit-1 lineage.	CGB7 CGB1	3.14e-06	5	20	2	12960102
Pubmed	Ovulatory surges of human CG prevent hormone-induced granulosa cell tumor formation leading to the identification of tumor-associated changes in the transcriptome.	CGB7 CGB1	3.14e-06	5	20	2	12040011
Pubmed	An Otx-related homeodomain protein binds an LHbeta promoter element important for activation during gonadotrope maturation.	CGB7 CGB1	3.14e-06	5	20	2	12040015
Pubmed	Luteinizing hormone beta promoter stimulation by adenylyl cyclase and cooperation with gonadotropin-releasing hormone 1 in transgenic mice and LBetaT2 Cells.	CGB7 CGB1	3.14e-06	5	20	2	17699734
Pubmed	The pleiotropic effects of excessive luteinizing hormone secretion in transgenic mice.	CGB7 CGB1	3.14e-06	5	20	2	17710732
Pubmed	Transgenic mice with chronically elevated luteinizing hormone are infertile due to anovulation, defects in uterine receptivity, and midgestation pregnancy failure.	CGB7 CGB1	3.14e-06	5	20	2	10342846
Pubmed	Stress levels of glucocorticoids inhibit LHβ-subunit gene expression in gonadotrope cells.	CGB7 CGB1	3.14e-06	5	20	2	22851703
Pubmed	The role of luteinizing hormone-beta gene polymorphism in the onset and progression of puberty in healthy boys.	CGB7 CGB1	3.14e-06	5	20	2	8784083
Pubmed	An i-motif-regulated enhancer, eRNA and adjacent lncRNA affect Lhb expression through distinct mechanisms in a sex-specific context.	CGB7 CGB1	3.14e-06	5	20	2	39158745
Pubmed	Effect of Soluble Adenylyl Cyclase (ADCY10) Inhibitors on the LH-Stimulated cAMP Synthesis in Mltc-1 Leydig Cell Line.	CGB7 CGB1	4.71e-06	6	20	2	33924969
Pubmed	Functional analysis of LHbeta knockout mice.	CGB7 CGB1	4.71e-06	6	20	2	17350160
Pubmed	Ablation of GalNAc-4-sulfotransferase-1 enhances reproduction by altering the carbohydrate structures of luteinizing hormone in mice.	CGB7 CGB1	4.71e-06	6	20	2	18431515
Pubmed	The calcium component of gonadotropin-releasing hormone-stimulated luteinizing hormone subunit gene transcription is mediated by calcium/calmodulin-dependent protein kinase type II.	CGB7 CGB1	4.71e-06	6	20	2	12746302
Pubmed	Development of a methodology for and assessment of pulsatile luteinizing hormone secretion in juvenile and adult male mice.	CGB7 CGB1	4.71e-06	6	20	2	24092638
Pubmed	Luteinizing hormone, a reproductive regulator that modulates the processing of amyloid-beta precursor protein and amyloid-beta deposition.	CGB7 CGB1	4.71e-06	6	20	2	14871891
Pubmed	Distinct mechanisms involving diverse histone deacetylases repress expression of the two gonadotropin beta-subunit genes in immature gonadotropes, and their actions are overcome by gonadotropin-releasing hormone.	CGB7 CGB1	4.71e-06	6	20	2	17371839
Pubmed	Differential activation of the luteinizing hormone beta-subunit promoter by activin and gonadotropin-releasing hormone: a role for the mitogen-activated protein kinase signaling pathway in LbetaT2 gonadotrophs.	CGB7 CGB1	4.71e-06	6	20	2	13679314
Pubmed	AMP-activated protein kinase is a key intermediary in GnRH-stimulated LHβ gene transcription.	CGB7 CGB1	4.71e-06	6	20	2	23518923
Pubmed	Free fatty acids induce Lhb mRNA but suppress Fshb mRNA in pituitary LβT2 gonadotropes and diet-induced obesity reduces FSH levels in male mice and disrupts the proestrous LH/FSH surge in female mice.	CGB7 CGB1	4.71e-06	6	20	2	23525221
Pubmed	Maximal activity of the luteinizing hormone beta-subunit gene requires beta-catenin.	CGB7 CGB1	4.71e-06	6	20	2	17244763
Pubmed	Increases in luteinizing hormone are associated with declines in cognitive performance.	CGB7 CGB1	4.71e-06	6	20	2	17376589
Pubmed	Luteinizing hormone promotes gonadal tumorigenesis in inhibin-deficient mice.	CGB7 CGB1	4.71e-06	6	20	2	18657590
Pubmed	The role of amino acid neurotransmitters in the regulation of pituitary gonadotropin release in fish.	CGB7 CGB1	4.71e-06	6	20	2	10949077
Pubmed	Different signaling pathways control acute induction versus long-term repression of LHbeta transcription by GnRH.	CGB7 CGB1	4.71e-06	6	20	2	12193554
Pubmed	The role of endocannabinoids in the regulation of luteinizing hormone and prolactin release. Differences between the effects of AEA and 2AG.	CGB7 CGB1	4.71e-06	6	20	2	18308464
Pubmed	CREB binding protein (CBP) activation is required for luteinizing hormone beta expression and normal fertility in mice.	CGB7 CGB1	4.71e-06	6	20	2	22508984
Pubmed	Secretoneurin stimulates the production and release of luteinizing hormone in mouse L{beta}T2 gonadotropin cells.	CGB7 CGB1	4.71e-06	6	20	2	21521715
Pubmed	Dependence of uterine cyclooxygenase2 expression on luteinizing hormone signaling.	CGB7 CGB1	4.71e-06	6	20	2	15814897
Pubmed	A new role for wilms tumor protein 1: differential activities of + KTS and -KTS variants to regulate LHβ transcription.	CGB7 CGB1	4.71e-06	6	20	2	25617744
Pubmed	Development of leydig cells in the insulin-like growth factor-I (igf-I) knockout mouse: effects of igf-I replacement and gonadotropic stimulation.	CGB7 CGB1	4.71e-06	6	20	2	14585811
Pubmed	Prolactin regulation of gonadotropin-releasing hormone neurons to suppress luteinizing hormone secretion in mice.	CGB7 CGB1	4.71e-06	6	20	2	17569755
Pubmed	The lack of estrogen and excess luteinizing hormone are responsible for the female ArKO mouse phenotype.	CGB7 CGB1	4.71e-06	6	20	2	20546829
Pubmed	FOXO1 transcription factor inhibits luteinizing hormone β gene expression in pituitary gonadotrope cells.	CGB7 CGB1	6.59e-06	7	20	2	22865884
Pubmed	Early growth response protein 1 binds to the luteinizing hormone-beta promoter and mediates gonadotropin-releasing hormone-stimulated gene expression.	CGB7 CGB1	6.59e-06	7	20	2	10319325
Pubmed	Icam5 Expression Exhibits Sex Differences in the Neonatal Pituitary and Is Regulated by Estradiol and Bisphenol A.	CGB7 CGB1	6.59e-06	7	20	2	26789235
Pubmed	PPARγ co-activator-1α co-activates steroidogenic factor 1 to stimulate the synthesis of luteinizing hormone and aldosterone.	CGB7 CGB1	6.59e-06	7	20	2	21108604
Pubmed	Embryonic expression of the luteinizing hormone beta gene appears to be coupled to the transient appearance of p8, a high mobility group-related transcription factor.	CGB7 CGB1	6.59e-06	7	20	2	12429736
Pubmed	Expression of the pituitary adenylate cyclase-activating polypeptide (PACAP) type 1 receptor (PAC1R) potentiates the effects of GnRH on gonadotropin subunit gene expression.	CGB7 CGB1	6.59e-06	7	20	2	21658369
Pubmed	Ovulation involves the luteinizing hormone-dependent activation of G(q/11) in granulosa cells.	CGB7 CGB1	6.59e-06	7	20	2	23836924
Pubmed	Redirecting intracellular trafficking and the secretion pattern of FSH dramatically enhances ovarian function in mice.	CGB7 CGB1	6.59e-06	7	20	2	24706813
Pubmed	Disruption of the single copy gonadotropin-releasing hormone receptor in mice by gene trap: severe reduction of reproductive organs and functions in developing and adult mice.	CGB7 CGB1	6.59e-06	7	20	2	20068010
Pubmed	Pulse sensitivity of the luteinizing hormone beta promoter is determined by a negative feedback loop Involving early growth response-1 and Ngfi-A binding protein 1 and 2.	CGB7 CGB1	6.59e-06	7	20	2	17299135
Pubmed	Evidence for cross-talk between the LH receptor and LH during implantation in mice.	CGB7 CGB1	6.59e-06	7	20	2	23464498
Pubmed	Reference intervals for serum testosterone, SHBG, LH and FSH in males from the NORIP project.	CGB7 CGB1	6.59e-06	7	20	2	19929279
Pubmed	The orphan nuclear receptors COUP-TFI and COUP-TFII regulate expression of the gonadotropin LHβ gene.	CGB7 CGB1	6.59e-06	7	20	2	20797425
Pubmed	Activin induces x-zone apoptosis that inhibits luteinizing hormone-dependent adrenocortical tumor formation in inhibin-deficient mice.	CGB7 CGB1	6.59e-06	7	20	2	12748296
Pubmed	Mutual Effects of Orexin and Bone Morphogenetic Proteins on Gonadotropin Expression by Mouse Gonadotrope Cells.	CGB7 CGB1	6.59e-06	7	20	2	36077179
Pubmed	Cyclic GMP signaling is involved in the luteinizing hormone-dependent meiotic maturation of mouse oocytes.	CGB7 CGB1	6.59e-06	7	20	2	19474061
Pubmed	Anterior pituitary development: short tales from dwarf mice.	CGB7 CGB1	6.59e-06	7	20	2	1505020
Pubmed	A null mutation in basigin, an immunoglobulin superfamily member, indicates its important roles in peri-implantation development and spermatogenesis.	CGB7 CGB1	6.59e-06	7	20	2	9501026
Pubmed	Assignment of the genes for the alpha and beta subunits of thyrotropin to different mouse chromosomes.	CGB7 CGB1	6.59e-06	7	20	2	6582507
Pubmed	Stress rapidly suppresses in vivo LH pulses and increases activation of RFRP-3 neurons in male mice.	CGB7 CGB1	6.59e-06	7	20	2	30382693
Pubmed	Absent Progesterone Signaling in Kisspeptin Neurons Disrupts the LH Surge and Impairs Fertility in Female Mice.	CGB7 CGB1	6.59e-06	7	20	2	26076042
Pubmed	Regulation of LH/FSH expression by secretoglobin 3A2 in the mouse pituitary gland.	CGB7 CGB1	6.59e-06	7	20	2	24514953
Pubmed	Biphasic Roles of Clock Genes and Bone Morphogenetic Proteins in Gonadotropin Expression by Mouse Gonadotrope Cells.	CGB7 CGB1	6.59e-06	7	20	2	34681844
Pubmed	LIM homeodomain transcription factor Isl-1 enhances follicle stimulating hormone-beta and luteinizing hormone-beta gene expression and mediates the activation of leptin on gonadotropin synthesis.	CGB7 CGB1	8.78e-06	8	20	2	20702576
Pubmed	The polycystic ovary syndrome-associated gene Yap1 is regulated by gonadotropins and sex steroid hormones in hyperandrogenism-induced oligo-ovulation in mouse.	CGB7 CGB1	8.78e-06	8	20	2	28961951
Pubmed	Transforming growth factor-beta1 null mutation causes infertility in male mice associated with testosterone deficiency and sexual dysfunction.	CGB7 CGB1	8.78e-06	8	20	2	17478551
Pubmed	Gonadotrope-specific deletion of Dicer results in severely suppressed gonadotropins and fertility defects.	CGB7 CGB1	8.78e-06	8	20	2	25525274
Pubmed	Dephosphorylation of juxtamembrane serines and threonines of the NPR2 guanylyl cyclase is required for rapid resumption of oocyte meiosis in response to luteinizing hormone.	CGB7 CGB1	8.78e-06	8	20	2	26522847
Pubmed	Gonadotrope and thyrotrope development in the human and mouse anterior pituitary gland.	CGB7 CGB1	8.78e-06	8	20	2	16806148
Pubmed	The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus.	CGB7 CGB1	8.78e-06	8	20	2	7659091
Pubmed	Pituitary homeobox 1 (Ptx1) is differentially expressed during pituitary development.	CGB7 CGB1	1.13e-05	9	20	2	10067870
Pubmed	Loss-of-function mutation in the prokineticin 2 gene causes Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism.	CGB7 CGB1	1.13e-05	9	20	2	17959774
Pubmed	Ontogeny of the prohormone convertases PC1 and PC2 in the mouse hypophysis and their colocalization with corticotropin and alpha-melanotropin.	CGB7 CGB1	1.13e-05	9	20	2	8389457
Pubmed	Hypothalamic dysregulation and infertility in mice lacking the homeodomain protein Six6.	CGB7 CGB1	1.13e-05	9	20	2	21228153
Pubmed	Chromosome assignment of genes encoding the alpha and beta subunits of glycoprotein hormones in man and mouse.	CGB7 CGB1	1.13e-05	9	20	2	6581542
Pubmed	Abnormal development of the olfactory bulb and reproductive system in mice lacking prokineticin receptor PKR2.	CGB7 CGB1	1.13e-05	9	20	2	16537498
Pubmed	The mouse cyclin E maps to chromosome 7.	CGB7 CGB1	1.41e-05	10	20	2	8833259
Pubmed	Follicle-stimulating hormone synthesis and fertility depend on SMAD4 and FOXL2.	CGB7 CGB1	1.41e-05	10	20	2	24739304
Pubmed	Steroidogenic Factor 1 Regulates Transcription of the Inhibin B Coreceptor in Pituitary Gonadotrope Cells.	CGB7 CGB1	1.41e-05	10	20	2	35957608
Cytoband	19q13.32	CGB7 CGB3 CGB1	4.49e-06	74	20	3	19q13.32
Cytoband	8q24.3	SLURP1 MROH5	1.11e-03	113	20	2	8q24.3
Cytoband	Ensembl 112 genes in cytogenetic band chr8q24	SLURP1 MROH5	1.03e-02	355	20	2	chr8q24
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	CGB7 CGB3 CGB1	1.43e-02	1192	20	3	chr19q13
GeneFamily	PDZ domain containing	MPDZ SIPA1L1 FRMPD3	2.46e-04	152	15	3	1220
ToppCell	droplet-Liver-Hepatocytes-24m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP30 SIPA1L1 SULF2	4.55e-05	157	20	3	ec433d2fe827abdb647be4176c231b7052482b6f
ToppCell	P15-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SLURP1 ADAMTSL1 SULF2	5.37e-05	166	20	3	545f6c91102568791443717e522f89cb3bd1a070
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L5-6_RORB_LINC00320\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LRP1B DNAH14 SULF2	6.07e-05	173	20	3	4ec147479b359cce1975d57a50ee1437a0e1e663
ToppCell	P28-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SLURP1 ADAMTSL1 SULF2	6.61e-05	178	20	3	1e05bc26591fea16e29bcfc5f538dda1dc427f05
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_8\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	PPM1D SIPA1L1 SULF2	6.72e-05	179	20	3	0624dd537a68736f4d7b8b4de2c56168ed0e60a9
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_8\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PPM1D SIPA1L1 SULF2	6.72e-05	179	20	3	163f5430d72ea0c1b239ea5d21e53be536636d3d
ToppCell	droplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l20-25\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SLURP1 DUOX1 SULF2	7.65e-05	187	20	3	0d4b7da81036c2aa678654b9fe49c939d08fcd9b
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	LRP1B ADAMTSL1 SULF2	8.14e-05	191	20	3	156b467187331ac6ca390d6ca861d9670bb7b956
ToppCell	COVID-19-Heart-EC_(POSTN)\|Heart / Disease (COVID-19 only), tissue and cell type	ADAMTSL1 SIPA1L1 SULF2	8.27e-05	192	20	3	c0c34785a7bdf461722029b322e9184e3d9b3c26
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	LRP1B DNAH14 ADAMTSL1	8.66e-05	195	20	3	19853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	LRP1B DNAH14 ADAMTSL1	8.66e-05	195	20	3	d3755929ebbbf5e3afde44281e9056ddb614a291
Disease	Uveal Melanoma	LRP1B ADAMTSL1	5.31e-04	53	19	2	EFO_1000616
Disease	response to alcohol	SIPA1L1 CAST	1.06e-03	75	19	2	EFO_0005526
Disease	QRS-T angle	ADAMTSL1 SIPA1L1	2.10e-03	106	19	2	EFO_0020097
Disease	pneumonia, COVID-19	LRP1B ADAMTSL1	2.38e-03	113	19	2	EFO_0003106, MONDO_0100096
Disease	lifestyle measurement, maximum cigarettes per day measurement	ADAMTSL1 SIPA1L1	2.77e-03	122	19	2	EFO_0009264, EFO_0010724
Disease	coronary artery calcification	LRP1B SIPA1L1 MROH5	2.85e-03	450	19	3	EFO_0004723
Disease	Malignant neoplasm of breast	PPM1D PDPK1 SIPA1L1 SULF2	4.37e-03	1074	19	4	C0006142
Disease	age at menarche	LRP1B SULF2 CAST	6.19e-03	594	19	3	EFO_0004703
Disease	X-12063 measurement	LRP1B DNAH14	6.30e-03	186	19	2	EFO_0021283

Protein segments in the cluster

Peptide	Gene	Start	Entry
CCPYTRRASKSSRPM	FBXO4	146	Q9UKT5
TTICAGYCPTMTRVL	CGB1	81	A6NKQ9
CRRASYISQDMICPS	DUOX1	951	Q9NRD9
MICPSPRVSARCSRS	DUOX1	961	Q9NRD9
PTSETTRTCMCTVGY	LRP1B	1851	Q9NZR2
PFSSSIRPCMLATCA	ADAMTSL1	836	Q8N6G6
TTICAGYCPTMTRVL	CGB7	51	P0DN87
YNSQETCVMTPSPCS	PPM1D	401	O15297
TTICAGYCPTMTRVL	CGB3	51	P0DN86
TYPMALQSPSCQSRS	FRMPD3	1161	Q5JV73
RQNCRVYPSMISSCT	DNAH14	2151	Q0VDD8
AVCRTSMCSIQSAPP	CAST	406	P20810
DYCLIPRTSPCSMIS	ARHGAP30	1026	Q7Z6I6
MDRQCSERPYSCTPT	MROH5	1	Q6ZUA9
SSVVLCSCPSPSMVR	PDPK1	16	O15530
CTPRRSCSETYRMPV	SIPA1L1	1031	O43166
PMTSASCRTITRCKP	SLURP1	31	P55000
VTMVCCRRTVPPTTQ	MPDZ	626	O75970
TRMHTGERPYTCTVC	ZBTB24	341	O43167
AFVTTPMCCPSRSSI	SULF2	81	Q8IWU5
STSCMTVSCPRQRYP	TM2D3	141	Q9BRN9