Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	dipeptidyl-peptidase activity	DPP9 DPP8	2.30e-04	12	38	2	GO:0008239
GeneOntologyBiologicalProcess	central nervous system segmentation	ZIC2 ZIC3	3.47e-05	5	39	2	GO:0035283
MousePheno	abnormal oviduct physiology	SAFB PRLR	5.40e-06	2	33	2	MP:0012018
MousePheno	abnormal hepatic vein connection	TULP4 ZIC2	3.23e-05	4	33	2	MP:0013973
Domain	-	DPP9 DPP8	7.01e-05	6	41	2	2.140.10.30
Domain	DPPIV_N	DPP9 DPP8	7.01e-05	6	41	2	PF00930
Domain	Peptidase_S9B_N	DPP9 DPP8	7.01e-05	6	41	2	IPR002469
Domain	Peptidase_S9	DPP9 DPP8	2.55e-04	11	41	2	PF00326
Domain	Peptidase_S9	DPP9 DPP8	2.55e-04	11	41	2	IPR001375
Domain	PTB	EPS8 TBC1D1	3.48e-03	40	41	2	SM00462
Domain	PTB/PI_dom	EPS8 TBC1D1	3.65e-03	41	41	2	IPR006020
Pubmed	Zic4, a zinc-finger transcription factor, is expressed in the developing mouse nervous system.	ZIC4 ZIC2 ZIC3	6.08e-09	4	41	3	15895369
Pubmed	Spatiotemporal expression of Zic genes during vertebrate inner ear development.	ZIC4 ZIC2 ZIC3	1.81e-07	10	41	3	23606270
Pubmed	CD spectra show the relational style between Zic-, Gli-, Glis-zinc finger protein and DNA.	ZIC4 ZIC2 ZIC3	1.81e-07	10	41	3	18298960
Pubmed	Structure-activity relationship studies on isoindoline inhibitors of dipeptidyl peptidases 8 and 9 (DPP8, DPP9): is DPP8-selectivity an attainable goal?	DPP9 DPP8	1.36e-06	2	41	2	21711053
Pubmed	DP8 and DP9 have extra-enzymatic roles in cell adhesion, migration and apoptosis.	DPP9 DPP8	1.36e-06	2	41	2	16700509
Pubmed	Identifying natural substrates for dipeptidyl peptidases 8 and 9 using terminal amine isotopic labeling of substrates (TAILS) reveals in vivo roles in cellular homeostasis and energy metabolism.	DPP9 DPP8	1.36e-06	2	41	2	23519473
Pubmed	Profibrotic mechanisms of DPP8 and DPP9 highly expressed in the proximal renal tubule epithelial cells.	DPP9 DPP8	1.36e-06	2	41	2	33932609
Pubmed	Inhibition of dipeptidyl peptidase 8/9 impairs preadipocyte differentiation.	DPP9 DPP8	1.36e-06	2	41	2	26242871
Pubmed	Expression profiling of dipeptidyl peptidase 8 and 9 in breast and ovarian carcinoma cell lines.	DPP9 DPP8	1.36e-06	2	41	2	22736146
Pubmed	Structural requirements for catalysis, expression, and dimerization in the CD26/DPIV gene family.	DPP9 DPP8	1.36e-06	2	41	2	12534281
Pubmed	Establishment of a dipeptidyl peptidases (DPP) 8/9 expressing cell model for evaluating the selectivity of DPP4 inhibitors.	DPP9 DPP8	1.36e-06	2	41	2	25464020
Pubmed	DPP8/9 inhibition attenuates the TGF-β1-induced excessive deposition of extracellular matrix (ECM) in human mesangial cells via Smad and Akt signaling pathways.	DPP9 DPP8	1.36e-06	2	41	2	38458339
Pubmed	Decrease of the pro-inflammatory M1-like response by inhibition of dipeptidyl peptidases 8/9 in THP-1 macrophages - quantitative proteomics of the proteome and secretome.	DPP9 DPP8	1.36e-06	2	41	2	32998073
Pubmed	The in vivo expression of dipeptidyl peptidases 8 and 9.	DPP9 DPP8	1.36e-06	2	41	2	19581630
Pubmed	Progesterone induces expression of the prolactin receptor gene through cooperative action of Sp1 and C/EBP.	PRLR PGR	1.36e-06	2	41	2	21238538
Pubmed	Lack of association between ZIC2 and ZIC3 genes and the risk of neural tube defects (NTDs) in Hispanic populations.	ZIC2 ZIC3	1.36e-06	2	41	2	12522805
Pubmed	ZIC2 and ZIC3 promote SWI/SNF recruitment to safeguard progression towards human primed pluripotency.	ZIC2 ZIC3	1.36e-06	2	41	2	39358345
Pubmed	Isoforms of dipeptidyl aminopeptidase IV from Pseudomonas sp. WO24: role of the signal sequence and overexpression in Escherichia coli.	DPP9 DPP8	4.06e-06	3	41	2	15866709
Pubmed	Expression of the receptor tyrosine kinase substrate genes eps8 and eps15 during mouse development.	EPS8 EPS15	4.06e-06	3	41	2	7566980
Pubmed	DPP9's Enzymatic Activity and Not Its Binding to CARD8 Inhibits Inflammasome Activation.	DPP9 DPP8	4.06e-06	3	41	2	31525884
Pubmed	Dipeptidyl peptidases in atherosclerosis: expression and role in macrophage differentiation, activation and apoptosis.	DPP9 DPP8	4.06e-06	3	41	2	23608773
Pubmed	Structural and biochemical mechanisms of NLRP1 inhibition by DPP9.	DPP9 DPP8	4.06e-06	3	41	2	33731929
Pubmed	DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation.	DPP9 DPP8	4.06e-06	3	41	2	33731932
Pubmed	The imitation switch protein SNF2L regulates steroidogenic acute regulatory protein expression during terminal differentiation of ovarian granulosa cells.	PRLR PGR	4.06e-06	3	41	2	16740656
Pubmed	The effect of CD26-deficiency on dipeptidyl peptidase 8 and 9 expression profiles in a mouse model of Crohn's disease.	DPP9 DPP8	4.06e-06	3	41	2	29693275
Pubmed	Extraenzymatic functions of the dipeptidyl peptidase IV-related proteins DP8 and DP9 in cell adhesion, migration and apoptosis.	DPP9 DPP8	4.06e-06	3	41	2	16704418
Pubmed	Cloning and characterization of dipeptidyl peptidase 10, a new member of an emerging subgroup of serine proteases.	DPP9 DPP8	4.06e-06	3	41	2	12662155
Pubmed	The role of Zic family zinc finger transcription factors in the proliferation and differentiation of retinal progenitor cells.	ZIC2 ZIC3	4.06e-06	3	41	2	22024047
Pubmed	The SUMO1-E67 interacting loop peptide is an allosteric inhibitor of the dipeptidyl peptidases 8 and 9.	DPP9 DPP8	4.06e-06	3	41	2	24072711
Pubmed	Genetic variants in ZIC1, ZIC2, and ZIC3 are not major risk factors for neural tube defects in humans.	ZIC2 ZIC3	4.06e-06	3	41	2	14679585
Pubmed	Progesterone receptor isoform-dependent cross-talk between prolactin and fatty acid synthase in breast cancer.	PRLR PGR	4.06e-06	3	41	2	33335078
Pubmed	Overlapping and distinct expression domains of Zic2 and Zic3 during mouse gastrulation.	ZIC2 ZIC3	4.06e-06	3	41	2	15261827
Pubmed	The mouse zic gene family. Homologues of the Drosophila pair-rule gene odd-paired.	ZIC2 ZIC3	4.06e-06	3	41	2	8557628
Pubmed	Inhibition of Dpp8/9 Activates the Nlrp1b Inflammasome.	DPP9 DPP8	8.12e-06	4	41	2	29396289
Pubmed	SUMOylation Potentiates ZIC Protein Activity to Influence Murine Neural Crest Cell Specification.	ZIC2 ZIC3	8.12e-06	4	41	2	34638777
Pubmed	Expression of dipeptidyl peptidase-IV activity and/or structure homologs in human meningiomas.	DPP9 DPP8	8.12e-06	4	41	2	20043068
Pubmed	An Evolutionarily Conserved Mesodermal Enhancer in Vertebrate Zic3.	ZIC2 ZIC3	8.12e-06	4	41	2	30297839
Pubmed	[The correlation between the expression of PRL-R and ER/PR in breast cancer].	PRLR PGR	8.12e-06	4	41	2	20335148
Pubmed	Disruption of steroid and prolactin receptor patterning in the mammary gland correlates with a block in lobuloalveolar development.	PRLR PGR	8.12e-06	4	41	2	12456789
Pubmed	Molecular properties of Zic proteins as transcriptional regulators and their relationship to GLI proteins.	ZIC2 ZIC3	8.12e-06	4	41	2	11053430
Pubmed	A novel zinc finger protein, zic, is involved in neurogenesis, especially in the cell lineage of cerebellar granule cells.	ZIC2 ZIC3	8.12e-06	4	41	2	7931345
Pubmed	Myogenic repressor I-mfa interferes with the function of Zic family proteins.	ZIC2 ZIC3	1.35e-05	5	41	2	15207726
Pubmed	Regulation of dipeptidyl peptidase 8 and 9 expression in activated lymphocytes and injured liver.	DPP9 DPP8	1.35e-05	5	41	2	23704821
Pubmed	Cyclin-dependent kinase activity is required for progesterone receptor function: novel role for cyclin A/Cdk2 as a progesterone receptor coactivator.	CCNA1 PGR	1.35e-05	5	41	2	15601848
Pubmed	Expression and prognostic assessment of dipeptidyl peptidase IV and related enzymes in B-cell chronic lymphocytic leukemia.	DPP9 DPP8	1.35e-05	5	41	2	20534982
Pubmed	DPP8/DPP9 inhibition elicits canonical Nlrp1b inflammasome hallmarks in murine macrophages.	DPP9 DPP8	2.03e-05	6	41	2	30718379
Pubmed	Molecular properties of Zic4 and Zic5 proteins: functional diversity within Zic family.	ZIC4 ZIC2	2.03e-05	6	41	2	15465018
Pubmed	Physical and functional interactions between Zic and Gli proteins.	ZIC2 ZIC3	2.03e-05	6	41	2	11238441
Pubmed	Zic2 patterns binocular vision by specifying the uncrossed retinal projection.	ZIC2 ZIC3	2.84e-05	7	41	2	13678579
Pubmed	DPP9 enzyme activity controls survival of mouse migratory tongue muscle progenitors and its absence leads to neonatal lethality due to suckling defect.	DPP9 DPP8	2.84e-05	7	41	2	28887018
Pubmed	Hierarchical CRMP2 posttranslational modifications control NaV1.7 function.	EPS15 UBE2I	2.84e-05	7	41	2	27940916
Pubmed	Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex.	UBE2I NUP153	2.84e-05	7	41	2	12192048
Pubmed	Mesp1 controls the chromatin and enhancer landscapes essential for spatiotemporal patterning of early cardiovascular progenitors.	ZIC2 ZIC3	2.84e-05	7	41	2	35817961
Pubmed	The expression of the mouse Zic1, Zic2, and Zic3 gene suggests an essential role for Zic genes in body pattern formation.	ZIC2 ZIC3	3.78e-05	8	41	2	9070329
Pubmed	The role of Zic genes in inner ear development in the mouse: Exploring mutant mouse phenotypes.	ZIC4 ZIC2	4.86e-05	9	41	2	25178196
Pubmed	Mouse Zic5 deficiency results in neural tube defects and hypoplasia of cephalic neural crest derivatives.	ZIC2 ZIC3	6.07e-05	10	41	2	15136147
Pubmed	A role for Zic1 and Zic2 in Myf5 regulation and somite myogenesis.	ZIC2 ZIC3	6.07e-05	10	41	2	21211521
Pubmed	FGF8 signaling patterns the telencephalic midline by regulating putative key factors of midline development.	ZIC4 ZIC2	7.41e-05	11	41	2	18547559
Pubmed	Fibroblast growth factor 8 organizes the neocortical area map and regulates sensory map topography.	ZIC2 ZIC3	7.41e-05	11	41	2	22623663
Pubmed	The Stat6-regulated KRAB domain zinc finger protein Zfp157 regulates the balance of lineages in mammary glands and compensates for loss of Gata-3.	PRLR PGR	1.22e-04	14	41	2	22588720
Pubmed	Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation.	RPS6KA6 UBE2I	1.22e-04	14	41	2	17709345
Pubmed	Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins.	DPP9 DPP8 PHAX	1.61e-04	89	41	3	23891004
Pubmed	New semidominant mutations that affect mouse development.	ZIC2 ZIC3	1.61e-04	16	41	2	15384171
Pubmed	Lack of CUL4B leads to increased abundance of GFAP-positive cells that is mediated by PTGDS in mouse brain.	ZIC4 ZIC3	1.82e-04	17	41	2	26025376
Pubmed	Zic2 and Zic3 synergistically control neurulation and segmentation of paraxial mesoderm in mouse embryo.	ZIC2 ZIC3	2.05e-04	18	41	2	17490632
Pubmed	HIF2α in the uterine stroma permits embryo invasion and luminal epithelium detachment.	PRLR PGR	2.29e-04	19	41	2	29911998
Pubmed	Genetic variation within the hypothalamus-pituitary-ovarian axis in women with recurrent miscarriage.	PRLR PGR	2.54e-04	20	41	2	20716560
Pubmed	Oxidized thioredoxin-1 restrains the NLRP1 inflammasome.	DPP9 DPP8	2.81e-04	21	41	2	36332009
Pubmed	The DNA Methyltransferase 1 (DNMT1) Controls the Shape and Dynamics of Migrating POA-Derived Interneurons Fated for the Murine Cerebral Cortex.	ZIC4 ZIC3	2.81e-04	21	41	2	29117290
Pubmed	Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations.	TBC1D1 RNASET2	3.09e-04	22	41	2	23850713
Pubmed	Zic deficiency in the cortical marginal zone and meninges results in cortical lamination defects resembling those in type II lissencephaly.	ZIC2 ZIC3	3.09e-04	22	41	2	18448648
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	EPS8 TLK1 TADA2A PHAX NUP153	3.11e-04	506	41	5	30890647
Pubmed	Two-hybrid analysis identifies PSMD11, a non-ATPase subunit of the proteasome, as a novel interaction partner of AMP-activated protein kinase.	FLNC UBE2I	3.68e-04	24	41	2	19616115
Pubmed	Lmx1b controls the differentiation and migration of the superficial dorsal horn neurons of the spinal cord.	ZIC4 ZIC2	4.00e-04	25	41	2	15229182
Pubmed	Zic1 and Zic3 regulate medial forebrain development through expansion of neuronal progenitors.	ZIC2 ZIC3	4.00e-04	25	41	2	17507568
Pubmed	Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells.	ZIC2 ZIC3	4.33e-04	26	41	2	22992956
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	EPS15 FLNC ADGRE5 TULP4	6.04e-04	329	41	4	17474147
Pubmed	Genome-wide association study of periodontal pathogen colonization.	ANKRD30A TBC1D1	6.17e-04	31	41	2	22699663
Pubmed	Functional proteomics mapping of a human signaling pathway.	EPS15 FLNC LIMK2 UBE2I TBC1D1	6.30e-04	591	41	5	15231748
Pubmed	Quantitative trait loci predicting circulating sex steroid hormones in men from the NCI-Breast and Prostate Cancer Cohort Consortium (BPC3).	PRLR PGR	9.28e-04	38	41	2	19574343
Pubmed	Charting the landscape of tandem BRCT domain-mediated protein interactions.	EPS8 SAFB TADA2A PHAX TBC1D1	1.10e-03	670	41	5	22990118
Cytoband	2q31.1	TLK1 HOXD12	2.59e-03	84	41	2	2q31.1
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	SAMD1 ADGRE5 SAFB DPP9	5.49e-03	797	41	4	chr19p13
Cytoband	Ensembl 112 genes in cytogenetic band chr10p11	ZNF438 ANKRD30A	5.80e-03	127	41	2	chr10p11
GeneFamily	CD molecules\|DASH family	DPP9 DPP8	4.16e-05	7	26	2	1205
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF438 ZIC4 ZIC2 ZIC3 ZNF316	3.20e-03	718	26	5	28
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ANKRD30A EPS8 TBC1D1 PRLR	1.31e-05	157	41	4	c17c5c01fcb65c453690c265ec4f300ecdfefd34
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Neuronal-Cajal-Retzius\|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.	SPOCK3 PGR ZIC2 ZIC3	1.51e-05	163	41	4	c1484e4de8b10e2f5fb14a7c02b2a015ffe0305e
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ANKRD30A EPS8 TBC1D1 PGR	1.59e-05	165	41	4	dc570154baed59ed109e5369589448e075ba66a9
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ANKRD30A EPS8 TBC1D1 PRLR	1.91e-05	173	41	4	0bc2aacae60c6d3276b0949eb0748b4ac1f56e54
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ANKRD30A EPS8 TBC1D1 PRLR	2.05e-05	176	41	4	c2c4306476989bc2fb30dab00250ef7915842f13
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ANKRD30A EPS8 TBC1D1 PRLR	2.09e-05	177	41	4	8e4005fad50e6f919da175f3b9ae58849dbd60b1
ToppCell	5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANKRD30A SPOCK3 TBC1D1 PRLR	2.28e-05	181	41	4	2b53a65ca5616a7b9f64232c3e0b7212d1e2f063
ToppCell	5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANKRD30A SPOCK3 TBC1D1 PRLR	2.28e-05	181	41	4	6aef84616e8d2faf54b7e9e6cd02f33c3066dabc
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ANKRD30A EPS8 TBC1D1 PRLR	2.28e-05	181	41	4	30729f0364f719c044712a51453e22dc2c1a232b
ToppCell	5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANKRD30A SPOCK3 TBC1D1 PRLR	2.28e-05	181	41	4	40df0afcb6848202da54670e84f22d7c3a515d01
ToppCell	5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANKRD30A SPOCK3 TBC1D1 PRLR	2.28e-05	181	41	4	40d3829ae4aaf81e8616c3499ff8933137fc1cc4
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ANKRD30A EPS8 TBC1D1 PRLR	2.59e-05	187	41	4	7b0168bdaa7c6c6b39878aff6a17f0943189a380
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	SAMD1 TADA2A PHAX TRMT2B	2.82e-05	191	41	4	cadb7a9de16f4bb21606de0e25cddd2d748c7f0b
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-Neuronal-midbrain/hindbrain_cells\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	ZIC4 PGM2L1 SPOCK3 ZIC2	3.12e-05	196	41	4	0767581b69bc7e6334d580ca02ed1e831b7b55da
Drug	UAMC00132	DPP9 DPP8	3.16e-06	2	41	2	ctd:C524159
Drug	SureCN3749646	DPP9 DPP8	9.48e-06	3	41	2	CID011530920
Drug	SureCN3745540	DPP9 DPP8	9.48e-06	3	41	2	CID011974437
Drug	SureCN3749947	DPP9 DPP8	9.48e-06	3	41	2	CID011974435
Drug	ABT-279	DPP9 DPP8	9.48e-06	3	41	2	CID016049769
Drug	Cyanopyrrolidine 38	DPP9 DPP8	9.48e-06	3	41	2	CID010932707
Drug	Cyanopyrrolidine 39	DPP9 DPP8	9.48e-06	3	41	2	CID011117606
Drug	SureCN3748611	DPP9 DPP8	9.48e-06	3	41	2	CID011974325
Drug	Diprolyl-alanine	DPP9 DPP8	9.48e-06	3	41	2	CID000193559
Drug	Arg-pro	EPS15 DPP9 DPP8 ZIC3	1.43e-05	82	41	4	CID000151003
Drug	RU 16117	SAFB PRLR PGR	1.72e-05	28	41	3	CID000066408
Drug	glycylproline 4-nitroanilide	DPP9 DPP8	1.89e-05	4	41	2	ctd:C042892
Drug	hexestrol	SAFB DHDH LPO	1.92e-05	29	41	3	CID000003606
Drug	butyl benzyl phthalate	SAFB TBC1D1 PGR	2.59e-05	32	41	3	CID000002347
Drug	prodipine	DPP9 DPP8	3.15e-05	5	41	2	CID000065775
Drug	arginyl(PMC)-pyrrolidine-2-nitrile	DPP9 DPP8	3.15e-05	5	41	2	CID000487437
Drug	alanylproline-4-nitroanilide	DPP9 DPP8	3.15e-05	5	41	2	ctd:C083013
Drug	Cyproterone Acetate	PRLR PGR LPO	3.41e-05	35	41	3	ctd:D017373
Drug	imazapyr	DPP9 DPP8 NUP153	4.04e-05	37	41	3	CID000054738
Drug	Protease Inhibitors	DPP9 DPP8	4.72e-05	6	41	2	ctd:D011480
Drug	cathepsin C substrate	DPP9 DPP8	4.72e-05	6	41	2	CID003508173
Drug	NVP-DPP728	DPP9 DPP8	4.72e-05	6	41	2	CID009796290
Drug	MK-251	DPP9 DPP8	4.72e-05	6	41	2	CID000176160
Drug	chrysosplenetin	CCNA1 PGR	4.72e-05	6	41	2	CID005281608
Drug	II 19	DPP9 DPP8	4.72e-05	6	41	2	CID000040321
Drug	NVP & EFV	DPP9 DPP8 HOXD12 ZIC2	6.60e-05	121	41	4	CID000492400
Drug	Epostatin	DPP9 DPP8	6.61e-05	7	41	2	CID006449105
Drug	Medroxyprogesterone	PGR LPO	6.61e-05	7	41	2	ctd:D008525
Drug	o-Py	DPP9 DPP8	6.61e-05	7	41	2	CID009942336
Drug	triphenylethylene	SAFB PRLR PGR	7.80e-05	46	41	3	CID000006025
Drug	CID6451162	DPP9 DPP8	8.80e-05	8	41	2	CID006451162
Drug	P32/98	DPP9 DPP8	8.80e-05	8	41	2	CID006918464
Drug	imidazolelactate	DPP9 DPP8	8.80e-05	8	41	2	CID000000793
Drug	o-dianisidine	DPP9 DPP8 LPO	1.00e-04	50	41	3	CID000008411
Drug	ORG 2058	SAFB PRLR PGR	1.06e-04	51	41	3	CID000119086
Drug	NSC-334212	DPP9 DPP8	1.13e-04	9	41	2	CID000333414
Drug	Gly-pro-na	DPP9 DPP8	1.13e-04	9	41	2	CID000194319
Drug	U23,469	SAFB PGR	1.13e-04	9	41	2	CID000161922
Drug	isoindoline	DPP9 DPP8	1.13e-04	9	41	2	CID000422477
Drug	Appna	DPP9 DPP8	1.13e-04	9	41	2	CID006453929
Drug	Phe-pro-ala	DPP9 DPP8	1.13e-04	9	41	2	CID000133668
Drug	SureCN475872	DPP9 DPP8	1.13e-04	9	41	2	CID011163584
Drug	4-tert-octylphenol	SAFB TBC1D1 PGR	1.26e-04	54	41	3	CID000008814
Drug	N-phenylphthalimide	DPP9 DPP8	1.41e-04	10	41	2	CID000068215
Drug	Hxp	DPP9 DPP8	1.41e-04	10	41	2	CID000449159
Drug	X1043	DPP9 DPP8	1.41e-04	10	41	2	CID011235728
Drug	mPDT	PRLR PGR	2.06e-04	12	41	2	CID006918514
Drug	trifluoroacetic acid	DPP9 DPP8 SPAG17	2.09e-04	64	41	3	CID000006422
Drug	4-nonylphenol	SAFB TBC1D1 PGR	2.09e-04	64	41	3	CID000001752
Drug	chlordecone	SAFB DHDH PGR	2.40e-04	67	41	3	CID000000299
Drug	ketononestrol aziridine	SAFB PGR	2.44e-04	13	41	2	CID000130642
Drug	DP-TAT-59	SAFB PGR	2.44e-04	13	41	2	CID003037015
Drug	sampatrilat	DPP9 DPP8	2.44e-04	13	41	2	CID006324648
Drug	17-alpha-hydroxy-progesterone caproate	PRLR PGR	2.44e-04	13	41	2	ctd:C020365
Drug	4-nitroaniline	DPP9 DPP8	2.44e-04	13	41	2	ctd:C019498
Drug	Gly-pro-mca	DPP9 DPP8	2.44e-04	13	41	2	CID000125640
Drug	1wvj	SAFB TBC1D1 PGR	2.61e-04	69	41	3	CID005288598
Drug	4-bromophenol	TBC1D1 PRLR PGR	2.73e-04	70	41	3	CID000007808
Drug	AC1MHZPD	DPP9 DPP8	2.84e-04	14	41	2	CID003035635
Drug	7-amino-4-trifluoromethylcoumarin	DPP9 DPP8	2.84e-04	14	41	2	CID000100641
Drug	AC1L4NWK	DPP9 DPP8	3.27e-04	15	41	2	CID000189017
Drug	AC1L322F	DPP9 DPP8	3.27e-04	15	41	2	CID000133040
Drug	Rifabutin [72559-06-9]; Down 200; 4.8uM; MCF7; HT_HG-U133A	LIMK2 SAFB TADA2A PRLR	3.31e-04	184	41	4	4349_DN
Drug	2f34	CCNA1 EPS15 PGM2L1 PGR	3.59e-04	188	41	4	CID006420160
Drug	TAT-59	SAFB PGR	3.74e-04	16	41	2	CID003034829
Drug	OH-PCB 30	SAFB PGR	3.74e-04	16	41	2	CID000105036
Drug	retinoic acid; Down 200; 1uM; MCF7; HT_HG-U133A_EA	ADGRE5 LIMK2 TULP4 PRLR	3.81e-04	191	41	4	991_DN
Drug	4-hydroxyestradiol	SAFB PGR LPO	3.90e-04	79	41	3	CID000001743
Drug	retinoic acid; Down 200; 1uM; MCF7; HT_HG-U133A	LIMK2 TADA2A TULP4 PRLR	4.12e-04	195	41	4	6971_DN
Drug	haloperidol; Down 200; 10uM; MCF7; HT_HG-U133A	ADGRE5 LIMK2 PGR ZIC3	4.20e-04	196	41	4	5604_DN
Drug	Trimethoprim [738-70-5]; Up 200; 13.8uM; MCF7; HT_HG-U133A	LIMK2 TLK1 PGR ZIC3	4.37e-04	198	41	4	4701_UP
Drug	Dicloxacillin sodium salt [13412-64-1]; Down 200; 8.2uM; MCF7; HT_HG-U133A	TLK1 TADA2A PRLR ZIC3	4.45e-04	199	41	4	3307_DN
Drug	Clonidine hydrochloride [4205-91-8]; Down 200; 15uM; MCF7; HT_HG-U133A	LIMK2 TLK1 SAFB TADA2A	4.45e-04	199	41	4	6814_DN
Drug	AC1NRATE	DPP9 DPP8 PRLR	4.51e-04	83	41	3	CID005288086
Drug	coproporphyrin I	DPP9 DPP8	4.75e-04	18	41	2	CID000068271
Drug	His-Ser	DPP9 DPP8	4.75e-04	18	41	2	CID000435727
Disease	hyperprolactinemia (is_implicated_in)	PRLR PGR	1.61e-06	2	38	2	DOID:12700 (is_implicated_in)
Disease	Mammary Carcinoma, Animal	UBE2I PRLR PGR	8.14e-04	142	38	3	C1257925
Disease	Animal Mammary Neoplasms	UBE2I PRLR PGR	8.14e-04	142	38	3	C0024667
Disease	word list delayed recall measurement, memory performance	TADA2A TBC1D1	8.31e-04	33	38	2	EFO_0004874, EFO_0006805
Disease	hyperthyroidism	PRLR RNASET2	9.35e-04	35	38	2	EFO_0009189
Disease	Mammary Neoplasms, Experimental	UBE2I PRLR PGR	1.05e-03	155	38	3	C0024668
Disease	Carcinomatosis	UBE2I PRLR PGR	1.21e-03	163	38	3	C0205699
Disease	Carcinoma, Spindle-Cell	UBE2I PRLR PGR	1.21e-03	163	38	3	C0205697
Disease	Undifferentiated carcinoma	UBE2I PRLR PGR	1.21e-03	163	38	3	C0205698
Disease	Anaplastic carcinoma	UBE2I PRLR PGR	1.21e-03	163	38	3	C0205696
Disease	Carcinoma	UBE2I PRLR PGR	1.23e-03	164	38	3	C0007097
Disease	monocyte percentage of leukocytes	TADA2A DPP8 UBE2I TBC1D1 LPO	2.35e-03	731	38	5	EFO_0007989
Disease	hippocampal atrophy	PGM2L1 TLK1	2.38e-03	56	38	2	EFO_0005039
Disease	idiopathic pulmonary fibrosis	DPP9 HECTD2	2.46e-03	57	38	2	EFO_0000768
Disease	susceptibility to hepatitis A infection measurement	SPAG17 TULP4	3.49e-03	68	38	2	EFO_0008415

Protein segments in the cluster

Peptide	Gene	Start	Entry
SCFSFPKPPVDPAKI	ARMC2	111	Q8NEN0
PGFKFIPEDPKVCTD	ADGRE5	146	P48960
FKAEPPGKPSAFEPA	ANKRD30A	631	Q9BXX3
VFCFDPKYGEPKRPP	MYADML2	251	A6NDP7
KFVPTDCPPAFFPLA	LIMK2	566	P53671
FPAKPEEFPPITKCS	HECTD2	296	Q5U5R9
AFKVFGFKPPIPVPE	PGM2L1	276	Q6PCE3
CFPIMFPPNDPKAGT	LPO	256	P22079
APPDCFPDKVKAFGP	FLNC	661	Q14315
PFPPESCFQEGAPKR	MYCLP1	211	P12525
PFKPASGKPDDTFCF	RPS6KA6	346	Q9UK32
GDFPDCAYPPDAEPK	PGR	356	P06401
PFSPGEDEFKCPIKE	DPP9	471	Q86TI2
GGLPAPSDFKCPIKE	DPP8	496	Q6V1X1
ENAFPPAGKKALPDC	CCNA1	111	P78396
APCAPGFKDDTKGPL	HOXD12	156	P35452
KEFPLPPVPKDCNFD	DHDH	266	Q9UQ10
FQPFPGNDSPKEKDP	EPS15	806	P42566
KPPPPDEFLDCFQKF	EPS8	321	Q12929
FGCPPGRKEKPSDPV	SAMD1	446	Q6SPF0
KCFNPPPKPEPFQFG	PHAX	86	Q9H814
FFPPKKSHGSCAPPV	PLD6	216	Q8N2A8
EPPKCKDFVPFGKGI	SLC4A11	316	Q8NBS3
CPPDPAKKLLGEPFV	TRMT2B	466	Q96GJ1
EPYIKCAECGPPPFF	TADA2A	26	O75478
KFDFDACNEVPPAPK	SAFB	356	Q15424
PPKCPPDTFGKDFFE	SPAG17	1856	Q6Q759
CEDGPVFYPPPKKTK	RNASET2	241	O00584
PPQPPVDVCLKKGDF	TULP4	856	Q9NRJ4
KPFPCPFPGCGKIFA	ZIC3	326	O60481
YLPPECFVVGKEPPK	TLK1	636	Q9UKI8
DDYPSSPPKCKFEPP	UBE2I	66	P63279
CEDGPFGPPPEEKKR	TBC1D1	701	Q86TI0
CIFPPVPGPKIKGFD	PRLR	266	P16471
KKTPPEDCEGPFRPA	NUP153	586	P49790
GKPFDQALDPAKDPC	SPOCK3	76	Q9BQ16
EKPFPCPFPGCGKVF	ZIC4	201	Q8N9L1
TGEKPFPCPDCGKRF	ZNF316	396	A6NFI3
KFRPAFPTGPKVPFC	ZDHHC8	356	Q9ULC8
GFSLPGPKADCDKIP	ZNF438	316	Q7Z4V0
KPFPCPFPGCGKVFA	ZIC2	331	O95409