Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled receptor activity	CCR2 OR6A2 OR2T27 OR52E6 OR6J1 OR6Y1 CCR3 OR8K3 GPR171 CCR8 OR51G1 OR51V1 OR52B2 GPR160	2.04e-05	884	85	14	GO:0004930
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	CCR2 OR6A2 PTPRB OR2T27 OR52E6 OR6J1 OR6Y1 CCR3 OR8K3 GPR171 CCR8 FGFR4 OR51G1 OR51V1 IL4R OR52B2 GPR160	4.72e-05	1353	85	17	GO:0004888
GeneOntologyMolecularFunction	olfactory receptor activity	OR6A2 OR2T27 OR52E6 OR6J1 OR6Y1 OR8K3 OR51G1 OR51V1 OR52B2	9.04e-05	431	85	9	GO:0004984
GeneOntologyMolecularFunction	C-C chemokine receptor activity	CCR2 CCR3 CCR8	1.24e-04	23	85	3	GO:0016493
GeneOntologyMolecularFunction	C-C chemokine binding	CCR2 CCR3 CCR8	1.41e-04	24	85	3	GO:0019957
GeneOntologyMolecularFunction	G protein-coupled chemoattractant receptor activity	CCR2 CCR3 CCR8	1.80e-04	26	85	3	GO:0001637
GeneOntologyMolecularFunction	chemokine receptor activity	CCR2 CCR3 CCR8	1.80e-04	26	85	3	GO:0004950
GeneOntologyMolecularFunction	chemokine binding	CCR2 CCR3 CCR8	3.70e-04	33	85	3	GO:0019956
GeneOntologyMolecularFunction	cytokine receptor activity	CCR2 CCR3 CCR8 IL4R	7.84e-04	97	85	4	GO:0004896
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR6A2 EYS OR2T27 OR52E6 OR6J1 OR6Y1 OR8K3 OR51G1 ASIC3 OR51V1 OR52B2	2.36e-05	582	84	11	GO:0050906
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR6A2 OR2T27 OR52E6 OR6J1 OR6Y1 OR8K3 OR51G1 ASIC3 OR51V1 OR52B2	2.74e-05	485	84	10	GO:0050907
GeneOntologyBiologicalProcess	cytoplasm protein quality control by the ubiquitin-proteasome system	UBR5 UBR4	4.90e-05	3	84	2	GO:0071629
GeneOntologyBiologicalProcess	cytoplasm protein quality control	UBR5 UBR4	4.90e-05	3	84	2	GO:0140455
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR6A2 OR2T27 OR52E6 OR6J1 OR6Y1 OR8K3 OR51G1 ASIC3 OR51V1 OR52B2	5.26e-05	524	84	10	GO:0009593
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR6A2 OR2T27 OR52E6 OR6J1 OR6Y1 OR8K3 OR51G1 OR51V1 OR52B2	6.55e-05	432	84	9	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR6A2 OR2T27 OR52E6 OR6J1 OR6Y1 OR8K3 OR51G1 ASIC3 OR51V1 OR52B2	7.53e-05	547	84	10	GO:0007606
GeneOntologyBiologicalProcess	sensory perception of smell	OR6A2 OR2T27 OR52E6 OR6J1 OR6Y1 OR8K3 OR51G1 OR51V1 OR52B2	1.15e-04	465	84	9	GO:0007608
GeneOntologyBiologicalProcess	detection of stimulus	OR6A2 EYS OR2T27 OR52E6 OR6J1 OR6Y1 OR8K3 OR51G1 ASIC3 OR51V1 OR52B2	1.63e-04	722	84	11	GO:0051606
Domain	G_PROTEIN_RECEP_F1_1	CCR2 OR6A2 OR2T27 OR52E6 OR6J1 OR6Y1 CCR3 OR8K3 GPR171 CCR8 OR51G1 OR51V1 OR52B2 GPR160	1.78e-06	685	83	14	PS00237
Domain	G_PROTEIN_RECEP_F1_2	CCR2 OR6A2 OR2T27 OR52E6 OR6J1 OR6Y1 CCR3 OR8K3 GPR171 CCR8 OR51G1 OR51V1 OR52B2 GPR160	1.97e-06	691	83	14	PS50262
Domain	GPCR_Rhodpsn	CCR2 OR6A2 OR2T27 OR52E6 OR6J1 OR6Y1 CCR3 OR8K3 GPR171 CCR8 OR51G1 OR51V1 OR52B2 GPR160	2.00e-06	692	83	14	IPR000276
Domain	GPCR_Rhodpsn_7TM	CCR2 OR6A2 OR2T27 OR52E6 OR6Y1 CCR3 OR8K3 GPR171 CCR8 OR51G1 OR51V1 OR52B2 GPR160	7.60e-06	670	83	13	IPR017452
Domain	7tm_1	CCR2 OR6A2 OR2T27 OR52E6 OR6J1 OR6Y1 CCR3 OR8K3 GPR171 CCR8 OR51G1 OR51V1 OR52B2	8.50e-06	677	83	13	PF00001
Domain	Chemokine_rcpt	CCR2 CCR3 CCR8	4.55e-05	16	83	3	IPR000355
Domain	Olfact_rcpt	OR6A2 OR2T27 OR52E6 OR6J1 OR6Y1 OR8K3 OR51G1 OR51V1 OR52B2	6.14e-05	393	83	9	IPR000725
Domain	ZF_UBR	UBR5 UBR4	4.04e-04	7	83	2	PS51157
Domain	zf-UBR	UBR5 UBR4	4.04e-04	7	83	2	PF02207
Domain	Znf_UBR	UBR5 UBR4	4.04e-04	7	83	2	IPR003126
Domain	ZnF_UBR1	UBR5 UBR4	4.04e-04	7	83	2	SM00396
Domain	ARM-type_fold	DOCK5 KIFAP3 XPO6 UBR4 ZNFX1 HUWE1 STAG3	7.77e-04	339	83	7	IPR016024
Domain	DOCK_C	DOCK5 DOCK7	1.05e-03	11	83	2	IPR010703
Domain	DHR-1_domain	DOCK5 DOCK7	1.05e-03	11	83	2	IPR027007
Domain	DHR_2	DOCK5 DOCK7	1.05e-03	11	83	2	PS51651
Domain	DHR_1	DOCK5 DOCK7	1.05e-03	11	83	2	PS51650
Domain	DOCK-C2	DOCK5 DOCK7	1.05e-03	11	83	2	PF14429
Domain	DHR-2	DOCK5 DOCK7	1.05e-03	11	83	2	IPR027357
Domain	DHR-2	DOCK5 DOCK7	1.05e-03	11	83	2	PF06920
Domain	DOCK	DOCK5 DOCK7	1.05e-03	11	83	2	IPR026791
Domain	Calpain_III	CAPN9 CAPN8	1.25e-03	12	83	2	IPR022683
Domain	calpain_III	CAPN9 CAPN8	1.25e-03	12	83	2	SM00720
Domain	C2_III	CAPN9 CAPN8	1.25e-03	12	83	2	IPR033883
Domain	ARM-like	KIFAP3 KATNBL1 XPO6 DAXX HUWE1 STAG3	1.29e-03	270	83	6	IPR011989
Domain	Calpain_domain_III	CAPN9 CAPN8	1.47e-03	13	83	2	IPR022682
Domain	Calpain_III	CAPN9 CAPN8	1.47e-03	13	83	2	PF01067
Domain	Calpain_cysteine_protease	CAPN9 CAPN8	1.72e-03	14	83	2	IPR022684
Domain	Zip	SLC39A12 SLC39A13	1.72e-03	14	83	2	PF02535
Domain	ZIP	SLC39A12 SLC39A13	1.72e-03	14	83	2	IPR003689
Domain	CysPc	CAPN9 CAPN8	1.97e-03	15	83	2	SM00230
Domain	Peptidase_C2_calpain_cat	CAPN9 CAPN8	1.97e-03	15	83	2	IPR001300
Domain	Peptidase_C2	CAPN9 CAPN8	1.97e-03	15	83	2	PF00648
Domain	CALPAIN_CAT	CAPN9 CAPN8	1.97e-03	15	83	2	PS50203
Domain	UIM_dom	PARP10 HUWE1	5.48e-03	25	83	2	IPR003903
Domain	THIOL_PROTEASE_CYS	CAPN9 CAPN8	5.92e-03	26	83	2	PS00139
Domain	HECT	UBR5 HUWE1	6.37e-03	27	83	2	PF00632
Domain	HECTc	UBR5 HUWE1	6.37e-03	27	83	2	SM00119
Domain	THIOL_PROTEASE_ASN	CAPN9 CAPN8	6.37e-03	27	83	2	PS00640
Domain	HECT_dom	UBR5 HUWE1	6.37e-03	27	83	2	IPR000569
Domain	THIOL_PROTEASE_HIS	CAPN9 CAPN8	6.37e-03	27	83	2	PS00639
Domain	HECT	UBR5 HUWE1	6.37e-03	27	83	2	PS50237
Domain	Pept_cys_AS	CAPN9 CAPN8	6.84e-03	28	83	2	IPR000169
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR6A2 OR2T27 OR52E6 OR6J1 OR6Y1 OR8K3 OR51G1 OR51V1 OR52B2	8.04e-05	417	62	9	M4072
Pubmed	HIV-1 infection and chemokine receptor modulation.	CCR2 CCR3 CCR8	1.45e-07	5	86	3	15053339
Pubmed	Use of alternate coreceptors on primary cells by two HIV-1 isolates.	CCR2 CCR3 CCR8	5.07e-07	7	86	3	15992849
Pubmed	The ubiquitin ligase TRIM25 targets ERG for degradation in prostate cancer.	UBR5 UBR4 HUWE1	5.21e-06	14	86	3	27626314
Pubmed	Calpain 8/nCL-2 and calpain 9/nCL-4 constitute an active protease complex, G-calpain, involved in gastric mucosal defense.	CAPN9 CAPN8	6.04e-06	2	86	2	20686710
Pubmed	A Gastrointestinal Calpain Complex, G-calpain, Is a Heterodimer of CAPN8 and CAPN9 Calpain Isoforms, Which Play Catalytic and Regulatory Roles, Respectively.	CAPN9 CAPN8	6.04e-06	2	86	2	27881674
Pubmed	UBR E3 ligases and the PDIA3 protease control degradation of unfolded antibody heavy chain by ERAD.	UBR5 UBR4	1.81e-05	3	86	2	32558906
Pubmed	Airway-Associated Macrophages in Homeostasis and Repair.	CCR2 IL4R	1.81e-05	3	86	2	33378665
Pubmed	Skin CD4(+) memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation.	CCR2 CCR8	1.81e-05	3	86	2	27160938
Pubmed	Crystal structures of Delta1-piperideine-2-carboxylate/Delta1-pyrroline-2-carboxylate reductase belonging to a new family of NAD(P)H-dependent oxidoreductases: conformational change, substrate recognition, and stereochemistry of the reaction.	ARHGEF12 SNTA1	1.81e-05	3	86	2	16192274
Pubmed	Inflammatory monocytes recruited to allergic skin acquire an anti-inflammatory M2 phenotype via basophil-derived interleukin-4.	CCR2 IL4R	1.81e-05	3	86	2	23434060
Pubmed	Genetic variants in the CCR gene cluster and spontaneous viral elimination in hepatitis C-infected patients.	CCR2 CCR3	1.81e-05	3	86	2	15086398
Pubmed	The genes encoding the human CC-chemokine receptors CC-CKR1 to CC-CKR5 (CMKBR1-CMKBR5) are clustered in the p21.3-p24 region of chromosome 3.	CCR2 CCR3	1.81e-05	3	86	2	8884276
Pubmed	Linkage and haplotype analysis for chemokine receptors clustered on chromosome 3p21.3 and transmitted in family pedigrees with asthma and atopy.	CCR2 CCR3	1.81e-05	3	86	2	20220260
Pubmed	Use of (alternative) coreceptors for HIV entry.	CCR2 CCR3 CCR8	1.88e-05	21	86	3	22842622
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	DOCK5 SFMBT1 TDRD15 UBR5 DOCK7 ABCC5 HUWE1 BIRC6 PCDH9 SNX1	2.24e-05	777	86	10	35844135
Pubmed	Linkages between HIV-1 specificity for CCR5 or CXCR4 and in vitro usage of alternative coreceptors during progressive HIV-1 subtype C infection.	CCR3 CCR8	3.61e-05	4	86	2	24041034
Pubmed	HIV-1 Tat protein mimicry of chemokines.	CCR2 CCR3	3.61e-05	4	86	2	9789057
Pubmed	Alveolar Macrophages Provide an Early Mycobacterium tuberculosis Niche and Initiate Dissemination.	CCR2 PYCARD	3.61e-05	4	86	2	30146391
Pubmed	A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons.	UBR5 UBR4	3.61e-05	4	86	2	16055722
Pubmed	Role of CCR8 and other chemokine pathways in the migration of monocyte-derived dendritic cells to lymph nodes.	CCR2 CCR8	3.61e-05	4	86	2	15534368
Pubmed	Monocyte-derived macrophages promote breast cancer bone metastasis outgrowth.	CCR2 IL4R	3.61e-05	4	86	2	32780802
Pubmed	The substrate recognition domains of the N-end rule pathway.	UBR5 UBR4	3.61e-05	4	86	2	19008229
Pubmed	The calpain family and human disease.	CAPN9 CAPN8	3.61e-05	4	86	2	11516996
Pubmed	Cardiac defects and altered ryanodine receptor function in mice lacking FKBP12.	SNTA1 RYR1	3.61e-05	4	86	2	9461216
Pubmed	Coreceptor utilization of HIV type 1 subtype E viral isolates from Thai men with HIV type 1-infected and uninfected wives.	CCR2 CCR8	3.61e-05	4	86	2	11804551
Pubmed	TRIM26 promotes non-small cell lung cancer survival by inducing PBX1 degradation.	UBR4 HUWE1	3.61e-05	4	86	2	37324936
Pubmed	CCR3, CCR2A and macrophage inflammatory protein (MIP)-1a, monocyte chemotactic protein-1 (MCP-1) in the mouse hippocampus during and after pilocarpine-induced status epilepticus (PISE) .	CCR2 CCR3	3.61e-05	4	86	2	19490431
Pubmed	Immunohistochemical analysis of CCR2, CCR3, CCR5, and CXCR4 in the human brain: potential mechanisms for HIV dementia.	CCR2 CCR3	3.61e-05	4	86	2	11115360
Pubmed	Functional impact of HIV coreceptor-binding site mutations.	CCR3 CCR8	3.61e-05	4	86	2	16631222
Pubmed	Chemokine Receptor Redundancy and Specificity Are Context Dependent.	CCR2 CCR3	3.61e-05	4	86	2	30784579
Pubmed	Analysis of combinatorial chemokine receptor expression dynamics using multi-receptor reporter mice.	CCR2 CCR3	3.61e-05	4	86	2	35699420
Pubmed	Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration.	FBXO3 UBR5 UBR4 HUWE1	4.54e-05	79	86	4	27325702
Pubmed	Cul3-KLHL20 E3 ubiquitin ligase plays a key role in the arms race between HIV-1 Nef and host SERINC5 restriction.	UBR5 UBR4 HUWE1	4.57e-05	28	86	3	35474067
Pubmed	The human olfactory receptor gene family.	OR6A2 OR2T27 OR52E6 OR6Y1 OR8K3 OR51G1 OR51V1 OR52B2	5.97e-05	541	86	8	14983052
Pubmed	RANTES-induced chemokine cascade in dendritic cells.	CCR2 CCR3	6.01e-05	5	86	2	11466387
Pubmed	Mapping of the mouse macrophage inflammatory protein-1 alpha receptor gene Scya3r and two related mouse beta chemokine receptor-like genes to chromosome 9.	CCR2 CCR3	6.01e-05	5	86	2	8530091
Pubmed	HIV type I envelope determinants for use of the CCR2b, CCR3, STRL33, and APJ coreceptors.	CCR2 CCR3	6.01e-05	5	86	2	9736741
Pubmed	Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ T(H)2 cells.	CCR2 CCR8	6.01e-05	5	86	2	21217759
Pubmed	The beta-chemokine receptor genes CCR1 (CMKBR1), CCR2 (CMKBR2), and CCR3 (CMKBR3) cluster within 285 kb on human chromosome 3p21.	CCR2 CCR3	6.01e-05	5	86	2	9143512
Pubmed	Genotypes and haplotypes of CCR2 and CCR3 genes in Japanese cedar pollinosis.	CCR2 CCR3	6.01e-05	5	86	2	17135764
Pubmed	Activity-Based Probes for HECT E3 Ubiquitin Ligases.	UBR5 HUWE1	6.01e-05	5	86	2	28425671
Pubmed	Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins.	DOCK5 DOCK7	6.01e-05	5	86	2	22158624
Pubmed	Coreceptor usage of HIV-1 isolates representing different genetic subtypes obtained from pregnant Cameroonian women. European Network for In Utero Transmission of HIV-1.	CCR2 CCR3	6.01e-05	5	86	2	10877489
Pubmed	Variants of chemokine receptor 2 and interleukin 4 receptor, but not interleukin 10 or Fas ligand, increase risk of cervical cancer.	CCR2 IL4R	6.01e-05	5	86	2	17688234
Pubmed	Polymorphisms in inflammatory genes and the risk of ischemic stroke and transient ischemic attack: results of a multilocus genotyping assay.	CCR2 CCR3 IL4R	7.55e-05	33	86	3	19028820
Pubmed	Differential impact of Lhx2 deficiency on expression of class I and class II odorant receptor genes in mouse.	OR6A2 OR51G1 OR52B2	7.55e-05	33	86	3	17350283
Pubmed	Identification of novel single nucleotide polymorphisms in inflammatory genes as risk factors associated with trachomatous trichiasis.	CCR2 CCR3 IL4R	7.55e-05	33	86	3	18974840
Pubmed	Single nucleotide polymorphisms in inflammation-related genes are associated with venous thromboembolism.	CCR2 CCR3 IL4R	8.26e-05	34	86	3	20603037
Pubmed	Association of genetic variants of the chemokine receptor CCR5 and its ligands, RANTES and MCP-2, with outcome of HCV infection.	CCR2 CCR3	9.01e-05	6	86	2	14647058
Pubmed	Evidence of extended alternate coreceptor usage by HIV-1 clade C envelope obtained from an Indian patient.	CCR2 CCR3	9.01e-05	6	86	2	22086059
Pubmed	IL-1α induces CD11b(low) alveolar macrophage proliferation and maturation during granuloma formation.	CCR2 PYCARD	9.01e-05	6	86	2	25421226
Pubmed	Polymorphisms in chemokine receptor genes and susceptibility to Kawasaki disease.	CCR2 CCR3	9.01e-05	6	86	2	17672867
Pubmed	Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases.	CCR2 CCR3	9.01e-05	6	86	2	19017998
Pubmed	Distinct Commensals Induce Interleukin-1β via NLRP3 Inflammasome in Inflammatory Monocytes to Promote Intestinal Inflammation in Response to Injury.	CCR2 PYCARD	9.01e-05	6	86	2	25862092
Pubmed	Constitutive homing of mast cell progenitors to the intestine depends on autologous expression of the chemokine receptor CXCR2.	CCR2 CCR3	9.01e-05	6	86	2	15705791
Pubmed	Structural interactions between chemokine receptors, gp120 Env and CD4.	CCR2 CCR3	9.01e-05	6	86	2	9653051
Pubmed	Tissue-specific signals control reversible program of localization and functional polarization of macrophages.	CCR2 IL4R	9.01e-05	6	86	2	24792964
Pubmed	CCL2/MCP-1 signaling drives extracellular matrix turnover by diverse macrophage subsets.	CCR2 IL4R	9.01e-05	6	86	2	33543002
Pubmed	Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat.	CCR2 IL4R	1.26e-04	7	86	2	24906148
Pubmed	Aggresomal sequestration and STUB1-mediated ubiquitylation during mammalian proteaphagy of inhibited proteasomes.	UBR5 UBR4 BIRC6	1.45e-04	41	86	3	32723828
Pubmed	CCR3 is a target for age-related macular degeneration diagnosis and therapy.	CCR2 CCR3	1.68e-04	8	86	2	19525930
Pubmed	The LZT proteins; the LIV-1 subfamily of zinc transporters.	SLC39A12 SLC39A13	1.68e-04	8	86	2	12659941
Pubmed	Recruited Monocytes and Type 2 Immunity Promote Lung Regeneration following Pneumonectomy.	CCR2 IL4R	1.68e-04	8	86	2	28506464
Pubmed	Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.	ATP2A3 RYR1	1.68e-04	8	86	2	19033399
Pubmed	AIM2 inflammasome-derived IL-1β induces postoperative ileus in mice.	CCR2 PYCARD	1.68e-04	8	86	2	31332247
Pubmed	Nucleic acid sensing by T cells initiates Th2 cell differentiation.	PYCARD IL4R	1.68e-04	8	86	2	24717539
Pubmed	Determination of the sites of tyrosine O-sulfation in peptides and proteins.	CCR2 CCR8	1.68e-04	8	86	2	17558413
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR6A2 OR6Y1 OR8K3 OR51G1 OR51V1 OR52B2	2.04e-04	340	86	6	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR6A2 OR6Y1 OR8K3 OR51G1 OR51V1 OR52B2	2.04e-04	340	86	6	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR6A2 OR6Y1 OR8K3 OR51G1 OR51V1 OR52B2	2.13e-04	343	86	6	32295537
Pubmed	Purification of ATP-binding cassette transporter A1 and associated binding proteins reveals the importance of beta1-syntrophin in cholesterol efflux.	ARHGEF12 SNTA1	2.15e-04	9	86	2	16192269
Pubmed	A micropeptide encoded by a putative long noncoding RNA regulates muscle performance.	ATP2A3 RYR1	2.15e-04	9	86	2	25640239
Pubmed	Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin.	CCR2 CCR8	2.15e-04	9	86	2	22729248
Pubmed	Human immunodeficiency virus type 1 Vpr links proteasomal degradation and checkpoint activation.	UBR5 UBR4	2.15e-04	9	86	2	17855541
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR6A2 OR6Y1 OR8K3 OR51G1 OR51V1 OR52B2	2.24e-04	346	86	6	14611657
Pubmed	Role of astrocytes and chemokine systems in acute TNFalpha induced demyelinating syndrome: CCR2-dependent signals promote astrocyte activation and survival via NF-kappaB and Akt.	CCR2 CCR3	2.68e-04	10	86	2	17949991
Pubmed	Embryonic expression and function of the chemokine SDF-1 and its receptor, CXCR4.	CCR2 CCR3	2.68e-04	10	86	2	10479460
Pubmed	A candidate gene association study of 77 polymorphisms in migraine.	CCR2 CCR3 IL4R	2.96e-04	52	86	3	19559392
Pubmed	Four novel coeliac disease regions replicated in an association study of a Swedish-Norwegian family cohort.	CCR2 CCR3	3.28e-04	11	86	2	19693089
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	STXBP2 UBR5 UBR4 PDCD11 HUWE1 BIRC6 ATP2A3 DHX29	3.59e-04	704	86	8	29955894
Pubmed	Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo.	CCR2 CCR3	3.93e-04	12	86	2	12149192
Pubmed	Variant heparan sulfates synthesized in developing mouse brain differentially regulate FGF signaling.	NDST3 FGFR4	3.93e-04	12	86	2	12460940
Pubmed	Mapping of murine fibroblast growth factor receptors refines regions of homology between mouse and human chromosomes.	FGFR4 IL4R	3.93e-04	12	86	2	7959747
Pubmed	HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1.	UBR5 UBR4	3.93e-04	12	86	2	17360488
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PCNX3 XPO6 INPPL1 UBR4 PDCD11 HUWE1 BIRC6 ATP2A3 IL4R RYR1	4.01e-04	1105	86	10	35748872
Pubmed	UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover.	UBR5 UBR4 HUWE1	4.97e-04	62	86	3	18775313
Pubmed	Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome.	CCR2 PYCARD	5.39e-04	14	86	2	27716507
Pubmed	Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.	DOCK5 DOCK7	5.39e-04	14	86	2	12432077
Pubmed	A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.	CCR2 CCR3 IL4R	5.45e-04	64	86	3	19131662
Pubmed	K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains.	UBR5 UBR4 HUWE1	5.71e-04	65	86	3	29378950
Pubmed	Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates.	UBR5 UBR4 HUWE1	5.97e-04	66	86	3	24811749
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	SFMBT1 UBR5 UBR4 DOCK7 HUWE1 BIRC6	6.08e-04	418	86	6	34709266
Pubmed	Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5.	CCR2 CCR3	6.21e-04	15	86	2	9139699
Pubmed	UBR5 Acts as an Antiviral Host Factor against MERS-CoV via Promoting Ubiquitination and Degradation of ORF4b.	UBR5 HUWE1	7.09e-04	16	86	2	35980206
Pubmed	A novel PrP partner HS-1 associated protein X-1 (HAX-1) protected the cultured cells against the challenge of H₂O₂.	KIFAP3 DOCK7	7.09e-04	16	86	2	21301993
Pubmed	A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.	DIS3L PDCD11 MAP3K15 HUWE1 BIRC6 ATP2A3	7.13e-04	431	86	6	33660365
Pubmed	Genome-wide association study of celiac disease in North America confirms FRMD4B as new celiac locus.	CCR2 CCR3	8.02e-04	17	86	2	24999842
Pubmed	Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control.	UBR5 UBR4	8.02e-04	17	86	2	29033132
Pubmed	HIV-1 Nef down-modulates C-C and C-X-C chemokine receptors via ubiquitin and ubiquitin-independent mechanism.	CCR2 CCR3	8.02e-04	17	86	2	24489825
Pubmed	Comparative human/murine sequence analysis of the common eliminated region 1 from human 3p21.3.	CCR2 CCR3	9.01e-04	18	86	2	12461651
Interaction	PSKH1 interactions	UBR5 UBR4 PDCD11 PIPSL SNTA1	6.33e-06	65	81	5	int:PSKH1
GeneFamily	CD molecules\|C-C motif chemokine receptors	CCR2 CCR3 CCR8	5.73e-06	10	67	3	1091
GeneFamily	Ubiquitin protein ligase E3 component n-recognins	UBR5 UBR4	2.81e-04	7	67	2	785
GeneFamily	Olfactory receptors, family 6	OR6A2 OR6J1 OR6Y1	8.92e-04	51	67	3	153
GeneFamily	C2 domain containing\|Calpains	CAPN9 CAPN8	1.38e-03	15	67	2	975
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	CCR2 CCR3 CCR8 FGFR4 ENPEP IL4R	3.36e-03	394	67	6	471
Disease	periapical granuloma (is_marker_for)	CCR2 CCR3	2.28e-05	3	82	2	DOID:4617 (is_marker_for)
Disease	Petit mal status	CCR2 CCR3 CCR8 SNTA1	3.72e-05	67	82	4	C0270823
Disease	Grand Mal Status Epilepticus	CCR2 CCR3 CCR8 SNTA1	3.72e-05	67	82	4	C0311335
Disease	Status Epilepticus, Subclinical	CCR2 CCR3 CCR8 SNTA1	3.72e-05	67	82	4	C0751522
Disease	Simple Partial Status Epilepticus	CCR2 CCR3 CCR8 SNTA1	3.72e-05	67	82	4	C0751524
Disease	Non-Convulsive Status Epilepticus	CCR2 CCR3 CCR8 SNTA1	3.72e-05	67	82	4	C0751523
Disease	Complex Partial Status Epilepticus	CCR2 CCR3 CCR8 SNTA1	3.72e-05	67	82	4	C0393734
Disease	Status Epilepticus	CCR2 CCR3 CCR8 SNTA1	3.94e-05	68	82	4	C0038220
Disease	intellectual disability (implicated_via_orthology)	CAPN9 CAPN8 NDST3 UBR4	5.79e-05	75	82	4	DOID:1059 (implicated_via_orthology)
Disease	oral squamous cell carcinoma (is_implicated_in)	CCR2 DAXX FGFR4	6.44e-05	28	82	3	DOID:0050866 (is_implicated_in)
Disease	rhinitis (is_implicated_in)	CCR2 CCR3 IL4R	7.96e-05	30	82	3	DOID:4483 (is_implicated_in)
Disease	Duchenne muscular dystrophy (implicated_via_orthology)	CAPN9 CAPN8 SNTA1	1.38e-04	36	82	3	DOID:11723 (implicated_via_orthology)
Disease	cholesteryl esters to total lipids in small VLDL percentage	NFE2L3 TDRD15 DOCK7	3.48e-04	49	82	3	EFO_0022256
Disease	cholesterol to total lipids in small VLDL percentage	NFE2L3 TDRD15 DOCK7	3.91e-04	51	82	3	EFO_0022242
Disease	ovary epithelial cancer (is_implicated_in)	DAXX CCR3	4.13e-04	11	82	2	DOID:2152 (is_implicated_in)
Disease	cholesteryl esters to total lipids in very large VLDL percentage	NFE2L3 TDRD15 DOCK7	4.38e-04	53	82	3	EFO_0022258
Disease	cholesterol to total lipids in very large VLDL percentage	NFE2L3 TDRD15 DOCK7	4.63e-04	54	82	3	EFO_0022244
Disease	free cholesterol to total lipids in medium VLDL percentage	NFE2L3 TDRD15 DOCK7	5.43e-04	57	82	3	EFO_0022284
Disease	triglycerides to total lipids in small VLDL percentage	NFE2L3 TDRD15 DOCK7	5.72e-04	58	82	3	EFO_0022338
Disease	triglycerides to total lipids in medium VLDL percentage	NFE2L3 TDRD15 DOCK7	7.28e-04	63	82	3	EFO_0022335
Disease	focal segmental glomerulosclerosis	FGFR4 DNAH6	8.93e-04	16	82	2	EFO_0004236
Disease	COVID-19, osteoarthritis	CCR2 CCR3	1.40e-03	20	82	2	MONDO_0005178, MONDO_0100096
Disease	unipolar depression, neuroticism measurement	ANO4 EYS	2.02e-03	24	82	2	EFO_0003761, EFO_0007660
Disease	childhood trauma measurement	NDST3 PCDH9	2.02e-03	24	82	2	EFO_0007979
Disease	aspartate measurement	NDST3 ENPEP	2.02e-03	24	82	2	EFO_0010462
Disease	cholesteryl ester measurement, intermediate density lipoprotein measurement	NFE2L3 TDRD15 DOCK7	2.31e-03	94	82	3	EFO_0008595, EFO_0010351
Disease	congestive heart failure (is_implicated_in)	CCR2 RYR1	2.56e-03	27	82	2	DOID:6000 (is_implicated_in)
Disease	low density lipoprotein cholesterol measurement, alcohol consumption measurement	NFE2L3 TDRD15 DOCK7	2.68e-03	99	82	3	EFO_0004611, EFO_0007878

Protein segments in the cluster

Peptide	Gene	Start	Entry
ELSSILLLLFLYVLQ	SLC33A1	71	O00400
LLLQALRESQSYLVE	PYCARD	176	Q9ULZ3
ILAETSSILLYLFLR	CFAP54	1076	Q96N23
EQLRTIIRYLLDTLL	BIRC6	2021	Q9NR09
IIRYLLDTLLSLLHA	BIRC6	2026	Q9NR09
VLLAVSEEYLDLRLT	FGFR4	746	P22455
IASLTLNEELLYRVV	CAPN8	111	A6NHC0
LALLLDLESLVQFLS	SLC7A4	381	O43246
LALLNNIIEIRLDAY	ANO4	736	Q32M45
NLDLILELLAYLDKS	DHX29	846	Q7Z478
LEQLLALYVAEIRRL	DAXX	191	Q9UER7
QFEDLLVRILLLAAL	ATP2A3	56	Q93084
IDLYTLLLEDILVLL	ARHGEF12	1036	Q9NZN5
LSLGTDRLLIEYDLL	CFAP251	761	Q8TBY9
RLTLSLDRYILVDID	NDST3	296	O95803
YDILLLTENGILLRN	PTPRB	1026	P23467
SISELVAYLLRIEDL	KATNBL1	176	Q9H079
PLLNALLVELSLLYD	MAP10	396	Q9P2G4
SYLLQELIVTRELSA	EYS	1321	Q5T1H1
LITLRDEISIDLYEL	MED22	116	Q15528
LLLILSFLDYRDLIN	FBXO3	21	Q9UK99
TSVRYERLALLALLD	PCNX3	771	Q9H6A9
VDSLLIFLSYALILR	OR51G1	211	Q8NGK1
LLLDAILILFSYILI	OR51V1	216	Q9H2C8
LDVILIAVSYSLILR	OR52B2	211	Q96RD2
DVLLIILSHIRILYA	OR52E6	211	Q96RD3
LRLDSAIAQELIYTI	PCDH9	16	Q9HC56
LSLAGLRVDLDLYLL	NFE2L3	21	Q9Y4A8
RLSDDLLLTIISYLD	FBXO36	96	Q8NEA4
LLLTIISYLDLEDIA	FBXO36	101	Q8NEA4
IYLINLLTADFLLTL	GPR171	51	O14626
ELAEELRLYQSTLLQ	KLHL41	6	O60662
LAILILFDEARYNLL	KRIT1	526	O00522
ETLILLDRLLYLQEQ	METTL25B	421	Q96FB5
LLSRYLDLLKDTNLI	ENPEP	831	Q07075
ELRAAVIQLLDTSYL	AP5B1	266	Q2VPB7
IGASLLTILEILDYL	ASIC3	446	Q9UHC3
FLLSQLSLRDILYIS	OR2T27	61	Q8NH04
LATRILLLTLLFEEL	HUWE1	1526	Q7Z6Z7
ERLLLYIGIIDILQS	PIPSL	341	A2A3N6
DLLLLVNISIILYFR	GPR160	66	Q9UJ42
LTRELYTAFINTLLL	ARHGAP6	481	O43182
QYSLLLVLGLLLTEI	ABCC5	216	O15440
QRLDVLLEQTLLTAY	DNAH6	3341	Q9C0G6
TELRLLYQLVFLLSE	IL4R	56	P24394
LRLLLQTKEDYEALI	CCDC63	96	Q8NA47
LVSSLLENLLDYRTI	DOCK5	1196	Q9H7D0
LSVLQLNRLLDLLYL	DOCK7	1351	Q96N67
IYLLNLAISDLLFLV	CCR3	71	P51677
LKLSQDLDDLAILYL	FGGY	411	Q96C11
LRSITDVYLLNLALS	CCR8	66	P51685
RSLYTLLEEIRDLAL	DIS3L	1031	Q8TF46
ILAADYSQLELRILA	POLQ	2326	O75417
LTDIYLLNLAISDLL	CCR2	76	P41597
YLLSVALRLLAELTF	GJD3	136	Q8N144
LLQLIVLRYADEELQ	CAPN9	631	O14815
LREEVVQRVSLLLLY	SLC39A12	106	Q504Y0
LLFLTALALELLERA	SLC39A13	16	Q96H72
EIVNLLYELLASLIR	RYR1	516	P21817
EQLLRVALYLLLNLA	KIFAP3	276	Q92845
VALYLLLNLAEDTRT	KIFAP3	281	Q92845
LLLLELYLENERRSG	PARP10	186	Q53GL7
LLLLAYVLVLTENTL	OR6A2	31	O95222
TSDIIINLLLSYRDI	MAP3K15	281	Q6ZN16
VISLYSLRESLALIA	AGXT	266	P21549
LLLYLSLPETREALS	SNTA1	321	Q13424
VEILVDDLLLLEYLN	TDRD15	1676	B5MCY1
YLDILRLLSLGDRQL	INPPL1	576	O15357
TLLALLILVLYLSTE	SMIM23	36	A6NLE4
VLDLLSYIRTEKLLL	WDR17	1136	Q8IZU2
LLLSLVRDLYEISLQ	PEX11A	131	O75192
FSLSREVELLLLVLL	OR6J1	16	Q8NGC5
DLISSLLIVLLSYLL	OR8K3	206	Q8NH51
FLATYLLTLLENLLI	OR6Y1	36	Q8NGX8
YTLVDILRAILLSLE	CLVS2	131	Q5SYC1
ALLSLRTSIIEAQYL	PDCD11	431	Q14690
RLYLDLILAILALEL	TMEM192	166	Q8IY95
YSTLLLEEASARLLV	SEMA4G	56	Q9NTN9
LLAELLSDYIRLLAI	SNX1	391	Q13596
RILLLSLKQLYTELL	STAG3	926	Q9UJ98
SRLGLILLLLQYSTE	TRAM2	211	Q15035
VLLLYILLRNGVSEE	STXBP2	406	Q15833
SLLLIIILALSLAYE	MT-ND3	91	P03897
RELLILALSVISYFL	SLC6A11	436	P48066
LRSEIQRLTYLVNLL	ZNFX1	1756	Q9P2E3
LVLREVLTLLINAAY	SFMBT1	536	Q9UHJ3
AVLNRYEDALVLLLT	XPO6	441	Q96QU8
YEDALVLLLTEVLNR	XPO6	446	Q96QU8
QVLDLLTSYLDELSI	UBR4	4161	Q5T4S7
LELLDVSVSELLLYS	UHMK1	111	Q8TAS1
RLDLLYRLLTATNLV	UBR5	1251	O95071