Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	folic acid receptor activity	FOLR1 FOLR2 FOLR3	4.50e-08	3	72	3	GO:0061714
GeneOntologyMolecularFunction	cargo receptor activity	FOLR1 FOLR2 FOLR3 SCARA5 SCARA3	1.39e-05	85	72	5	GO:0038024
GeneOntologyMolecularFunction	folic acid binding	FOLR1 FOLR2 FOLR3	4.90e-05	20	72	3	GO:0005542
GeneOntologyMolecularFunction	histone H3K4me/H3K4me2/H3K4me3 demethylase activity	KDM5C KDM5D	1.91e-04	6	72	2	GO:0034647
GeneOntologyMolecularFunction	histone H3K4 demethylase activity	KDM5C KDM5D	3.54e-04	8	72	2	GO:0032453
GeneOntologyMolecularFunction	modified amino acid binding	FOLR1 FOLR2 FOLR3 TLN1	9.90e-04	122	72	4	GO:0072341
GeneOntologyBiologicalProcess	folic acid transport	FOLR1 FOLR2 FOLR3	6.88e-06	11	73	3	GO:0015884
GeneOntologyBiologicalProcess	cellular response to folic acid	FOLR1 FOLR2	1.24e-05	2	73	2	GO:0071231
GeneOntologyBiologicalProcess	post-translational protein targeting to endoplasmic reticulum membrane	FOLR1 FOLR2 FOLR3	5.40e-05	21	73	3	GO:0006620
Domain	Folate_rcpt	FOLR1 FOLR2 FOLR3	6.18e-07	5	75	3	IPR004269
Domain	Folate_rcpt-like	FOLR1 FOLR2 FOLR3	3.43e-06	8	75	3	IPR018143
Domain	Folate_rec	FOLR1 FOLR2 FOLR3	3.43e-06	8	75	3	PF03024
Domain	-	TLN1 TLN2	1.59e-05	2	75	2	1.20.1420.10
Domain	Talin_middle	TLN1 TLN2	1.59e-05	2	75	2	PF09141
Domain	VBS	TLN1 TLN2	1.59e-05	2	75	2	PF08913
Domain	Vinculin-bd_dom	TLN1 TLN2	1.59e-05	2	75	2	IPR015009
Domain	Talin_cent	TLN1 TLN2	1.59e-05	2	75	2	IPR015224
Domain	Talin-1	TLN1 TLN2	4.76e-05	3	75	2	IPR015710
Domain	I_LWEQ	TLN1 TLN2	9.50e-05	4	75	2	PF01608
Domain	ILWEQ_dom	TLN1 TLN2	9.50e-05	4	75	2	IPR002558
Domain	I_LWEQ	TLN1 TLN2	9.50e-05	4	75	2	PS50945
Domain	Lys_sp_deMease-like_dom	KDM5C KDM5D	9.50e-05	4	75	2	IPR013637
Domain	ILWEQ	TLN1 TLN2	9.50e-05	4	75	2	SM00307
Domain	PLU-1	KDM5C KDM5D	9.50e-05	4	75	2	PF08429
Domain	FERM_f0	TLN1 TLN2	9.50e-05	4	75	2	IPR032425
Domain	FERM_f0	TLN1 TLN2	9.50e-05	4	75	2	PF16511
Domain	ILWEQ	TLN1 TLN2	9.50e-05	4	75	2	PD011820
Domain	-	TLN1 TLN2	9.50e-05	4	75	2	1.20.1410.10
Domain	zf-C5HC2	KDM5C KDM5D	1.58e-04	5	75	2	PF02928
Domain	Znf_C5HC2	KDM5C KDM5D	1.58e-04	5	75	2	IPR004198
Domain	FATC	SMG1 ATR	1.58e-04	5	75	2	PF02260
Domain	FAT	SMG1 ATR	2.36e-04	6	75	2	PS51189
Domain	FATC	SMG1 ATR	2.36e-04	6	75	2	PS51190
Domain	FATC_dom	SMG1 ATR	2.36e-04	6	75	2	IPR003152
Domain	PIK_FAT	SMG1 ATR	2.36e-04	6	75	2	IPR014009
Domain	FATC	SMG1 ATR	2.36e-04	6	75	2	SM01343
Domain	Vinculin/catenin	TLN1 TLN2	3.30e-04	7	75	2	IPR006077
Domain	JmjN	KDM5C KDM5D	7.01e-04	10	75	2	SM00545
Domain	JMJN	KDM5C KDM5D	7.01e-04	10	75	2	PS51183
Domain	JmjN	KDM5C KDM5D	7.01e-04	10	75	2	PF02375
Domain	JmjN	KDM5C KDM5D	7.01e-04	10	75	2	IPR003349
Domain	Leu-rich_rpt	FBXL20 CD180 LRRC37B PHLPP2 NLRP13 NLRP5	7.69e-04	271	75	6	IPR001611
Domain	GAIN_dom_N	ADGRB3 ADGRL4	8.55e-04	11	75	2	IPR032471
Domain	GAIN	ADGRB3 ADGRL4	8.55e-04	11	75	2	PF16489
Domain	ZINC_FINGER_C2H2_2	ZNF280A ZNF502 ZNF131 ZBTB48 ZNF200 ZNF727 ZNF525 ZNF319 ZNF354B ZNF354C	1.03e-03	775	75	10	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF280A ZNF502 ZNF131 ZBTB48 ZNF200 ZNF727 ZNF525 ZNF319 ZNF354B ZNF354C	1.05e-03	777	75	10	PS00028
Domain	FBOX	FBXO10 FBXL20 FBXO34	1.19e-03	52	75	3	SM00256
Domain	Znf_C2H2	ZNF280A ZNF502 ZNF131 ZBTB48 ZNF200 ZNF727 ZNF525 ZNF319 ZNF354B ZNF354C	1.37e-03	805	75	10	IPR007087
Domain	IRS_PTB	TLN1 TLN2	1.40e-03	14	75	2	IPR002404
Domain	IRS	TLN1 TLN2	1.40e-03	14	75	2	PF02174
Domain	LRR_6	FBXL20 NLRP13 NLRP5	1.40e-03	55	75	3	PF13516
Domain	ZnF_C2H2	ZNF280A ZNF502 ZNF131 ZBTB48 ZNF200 ZNF727 ZNF525 ZNF319 ZNF354B ZNF354C	1.41e-03	808	75	10	SM00355
Domain	-	ZNF280A ZNF502 ZNF131 ZBTB48 ZNF200 ZNF727 ZNF319 ZNF354B ZNF354C	1.55e-03	679	75	9	3.30.160.60
Domain	-	KDM5C KDM5D	1.62e-03	15	75	2	1.10.150.60
Domain	BRIGHT	KDM5C KDM5D	1.62e-03	15	75	2	SM00501
Domain	ARID_dom	KDM5C KDM5D	1.62e-03	15	75	2	IPR001606
Domain	ARID	KDM5C KDM5D	1.62e-03	15	75	2	PS51011
Domain	ARID	KDM5C KDM5D	1.62e-03	15	75	2	PF01388
Domain	PI3/4_kinase_CS	SMG1 ATR	1.62e-03	15	75	2	IPR018936
Domain	zf-C2H2_6	ZNF502 ZBTB48 ZNF200 ZNF727 ZNF354B ZNF354C	1.64e-03	314	75	6	PF13912
Domain	zf-C2H2	ZNF502 ZNF131 ZBTB48 ZNF200 ZNF727 ZNF525 ZNF319 ZNF354B ZNF354C	1.78e-03	693	75	9	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF280A ZNF502 ZNF131 ZBTB48 ZNF200 ZNF727 ZNF319 ZNF354B ZNF354C	1.80e-03	694	75	9	IPR013087
Domain	-	FBXL20 CD180 LRRC37B PHLPP2 NLRP13 NLRP5	1.83e-03	321	75	6	3.80.10.10
Domain	-	SMG1 ATR	1.84e-03	16	75	2	1.10.1070.11
Domain	PI3Kc	SMG1 ATR	1.84e-03	16	75	2	SM00146
Domain	L_dom-like	FBXL20 CD180 LRRC37B PHLPP2 NLRP13 NLRP5	2.04e-03	328	75	6	IPR032675
Domain	RUN	RUFY2 RUFY1	2.34e-03	18	75	2	SM00593
Domain	PI3/4_kinase_cat_dom	SMG1 ATR	2.34e-03	18	75	2	IPR000403
Domain	PI3_PI4_kinase	SMG1 ATR	2.34e-03	18	75	2	PF00454
Domain	PI3_4_KINASE_3	SMG1 ATR	2.34e-03	18	75	2	PS50290
Domain	PI3_4_KINASE_1	SMG1 ATR	2.34e-03	18	75	2	PS00915
Domain	PI3_4_KINASE_2	SMG1 ATR	2.34e-03	18	75	2	PS00916
Domain	F-box	FBXO10 FBXL20 FBXO34	2.48e-03	67	75	3	PF00646
Domain	RUN	RUFY2 RUFY1	2.60e-03	19	75	2	PS50826
Domain	RUN	RUFY2 RUFY1	2.60e-03	19	75	2	PF02759
Domain	Run_dom	RUFY2 RUFY1	2.60e-03	19	75	2	IPR004012
Domain	Znf_FYVE_PHD	RUFY2 KDM5C KDM5D RUFY1	2.90e-03	147	75	4	IPR011011
Domain	FBOX	FBXO10 FBXL20 FBXO34	3.04e-03	72	75	3	PS50181
Domain	SRCR	CD5 SCARA5	3.18e-03	21	75	2	PF00530
Domain	F-box_dom	FBXO10 FBXL20 FBXO34	3.41e-03	75	75	3	IPR001810
Domain	DAPIN	NLRP13 NLRP5	3.49e-03	22	75	2	PS50824
Domain	PYRIN	NLRP13 NLRP5	3.49e-03	22	75	2	PF02758
Domain	DAPIN	NLRP13 NLRP5	3.49e-03	22	75	2	IPR004020
Domain	PYRIN	NLRP13 NLRP5	3.49e-03	22	75	2	SM01289
Domain	NACHT	NLRP13 NLRP5	3.81e-03	23	75	2	PS50837
Domain	NACHT_NTPase	NLRP13 NLRP5	3.81e-03	23	75	2	IPR007111
Pubmed	Increased expression and characterization of two distinct folate binding proteins in murine erythroleukemia cells.	FOLR1 FOLR2 FOLR3	1.04e-08	3	77	3	8304978
Pubmed	Characterization of two cDNAs encoding folate-binding proteins from L1210 murine leukemia cells. Increased expression associated with a genomic rearrangement.	FOLR1 FOLR2 FOLR3	1.04e-08	3	77	3	1894617
Pubmed	Identification of amino acid residues that determine the differential ligand specificities of folate receptors alpha and beta.	FOLR1 FOLR2 FOLR3	1.04e-08	3	77	3	9166787
Pubmed	Renal tubular reabsorption of folate mediated by folate binding protein 1.	FOLR1 FOLR2 FOLR3	1.04e-08	3	77	3	15703271
Pubmed	Developmental consequences of in utero sodium arsenate exposure in mice with folate transport deficiencies.	FOLR1 FOLR2 FOLR3	1.04e-08	3	77	3	15694460
Pubmed	Expression patterns of folate binding proteins one and two in the developing mouse embryo.	FOLR1 FOLR2 FOLR3	1.04e-08	3	77	3	9973545
Pubmed	Mice lacking the folic acid-binding protein Folbp1 are defective in early embryonic development.	FOLR1 FOLR2 FOLR3	1.04e-08	3	77	3	10508523
Pubmed	Growing Mouse Oocytes Transiently Activate Folate Transport via Folate Receptors As They Approach Full Size.	FOLR1 FOLR2 FOLR3	4.17e-08	4	77	3	27122634
Pubmed	Identification of two putative novel folate receptor genes in humans and mouse.	FOLR1 FOLR2 FOLR3	4.17e-08	4	77	3	11111049
Pubmed	Mutations in folate transporter genes and risk for human myelomeningocele.	FOLR1 FOLR2 FOLR3	4.17e-08	4	77	3	28948692
Pubmed	Association of folate receptor (FOLR1, FOLR2, FOLR3) and reduced folate carrier (SLC19A1) genes with meningomyelocele.	FOLR1 FOLR2 FOLR3	4.17e-08	4	77	3	20683905
Pubmed	Folate transport in mouse cumulus-oocyte complexes and preimplantation embryos.	FOLR1 FOLR2 FOLR3	2.08e-07	6	77	3	23904512
Pubmed	Spatial and temporal expression of folate-related transporters and metabolic enzymes during mouse placental development.	FOLR1 FOLR2 FOLR3	5.80e-07	8	77	3	22365888
Pubmed	Preferred sites of glycosylphosphatidylinositol modification in folate receptors and constraints in the primary structure of the hydrophobic portion of the signal.	FOLR1 FOLR2	4.84e-06	2	77	2	7578066
Pubmed	Both Talin-1 and Talin-2 correlate with malignancy potential of the human hepatocellular carcinoma MHCC-97 L cell.	TLN1 TLN2	4.84e-06	2	77	2	26822056
Pubmed	Extracellular rigidity sensing by talin isoform-specific mechanical linkages.	TLN1 TLN2	4.84e-06	2	77	2	26523364
Pubmed	Differential effects of arsenic on folate binding protein 2 (Folbp2) null and wild type fibroblasts.	FOLR2 FOLR3	4.84e-06	2	77	2	12368056
Pubmed	Valproate-induced neural tube defects in folate-binding protein-2 (Folbp2) knockout mice.	FOLR2 FOLR3	4.84e-06	2	77	2	14745917
Pubmed	Folate-binding proteins.	FOLR1 FOLR2	4.84e-06	2	77	2	2166548
Pubmed	Mouse H-Y encoding Smcy gene and its X chromosomal homolog Smcx.	KDM5C KDM5D	4.84e-06	2	77	2	10441747
Pubmed	Identification of a novel folate receptor, a truncated receptor, and receptor type beta in hematopoietic cells: cDNA cloning, expression, immunoreactivity, and tissue specificity.	FOLR2 FOLR3	4.84e-06	2	77	2	8110752
Pubmed	Inefficient purifying selection: the mammalian Y chromosome in the rodent genus Mus.	KDM5C KDM5D	4.84e-06	2	77	2	16416087
Pubmed	Expression of functional folate receptors in multiple myeloma.	FOLR1 FOLR2	4.84e-06	2	77	2	29616859
Pubmed	Folate modulates Hox gene-controlled skeletal phenotypes.	FOLR2 FOLR3	4.84e-06	2	77	2	15282741
Pubmed	Association of periconceptional folate supplements and FOLR1 and FOLR2 gene polymorphisms with risk of congenital heart disease in offspring: A hospital-based case-control study.	FOLR1 FOLR2	4.84e-06	2	77	2	35545363
Pubmed	Increased expression and genomic organization of a folate-binding protein homologous to the human placental isoform in L1210 murine leukemia cell lines with a defective reduced folate carrier.	FOLR2 FOLR3	4.84e-06	2	77	2	8307991
Pubmed	Mutations of histone demethylase genes encoded by X and Y chromosomes, Kdm5c and Kdm5d, lead to noncompaction cardiomyopathy in mice.	KDM5C KDM5D	4.84e-06	2	77	2	32081420
Pubmed	Effects of dietary folate intake and folate binding protein-2 (Folbp2) on urinary speciation of sodium arsenate in mice.	FOLR2 FOLR3	4.84e-06	2	77	2	21783456
Pubmed	18F-AzaFol for Detection of Folate Receptor-β Positive Macrophages in Experimental Interstitial Lung Disease-A Proof-of-Concept Study.	FOLR2 FOLR3	4.84e-06	2	77	2	31824505
Pubmed	Arsenic-induced congenital malformations in genetically susceptible folate binding protein-2 knockout mice.	FOLR2 FOLR3	4.84e-06	2	77	2	11749123
Pubmed	Mutational analysis of FOLR1 and FOLR2 genes in children with Myelomeningocele.	FOLR1 FOLR2	4.84e-06	2	77	2	37883728
Pubmed	Analysis of mutation rates in the SMCY/SMCX genes shows that mammalian evolution is male driven.	KDM5C KDM5D	4.84e-06	2	77	2	9060413
Pubmed	New isoform-specific monoclonal antibodies reveal different sub-cellular localisations for talin1 and talin2.	TLN1 TLN2	4.84e-06	2	77	2	22306379
Pubmed	Expression of functional folate receptors by human parathyroid cells.	FOLR1 FOLR2	4.84e-06	2	77	2	24206618
Pubmed	Scavenger receptor-mediated uptake of cell-penetrating peptide nanocomplexes with oligonucleotides.	SCARA5 SCARA3	4.84e-06	2	77	2	22138034
Pubmed	Ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase inhibition is synthetically lethal in XRCC1 deficient ovarian cancer cells.	ATR XRCC1	4.84e-06	2	77	2	23451157
Pubmed	Folate receptor beta as a potential delivery route for novel folate antagonists to macrophages in the synovial tissue of rheumatoid arthritis patients.	FOLR1 FOLR2	4.84e-06	2	77	2	19116913
Pubmed	Molecular imaging of folate receptor β-positive macrophages during acute lung inflammation.	FOLR2 FOLR3	4.84e-06	2	77	2	25375039
Pubmed	A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens.	KDM5C KDM5D	4.84e-06	2	77	2	7524912
Pubmed	Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions.	TLN1 TLN2	1.45e-05	3	77	2	12422220
Pubmed	Genomic organization of the human folate receptor genes on chromosome 11q13.	FOLR1 FOLR2	1.45e-05	3	77	2	1330883
Pubmed	Mechanotransduction in talin through the interaction of the R8 domain with DLC1.	TLN1 TLN2	1.45e-05	3	77	2	30028837
Pubmed	Identification of a mouse male-specific transplantation antigen, H-Y.	KDM5C KDM5D	1.45e-05	3	77	2	7544442
Pubmed	Vinculin and talin: focus on the myocardium.	TLN1 TLN2	1.45e-05	3	77	2	19952892
Pubmed	Talin depletion reveals independence of initial cell spreading from integrin activation and traction.	TLN1 TLN2	1.45e-05	3	77	2	19160486
Pubmed	Selective reprogramming of regulatory T cells in solid tumors can strongly enhance or inhibit tumor growth.	FOLR2 FOLR3	1.45e-05	3	77	2	37928524
Pubmed	Talin and vinculin are downregulated in atherosclerotic plaque; Tampere Vascular Study.	TLN1 TLN2	1.45e-05	3	77	2	27816808
Pubmed	Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion.	TLN1 TLN2	1.45e-05	3	77	2	15494027
Pubmed	Interaction between tyrosine kinase Etk and a RUN domain- and FYVE domain-containing protein RUFY1. A possible role of ETK in regulation of vesicle trafficking.	RUFY2 RUFY1	1.45e-05	3	77	2	11877430
Pubmed	Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells.	TLN1 TLN2	1.45e-05	3	77	2	18792400
Pubmed	Vinculin controls talin engagement with the actomyosin machinery.	TLN1 TLN2	1.45e-05	3	77	2	26634421
Pubmed	CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy.	FOLR2 FOLR3	1.45e-05	3	77	2	33563975
Pubmed	Arginylation-dependent regulation of a proteolytic product of talin is essential for cell-cell adhesion.	TLN1 TLN2	1.45e-05	3	77	2	22665520
Pubmed	The ATM-related kinase, hSMG-1, bridges genome and RNA surveillance pathways.	SMG1 ATR	1.45e-05	3	77	2	15279777
Pubmed	An essential role for talin during alpha(M)beta(2)-mediated phagocytosis.	TLN1 TLN2	1.45e-05	3	77	2	17202407
Pubmed	Loss of mouse cardiomyocyte talin-1 and talin-2 leads to β-1 integrin reduction, costameric instability, and dilated cardiomyopathy.	TLN1 TLN2	1.45e-05	3	77	2	28698364
Pubmed	Novel JARID1C/SMCX mutations in patients with X-linked mental retardation.	KDM5C KDM5D	2.89e-05	4	77	2	16541399
Pubmed	Rap1 binding to the talin 1 F0 domain makes a minimal contribution to murine platelet GPIIb-IIIa activation.	TLN1 TLN2	2.89e-05	4	77	2	30242097
Pubmed	The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases.	KDM5C KDM5D	2.89e-05	4	77	2	17320160
Pubmed	Structural diversity in integrin/talin interactions.	TLN1 TLN2	2.89e-05	4	77	2	21134644
Pubmed	Vinculin regulates assembly of talin: β3 integrin complexes.	TLN1 TLN2	2.89e-05	4	77	2	24446374
Pubmed	Expression of folate receptors alpha and beta in normal and cancerous gynecologic tissues: correlation of expression of the beta isoform with macrophage markers.	FOLR1 FOLR2	2.89e-05	4	77	2	25971554
Pubmed	Endothelial cell talin1 is essential for embryonic angiogenesis.	TLN1 TLN2	2.89e-05	4	77	2	21081121
Pubmed	X- and Y-Linked Chromatin-Modifying Genes as Regulators of Sex-Specific Cancer Incidence and Prognosis.	KDM5C KDM5D	2.89e-05	4	77	2	32732223
Pubmed	A novel X gene with a widely transcribed Y-linked homologue escapes X-inactivation in mouse and human.	KDM5C KDM5D	2.89e-05	4	77	2	7951230
Pubmed	Early-Onset Alzheimer Disease and Candidate Risk Genes Involved in Endolysosomal Transport.	TCIRG1 RUFY1	2.89e-05	4	77	2	28738127
Pubmed	Intrasteric inhibition mediates the interaction of the I/LWEQ module proteins Talin1, Talin2, Hip1, and Hip12 with actin.	TLN1 TLN2	2.89e-05	4	77	2	15581353
Pubmed	Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A: a pathway-wide association study.	FOLR1 FOLR2 FOLR3	3.66e-05	29	77	3	19048631
Pubmed	Clustering of alpha(5)beta(1) integrins determines adhesion strength whereas alpha(v)beta(3) and talin enable mechanotransduction.	TLN1 TLN2	4.82e-05	5	77	2	19805288
Pubmed	Talin1 regulates integrin turnover to promote embryonic epithelial morphogenesis.	TLN1 TLN2	4.82e-05	5	77	2	21670148
Pubmed	Quantification of integrin receptor agonism by fluorescence lifetime imaging.	TLN1 TLN2	4.82e-05	5	77	2	18216331
Pubmed	Talin is required for integrin-mediated platelet function in hemostasis and thrombosis.	TLN1 ITGA2	4.82e-05	5	77	2	18086863
Pubmed	Standardizing scavenger receptor nomenclature.	SCARA5 SCARA3	4.82e-05	5	77	2	24563502
Pubmed	Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin.	TLN1 TLN2	4.82e-05	5	77	2	26821125
Pubmed	Molecular characterization and gene content of breakpoint boundaries in patients with neurofibromatosis type 1 with 17q11.2 microdeletions.	ATAD5 LRRC37B	7.22e-05	6	77	2	11468690
Pubmed	Mice carrying a complete deletion of the talin2 coding sequence are viable and fertile.	TLN1 TLN2	7.22e-05	6	77	2	22925892
Pubmed	Talin regulates integrin β1-dependent and -independent cell functions in ureteric bud development.	TLN1 TLN2	1.01e-04	7	77	2	28993400
Pubmed	Osteoclasts adapt to physioxia perturbation through DNA demethylation.	TET2 TCIRG1	1.01e-04	7	77	2	34661337
Pubmed	A common set of at least 11 functional genes is lost in the majority of NF1 patients with gross deletions.	ATAD5 LRRC37B	1.01e-04	7	77	2	10843809
Pubmed	Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles.	FOLR2 FOLR3	1.01e-04	7	77	2	34995099
Pubmed	SHARPIN is an endogenous inhibitor of β1-integrin activation.	TLN1 ITGA2	1.01e-04	7	77	2	21947080
Pubmed	Talin1 has unique expression versus talin 2 in the heart and modifies the hypertrophic response to pressure overload.	TLN1 TLN2	1.01e-04	7	77	2	23266827
Pubmed	The small muscle-specific protein Csl modifies cell shape and promotes myocyte fusion in an insulin-like growth factor 1-dependent manner.	TLN1 TLN2	1.34e-04	8	77	2	11381084
Pubmed	A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.	SMG1 ATR	1.34e-04	8	77	2	20810650
Pubmed	β2 integrin adhesion complexes maintain the integrity of HIV-1 assembly compartments in primary macrophages.	TLN1 TLN2	1.34e-04	8	77	2	22017400
Pubmed	Arginylation-dependent neural crest cell migration is essential for mouse development.	TLN1 TLN2	1.34e-04	8	77	2	20300656
Pubmed	Single-nucleotide polymorphisms within the antioxidant defence system and associations with aggressive prostate cancer.	PPARGC1B XRCC1	1.34e-04	8	77	2	20477822
Pubmed	Comparative phenotypic analysis of the two major splice isoforms of phosphatidylinositol phosphate kinase type Iγ in vivo.	TLN1 TLN2	1.72e-04	9	77	2	22976293
Pubmed	The human RNA surveillance factor UPF1 is required for S phase progression and genome stability.	SMG1 ATR	1.72e-04	9	77	2	16488880
Pubmed	BRCA1-mediated chromatin silencing is limited to oocytes with a small number of asynapsed chromosomes.	ATR SYCP1	1.72e-04	9	77	2	19531582
Pubmed	Rufy3, a protein specifically expressed in neurons, interacts with actin-bundling protein Fascin to control the growth of axons.	RUFY2 RUFY1	1.72e-04	9	77	2	24720729
Pubmed	Tonic B cell activation by Radioprotective105/MD-1 promotes disease progression in MRL/lpr mice.	TIRAP CD180	1.72e-04	9	77	2	18492657
Pubmed	Dual functions of ASCIZ in the DNA base damage response and pulmonary organogenesis.	ATR XRCC1	1.72e-04	9	77	2	20975950
Pubmed	An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1).	FOLR1 FOLR2 FOLR3	1.79e-04	49	77	3	19161160
Pubmed	Tel2 regulates the stability of PI3K-related protein kinases.	SMG1 ATR	2.15e-04	10	77	2	18160036
Pubmed	Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis.	ATR ATAD5	2.15e-04	10	77	2	15983387
Pubmed	Assembly of the cochlear gap junction macromolecular complex requires connexin 26.	TLN1 TLN2	2.15e-04	10	77	2	24590285
Pubmed	Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.	SMG1 ATR	2.63e-04	11	77	2	20427287
Pubmed	Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions.	FOLR1 FOLR2	2.63e-04	11	77	2	17035141
Pubmed	Human transcription factor protein interaction networks.	TET2 SMG1 ZNF131 EPC2 FBN1 ATAD5 WDCP ZMYM2 XRCC1 HERC1 ZNF319	3.00e-04	1429	77	11	35140242
Cytoband	10q24.1	TCTN3 SFRP5	6.28e-04	22	77	2	10q24.1
Cytoband	12q12	MUC19 ADAMTS20	2.86e-03	47	77	2	12q12
Cytoband	Ensembl 112 genes in cytogenetic band chr17q11	ATAD5 PROCA1 LRRC37B	3.03e-03	171	77	3	chr17q11
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF502 ZNF131 ZBTB48 ZNF200 ZNF727 ZNF525 ZNF319 ZNF354B ZNF354C	1.86e-04	718	52	9	28
GeneFamily	AT-rich interaction domain containing	KDM5C KDM5D	8.32e-04	15	52	2	418
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM5C KDM5D	2.15e-03	24	52	2	485
GeneFamily	Pyrin domain containing\|Pyrin and HIN domain family	NLRP13 NLRP5	2.33e-03	25	52	2	994
GeneFamily	NLR family	NLRP13 NLRP5	2.33e-03	25	52	2	666
GeneFamily	C2-set domain containing\|Immunoglobulin like domain containing\|Scavenger receptors	SCARA5 SCARA3	2.72e-03	27	52	2	1253
GeneFamily	Zinc fingers FYVE-type\|Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors	RUFY2 RUFY1	3.58e-03	31	52	2	81
GeneFamily	Cyclins\|F-boxes other	FBXO10 FBXO34	5.62e-03	39	52	2	560
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	TLN1 TLN2	9.10e-03	50	52	2	1293
Coexpression	TSUNODA_CISPLATIN_RESISTANCE_DN	FBN1 FOLR1 FOLR2 FOLR3	1.36e-05	50	76	4	M5014
Disease	syndromic X-linked intellectual disability Claes-Jensen type (implicated_via_orthology)	KDM5C KDM5D	3.41e-05	4	71	2	DOID:0060809 (implicated_via_orthology)
Disease	pulmonary function measurement, forced expiratory volume	TET2 FOLR1 FOLR2	9.78e-05	37	71	3	EFO_0003892, EFO_0004314
Disease	Marfan syndrome (implicated_via_orthology)	FBN1 MATN3	2.54e-04	10	71	2	DOID:14323 (implicated_via_orthology)
Disease	autism spectrum disorder (implicated_via_orthology)	ZNF280A KDM5C TRPC5 KDM5D	5.03e-04	152	71	4	DOID:0060041 (implicated_via_orthology)
Disease	nasopharynx carcinoma (is_implicated_in)	TET2 XRCC1	5.87e-04	15	71	2	DOID:9261 (is_implicated_in)
Disease	susceptibility to hepatitis A infection measurement	OMA1 FOLR1 FOLR2	5.98e-04	68	71	3	EFO_0008415
Disease	syndromic intellectual disability (implicated_via_orthology)	KDM5C KDM5D	6.70e-04	16	71	2	DOID:0050888 (implicated_via_orthology)
Disease	intellectual disability (implicated_via_orthology)	ZNF280A KDM5C KDM5D	7.96e-04	75	71	3	DOID:1059 (implicated_via_orthology)
Disease	Disproportionate short stature	TCTN3 FBN1 MATN3	8.60e-04	77	71	3	C0878659
Disease	Infiltrating duct carcinoma of female breast	SMG1 ATR	1.16e-03	21	71	2	C3165106
Disease	alpha-linolenic acid measurement	SFRP5 NLRP5	1.65e-03	25	71	2	EFO_0007759
Disease	Iniencephaly	FOLR1 FOLR2	2.07e-03	28	71	2	C0152234
Disease	Tethered Cord Syndrome	FOLR1 FOLR2	2.07e-03	28	71	2	C0080218
Disease	Spinal Cord Myelodysplasia	FOLR1 FOLR2	2.07e-03	28	71	2	C0344479
Disease	Exencephaly	FOLR1 FOLR2	2.07e-03	28	71	2	C0266453
Disease	Neurenteric Cyst	FOLR1 FOLR2	2.07e-03	28	71	2	C0027806
Disease	Acrania	FOLR1 FOLR2	2.07e-03	28	71	2	C0702169
Disease	Diastematomyelia	FOLR1 FOLR2	2.07e-03	28	71	2	C0011999
Disease	Craniorachischisis	FOLR1 FOLR2	2.22e-03	29	71	2	C0152426
Disease	Neural Tube Defects	FOLR1 FOLR2	2.38e-03	30	71	2	C0027794
Disease	myelodysplastic syndrome (is_implicated_in)	TET2 XRCC1	2.38e-03	30	71	2	DOID:0050908 (is_implicated_in)
Disease	resting heart rate, chronic obstructive pulmonary disease	PLB1 HERC1	2.38e-03	30	71	2	EFO_0000341, EFO_0004351

Protein segments in the cluster

Peptide	Gene	Start	Entry
THFRTCHENTKNLLC	ZNF280A	411	P59817
CNECEKTFSHRSSLL	ZNF354C	246	Q86Y25
QSTRTTIHKNLCCSL	ADGRL4	456	Q9HBW9
RCSGLNCHHKLQTTS	C2orf16	1126	Q68DN1
KKCSALVSHCLNSLS	ATAD5	1636	Q96QE3
NASSKHCENRLSLSE	EPC2	501	Q52LR7
ASHTKCLCDRLSTFA	ADGRB3	846	O60242
LLASIDQHCSTTRLC	FBXO10	166	Q9UK96
QRASALLASCSKNCT	FBXO34	216	Q9NWN3
NSSCTSLEHCFRKIK	CD5	241	P06127
DCCSLQLKNLSHLQT	CD180	386	Q99467
LNCSTSCERKDSHQR	ADAMTS20	1541	P59510
TSLSSCFAQLCHKAQ	GOPC	71	Q9HD26
TDLTACDNRLCASIH	NUDCD1	106	Q96RS6
NRLHCLRNTSLESCL	FAM106C	16	P0CH98
TNCSAAHSRQALSCK	LFNG	166	Q8NES3
KKTCSALDRCALNTH	MATN3	301	O15232
AACCLSSRLSSQHRQ	HERC1	3371	Q15751
LSHINDLCKCSSSRQ	KDM5D	721	Q9BY66
ERAKALNTCISHISC	OR51B2	231	Q9Y5P1
NVKACNSSCRSLSER	MUC19	1086	Q7Z5P9
QLLSSSKHCTRNTAA	CSNKA2IP	371	A0A1B0GTH6
TTKHECSDKLAQCRQ	FAM214A	56	Q32MH5
TVKLHCNTACLTNSI	LRRC37B	731	Q96QE4
KKNACCTASTSQELH	FOLR3	61	P41439
CEALSLALSCNRHLT	NLRP5	1111	P59047
RLAHECLSQSCDSAK	MED29	121	Q9NX70
KSNCCQHSSALGLAR	CLPS	41	P04118
NFRHTKELNCRTASC	ITGA2	1041	P17301
NRLTNCITTSCLGDH	RGL4	271	Q8IZJ4
CCDLTTLVKAHNTQR	CHN2	276	P52757
FCRNLKATSQHECSS	ATR	741	Q13535
HLCEETTNRLCVSNK	DHRS4-AS1	21	Q9P1J3
SSPKSRNHSKQECCC	FBN1	2071	P35555
QKLSHCISCASSARE	IL26	116	Q9NPH9
KNACCTASTSQELHK	FOLR2	56	P14207
KRLDGSTECCNNHSL	MBTPS2	326	O43462
NCLSKSFQTLNHCRL	KRTAP24-1	156	Q3LI83
LAHSRCLQSESCNTQ	DYNAP	86	Q8N1N2
RCSRCQKNLSLHTSV	SCARA3	41	Q6AZY7
SICCTQLGSLSALKH	SCARA5	46	Q6ZMJ2
VNHCNCNSRLKDSSE	PROCA1	96	Q8NCQ7
RKNACCSTNTSQEAH	FOLR1	61	P15328
CLELVSNCEQKLSSH	TRMT11	391	Q7Z4G4
HTICRQCLEKLLASS	TRIM32	41	Q13049
CNGCKRLLTVSSHNL	PSAPL1	396	Q6NUJ1
DSCHALLIQRCSSNL	RUFY2	591	Q8WXA3
LAKRCHSDTQVFLCS	SFRP5	96	Q5T4F7
VCDSCHTLLLQRCSS	RUFY1	691	Q96T51
FCSKLRHLDLASCTS	FBXL20	141	Q96IG2
CLQACSSLHALSSSL	SMG1	776	Q96Q15
RSCTELHKHLTSAQC	PPARGC1B	211	Q86YN6
LHKHLTSAQCCLQDR	PPARGC1B	216	Q86YN6
CTCLRHSQSSLEKQE	PLB1	1276	Q6P1J6
RKCNTLASTSRGCHQ	OMA1	26	Q96E52
CRTTHSNQEVLQSCL	PYCR3	56	Q53H96
HQDKRTRCALCHSQT	PGBD2	556	Q6P3X8
KTFSQELSLTCHCRL	ZNF525	446	Q8N782
TCAKCFLSRTELQLH	ZBTB48	411	P10074
NGIHQCLSATRSKTC	ZNF727	131	A8MUV8
LTITKAHSNAISNCC	WDR88	266	Q6ZMY6
LSSLCSLEQLHCGRN	PHLPP2	456	Q6ZVD8
NNATRHLCNLLKETC	SYCP1	176	Q15431
TIVAKHTSALCNSCR	TLN1	1496	Q9Y490
HTSALCNSCRLASAR	TLN1	1501	Q9Y490
LSNCTRHEKTHSACK	ZNF200	376	P98182
QRKGSAHLFCSTTCL	ZMYM2	346	Q9UBW7
SELCQALSSSHCRVL	TIRAP	131	P58753
KCTLCDKSFSQSSHL	ZNF319	231	Q9P2F9
SCSSQDSTHCAENLL	XRCC1	11	P18887
ICSECGSSFRKHSNL	ZNF502	296	Q8TBZ5
AKHTSALCNACRIAS	TLN2	1501	Q9Y4G6
LRSKESCNSSSENCH	SCN11A	1561	Q9UI33
LHCASSICSSNSKLL	TRPC5	926	Q9UL62
ARNSTLKCHLTACQT	ZNF131	366	P52739
CSTCEKAFIHNSSLR	ZNF354B	216	Q96LW1
SAQKTLHRCSSCLVF	WDCP	186	Q9H6R7
ILNRHCSISAINCTS	TCTN3	476	Q6NUS6
SACKIQVSCSNNTHL	TET2	826	Q6N021
LNQCSVSTTHKCLIA	TCIRG1	306	Q13488
LSHINDLCKCSSSRQ	KDM5C	731	P41229
CCQHLFSVLSSSKSL	NLRP13	996	Q86W25