Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	tricellular tight junction	LSR SIPA1L3	9.52e-05	4	84	2	GO:0061689
Domain	Aquaporin_12	AQP12A AQP12B	1.95e-05	2	83	2	IPR023265
Domain	TF_fork_head_CS_2	FOXL2 FOXD4L3 FOXD4L6 FOXD4	5.13e-05	46	83	4	IPR030456
Domain	TF_fork_head_CS_1	FOXL2 FOXD4L3 FOXD4L6 FOXD4	5.59e-05	47	83	4	IPR018122
Domain	Aquaporin_11/12	AQP12A AQP12B	5.84e-05	3	83	2	IPR016697
Domain	FH	FOXL2 FOXD4L3 FOXD4L6 FOXD4	6.60e-05	49	83	4	SM00339
Domain	FORK_HEAD_1	FOXL2 FOXD4L3 FOXD4L6 FOXD4	6.60e-05	49	83	4	PS00657
Domain	FORK_HEAD_2	FOXL2 FOXD4L3 FOXD4L6 FOXD4	6.60e-05	49	83	4	PS00658
Domain	Fork_head_dom	FOXL2 FOXD4L3 FOXD4L6 FOXD4	6.60e-05	49	83	4	IPR001766
Domain	FORK_HEAD_3	FOXL2 FOXD4L3 FOXD4L6 FOXD4	6.60e-05	49	83	4	PS50039
Domain	Forkhead	FOXL2 FOXD4L3 FOXD4L6 FOXD4	6.60e-05	49	83	4	PF00250
Domain	CEBP_ZZ	CPEB2 CPEB4	1.16e-04	4	83	2	IPR032296
Domain	CEBP_ZZ	CPEB2 CPEB4	1.16e-04	4	83	2	PF16366
Domain	RRM_7	CPEB2 CPEB4	1.16e-04	4	83	2	PF16367
Domain	WxxW_domain	CILP2 MUC5AC	2.89e-04	6	83	2	IPR025155
Domain	Mucin2_WxxW	CILP2 MUC5AC	2.89e-04	6	83	2	PF13330
Domain	MIP	AQP12A AQP12B	1.72e-03	14	83	2	PS00221
Domain	MIP	AQP12A AQP12B	1.72e-03	14	83	2	PF00230
Domain	MIP	AQP12A AQP12B	1.97e-03	15	83	2	IPR000425
Domain	-	AQP12A AQP12B	1.97e-03	15	83	2	1.20.1080.10
Domain	Aquaporin-like	AQP12A AQP12B	1.97e-03	15	83	2	IPR023271
Domain	-	LARP4B FOXL2 FOXD4L3 FOXD4L6 FOXD4	2.87e-03	218	83	5	1.10.10.10
Domain	-	PITPNM1 ATP9B PGP	2.90e-03	64	83	3	3.40.50.1000
Domain	RRM	CPEB2 LARP4B CPEB4 TNRC6B SPEN	3.61e-03	230	83	5	PS50102
Domain	WHTH_DNA-bd_dom	LARP4B FOXL2 FOXD4L3 FOXD4L6 FOXD4	4.48e-03	242	83	5	IPR011991
Domain	-	CPEB2 LARP4B CPEB4 TNRC6B SPEN	4.64e-03	244	83	5	3.30.70.330
Domain	HAD-like_dom	PITPNM1 ATP9B PGP	5.25e-03	79	83	3	IPR023214
Domain	Nucleotide-bd_a/b_plait	CPEB2 LARP4B CPEB4 TNRC6B SPEN	5.86e-03	258	83	5	IPR012677
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	LRPPRC ITCH AGO2 CLASP1 ZC3H4 PRRC2C SH3D19 SIPA1L3 TNRC6B GRIA1 BSN BCOR AGRN SHANK3 BEGAIN	1.87e-08	963	88	15	28671696
Pubmed	Neural transcription factors bias cleavage stage blastomeres to give rise to neural ectoderm.	FOXD4L3 FOXD4L6 FOXD4	3.11e-07	6	88	3	27092474
Pubmed	The mouse fkh-2 gene. Implications for notochord, foregut, and midbrain regionalization.	FOXD4L3 FOXD4L6 FOXD4	8.69e-07	8	88	3	8530406
Pubmed	An amphioxus winged helix/forkhead gene, AmphiFoxD: insights into vertebrate neural crest evolution.	FOXD4L3 FOXD4L6 FOXD4	1.30e-06	9	88	3	12412011
Pubmed	A genetic study of the suppressors of the Engrailed-1 cerebellar phenotype.	FOXD4L3 FOXD4L6 FOXD4	4.40e-06	13	88	3	16884697
Pubmed	Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending.	FOXD4L3 FOXD4L6 FOXD4	4.40e-06	13	88	3	7957066
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	PITPNM1 LRPPRC LARP4B PRRC2C COX5B CPEB4 TNRC6B GRIA1 BSN LRP1B SHANK3 PCK2 BEGAIN	5.74e-06	1139	88	13	36417873
Pubmed	[Regulation of sphingosine kinase 1 in the TNF-α-induced expression of MUC5AC in airway epithelial cells].	SPHK1 MUC5AC	6.33e-06	2	88	2	21418911
Pubmed	ATAD2 interacts with C/EBPβ to promote esophageal squamous cell carcinoma metastasis via TGF-β1/Smad3 signaling.	CEBPB ATAD2	6.33e-06	2	88	2	33757572
Pubmed	Structural features of Argonaute-GW182 protein interactions.	AGO2 TNRC6B	6.33e-06	2	88	2	24043833
Pubmed	Control of anteroposterior and dorsoventral domains of Nkx-6.1 gene expression relative to other Nkx genes during vertebrate CNS development.	NKX6-2 NKX6-1	6.33e-06	2	88	2	9533954
Pubmed	The Tumor-Suppressive Human Circular RNA CircITCH Sponges miR-330-5p to Ameliorate Doxorubicin-Induced Cardiotoxicity Through Upregulating SIRT6, Survivin, and SERCA2a.	ITCH AGO2	6.33e-06	2	88	2	32392088
Pubmed	Insights into extracellular matrix functions from mutant mouse models.	ELN AGRN	6.33e-06	2	88	2	11082275
Pubmed	Identification of a novel aquaporin, AQP12, expressed in pancreatic acinar cells.	AQP12A AQP12B	6.33e-06	2	88	2	15809071
Pubmed	Increased phosphoenolpyruvate carboxykinase gene expression and steatosis during hepatitis C virus subgenome replication: role of nonstructural component 5A and CCAAT/enhancer-binding protein β.	CEBPB PCK2	6.33e-06	2	88	2	22955269
Pubmed	Pancreas-specific aquaporin 12 null mice showed increased susceptibility to caerulein-induced acute pancreatitis.	AQP12A AQP12B	6.33e-06	2	88	2	19726746
Pubmed	Genetic analysis of the aquaporin water channels AQP12A and AQP12B in patients with chronic pancreatitis.	AQP12A AQP12B	6.33e-06	2	88	2	36167651
Pubmed	Six members of the mouse forkhead gene family are developmentally regulated.	FOXD4L3 FOXD4L6 FOXD4	6.97e-06	15	88	3	7689224
Pubmed	Strain-specific modifier genes of Cecr2-associated exencephaly in mice: genetic analysis and identification of differentially expressed candidate genes.	FOXD4L3 FOXD4L6 FOXD4	6.97e-06	15	88	3	22045912
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	SIPA1L3 SEC24B TNRC6B BCOR SPEN NBR1	7.64e-06	184	88	6	32908313
Pubmed	Expression of the winged helix genes fkh-4 and fkh-5 defines domains in the central nervous system.	FOXD4L3 FOXD4L6 FOXD4	8.56e-06	16	88	3	8861101
Pubmed	Developmental competence of the gut endoderm: genetic potentiation by GATA and HNF3/fork head proteins.	FOXD4L3 FOXD4L6 FOXD4	8.56e-06	16	88	3	10208738
Pubmed	Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing.	CPEB2 CPEB4 TNRC6B	1.24e-05	18	88	3	30111840
Pubmed	Functional equivalency between Otx2 and Otx1 in development of the rostral head.	FOXD4L3 FOXD4L6 FOXD4	1.47e-05	19	88	3	9895322
Pubmed	Forkhead transcription factor Foxf2 (LUN)-deficient mice exhibit abnormal development of secondary palate.	FOXD4L3 FOXD4L6 FOXD4	1.73e-05	20	88	3	12812790
Pubmed	Ankmy2 Prevents Smoothened-Independent Hyperactivation of the Hedgehog Pathway via Cilia-Regulated Adenylyl Cyclase Signaling.	PTCH2 NKX6-1 ADCY5	1.73e-05	20	88	3	32702291
Pubmed	RNA-seq analysis of developing olfactory bulb projection neurons.	CLASP1 TBR1	1.90e-05	3	88	2	27073125
Pubmed	Opposing roles of PAK2 and PAK4 in synergistic induction of MUC5AC mucin by bacterium NTHi and EGF.	PAK4 MUC5AC	1.90e-05	3	88	2	17555715
Pubmed	Shank3-Rich2 interaction regulates AMPA receptor recycling and synaptic long-term potentiation.	GRIA1 SHANK3	1.90e-05	3	88	2	23739967
Pubmed	CPEB2, a novel putative translational regulator in mouse haploid germ cells.	CPEB2 CPEB4	1.90e-05	3	88	2	12672660
Pubmed	C/EBPβ is AMP kinase sensitive and up-regulates PEPCK in response to ER stress in hepatoma cells.	CEBPB PCK2	1.90e-05	3	88	2	20797423
Pubmed	Emotional Stress Induces Structural Plasticity in Bergmann Glial Cells via an AC5-CPEB3-GluA1 Pathway.	GRIA1 ADCY5	1.90e-05	3	88	2	32229518
Pubmed	CircDYM attenuates microglial apoptosis via CEBPB/ZC3H4 axis in LPS-induced mouse model of depression.	CEBPB ZC3H4	1.90e-05	3	88	2	37944732
Pubmed	A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain.	AGO2 TNRC6B	1.90e-05	3	88	2	17891150
Pubmed	Global Analysis of CPEBs Reveals Sequential and Non-Redundant Functions in Mitotic Cell Cycle.	CPEB2 CPEB4	1.90e-05	3	88	2	26398195
Pubmed	The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.	AGO2 SIPA1L3 CPEB4 TNRC6B BSN NYAP1	2.00e-05	218	88	6	33378226
Pubmed	Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification.	FOXD4L3 FOXD4L6 FOXD4	2.01e-05	21	88	3	9449667
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	LSR LARP4B CEBPB CLASP1 COX5B SIPA1L3 SEC24B PPP1R18 TNRC6B MSL1 BCOR ATAD2 SPEN AGRN	2.29e-05	1497	88	14	31527615
Pubmed	Crucial roles of Foxa2 in mouse anterior-posterior axis polarization via regulation of anterior visceral endoderm-specific genes.	FOXD4L3 FOXD4L6 FOXD4	2.33e-05	22	88	3	17389379
Pubmed	Otx2 is required to respond to signals from anterior neural ridge for forebrain specification.	FOXD4L3 FOXD4L6 FOXD4	3.05e-05	24	88	3	11820816
Pubmed	A Requirement for Zic2 in the Regulation of Nodal Expression Underlies the Establishment of Left-Sided Identity.	FOXD4L3 FOXD4L6 FOXD4	3.05e-05	24	88	3	29992973
Pubmed	CPEB2-dependent translation of long 3'-UTR Ucp1 mRNA promotes thermogenesis in brown adipose tissue.	CPEB2 CPEB4	3.79e-05	4	88	2	30177570
Pubmed	Identification of novel argonaute-associated proteins.	AGO2 TNRC6B	3.79e-05	4	88	2	16289642
Pubmed	Two previously undescribed members of the mouse CPEB family of genes and their inducible expression in the principal cell layers of the hippocampus.	CPEB2 CPEB4	3.79e-05	4	88	2	12871996
Pubmed	Sphingosine kinase 1 regulates mucin production via ERK phosphorylation.	SPHK1 MUC5AC	3.79e-05	4	88	2	19835973
Pubmed	MOV10 Is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs.	AGO2 TNRC6B	3.79e-05	4	88	2	24726324
Pubmed	Deficiency of Wdr60 and Wdr34 cause distinct neural tube malformation phenotypes in early embryos.	NKX6-2 PTCH2 NKX6-1	3.90e-05	26	88	3	37228654
Pubmed	Ssdp1 regulates head morphogenesis of mouse embryos by activating the Lim1-Ldb1 complex.	FOXD4L3 FOXD4L6 FOXD4	3.90e-05	26	88	3	15857913
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	ZNF703 ZNF668 LARP4B AGO2 ZC3H4 PRRC2C TNRC6B MSL1 ZNF467	4.29e-05	655	88	9	35819319
Pubmed	Chd2 Is Necessary for Neural Circuit Development and Long-Term Memory.	SLC6A13 AGO2 TBR1	4.38e-05	27	88	3	30344048
Pubmed	Molecular profiling of synovial joints: use of microarray analysis to identify factors that direct the development of the knee and elbow.	FOXD4L3 FOXD4L6 FOXD4	5.45e-05	29	88	3	22972626
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	PITPNM1 CPEB2 LRPPRC AGO2 CLASP1 PRRC2C SIPA1L3 CPEB4 PPP1R18 GRIA1 BSN DNAH6 SHANK3	6.23e-05	1431	88	13	37142655
Pubmed	Direct interaction of post-synaptic density-95/Dlg/ZO-1 domain-containing synaptic molecule Shank3 with GluR1 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor.	GRIA1 SHANK3	6.30e-05	5	88	2	16606358
Pubmed	A novel role of CPEB3 in regulating EGFR gene transcription via association with Stat5b in neurons.	CPEB2 CPEB4	6.30e-05	5	88	2	20639532
Pubmed	Ago-TNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps.	AGO2 TNRC6B	6.30e-05	5	88	2	19838187
Pubmed	Prdm12 specifies V1 interneurons through cross-repressive interactions with Dbx1 and Nkx6 genes in Xenopus.	NKX6-2 NKX6-1	6.30e-05	5	88	2	26443638
Pubmed	FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines.	FOXD4L6 FOXD4	6.30e-05	5	88	2	12234674
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	LSR LRPPRC ITCH CLASP1 PRRC2C SH3D19 SIPA1L3 PAK4 SEC24B BOD1L1	6.49e-05	861	88	10	36931259
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	AGO2 PRRC2C SH3D19 SEC24B TNRC6B BOD1L1 BCOR SPEN	7.79e-05	549	88	8	38280479
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	SH3D19 SIPA1L3 PAK4 SEC24B NPDC1 ATP9B AGRN PGGT1B NBR1	8.76e-05	719	88	9	35337019
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	ZNF703 LARP4B AGO2 ZC3H4 PRRC2C PAK4 CPEB4 TNRC6B SPEN	9.23e-05	724	88	9	36232890
Pubmed	IVIG immunotherapy protects against synaptic dysfunction in Alzheimer's disease through complement anaphylatoxin C5a-mediated AMPA-CREB-C/EBP signaling pathway.	CEBPB GRIA1	9.43e-05	6	88	2	23911420
Pubmed	Endodermal expression of Nkx6 genes depends differentially on Pdx1.	NKX6-2 NKX6-1	9.43e-05	6	88	2	16297379
Pubmed	Coordinate regulation of motor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2.	NKX6-2 NKX6-1	9.43e-05	6	88	2	11567616
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	LSR LRPPRC ITCH CEBPB ZC3H4 SIPA1L3 SEC24B TNRC6B MSL1 BCOR	1.14e-04	922	88	10	27609421
Pubmed	Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives.	ITCH FOXD4L3 ZC3H4 FOXD4L6 ATAD2 FOXD4	1.31e-04	306	88	6	18973680
Pubmed	Dynamic expression patterns of Nkx6.1 and Nkx6.2 in the developing mes-diencephalic basal plate.	NKX6-2 NKX6-1	1.32e-04	7	88	2	20549744
Pubmed	Functional dissection of the human TNRC6 (GW182-related) family of proteins.	AGO2 TNRC6B	1.32e-04	7	88	2	19470757
Pubmed	Cloning and characterization of the mouse AP-2 epsilon gene: a novel family member expressed in the developing olfactory bulb.	TFAP2E GRIA1	1.32e-04	7	88	2	14572467
Pubmed	Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3.	GRIA1 SHANK3	1.32e-04	7	88	2	21558424
Pubmed	Direct interaction of GluRdelta2 with Shank scaffold proteins in cerebellar Purkinje cells.	GRIA1 SHANK3	1.32e-04	7	88	2	15207857
Pubmed	The protocadherin-alpha family is involved in axonal coalescence of olfactory sensory neurons into glomeruli of the olfactory bulb in mouse.	GRIA1 BSN	1.32e-04	7	88	2	18353676
Pubmed	The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins.	AGO2 TNRC6B	1.32e-04	7	88	2	19383768
Pubmed	Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.	LSR ITCH SIPA1L3 PAK4	1.35e-04	102	88	4	15778465
Pubmed	ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure.	AGO2 PRRC2C PAK4 PPP1R18 TNRC6B ATAD2	1.53e-04	315	88	6	26777405
Pubmed	Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells.	LARP4B AGO2 PRRC2C TNRC6B	1.62e-04	107	88	4	30995489
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	CPEB2 CEBPB PRRC2C FAM222B TNRC6B BCOR PCK2	1.64e-04	457	88	7	32344865
Pubmed	Proximity labeling reveals dynamic changes in the SQSTM1 protein network.	AGO2 FAM222B CPEB4 SEC24B TNRC6B NBR1	1.72e-04	322	88	6	39098523
Pubmed	Mice lacking the Nkx6.2 (Gtx) homeodomain transcription factor develop and reproduce normally.	NKX6-2 NKX6-1	1.75e-04	8	88	2	11390667
Pubmed	Synaptic profiles during neurite extension, refinement and retraction in the developing cochlea.	GRIA1 BSN	1.75e-04	8	88	2	23217150
Pubmed	MKP1 regulates the induction of MUC5AC mucin by Streptococcus pneumoniae pneumolysin by inhibiting the PAK4-JNK signaling pathway.	PAK4 MUC5AC	1.75e-04	8	88	2	18782768
Pubmed	Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.	PRDM13 LRP1B BEGAIN	2.20e-04	46	88	3	21102462
Pubmed	A sonic hedgehog signaling domain in the arterial adventitia supports resident Sca1+ smooth muscle progenitor cells.	PTCH2 ELN	2.25e-04	9	88	2	18591670
Pubmed	Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP.	RIDA CPEB4	2.25e-04	9	88	2	22210626
Pubmed	Early motor neuron pool identity and muscle nerve trajectory defined by postmitotic restrictions in Nkx6.1 activity.	NKX6-2 NKX6-1	2.25e-04	9	88	2	18215620
Pubmed	A Novel Human CAMK2A Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors.	GRIA1 SHANK3	2.25e-04	9	88	2	28130356
Pubmed	Prox1 regulates Olig2 expression to modulate binary fate decisions in spinal cord neurons.	NKX6-2 NKX6-1	2.25e-04	9	88	2	25411508
Pubmed	Superresolution imaging of chemical synapses in the brain.	GRIA1 BSN	2.25e-04	9	88	2	21144999
Pubmed	A spontaneous mouse mutation, mesenchymal dysplasia (mes), is caused by a deletion of the most C-terminal cytoplasmic domain of patched (ptc).	PTCH2 NKX6-1	2.25e-04	9	88	2	11784021
Pubmed	Human transcription factor protein interaction networks.	ZNF703 LARP4B AGO2 PRRC2C COX5B SEC24B TNRC6B IRF2BPL MSL1 TBR1 BCOR SPEN	2.53e-04	1429	88	12	35140242
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	LARP4B SIPA1L3 DNAH17 CPEB4 IRF2BPL ZNF518B SHANK3	2.60e-04	493	88	7	15368895
Pubmed	FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates.	LARP4B AGO2 PRRC2C TNRC6B NBR1	2.63e-04	223	88	5	34226595
Pubmed	An improved smaller biotin ligase for BioID proximity labeling.	ZNF703 PRRC2C TNRC6B BCOR	2.76e-04	123	88	4	26912792
Pubmed	Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling.	PTCH2 NKX6-1	2.81e-04	10	88	2	28344083
Pubmed	Deficiency of CPEB2-Confined Choline Acetyltransferase Expression in the Dorsal Motor Nucleus of Vagus Causes Hyperactivated Parasympathetic Signaling-Associated Bronchoconstriction.	CPEB2 CPEB4	2.81e-04	10	88	2	27810937
Pubmed	PAK4 kinase is essential for embryonic viability and for proper neuronal development.	PAK4 NKX6-1	2.81e-04	10	88	2	14517283
Pubmed	Integrative genomics positions MKRN1 as a novel ribonucleoprotein within the embryonic stem cell gene regulatory network.	LARP4B AGO2 PRRC2C	3.16e-04	52	88	3	26265008
Pubmed	Notch Activation by Shootin1 Opposing Activities on 2 Ubiquitin Ligases.	ITCH TBR1	3.43e-04	11	88	2	28981589
Pubmed	Dlg5 regulates dendritic spine formation and synaptogenesis by controlling subcellular N-cadherin localization.	GRIA1 TBR1	3.43e-04	11	88	2	25232112
Pubmed	Nkx6 transcription factors and Ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors.	NKX6-2 NKX6-1	3.43e-04	11	88	2	20627083
Interaction	RBMS1 interactions	RIDA LARP4B AGO2 CEBPB PRRC2C CPEB4 TNRC6B NBR1	2.64e-06	207	85	8	int:RBMS1
Interaction	CELF1 interactions	ZNF703 LARP4B AGO2 CEBPB ZC3H4 PRRC2C CPEB4 TNRC6B	2.93e-05	288	85	8	int:CELF1
Interaction	FUBP3 interactions	LARP4B AGO2 CEBPB FOXL2 PRRC2C CPEB4 TNRC6B BCOR	3.65e-05	297	85	8	int:FUBP3
Interaction	UBAP2L interactions	LARP4B ITCH AGO2 CEBPB PRRC2C CPEB4 TNRC6B BCOR	3.73e-05	298	85	8	int:UBAP2L
Interaction	MEX3B interactions	CPEB2 LARP4B AGO2 PRRC2C CPEB4 TNRC6B NBR1	4.27e-05	222	85	7	int:MEX3B
Interaction	CPEB4 interactions	CPEB2 LARP4B AGO2 PRRC2C CPEB4 TNRC6B	5.16e-05	156	85	6	int:CPEB4
GeneFamily	Aquaporins	AQP12A AQP12B	7.50e-04	14	53	2	305
GeneFamily	Dyneins, axonemal	DNAH17 DNAH6	1.11e-03	17	53	2	536
GeneFamily	CD molecules\|Mucins	OVGP1 MUC5AC	1.71e-03	21	53	2	648
ToppCell	droplet-Bladder-BLADDER-1m-Epithelial-basal_bladder_epithelial_cell_(Krt5+Krt14+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LSR CPEB4 IRF2BPL NKX6-1 TBR1 ATAD2 AGRN	4.39e-08	168	88	7	ca65321259711321c175ede67bd67a47aad81d7a
ToppCell	BAL-Control-Myeloid-MoAM-MoAM4\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	ADM SDSL ZNF703 LSR SPHK1 NPDC1	1.83e-06	185	88	6	274b8acccdfe434d14af4cb32fb615c06ec98435
ToppCell	BAL-Control-Myeloid-MoAM-MoAM4-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ADM SDSL ZNF703 LSR SPHK1 NPDC1	1.83e-06	185	88	6	b640d9ed6a1e6aa595053065bb992efc0402353e
ToppCell	Control-Myeloid-MoAM4\|Control / Disease group,lineage and cell class （2021.01.30）	ADM SDSL ZNF703 LSR SPHK1 NPDC1	2.26e-06	192	88	6	1da7c303a2e36af4a9d8ec30a11380d9b1897922
ToppCell	LA-10._Endothelium_II\|World / Chamber and Cluster_Paper	SPHK1 PPP1R18 GRIA1 ELN SHANK3	5.59e-06	128	88	5	071becbe97598c2b65580b0989eb664d6fd6c85a
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRIA1 BSN NYAP1 SHANK3 BEGAIN	2.75e-05	178	88	5	a74e5a390cbeaca9de1fdb7b2a0e50783bd202dd
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRIA1 BSN NYAP1 SHANK3 BEGAIN	2.75e-05	178	88	5	1bddbc083c36657bd6910f7466126ab325e88176
ToppCell	15-Airway-Epithelial-Multiciliated_precursor\|Airway / Age, Tissue, Lineage and Cell class	PITPNM1 NKX6-2 DNAH17 C7orf57 DNAH6	2.75e-05	178	88	5	d8e0a696bdd6af6422d72af0413f9dbd6bc02afa
ToppCell	BAL-Control-Myeloid-MoAM-MoAM4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SDSL ZNF703 LSR SPHK1 NPDC1	3.31e-05	185	88	5	29d7ddcb9a2e45f76cd5611f7c52b6df689effd3
ToppCell	BAL-Control-Myeloid-MoAM-MoAM4-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SDSL ZNF703 LSR SPHK1 NPDC1	3.31e-05	185	88	5	780bdb63ef913a09930063286011c9108381d3a9
ToppCell	droplet-Spleen-nan-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SDSL SPHK1 FER1L4 PKLR SHANK3	3.48e-05	187	88	5	c81d11d9fdc22dc39222f62c2888025c2e8c3e65
Disease	Neurodevelopmental Disorders	ZC3H4 TNRC6B TBR1 ADCY5	1.40e-04	93	83	4	C1535926
Disease	Immature Reticulocyte Fraction Measurement	SPHK1 PKLR	3.47e-04	10	83	2	EFO_0009253
Disease	total cholesterol measurement, triglyceride measurement, low density lipoprotein cholesterol measurement, high density lipoprotein cholesterol measurement	ZC3H4 CPEB4 ADCY5	3.60e-04	49	83	3	EFO_0004530, EFO_0004574, EFO_0004611, EFO_0004612
Disease	reticulocyte measurement	LARP4B CLASP1 ZC3H4 SPHK1 DNAH17 CPEB4 PKLR TNRC6B BSN NYAP1	7.38e-04	1053	83	10	EFO_0010700
Disease	prostate carcinoma	SDSL LARP4B CILP2 SH3D19 SIPA1L3 TNRC6B ATP9B BSN SPEN	8.95e-04	891	83	9	EFO_0001663
Disease	central nervous system disease (implicated_via_orthology)	GRIA1 IRF2BPL	9.14e-04	16	83	2	DOID:331 (implicated_via_orthology)
Disease	prion disease	RIDA CPEB4	1.30e-03	19	83	2	EFO_0004720
Disease	creatinine measurement	SLC6A13 LARP4B CILP2 PRRC2C SIPA1L3 OBSCN TNRC6B ATP9B BSN	1.92e-03	995	83	9	EFO_0004518
Disease	reticulocyte count	CLASP1 ZC3H4 SPHK1 DNAH17 CPEB4 PKLR TNRC6B BSN NYAP1	2.67e-03	1045	83	9	EFO_0007986

Protein segments in the cluster

Peptide	Gene	Start	Entry
NKYRAPRGKPAPASG	AQP12A	256	Q8IXF9
PGKKADGRASPLYAS	BEGAIN	456	Q9BUH8
PLYVGGAPDFSKLAR	AGRN	1766	O00468
YGPPGTGKTLVARAL	ATAD2	466	Q6PL18
GAEGSPKPAVYATRK	CCDC144CP	11	Q8IYA2
GAGGSPKPAVYATRK	CCDC144NL	11	Q6NUI1
GYAAQKTAAPAPRGG	ADCY5	11	O95622
NKYRAPRGKPAPASG	AQP12B	256	A6NM10
ARLSNGKYPKAPEGG	BCOR	386	Q6W2J9
PSILYGGRNKAIATP	AGO2	416	Q9UKV8
SYPTGLADVKAGPAQ	ADM	51	P35318
GARLSSLPQAAYGPA	TFAP2E	21	Q6VUC0
IDPTKARYIGGGPSA	LRP1B	4516	Q9NZR2
PVYAGAPKKAEGAAL	FOXD4L3	276	Q6VB84
KRAAYYSAAGPRPGA	ATP9B	21	O43861
GLPAPEYRAGAVKVG	FER1L4	1381	A9Z1Z3
GYRAGVAAPDLLDPK	KCNK2	11	O95069
NPSAYAKREAGPGRV	LARP4B	466	Q92615
AEGPVYLGKPAAAKA	BSN	2276	Q9UPA5
SKAGPRGSVQYLPDL	FETUB	296	Q9UGM5
KPAVLAAPSGLERYG	IRF2BPL	136	Q9H1B7
PAGKKRYVAAAFPSA	PCK2	291	Q16822
VTGAVAYLKPGSDAP	OR14K1	251	Q8NGZ2
QRLAGAPAPKAYVLG	PGP	111	A6NDG6
PYNVLAPKGASGTRE	COX5B	61	P10606
RELAGPGFVGKAPAY	FAM222B	396	Q8WU58
AAAVVKGLAGPAASY	FOXL2	241	P58012
APGGPAGYLRRASVA	PKLR	31	P30613
AASYLPAARAGPVAG	LRPPRC	36	P42704
PRYSNLTKAAPAAGS	NALF2	116	O75949
GKSYRPGAVVPSDKN	MUC5AC	1241	P98088
AGAGCSPRPKYQAVL	MSL1	121	Q68DK7
APAYAGAPKKAEGAD	FOXD4	271	Q12950
PYPVAKSGKRALAGG	NUTM1	1066	Q86Y26
YATAKAPGSPAAPRI	NPDC1	221	Q9NQX5
LSPGPKYEVQASAGR	OBSCN	746	Q5VST9
YIDPRTGKSALDNGP	ITCH	506	Q96J02
ATAPAYKPGRGTGVN	BOD1L1	1176	Q8NFC6
PGYAGRTELPDNLKA	DNAH6	1576	Q9C0G6
PELKYPKGAGRVAFS	CPEB2	476	Q7Z5Q1
PGYAGRAELPENLKA	DNAH17	1951	Q9UFH2
FAPGTRKGSPVAYSL	C7orf57	86	Q8NEG2
LAAAYGGKAAPAAPP	CEBPB	36	P17676
AVKGAALGYPSSPAI	EFS	521	O43281
PELKYPKGAGRVAFS	CPEB4	616	Q17RY0
GAEGSPKPAVYATRK	CCDC144A	11	A2RUR9
YGIATPKGSALRNPV	GRIA1	746	P42261
LVPGGVADAAAAYKA	ELN	91	P15502
AAVPGAGKKRYPTAE	PPP1R18	496	Q6NYC8
AFYPGVRSAFKPAGL	PRDM13	286	Q9H4Q3
AASARIPPKFGGAAV	SEC24B	11	O95487
AGKAATSGVPSIYAP	LSR	311	Q86X29
GLQARAIGPASPGKY	OVGP1	276	Q12889
GAKLAAGRPFNTYPR	PAK4	196	O96013
AAPAERGKPATYTGD	INAFM2	6	P0DMQ5
AGLKRPPAYESLKAG	NYAP1	556	Q6ZVC0
AREAYPLGAPEASGK	GPR68	316	Q15743
RGSSYLGIPFNPSKA	PGGT1B	96	P53609
YAAAGVKALPLQAAG	TBR1	516	Q16650
VPPRLAGASQAKAYK	SH3D19	166	Q5HYK7
AAAVAAVGRYPKPLA	NKX6-1	181	P78426
AAAVARGYPKPLAEL	NKX6-2	96	Q9C056
SVAASAYKALFAGPP	NBR1	891	Q14596
PVYAGAPKKAEGAAL	FOXD4L6	276	Q3SYB3
AKLQGGSAYLPGRPD	PTCH2	196	Q9Y6C5
SGSQPRPAVLSGYFK	PRRC2C	651	Q9Y520
AARATPAAAPYLVSG	SHC3	36	Q92529
PAAAPYLVSGEALRK	SHC3	41	Q92529
APAVAGQSKGYRPKL	SIPA1L3	1366	O60292
AVPGNPLGYLSFLAK	PLA2G3	36	Q9NZ20
GIAAAYAARKLGIPA	SDSL	76	Q96GA7
LPSGAFRRADGKPYS	CILP2	586	Q8IUL8
RGAPDPFLGVKAAAA	CHPF2	536	Q9P2E5
AAALPPGSYASLGRI	CLASP1	626	Q7Z460
TAKAPGAIGPYSQAV	RIDA	11	P52758
GPPRAALGKSSYGVA	PITPNM1	1181	O00562
SPLARAPAGGAAYVK	STK35	6	Q8TDR2
ALPGAEKLLAAYPGA	ZNF703	486	Q9H7S9
GEKVSGSAAKPRPYA	ZNF668	71	Q96K58
SKPRNVPAAYRGVGD	M6PR	246	P20645
ASAAYKADAPEGLAP	SPEN	2186	Q96T58
GASPDYKDSRGLTPL	SHANK3	206	Q9BYB0
FAKTGALRGAALGPP	SPRED3	241	Q2MJR0
AESGPGLAFIAYPRA	SLC6A13	351	Q9NSD5
ISLYDPRTPNAGGKA	ZC3H4	1146	Q9UPT8
AYLPVGRVGSKTPAS	SPHK1	211	Q9NYA1
AAAYKLEPGAPGALS	ZNF467	131	Q7Z7K2
AIVAPGKTRGGSPYN	TNRC6B	1421	Q9UPQ9
RSLGAASNPFPYKAA	ZNF518B	496	Q9C0D4