Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	cellular response to camptothecin	BLM FANCB SPIDR	7.35e-06	5	188	3	GO:0072757
GeneOntologyBiologicalProcess	response to camptothecin	BLM FANCB SPIDR	7.35e-06	5	188	3	GO:1901563
Domain	-	PIAS1 MRTFB HNRNPUL2 CCAR1 MRTFA	1.66e-06	21	186	5	1.10.720.30
Domain	HEAT	NCAPD3 CAND2 CLASP1 RANBP6 CLASP2 PPP2R1A EIF4G3	1.70e-06	58	186	7	IPR000357
Domain	SAP	PIAS1 MRTFB HNRNPUL2 CCAR1 MRTFA	2.13e-06	22	186	5	PF02037
Domain	SAP	PIAS1 MRTFB HNRNPUL2 CCAR1 MRTFA	2.70e-06	23	186	5	SM00513
Domain	SAP	PIAS1 MRTFB HNRNPUL2 CCAR1 MRTFA	4.20e-06	25	186	5	PS50800
Domain	SAP_dom	PIAS1 MRTFB HNRNPUL2 CCAR1 MRTFA	4.20e-06	25	186	5	IPR003034
Domain	HEAT_REPEAT	NCAPD3 CAND2 CLASP1 RANBP6 CLASP2 PPP2R1A EIF4G3	6.13e-06	70	186	7	PS50077
Domain	HEAT	NCAPD3 CAND2 CLASP1 RANBP6 CLASP2 PPP2R1A	7.80e-06	48	186	6	PF02985
Domain	ARM-type_fold	NCAPD3 CAND2 CLASP1 RANBP6 CLASP2 LYST PPP2R1A PIK3C2A PIK3CB NOM1 ASPM PKP2 DAAM2 EIF4G3	8.00e-06	339	186	14	IPR016024
Domain	Vps54_N	VPS50 VPS54	9.86e-05	2	186	2	PF10475
Domain	VPS54_N	VPS50 VPS54	9.86e-05	2	186	2	IPR019515
Domain	GPCR3_GABA-B	GPR156 GABBR1	2.94e-04	3	186	2	IPR002455
Domain	-	NCAPD3 CAND2 CLASP1 RANBP6 CLASP2 PPP2R1A ASPM PKP2 DAAM2	3.95e-04	222	186	9	1.25.10.10
Domain	CLASP_N	CLASP1 CLASP2	5.84e-04	4	186	2	PF12348
Domain	CLASP_N_dom	CLASP1 CLASP2	5.84e-04	4	186	2	IPR024395
Domain	Multidrug-R_assoc	ABCC1 ABCC6	5.84e-04	4	186	2	IPR005292
Domain	Helicase_C	EP400 TDRD9 BLM DDX46 DDX18 SNRNP200	7.08e-04	107	186	6	PF00271
Domain	HELICc	EP400 TDRD9 BLM DDX46 DDX18 SNRNP200	7.08e-04	107	186	6	SM00490
Domain	Helicase_C	EP400 TDRD9 BLM DDX46 DDX18 SNRNP200	7.43e-04	108	186	6	IPR001650
Domain	HELICASE_CTER	EP400 TDRD9 BLM DDX46 DDX18 SNRNP200	7.80e-04	109	186	6	PS51194
Domain	HELICASE_ATP_BIND_1	EP400 TDRD9 BLM DDX46 DDX18 SNRNP200	7.80e-04	109	186	6	PS51192
Domain	DEXDc	EP400 TDRD9 BLM DDX46 DDX18 SNRNP200	7.80e-04	109	186	6	SM00487
Domain	DEAD/DEAH_box_helicase_dom	TDRD9 BLM DDX46 DDX18 SNRNP200	8.06e-04	73	186	5	IPR011545
Domain	DEAD	TDRD9 BLM DDX46 DDX18 SNRNP200	8.06e-04	73	186	5	PF00270
Domain	Helicase_ATP-bd	EP400 TDRD9 BLM DDX46 DDX18 SNRNP200	8.18e-04	110	186	6	IPR014001
Pathway	REACTOME_TGFBR3_REGULATES_TGF_BETA_SIGNALING	TGFB2 TGFBR1 ARRB2	5.63e-05	8	144	3	M48252
Pathway	REACTOME_TGFBR3_REGULATES_TGF_BETA_SIGNALING	TGFB2 TGFBR1 ARRB2	5.63e-05	8	144	3	MM17233
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	ATG16L1 HDAC4 ACACA CLASP1 FNTB RANBP9 PHB2 TTC27 PLEKHJ1 SAE1 TSC1 CLASP2 PFKP COPS2 PPP2R1A ARRB2 RPL7L1 SARS1 NOM1 ASB3 MRPS14 ASPM FES EIF4G3 PLOD2 RPL3 SNRNP200	2.76e-09	1284	192	27	17353931
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	LINGO2 KMT2D KIAA1549L NOM1 CEP250 NGEF ASPM CCAR1 KIF13A DNAH5 SNRNP200 GOLGB1	8.25e-09	234	192	12	36243803
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	MPO ACACA EP400 RANBP9 PHB2 TTC27 SAE1 DGKD TSC1 PFKP BLM PPP2R1A ARRB2 RPL7L1 TFB1M PIK3C2A HNRNPUL2 DDX18 ASPM CCAR1 PKP2 AATF MGA RPL3 SNRNP200 RPL19	3.43e-08	1353	192	26	29467282
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	MPO CACNA2D1 CLASP1 CARMIL1 PHB2 TTC27 CLASP2 COPS2 BLM PACS1 FANCB PPP2R1A TRAP1 DDX46 ARRB2 PAXBP1 HNRNPUL2 ASPM CCAR1 PLOD2 SNRNP200 IQGAP3 USP47	1.21e-07	1155	192	23	20360068
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	MPO NCAPD3 CTNNAL1 CAND2 CLASP1 FNTB RANBP9 TTC27 SAE1 RANBP6 PFKP PPP2R1A THOP1 HNRNPUL2 PRKAA2 GOLIM4 PRORP RPL3 SNRNP200 USP47 RPL19	1.22e-07	974	192	21	28675297
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	HDAC4 EP400 ARHGEF5 ARHGEF18 SIN3A PIAS1 MRTFB ARRB2 PLCH2 MLLT6 EIF4G3 EPN1 MGA MRTFA	1.40e-07	430	192	14	35044719
Pubmed	Network organization of the human autophagy system.	STX8 ATG16L1 ACACA PHB2 TSC1 PFKP SARS1 PIK3C2A PRKAA2 CCAR1 MAP3K15 STX7 RUBCN WIPI2	1.71e-07	437	192	14	20562859
Pubmed	Functional proteomics mapping of a human signaling pathway.	RANBP9 RANBP6 PIAS1 SVEP1 PPP2R1A KMT2D MRTFB ARRB2 NOM1 CEP250 PKP2 KIF13A EPN1 MGA RUBCN GOLGB1	2.16e-07	591	192	16	15231748
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	NCAPD3 EP400 CLASP1 CLASP2 ODF2 PFKP PIAS1 KIAA2013 CYFIP2 BLM TMEM120A DDX46 MRTFB PAXBP1 RPL7L1 TFB1M PIK3C2A NOM1 MRPS14 CCAR1 GOLIM4 AATF EIF4G3 EPN1 IQGAP3 GOLGB1	2.46e-07	1497	192	26	31527615
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	RPGRIP1 LCA5 ATG16L1 CAND2 HDAC4 CLASP1 CARMIL1 VPS50 RANBP9 PHB2 CLASP2 BBS5 PFKP COPS2 BLM PACS1 FANCB PPP2R1A TRAP1 TMEM120A EXOC6B CFAP161 SNRNP200 IQGAP3	3.35e-07	1321	192	24	27173435
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	NCAPD3 ACACA EP400 CLASP1 CARMIL1 SIN3A ODF2 PFKP BLM PACS1 KMT2D DDX46 PAXBP1 GZMB CCAR1 SNRNP200 MRTFA USP47	3.44e-07	774	192	18	15302935
Pubmed	Oxidative Stress Enhances the TGF-β2-RhoA-MRTF-A/B Axis in Cells Entering Endothelial-Mesenchymal Transition.	TGFB2 MRTFB MRTFA	6.60e-07	4	192	3	35216178
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	ACACA CLASP1 CARMIL1 VPS50 RAPGEF4 TSC1 CLASP2 COPS2 BLM PPP2R1A MIDN DDX46 SARS1 CCAR1	7.96e-07	497	192	14	36774506
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	ABCC1 NCAPD3 CAND2 SGSH PHB2 TTC27 RANBP6 PFKP CTDNEP1 KIAA2013 PPP2R1A RPL7L1 SARS1 LMBR1L GOLIM4 EIF4G3 STX7 PLOD2 IQGAP3	1.35e-06	942	192	19	31073040
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	RPGRIP1 SCN11A PHB2 TRIM43 TSC1 CAGE1 ODF2 PFKP RNF17 LYST SLC4A3 KIAA2013 CYFIP2 TRIM43B TRAP1 ASPM CCAR1 CFAP74 AATF EIF4G3 IL1R1 RPL3 GOLGB1 RPL19	1.57e-06	1442	192	24	35575683
Pubmed	PAPILLARY THYROID CANCER IS CHARACTERIZED BY ALTERED EXPRESSION OF GENES INVOLVED IN THE SUMOYLATION PROCESS.	SAE1 ZMIZ1 PIAS1	1.64e-06	5	192	3	26403403
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	CCDC9B ACAA1 HDAC4 ACACA RANBP9 TTC27 SAE1 CLASP2 PFKP CYFIP2 TGFB2 PPP2R1A THOP1 PAXBP1 SARS1 PIK3C2A DDX18 PKP2 MLLT6 MGA RPL3 RPL19	1.74e-06	1247	192	22	27684187
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CACNA2D1 HDAC4 CLASP1 RAPGEF4 RANBP9 PHB2 ARHGEF18 DAPK1 TSC1 CLASP2 CYFIP2 PPP2R1A HNRNPUL2 NGEF CCAR1 MGA GOLGA8A CDH11 GOLGB1	1.87e-06	963	192	19	28671696
Pubmed	PTPN9-mediated dephosphorylation of VTI1B promotes ATG16L1 precursor fusion and autophagosome formation.	STX8 ATG16L1 STX7	3.27e-06	6	192	3	33112705
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	ACACA CLASP1 CARMIL1 RANBP9 PHB2 TTC27 TSC1 CLASP2 SIN3A PFKP PPP2R1A DDX46 THOP1 ARRB2 PAXBP1 SARS1 DDX18 MRPS14 GOLIM4 RPL3 SNRNP200 GOLGB1 RPL19	3.90e-06	1415	192	23	28515276
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	NCAPD3 EP400 ODF2 PIAS1 BLM DDX18 AATF MGA IQGAP3	4.40e-06	222	192	9	37071664
Pubmed	Charting the landscape of tandem BRCT domain-mediated protein interactions.	RPGRIP1 NCAPD3 BTBD6 RANBP9 PHB2 CLASP2 PIAS1 TMEM120A HNRNPUL2 NOM1 DDX18 ASPM CCAR1 EIF4G3 SNRNP200	5.37e-06	670	192	15	22990118
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	EP400 PHB2 CYFIP2 TGFB2 DDX46 MRTFB PAXBP1 ASPM RPL3 SNRNP200 GOLGB1 MRTFA RPL19	5.40e-06	506	192	13	30890647
Pubmed	Vitamin D deficiency causes airway hyperresponsiveness, increases airway smooth muscle mass, and reduces TGF-β expression in the lungs of female BALB/c mice.	TGFB2 TGFBR1 ALK	5.70e-06	7	192	3	24760528
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	CAND2 ACACA FNTB RANBP9 SAE1 CLASP2 PFKP COPS2 CYFIP2 PPP2R1A TRAP1 DDX46 SARS1 EIF4G3 STX7 PLOD2 RPL3 SNRNP200 IQGAP3 RPL19	6.45e-06	1149	192	20	35446349
Pubmed	The nuclear localization pattern and interaction partners of GTF2IRD1 demonstrate a role in chromatin regulation.	NAP1L2 PIAS1 FHAD1 SCNM1 PKP2	8.43e-06	50	192	5	26275350
Pubmed	A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes.	HDAC4 CLASP1 TSC1 CLASP2 CEP250 PKP2	9.12e-06	87	192	6	17979178
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	CCDC9B ACACA PLEKHJ1 CPED1 CYFIP2 PPP2R1A TRAP1 SARS1 PIK3C2A NOM1 DDX18 CCAR1 AATF EIF4G3 MGA	1.34e-05	724	192	15	36232890
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	STX8 ABCC1 CACNA2D1 NCAPD3 CAND2 RANBP9 PHB2 TTC27 RANBP6 PFKP COPS2 PPP2R1A TRAP1 DDX46 RPL7L1 PIK3C2A HNRNPUL2 NOM1 STX7 EPN1 PLOD2 SNRNP200	1.68e-05	1440	192	22	30833792
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	EP400 ARHGEF18 PPP2R1A KMT2D PAXBP1 HNRNPUL2 MRPS14 PKP2 MGA SNRNP200 RPL19	1.95e-05	410	192	11	26949251
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	CCDC134 STX8 ATG16L1 CTNNAL1 ABCA4 CAND2 ACAA1 CARMIL1 ARHGEF18 SH2D5 CYFIP2 BNIP2 CBX6 PIK3CB NOM1 CEP250 ASPM FBXO7 DAAM2 ARAP2	1.98e-05	1242	192	20	30973865
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	NCAPD3 CLASP1 SIN3A BLM DDX46 RPL7L1 HNRNPUL2 NOM1 DDX18 ASPM AATF EIF4G3 SNRNP200 IQGAP3 RPL19	2.32e-05	759	192	15	35915203
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	HDAC4 ACACA CLASP1 ARHGEF5 CARMIL1 CLASP2 PFKP LYST FSIP2 PIK3C2A PRKAA2 PKP2 EIF4G3 KIF13A GOLGB1 ARAP2	2.60e-05	861	192	16	36931259
Pubmed	Small heterodimer partner SHP mediates liver X receptor (LXR)-dependent suppression of inflammatory signaling by promoting LXR SUMOylation specifically in astrocytes.	HDAC4 BBS5 PIAS1	2.65e-05	11	192	3	27485016
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	NCAPD3 PDPR CLASP1 PHB2 TTC27 RANBP6 CLASP2 PFKP CTDNEP1 BLM TGFB2 TGFBR1 PRPF40B ANGPT4 GOLIM4 STX7 EPN1 GOLGB1	2.68e-05	1061	192	18	33845483
Pubmed	Defining the membrane proteome of NK cells.	CCDC134 ABCC1 NCAPD3 ACAA1 CLASP1 VPS50 OAS2 CLASP2 PFKP KIAA2013 CYFIP2 TRAP1 PIK3C2A HNRNPUL2 DDX18 GZMB GOLIM4 GOLGB1 RPL19	2.82e-05	1168	192	19	19946888
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	PDPR PHB2 RANBP6 TSC1 BLM LYRM2 TRAP1 ARRB2 RPL7L1 SARS1 PIK3C2A HNRNPUL2 NOM1 DDX18 MRPS14 FBXO7 AATF PNPLA8 PRORP RPL3 GOLGB1 USP47	2.99e-05	1496	192	22	32877691
Pubmed	Let-7c-3p suppresses lens epithelial-mesenchymal transition by inhibiting cadherin-11 expression in fibrotic cataract.	TGFB2 CDH11	3.03e-05	2	192	2	37171723
Pubmed	Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function.	CLASP1 CLASP2	3.03e-05	2	192	2	16914514
Pubmed	Segregated expressions of autism risk genes Cdh11 and Cdh9 in autism-relevant regions of developing cerebellum.	CDH9 CDH11	3.03e-05	2	192	2	31046797
Pubmed	Mammalian CLASPs are required for mitotic spindle organization and kinetochore alignment.	CLASP1 CLASP2	3.03e-05	2	192	2	16866869
Pubmed	The SNP rs560426 Within ABCA4-ARHGAP29 Locus and the Risk of Nonsyndromic Oral Clefts.	ABCA4 ARHGAP29	3.03e-05	2	192	2	31950859
Pubmed	Golgi-derived CLASP-dependent microtubules control Golgi organization and polarized trafficking in motile cells.	CLASP1 CLASP2	3.03e-05	2	192	2	19701196
Pubmed	Myocardin related transcription factors are required for coordinated cell cycle progression.	MRTFB MRTFA	3.03e-05	2	192	2	23656782
Pubmed	MRTF-A/B suppress the oncogenic properties of v-ras- and v-src-mediated transformants.	MRTFB MRTFA	3.03e-05	2	192	2	20338973
Pubmed	Depletion of the transcriptional coactivators megakaryoblastic leukaemia 1 and 2 abolishes hepatocellular carcinoma xenograft growth by inducing oncogene-induced senescence.	MRTFB MRTFA	3.03e-05	2	192	2	23853104
Pubmed	Mutations in a gene encoding an ABC transporter cause pseudoxanthoma elasticum.	ABCC1 ABCC6	3.03e-05	2	192	2	10835642
Pubmed	The MRTF-A/B function as oncogenes in pancreatic cancer.	MRTFB MRTFA	3.03e-05	2	192	2	26498848
Pubmed	Megakaryoblastic leukemia 1, a potent transcriptional coactivator for serum response factor (SRF), is required for serum induction of SRF target genes.	MRTFB MRTFA	3.03e-05	2	192	2	12944485
Pubmed	Early increases in multiple biomarkers predict subsequent cardiotoxicity in patients with breast cancer treated with doxorubicin, taxanes, and trastuzumab.	MPO TNNI3	3.03e-05	2	192	2	24291281
Pubmed	Association of CDH11 with Autism Spectrum Disorder Revealed by Matched-gene Co-expression Analysis and Mouse Behavioral Studies.	CDH9 CDH11	3.03e-05	2	192	2	34523068
Pubmed	Myocardin-related transcription factors are required for skeletal muscle development.	MRTFB MRTFA	3.03e-05	2	192	2	27385017
Pubmed	Pseudoxanthoma elasticum: mutations in the MRP6 gene encoding a transmembrane ATP-binding cassette (ABC) transporter.	ABCC1 ABCC6	3.03e-05	2	192	2	10811882
Pubmed	Proteomics analysis reveals the role of ubiquitin specific protease (USP47) in Epithelial to Mesenchymal Transition (EMT) induced by TGFβ2 in breast cells.	TGFB2 USP47	3.03e-05	2	192	2	32201364
Pubmed	Myocardin-related transcription factors are required for cardiac development and function.	MRTFB MRTFA	3.03e-05	2	192	2	26386146
Pubmed	Structural basis for membrane recruitment of ATG16L1 by WIPI2 in autophagy.	ATG16L1 WIPI2	3.03e-05	2	192	2	34505572
Pubmed	WIPI2b and Atg16L1: setting the stage for autophagosome formation.	ATG16L1 WIPI2	3.03e-05	2	192	2	25233411
Pubmed	Human CLASP1 is an outer kinetochore component that regulates spindle microtubule dynamics.	CLASP1 CLASP2	3.03e-05	2	192	2	12837247
Pubmed	Reorganization of the actin cytoskeleton via transcriptional regulation of cytoskeletal/focal adhesion genes by myocardin-related transcription factors (MRTFs/MAL/MKLs).	MRTFB MRTFA	3.03e-05	2	192	2	17714703
Pubmed	ABCC6/MRP6 mutations: further insight into the molecular pathology of pseudoxanthoma elasticum.	ABCA4 ABCC6	3.03e-05	2	192	2	12673275
Pubmed	Divergent Regulation of Actin Dynamics and Megakaryoblastic Leukemia-1 and -2 (Mkl1/2) by cAMP in Endothelial and Smooth Muscle Cells.	MRTFB MRTFA	3.03e-05	2	192	2	28623279
Pubmed	Differential roles of syntaxin 7 and syntaxin 8 in endosomal trafficking.	STX8 STX7	3.03e-05	2	192	2	10564279
Pubmed	Mast, a conserved microtubule-associated protein required for bipolar mitotic spindle organization.	CLASP1 CLASP2	3.03e-05	2	192	2	10899121
Pubmed	Synaptic localisation of SRF coactivators, MKL1 and MKL2, and their role in dendritic spine morphology.	MRTFB MRTFA	3.03e-05	2	192	2	29335431
Pubmed	Coiled-coil-mediated dimerization of Atg16 is required for binding to the PROPPIN Atg21.	ATG16L1 WIPI2	3.03e-05	2	192	2	37989223
Pubmed	Differential palmitoylation of the endosomal SNAREs syntaxin 7 and syntaxin 8.	STX8 STX7	3.03e-05	2	192	2	18980942
Pubmed	Induction of renal tumorigenesis with elevated levels of somatic loss of heterozygosity in Tsc1+/- mice on a Blm-deficient background.	TSC1 BLM	3.03e-05	2	192	2	16288003
Pubmed	Expression of the Abca-subfamily of genes in Abcc6-/- mice--upregulation of Abca4.	ABCA4 ABCC6	3.03e-05	2	192	2	21435020
Pubmed	Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.	ACACA EP400 PHB2 PIAS1 BLM DDX46 MGA RPL3 SNRNP200 RPL19	3.25e-05	357	192	10	37059091
Pubmed	AMP-activated protein kinase (AMPK) activity is not required for neuronal development but regulates axogenesis during metabolic stress.	ACACA TSC1 PRKAA2	3.51e-05	12	192	3	21436046
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	NCAPD3 PDPR CAND2 ACACA PHB2 SAE1 SIN3A PFKP COPS2 CCAR1 EIF4G3 DNAH5 SNRNP200 IQGAP3	4.08e-05	704	192	14	29955894
Pubmed	WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy.	ATG16L1 PRKAA2 WIPI2	4.55e-05	13	192	3	28561066
Pubmed	UVRAG is required for virus entry through combinatorial interaction with the class C-Vps complex and SNAREs.	STX8 ATG16L1 STX7	4.55e-05	13	192	3	24550300
Pubmed	The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins.	CAND2 RANBP6 CLASP2 SIN3A COPS2 TRAP1 TFB1M DDX18 MRPS14 MGA RPL3 WIPI2	5.80e-05	547	192	12	37267103
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	ATG16L1 ACACA FNTB RANBP9 SAE1 RANBP6 PFKP COPS2 PPP2R1A TRAP1 BNIP2 THOP1 SARS1 HNRNPUL2 KIF13A EPN1 PLOD2 RPL3 SNRNP200 USP47 RPL19	5.98e-05	1455	192	21	22863883
Pubmed	Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKα.	NCAPD3 ACACA SIN3A PFKP TRAP1 RPL3 SNRNP200	7.25e-05	182	192	7	32239614
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	NCAPD3 ARHGEF5 SIN3A PIAS1 PACS1 HNRNPUL2 NOM1 ASB3 CCAR1 EPN1 RPL3 IQGAP3 RUBCN	7.29e-05	650	192	13	38777146
Pubmed	Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.	ARHGEF5 TTC27 PFKP PPP2R1A PIK3CB EXOC6B IQGAP3	7.51e-05	183	192	7	23956138
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	ACACA PFKP BLM PPP2R1A DDX46 DDX18 CCAR1 AATF EIF4G3 RPL3 SNRNP200 USP47 RPL19	7.63e-05	653	192	13	22586326
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	STX8 PDPR CAND2 PHB2 CLASP2 PFKP BLM PAXBP1 RPL7L1 SARS1 PIK3C2A DDX18 MRPS14 ASPM PNPLA8 EIF4G3 STX7 PLOD2 RPL3 SNRNP200 GOLGB1	8.12e-05	1487	192	21	33957083
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	HDAC4 ACACA CARMIL1 ARHGEF18 CLASP2 VPS54 ZMIZ1 SLC30A4 PACS1 EXD3 THOP1 MRTFB ARRB2 PRKAA2 NGEF EXOC6B CCAR1 SPIDR PRORP EIF4G3 GOLGB1	8.27e-05	1489	192	21	28611215
Pubmed	Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis.	EP400 SIN3A PPP2R1A MGA	8.55e-05	42	192	4	29028833
Pubmed	Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.	NCAPD3 PFKP TRAP1 DDX46 RPL7L1 NOM1 DDX18 PRORP RPL3 SNRNP200 IQGAP3	8.99e-05	486	192	11	30940648
Pubmed	CLASP2 Links Reelin to the Cytoskeleton during Neocortical Development.	CLASP1 CLASP2	9.06e-05	3	192	2	28285824
Pubmed	A novel inhibitory mechanism of MRTF-A/B on the ICAM-1 gene expression in vascular endothelial cells.	MRTFB MRTFA	9.06e-05	3	192	2	26024305
Pubmed	The RAB11A-Positive Compartment Is a Primary Platform for Autophagosome Assembly Mediated by WIPI2 Recognition of PI3P-RAB11A.	ATG16L1 WIPI2	9.06e-05	3	192	2	29634932
Pubmed	Tsc1 haploinsufficiency without mammalian target of rapamycin activation is sufficient for renal cyst formation in Tsc1+/- mice.	TSC1 BLM	9.06e-05	3	192	2	16912167
Pubmed	Myocardin-related transcription factor contributes to renal fibrosis through the regulation of extracellular microenvironment surrounding fibroblasts.	MRTFB MRTFA	9.06e-05	3	192	2	37289107
Pubmed	Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis.	MRTFB MRTFA	9.06e-05	3	192	2	19198601
Pubmed	WIPI2b recruitment to phagophores and ATG16L1 binding are regulated by ULK1 phosphorylation.	ATG16L1 WIPI2	9.06e-05	3	192	2	39152217
Pubmed	Preferential β-arrestin signalling at low receptor density revealed by functional characterization of the human FSH receptor A189 V mutation.	ARRB2 FSHR	9.06e-05	3	192	2	20801186
Pubmed	Changes in expression of genes related to cell proliferation in human mesenchymal stem cells during in vitro culture in comparison with cancer cells.	TGFB2 TGFBR1	9.06e-05	3	192	2	16998703
Pubmed	Control of phenotypic plasticity of smooth muscle cells by bone morphogenetic protein signaling through the myocardin-related transcription factors.	MRTFB MRTFA	9.06e-05	3	192	2	17947237
Pubmed	Expression and localization of ATP binding cassette (ABC) family of drug transporters in gastric hepatoid adenocarcinomas.	ABCC1 ABCC6	9.06e-05	3	192	2	18439156
Pubmed	A novel protein distinguishes between quiescent and activated forms of the type I transforming growth factor beta receptor.	TGFBR1 TRAP1	9.06e-05	3	192	2	9545258
Pubmed	MKL1 and MKL2 play redundant and crucial roles in megakaryocyte maturation and platelet formation.	MRTFB MRTFA	9.06e-05	3	192	2	22806889
Pubmed	Metformin Inhibits Hepatic mTORC1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex.	TSC1 PRKAA2	9.06e-05	3	192	2	28089566
Pubmed	Vitamin D levels in multiple sclerosis patients: Association with TGF-β2, TGF-βRI, and TGF-βRII expression.	TGFB2 TGFBR1	9.06e-05	3	192	2	26037400
Pubmed	Megakaryoblastic leukemia-1/2, a transcriptional co-activator of serum response factor, is required for skeletal myogenic differentiation.	MRTFB MRTFA	9.06e-05	3	192	2	14565952
Pubmed	Pseudoxanthoma elasticum: Point mutations in the ABCC6 gene and a large deletion including also ABCC1 and MYH11.	ABCC1 ABCC6	9.06e-05	3	192	2	11439001
Interaction	TMEM74 interactions	STX8 ATG16L1 ARRB2 PIK3C2A CBX6 PIK3CB GOLIM4 MGA GOLGB1	2.55e-06	125	187	9	int:TMEM74
Cytoband	16p13.1	ABCC1 ABCC6	1.04e-04	4	192	2	16p13.1
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ARHGEF5 ARHGEF18 PREX2 NGEF	7.48e-04	66	112	4	722
GeneFamily	Zinc fingers MIZ-type	ZMIZ1 PIAS1	7.83e-04	7	112	2	85
GeneFamily	Phosphatidylinositol 3-kinase subunits	PIK3C2A PIK3CB	1.04e-03	8	112	2	831
Coexpression	MURARO_PANCREAS_BETA_CELL	CACNA2D1 MAN2A2 NAP1L2 DGKD CLASP2 ZMIZ1 COPS2 LYST CYFIP2 TTLL7 SARS1 PIK3C2A FBXO7 PKP2 EIF4G3 KIF13A DNAH5 GOLGA8A PLOD2 RPL3 GOLGB1	6.67e-06	946	192	21	M39169
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LCA5 CACNA2D1 CTNNAL1 CARMIL1 FSTL4 LINGO2 MRTFB KIAA1549L NGEF ARAP2	1.08e-08	190	192	10	d594da827e3c16644952b9589cc12b947ce36279
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LCA5 CACNA2D1 CARMIL1 FSTL4 LINGO2 MRTFB KIAA1549L NGEF ARAP2	1.47e-07	190	192	9	49e09cdb843b3d889a06a811aa5affae68b25a75
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DGKD CPED1 BLM PLCH2 ASPM ADAMTS17 GOLIM4 PLOD2	1.14e-06	179	192	8	d1365d48d1b017a7917f4f63a82ac4720c3d87df
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Mesenchymal-Ependyma\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC60 CAND2 HOATZ PFKP FHAD1 PRPF40B MAP3K15 CFAP161	1.19e-06	180	192	8	729f0d7af573c7796d8e28e6eec3af2fc0bd33a2
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Mesenchymal-ependymal_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC60 CAND2 HOATZ PFKP FHAD1 PRPF40B MAP3K15 CFAP161	1.19e-06	180	192	8	9ef79a7c60227e352ac166c7274adb31f585f5ca
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_vein\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CTNNAL1 RAPGEF4 PREX2 MRTFB ARHGAP29 CFAP161 IL1R1 CDH11	1.58e-06	187	192	8	e35716f8b482be3bf5ab79f087a9caf67a9d197a
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DGKD CPED1 GPR149 ASPM ADAMTS17 GOLIM4 PLOD2 ALK	1.64e-06	188	192	8	8de5a07301f9b5984680c873e5a92395b5ed3dd3
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LCA5 CACNA2D1 CARMIL1 FSTL4 LINGO2 MRTFB NGEF ARAP2	1.71e-06	189	192	8	c3df0e3c50af8f1cfb4d790e668bd7f42b276992
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LCA5 CACNA2D1 CARMIL1 FSTL4 LINGO2 MRTFB NGEF ARAP2	1.71e-06	189	192	8	a75226616340045b581d08429d2e123e041dee55
ToppCell	COVID-19-lung-Vein_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CTNNAL1 RAPGEF4 LYST PREX2 MRTFB PIK3C2A ARHGAP29 IL1R1	1.78e-06	190	192	8	1caeaef78326734c1e31a0c4739190d5c5a77b9e
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DGKD CPED1 BLM GPR149 ASPM ADAMTS17 GOLIM4 ALK	2.00e-06	193	192	8	c4b22b62f3cc7bf0ec0eba76e1504c236290bbc9
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DGKD CPED1 ASPM ADAMTS17 GOLIM4 PLOD2 ALK CDH9	2.00e-06	193	192	8	5581a5ebcd21a2a8062ccfb917f088ec67a10a9c
ToppCell	Control_saline-Epithelial_airway-airway_epithelial-Ciliated\|Control_saline / Treatment groups by lineage, cell group, cell type	CCDC60 C21orf58 HOATZ FHAD1 PLCH2 CFAP161 DNAH5 CCDC65	2.16e-06	195	192	8	60067b5359174f0d1a8b5748bfc0690762e9e740
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	ACACA CLASP1 CLASP2 VPS54 PACS1 EXOC6B SPIDR EIF4G3	2.51e-06	199	192	8	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-SULF1\|Neuronal / cells hierarchy compared to all cells using T-Statistic	DGKD CPED1 BLM GPR149 ASPM ADAMTS17 GOLIM4 ALK	2.60e-06	200	192	8	fbeee1c16ac0a7fe28d90491c8b079f21ce80bdc
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-SULF1--L4-6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	DGKD CPED1 BLM GPR149 ASPM ADAMTS17 GOLIM4 ALK	2.60e-06	200	192	8	4a426ef88376d8bb2b9dc50aa06e7b9fc50ecc9c
ToppCell	LPS_IL1RA_TNF-Epithelial_airway-airway_epithelial-Ciliated\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	CCDC60 TDRD9 C21orf58 HOATZ FHAD1 CFAP161 DNAH5 CCDC65	2.60e-06	200	192	8	96701a4d57753f5ec0dd5c7550054bbcc946bc5f
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated\|COVID-19_Mild / Disease, condition lineage and cell class	OAS2 CYFIP2 TGFBR1 RSAD2 GZMB MLLT6 EIF4G3 ARAP2	2.60e-06	200	192	8	2281debd86e5d92e8fe0397aec9ef670800f7471
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-SULF1-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	DGKD CPED1 BLM GPR149 ASPM ADAMTS17 GOLIM4 ALK	2.60e-06	200	192	8	c6eda342ea0cb37d71d89dbb8d11e819e0745172
ToppCell	facs-Liver-Non-hepatocytes-3m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA4 POU5F2 DUSP8 OAS2 RNF17 CATSPER2 PIK3CB	4.43e-06	152	192	7	b61d2f6ee819c8dd4b4b601a8bc8388b1983de58
ToppCell	343B-Myeloid-Macrophage-FABP4+_Macrophage_proliferating_2\|343B / Donor, Lineage, Cell class and subclass (all cells)	NCAPD3 CAMP ARHGEF18 CAGE1 FANCB ANGPT4 IQGAP3	8.22e-06	167	192	7	7efa0081e79f22b219eac64ffcaedb2179cde299
ToppCell	droplet-Marrow-nan-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAMP OLFM4 LYST RSAD2 PIK3CB GOLIM4 PNPLA8	9.96e-06	172	192	7	d354424c1f861b6607dfd63b9724f4c237b30275
ToppCell	C_00\|World / shred on cell type and cluster	C21orf58 OLFM4 DDX46 NOM1 ASPM GOLGA8A GOLGB1	1.29e-05	179	192	7	da2dadc3266ffebd4a34ac61bfa05fddcadcde4c
ToppCell	ASK454-Epithelial-Ciliated\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	LCA5 CCDC60 HOATZ TTLL7 FHAD1 DNAH5 CCDC65	1.29e-05	179	192	7	f21919ef9d3d984e2925ef3d24f89e20fe265dcd
ToppCell	COVID-19-Heart-CM_3\|Heart / Disease (COVID-19 only), tissue and cell type	CACNA2D1 DGKD CPED1 TGFB2 PRKAA2 EXOC6B PKP2	1.44e-05	182	192	7	287fcc3897ae08841f6f85ae6c9cef16f75b1dd1
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Epithelial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC60 HOATZ CFAP74 CFAP161 DNAH5 CCDC65 SLC44A3	1.54e-05	184	192	7	264e14aa1859cfc0ed5fb40e97ea189aed9ef4a5
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Epithelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC60 HOATZ CFAP74 CFAP161 DNAH5 CCDC65 SLC44A3	1.54e-05	184	192	7	d7eccbd21c480d907fdc8eff2bf5ae22ae452221
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Epithelial-neuroepithelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC60 HOATZ CFAP74 CFAP161 DNAH5 CCDC65 SLC44A3	1.54e-05	184	192	7	22010cfe0428ebfa40952cc1a1a12ad3d25b35c9
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-Lgr5-_amplifying_undifferentiated_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BLM PAXBP1 CEP250 DDX18 ASPM IQGAP3 RPL19	1.65e-05	186	192	7	15ab6666748a641226e42e6ca6eeaf186a501c95
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-epithelial_cell_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BLM PAXBP1 CEP250 DDX18 ASPM IQGAP3 RPL19	1.65e-05	186	192	7	4ed1b97e2552f3c4134f25665d7513498ffac16c
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DGKD CPED1 GPR149 ASPM ADAMTS17 GOLIM4 ALK	1.71e-05	187	192	7	d413fb4b1531b297af5012a392b88128510c2de8
ToppCell	tumor_Lung-Epithelial_cells-tS3\|Epithelial_cells / Location, Cell class and cell subclass	LCA5 C21orf58 HOATZ TTLL7 FHAD1 CFAP74 DNAH5	1.71e-05	187	192	7	3cea677279e71fdb9879530dea10a5e6393beacd
ToppCell	COVID-19-Endothelial_cells-Pulmonary_venous_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	CTNNAL1 RAPGEF4 PREX2 MRTFB KIAA1549L ARHGAP29 IL1R1	1.71e-05	187	192	7	2d20193a6cacdfa4877457c97b0077408942186c
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LCA5 CACNA2D1 FSTL4 LINGO2 MRTFB NGEF ARAP2	1.71e-05	187	192	7	f18628ffc7ff7c762b8339ba8822cf0c3157f469
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LCA5 CACNA2D1 FSTL4 LINGO2 MRTFB NGEF ARAP2	1.77e-05	188	192	7	50c1b1d690f0e9443082f2adf4f1b8e9ce4cd337
ToppCell	COVID-19-lung-Vein_EC\|lung / Disease (COVID-19 only), tissue and cell type	CTNNAL1 RAPGEF4 PREX2 MRTFB PIK3C2A ARHGAP29 IL1R1	1.77e-05	188	192	7	d582b76fc2faac526c9bf97503041129e1a6a211
ToppCell	Smart-seq2-bone_marrow_(Smart-seq2)\|Smart-seq2 / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MPO C21orf58 CAMP OLFM4 GZMB ASPM KEL	1.77e-05	188	192	7	557a0ac069a6ff4e687cac032f64170b9b247165
ToppCell	facs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPO RAPGEF4 OLFM4 CYFIP2 SCNN1B IL1R1 GOLGB1	1.77e-05	188	192	7	a91443aa8fa8fa87f7501c59219daa0305bd0bbf
ToppCell	droplet-Lung-immune-endo-depleted-3m-Epithelial-Ciliated_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC60 C21orf58 HOATZ FHAD1 CFAP161 DNAH5 CCDC65	1.83e-05	189	192	7	efee01edd171bf569267b672fab05c421de6c92d
ToppCell	facs-Lung-24m-Epithelial-airway_epithelial-lung_ciliated_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	C21orf58 HOATZ FHAD1 CFAP161 DNAH5 CCDC65 SLC44A3	1.83e-05	189	192	7	1c28ad1263891d963e483b6847d8e89cc1b2d07e
ToppCell	droplet-Lung-18m-Epithelial-airway_epithelial\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CCDC60 C21orf58 HOATZ FHAD1 CFAP161 DNAH5 CCDC65	1.83e-05	189	192	7	fe958fdf9963c2dfe270f67f0da36b3264d0017c
ToppCell	droplet-Lung-immune-endo-depleted-3m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC60 C21orf58 HOATZ FHAD1 CFAP161 DNAH5 CCDC65	1.83e-05	189	192	7	28c750ac56e3861fe7280e32839a4d8ce8bd8692
ToppCell	facs-Lung-24m-Epithelial-airway_epithelial-lung_ciliated_cell-ciliated_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	C21orf58 HOATZ FHAD1 CFAP161 DNAH5 CCDC65 SLC44A3	1.83e-05	189	192	7	00b20c2ed7876486c8e42e3a5b13023f44987a34
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DGKD CPED1 GPR149 ASPM ADAMTS17 GOLIM4 ALK	1.83e-05	189	192	7	99a13b1b669b0cd36e3096632351d9ade25d1173
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DGKD PREX2 SVEP1 ASPM GOLIM4 PKP2 ALK	1.90e-05	190	192	7	2f54da2bee411f8868348a4c37034184b8f58a89
ToppCell	facs-Lung-24m-Epithelial-airway_epithelial\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	C21orf58 HOATZ FHAD1 CFAP161 DNAH5 CCDC65 SLC44A3	1.90e-05	190	192	7	73ac7be02742ee6cb003600631f6a03eecbf2083
ToppCell	facs-Lung-18m-Epithelial-airway_epithelial-lung_ciliated_cell-ciliated_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CCDC60 C21orf58 HOATZ FHAD1 CFAP161 DNAH5 CCDC65	1.90e-05	190	192	7	9ffd18ef358f8e32c610ab6420f479067c8ba44b
ToppCell	facs-Lung-18m-Epithelial-airway_epithelial-lung_ciliated_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CCDC60 C21orf58 HOATZ FHAD1 CFAP161 DNAH5 CCDC65	1.90e-05	190	192	7	3ef39d61c98de4e5df946b995847aa65eba6a4b6
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DGKD CPED1 GPR149 ASPM ADAMTS17 GOLIM4 ALK	1.90e-05	190	192	7	305fbef734c350cfbf786ca7ff6e07093aab56ea
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DGKD CPED1 GPR149 ASPM ADAMTS17 GOLIM4 ALK	1.90e-05	190	192	7	8c9c230a509afaeee50644153974a5642b01a2b8
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	MPO KMT2D KCND1 ASPM IQGAP3 RUBCN USP47	1.90e-05	190	192	7	3f0c7d130f66faea778fe567604edf1b4cdf85b3
ToppCell	E16.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CCDC60 C21orf58 HOATZ FHAD1 CFAP74 CFAP161 CCDC65	1.96e-05	191	192	7	1e21de183a9c09cfb6aad3f9b948087fb6bad061
ToppCell	COVID-19-Heart-EC_(POSTN)\|Heart / Disease (COVID-19 only), tissue and cell type	RAPGEF4 DAPK1 MRTFB KIAA1549L PIK3C2A IL1R1 CDH11	2.03e-05	192	192	7	c0c34785a7bdf461722029b322e9184e3d9b3c26
ToppCell	E16.5-Epithelial-Epithelial_Airway\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CCDC60 C21orf58 HOATZ FHAD1 CFAP74 CFAP161 CCDC65	2.03e-05	192	192	7	bb7eb51bc079acacde42d8e55ba06d03eba2ea28
ToppCell	E16.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CCDC60 C21orf58 HOATZ FHAD1 CFAP74 CFAP161 CCDC65	2.03e-05	192	192	7	a50a6279371b3be682e334082637b7ab76b9a6e5
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DGKD CPED1 GPR149 ASPM ADAMTS17 GOLIM4 ALK	2.03e-05	192	192	7	0003d7ef9a8e521e70ac33c63aad843d9b6215c2
ToppCell	PND14-Mesenchymal-Mesenchymal_structural\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CACNA2D1 CPED1 PREX2 SVEP1 ST8SIA2 ADAMTS17 CDH11	2.03e-05	192	192	7	25492568f9cbe097b7bb1db50d8b817c80ea87d7
ToppCell	PND14-Mesenchymal-Mesenchymal_structural-Fibroblastic\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CACNA2D1 CPED1 PREX2 SVEP1 ST8SIA2 ADAMTS17 CDH11	2.03e-05	192	192	7	de9c1536d5aee86f9c62acbc54ca8fa581c00f17
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MPO KMT2D KCND1 ASPM IQGAP3 RUBCN USP47	2.03e-05	192	192	7	c09dcc73ff9c3855a0f3d7bfa0d5c99c09a117f2
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LCA5 CARMIL1 FSTL4 LINGO2 MRTFB KIAA1549L NGEF	2.03e-05	192	192	7	5c7e8b80b44d9ce55c797cdf8267ac5382e26cac
ToppCell	wk_15-18-Epithelial-Proximal_epithelial\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	CCDC60 C21orf58 HOATZ FHAD1 CFAP74 DNAH5 CCDC65	2.17e-05	194	192	7	b0477583301dc6d9767b667bd2f8f94fbfaa6f81
ToppCell	PND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CACNA2D1 CPED1 PREX2 SVEP1 ST8SIA2 ADAMTS17 CDH11	2.24e-05	195	192	7	3a0cad69cfc150a27a0666f612f5294c817197d7
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-Ciliated\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	CCDC60 HOATZ FHAD1 CFAP74 CFAP161 DNAH5 CCDC65	2.24e-05	195	192	7	cfcf554b436083179dea1d6fd6e3a800ea2430fe
ToppCell	PND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CACNA2D1 CPED1 PREX2 SVEP1 ST8SIA2 ADAMTS17 CDH11	2.24e-05	195	192	7	2b8ee7990267bb52b7e6ae03f509ffebf8908122
ToppCell	COVID-19_Severe-Lymphoid_T/NK-gd_T\|COVID-19_Severe / Disease group, lineage and cell class	CYFIP2 TGFBR1 FHAD1 GZMB MLLT6 CCDC65 ARAP2	2.24e-05	195	192	7	9990440bda7fac5d00ef80444fab07459be625e1
ToppCell	critical-Epithelial-Ciliated\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	LCA5 CCDC60 C21orf58 FHAD1 CFAP74 DNAH5 CCDC65	2.32e-05	196	192	7	27b855c6e1ae44f16db998cf0e81bd686b9cee7e
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	CYFIP2 TGFBR1 FHAD1 GZMB MLLT6 CCDC65 ARAP2	2.32e-05	196	192	7	418e8e0a51c5cb60e3b903e7d2d800dc8b9f3d5c
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CYFIP2 TGFBR1 FHAD1 GZMB MLLT6 CCDC65 ARAP2	2.32e-05	196	192	7	6beaf0c2799424c59819b286fbb5c1a83d85e4d1
ToppCell	LPS_anti-TNF-Epithelial_airway-airway_epithelial-Ciliated\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	CCDC60 C21orf58 HOATZ FHAD1 CFAP161 DNAH5 CCDC65	2.55e-05	199	192	7	15f7814b7074170eee7ccacaa670b1d128fc68bb
ToppCell	Bronchial-10x5prime-Endothelial-Endothelia_vascular-VE_pulmonary_venous\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CTNNAL1 RAPGEF4 PREX2 MRTFB PIK3C2A ARHGAP29 IL1R1	2.64e-05	200	192	7	84e145619a500530f42ed0fe72468ae95f4cbf1e
ToppCell	Tracheal\|World / Cell types per location group and 10X technology with lineage, and cell group designations	CACNA2D1 GARNL3 PACS1 PRKAA2 ADAMTS17 PKP2 BPIFB2	2.64e-05	200	192	7	682960e28542a3d6c119047cd0131941932cfdea
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-5w-Neuroepithelial\|5w / Sample Type, Dataset, Time_group, and Cell type.	CPED1 ABCC6 FHAD1 ARHGAP29 DAAM2 RPL3 RPL19	2.64e-05	200	192	7	69707f9576d326a06faac49701ef5cd632e760f6
ToppCell	Neuronal-Excitatory\|Neuronal / cells hierarchy compared to all cells using T-Statistic	LCA5 CACNA2D1 CARMIL1 FSTL4 MRTFB NGEF ARAP2	2.64e-05	200	192	7	4409065bc7aa995354c71e0f9d6f3726cf393d6b
ToppCell	Lung_Parenchyma-Control-Epithelial-Epithelial-Ciliated-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CCDC60 C21orf58 HOATZ FHAD1 CFAP74 DNAH5 CCDC65	2.64e-05	200	192	7	918b576fd9491d23c2bb9d663fa5fb3505cb1c7e
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW23-Neuronal-Intermediate\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	LRRC8E CCDC134 PDPR PRPF40B NGEF EXOC6B MAP3K15	2.64e-05	200	192	7	fe772d98c461c973dfc082e1fc50117c27ced804
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	DGKD CPED1 GPR149 ASPM ADAMTS17 GOLIM4 ALK	2.64e-05	200	192	7	1276bfa911fddada4235e12e3081baa53164574b
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_ciliated\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	C21orf58 HOATZ FHAD1 CFAP74 CFAP161 DNAH5 CCDC65	2.64e-05	200	192	7	31d75c26055177d656df1fbb10b764cebd61e122
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_airway_ciliated\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CCDC60 C21orf58 HOATZ CFAP74 CFAP161 DNAH5 CCDC65	2.64e-05	200	192	7	85c98da55f7cd4ffdf9d309b56c8cc5d43f3c04c
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_ciliated-Ciliated\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	C21orf58 HOATZ FHAD1 CFAP74 CFAP161 DNAH5 CCDC65	2.64e-05	200	192	7	e1dce91c6c531bb212002a14705e496d77ad3490
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_airway_ciliated-Ciliated\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CCDC60 C21orf58 HOATZ CFAP74 CFAP161 DNAH5 CCDC65	2.64e-05	200	192	7	12bc7d95c4166d12487081a76d210b7abe5991b0
ToppCell	Lung_Parenchyma-Control-Epithelial-Epithelial-Ciliated\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	CCDC60 C21orf58 HOATZ FHAD1 CFAP74 DNAH5 CCDC65	2.64e-05	200	192	7	ddd39b754bfaa98249d497dfb7e97ec58617a11a
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-5w-Neuroepithelial-Proteoglycan-expressing_cell\|5w / Sample Type, Dataset, Time_group, and Cell type.	CPED1 ABCC6 FHAD1 ARHGAP29 DAAM2 RPL3 RPL19	2.64e-05	200	192	7	f94381d0a3b5b81cdbb13b75fc0e4910cbd70382
ToppCell	Parenchyma_Control_(B.)-Epithelial-TX-Ciliated\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	CCDC60 C21orf58 HOATZ FHAD1 CFAP74 DNAH5 CCDC65	2.64e-05	200	192	7	a521cf837cadf280505ff9d7e641a205af7d6513
ToppCell	COVID-19-COVID-19_Severe-Lymphocyte-T/NK-gd_T\|COVID-19_Severe / Disease, condition lineage and cell class	CYFIP2 TGFBR1 FHAD1 GZMB MLLT6 CCDC65 ARAP2	2.64e-05	200	192	7	f72bc3f6606ae77fe1b0a972e35b3ce0727804d9
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_low-phase\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HOATZ THOP1 FSHR ASPM CFAP74 IQGAP3	4.62e-05	149	192	6	a6406c4c9404271a2f4c615c6cd3265b2d759b12
ToppCell	E18.5-Immune-Immune_Myeloid-Granulocytic\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MPO CAMP OLFM4 ARHGEF18 ARRB2 FES	4.62e-05	149	192	6	5a5e9660f7d9b527f50a92d94d4c0c8aedb82c0b
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c06-NR4A2\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SCN11A FANCB TP53TG5 GZMB GOLGA8A CDH11	4.98e-05	151	192	6	d19fc363ba1d7ff77e0adcaacafa4c64e1143f40
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	HDAC4 FSTL4 OLFM4 GPRC6A LINGO2 KEL	5.36e-05	153	192	6	9b6675ace8a83c8d446b722301d0ec4e6840f3fc
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	HDAC4 FSTL4 OLFM4 GPRC6A LINGO2 KEL	6.18e-05	157	192	6	2c5295043611bac7dfa4aef2146681bce4a33a8f
ToppCell	droplet-Liver-LIVER_HEP-30m-Myeloid-myeloid_leukocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GARNL3 CAGE1 LYST BLM ASPM IQGAP3	6.40e-05	158	192	6	91d265e95156f16459924d3e4dd11c180e164eee
ToppCell	facs-Lung-Endomucin-24m-Lymphocytic-mature_NK_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC9B TDRD9 CAMP ARHGEF18 TRIM43B GPR156	6.63e-05	159	192	6	4000ed0d3b7d488722bcd0042fa2ff4405aaab82
ToppCell	facs-Lung-Endomucin-24m-Lymphocytic-Natural_Killer_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC9B TDRD9 CAMP ARHGEF18 TRIM43B GPR156	6.63e-05	159	192	6	7619d0d49738dd08daf01b42664691a5323aa793
ToppCell	Globus_pallidus-Neuronal-Excitatory\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	CACNA2D1 FSTL4 SH2D5 MRTFB NGEF PKP2	6.87e-05	160	192	6	f843287ed57d2d5a3b3f6dfb03b6934e330e6645
ToppCell	droplet-Liver-LIVER_HEP-30m-Myeloid-macrophage/monocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAGE1 LYST CYFIP2 BLM ASPM IQGAP3	7.35e-05	162	192	6	93bd29c52846c3156b8b0d2e39c552373efdfe93
ToppCell	Ionocyte-iono-1\|World / Class top	DUSP8 RAPGEF4 PFKP ABCC6 TTLL7 SCNN1B	9.29e-05	169	192	6	4b68bcb4b5fc3cd2db23cd4edace7444aa2d605c
ToppCell	E17.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	NAP1L2 PREX2 SVEP1 SPATA21 ADAMTS17 CDH11	9.59e-05	170	192	6	7fa022471e14ac8a3bc147c793368a4d56a8e591
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.4.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MPO CAMP OLFM4 ASPM IQGAP3 GABBR1	9.59e-05	170	192	6	cf22a843ae2d9cd6693507fed2b7c6a45abea10e
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GPX7 CPED1 KIAA1549L ANGPT4 ST8SIA2 CDH11	9.91e-05	171	192	6	15cb4670ff4234ac46aea8a5911138d6913c4482
ToppCell	facs-GAT-Fat-18m-Lymphocytic-T_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCN11A TDRD9 FSTL4 RNF17 CYFIP2 ARAP2	1.02e-04	172	192	6	17a486c5d0430abb133eab9f087e2ef8b60f7d25
ToppCell	PND28-Endothelial-Endothelial_lymphatic\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CTNNAL1 CAND2 SGSH APOBEC2 PRKAA2 SPIDR	1.06e-04	173	192	6	2978c744d3c8dcaa2b9bb225abf846f82e8f9176
Disease	Ciliopathies	RPGRIP1 LCA5 TSC1 BBS5 SCNN1B DNAH5	6.78e-05	110	184	6	C4277690
Disease	Loeys-Dietz syndrome (implicated_via_orthology)	TGFB2 TGFBR1	1.16e-04	3	184	2	DOID:0050466 (implicated_via_orthology)
Disease	46 XX gonadal dysgenesis (is_implicated_in)	FSHR SPIDR	1.16e-04	3	184	2	DOID:14450 (is_implicated_in)
Disease	retinitis pigmentosa (is_implicated_in)	RPGRIP1 ABCA4 ARHGEF18 SNRNP200	1.24e-04	41	184	4	DOID:10584 (is_implicated_in)
Disease	Colorectal Carcinoma	MPO ABCC1 TFEC CCDC9B ABCA4 ACACA ZMIZ1 ABCC6 PREX2 TGFBR1 SCNN1B CCAR1 BPIFB2 SNRNP200	1.41e-04	702	184	14	C0009402
Disease	Loeys-Dietz syndrome	TGFB2 TGFBR1	2.30e-04	4	184	2	cv:C2697932
Disease	CD166 antigen measurement	ABCC1 ABCC6	2.30e-04	4	184	2	EFO_0020245
Disease	progression free survival, ovarian serous carcinoma	PNPLA8 MGA IQGAP3	3.37e-04	22	184	3	EFO_0004920, EFO_1001516
Disease	HbA1c measurement	PXMP4 ABCC1 CCDC9B CLASP1 CARMIL1 GPX7 PHB2 IP6K1 ZMIZ1 PFKP OR10R2 KEL ABCG5	3.40e-04	675	184	13	EFO_0004541
Disease	Loeys-Dietz Syndrome, Type 1a	TGFB2 TGFBR1	3.82e-04	5	184	2	C4551955
Disease	Loeys-Dietz Aortic Aneurysm Syndrome	TGFB2 TGFBR1	3.82e-04	5	184	2	C1836635
Disease	Retinal Dystrophy, Early Onset Severe	LCA5 ABCA4	3.82e-04	5	184	2	C1858080
Disease	Diffuse Large B-Cell Lymphoma	KMT2D PIK3CB NOM1 ALK	3.89e-04	55	184	4	C0079744
Disease	retinitis pigmentosa (implicated_via_orthology)	RPGRIP1 CEP250 SNRNP200	6.25e-04	27	184	3	DOID:10584 (implicated_via_orthology)
Disease	lifestyle measurement, alcohol consumption measurement	TTC27 RANBP6 GPR139 DAAM2 PLOD2	7.88e-04	115	184	5	EFO_0007878, EFO_0010724
Disease	Loeys-Dietz Syndrome	TGFB2 TGFBR1	7.96e-04	7	184	2	C2697932
Disease	Pure Gonadal Dysgenesis, 46, XX	FSHR SPIDR	1.06e-03	8	184	2	C0685837
Disease	Gonadal Dysgenesis, 46,XX	FSHR SPIDR	1.06e-03	8	184	2	C0949595
Disease	granulocyte colony-stimulating factor measurement	LINC01387 LINGO2 ALK	1.24e-03	34	184	3	EFO_0008142
Disease	osteochondrodysplasia (implicated_via_orthology)	TGFBR1 GOLGB1	1.35e-03	9	184	2	DOID:2256 (implicated_via_orthology)
Disease	retinal degeneration (is_implicated_in)	ABCA4 HDAC4	1.35e-03	9	184	2	DOID:8466 (is_implicated_in)
Disease	cancer (implicated_via_orthology)	CAND2 RANBP6 SIN3A CBX6 PIK3CB STX7 ALK	1.52e-03	268	184	7	DOID:162 (implicated_via_orthology)
Disease	rheumatoid arthritis, Crohn's disease	ATG16L1 ZMIZ1 RPL3	1.71e-03	38	184	3	EFO_0000384, EFO_0000685
Disease	Other specified cardiac arrhythmias	CACNA2D1 PKP2	2.05e-03	11	184	2	C0348626
Disease	Nodal rhythm disorder	CACNA2D1 PKP2	2.05e-03	11	184	2	C0264893
Disease	Ectopic rhythm	CACNA2D1 PKP2	2.05e-03	11	184	2	C1399226
Disease	Shortened QT interval	CACNA2D1 SLC4A3	2.05e-03	11	184	2	C0151879
Disease	CARDIAC CONDUCTION DEFECT, NONSPECIFIC (disorder)	CACNA2D1 PKP2	2.05e-03	11	184	2	C2748542
Disease	influenza A (H1N1)	LINGO2 DDX18 CFAP74 ARAP2	2.18e-03	87	184	4	EFO_1001488
Disease	chronic musculoskeletal pain	GPX7 EXD3	2.45e-03	12	184	2	EFO_0022195
Disease	very long-chain saturated fatty acid measurement	LCA5 IL1R1 CDH11	2.62e-03	44	184	3	EFO_0006796
Disease	glioblastoma (is_marker_for)	CBX6 PIK3CB ASPM	2.62e-03	44	184	3	DOID:3068 (is_marker_for)
Disease	asthma exacerbation measurement	CACNA2D1 FSTL4 RANBP6 IL1R1	2.77e-03	93	184	4	EFO_0007614
Disease	hematologic cancer (implicated_via_orthology)	SAE1 PIAS1	2.88e-03	13	184	2	DOID:2531 (implicated_via_orthology)
Disease	colon carcinoma (is_marker_for)	TGFB2 KMT2D	2.88e-03	13	184	2	DOID:1520 (is_marker_for)
Disease	Brugada Syndrome 1	CACNA2D1 PKP2	2.88e-03	13	184	2	C4551804
Disease	obsolete aging, epigenetic status	CARMIL1 PIK3CB KIF13A	2.97e-03	46	184	3	EFO_0000473, GO_0007568
Disease	response to angiotensin-converting enzyme inhibitor, Cough	CLASP1 TGFBR1 EXOC6B	2.97e-03	46	184	3	EFO_0005325, HP_0012735
Disease	Heart Diseases	ABCC1 SLC4A3 TNNI3	2.97e-03	46	184	3	C0018799
Disease	Malignant neoplasm of breast	ABCC1 ABCA4 HDAC4 ZMIZ1 KMT2D PIK3CB SPATA21 DDX18 GZMB PRKAA2 SCNN1B ARHGAP29 GOLIM4 ALK GOLGB1	3.11e-03	1074	184	15	C0006142
Disease	cannabis dependence measurement	LINGO2 DDX18 CCAR1	3.36e-03	48	184	3	EFO_0008457
Disease	bipolar disorder	GARNL3 TDRD9 CLASP1 CARMIL1 ZMIZ1 SVEP1 LYRM2 PACS1 KMT2D NGEF	3.50e-03	577	184	10	MONDO_0004985
Disease	Sinus Node Dysfunction (disorder)	CACNA2D1 PKP2	3.85e-03	15	184	2	C0428908
Disease	Retinitis Pigmentosa	RPGRIP1 ABCA4 ARHGEF18 SNRNP200	4.14e-03	104	184	4	C0035334
Disease	obesity	DGKD LINGO2 OR10R2 GPR139 PACS1 DDX18	4.15e-03	241	184	6	EFO_0001073
Disease	peak expiratory flow	HDAC4 CARMIL1 COPS2 TGFB2 PACS1 ADAMTS17 MLLT6 ABCG5 MRTFA	4.21e-03	498	184	9	EFO_0009718
Disease	wellbeing measurement	CACNA2D1 CAND2 POU5F2 CARMIL1 LINGO2 VPS54 TFB1M CBX6 FSHR EIF4G3 CDH9	4.28e-03	692	184	11	EFO_0007869
Disease	Leber congenital amaurosis	RPGRIP1 LCA5	4.38e-03	16	184	2	cv:C0339527
Disease	T-Cell Lymphoma	KMT2D MGA	4.38e-03	16	184	2	C0079772
Disease	thyroid volume	AATF DNAH5	4.38e-03	16	184	2	EFO_0004865
Disease	primary autosomal recessive microcephaly (is_implicated_in)	NCAPD3 ASPM	4.38e-03	16	184	2	DOID:0070296 (is_implicated_in)
Disease	Peripheral Nervous System Diseases	ABCC1 DAPK1 LYST	4.69e-03	54	184	3	C4721453
Disease	Pulmonary Emphysema	TGFB2 TGFBR1	4.95e-03	17	184	2	C0034067
Disease	complement factor H-related protein 1 measurement	DDX46 KIAA1549L ASPM	5.19e-03	56	184	3	EFO_0600054
Disease	creatine kinase measurement	CAND2 IQGAP3 MRTFA	6.00e-03	59	184	3	EFO_0004534
Disease	sleep apnea measurement	STX8 HDAC4 ASB3 ADAMTS17	6.09e-03	116	184	4	EFO_0007817
Disease	Phenyllactate (PLA) measurement	DAPK1 ADAMTS17	6.17e-03	19	184	2	EFO_0021662

Protein segments in the cluster

Peptide	Gene	Start	Entry
LNVKSNLAIARLKRT	nan	281	A8MVM7
QLRLNSIKKLSTIAL	PPP2R1A	26	P30153
LLQKLKSEGRRVLIL	EP400	1906	Q96L91
NIQILQLLIKRGSRI	DAPK1	391	P53355
ITALIVSQKARRLLK	SLC4A3	1006	P48751
LSLTAKKERLQILNV	MLLT6	741	P55198
KLRSALIQNKQLRLL	BBS5	141	Q8N3I7
NLIKKIGNFSIVRRL	ARHGEF18	576	Q6ZSZ5
KSRLEKLLTQVRNLQ	CAGE1	506	Q8TC20
RSLKLLAQFRQIQII	CATSPER2	216	Q96P56
LRNIRTQVLIKLIKP	COPS2	351	P61201
RNRIILNLKVIDKGA	CBX6	171	O95503
LKRENLLNILVIIKT	CPED1	876	A4D0V7
TLLRFNAVLRKLLIV	ABCA4	1821	P78363
LSRAQVKKLLNKVVL	CCAR1	956	Q8IX12
KRRLQQGKVTIAELI	DUSP8	56	Q13202
LLKVIDLRTNAIKQT	ATG16L1	511	Q676U5
KVAVKILNRQKIRSL	PRKAA2	41	P54646
KIELKRLGVVLAQNL	BTBD6	441	Q96KE9
RITRLKLLLQNILKR	ARHGEF5	1316	Q12774
LVQLRKLKAQRTQAR	CCDC65	301	Q8IXS2
LLQLERKAKRTRAVQ	GZMB	111	P10144
LRVLQAELKINIRLT	ACACA	1506	Q13085
HRRRILKQLQIILSK	ARAP2	56	Q8WZ64
GKLLIQRSRRLKQNL	CFAP161	36	Q6P656
QVSKLREKLQLISAL	EFCAB14	366	O75071
LAVINFLAKQRLRKR	ASPM	1301	Q8IZT6
KRNSVRLVIRKVQFA	ARRB2	161	P32121
KINIQVTKLVLLRQR	ADAMTS17	276	Q8TE56
KTKNLRLLILVGRLF	APOBEC2	141	Q9Y235
IINLKKDLIRSRFLI	CCDC60	46	Q8IWA6
LASIKNRQRIQKLVL	RANBP9	401	Q96S59
RVLALKKLQTRAANL	NAP1L2	111	Q9ULW6
RRAQNCIILLSKLKL	DAAM2	676	Q86T65
AQQKVRLARIRLAKS	KCND1	426	Q9NSA2
AAKLLQQRLSVSKIL	HDAC4	821	P56524
QLLVRVKRRIGVKNA	HSFY1	186	Q96LI6
LIGQKNLLTRKRNIL	MGA	2481	Q8IWI9
NLLTRKRNILIRKVS	MGA	2486	Q8IWI9
VKNLKRQDARIIVGL	GABBR1	351	Q9UBS5
RVKLKLTRIVTTLVN	FSIP2	4976	Q5CZC0
LDRRIVALRKKNQAL	CCDC9B	66	Q6ZUT6
LIKRTIRALENLKIG	KIAA1586	556	Q9HCI6
RLREELLKQTKLVQL	PIK3C2A	1041	O00443
RLISLKRINAGLNVI	PDPR	136	Q8NCN5
LSENRARKKRLNIII	PFKP	256	Q01813
QLGTVLRNLKLARKL	MPO	616	P05164
KLVQIASRTKRNFIL	HNRNPUL2	521	Q1KMD3
KSLKEVLQLRLQQRR	MRTFB	36	Q9ULH7
LQQLAKELRQKRLSL	POU5F2	126	Q8N7G0
TKRILSARLLKINEL	LCA5	101	Q86VQ0
NLRSLRLKGNRLKLV	LINGO2	106	Q7L985
KLLVKTVLFLTQRRV	KIAA1549L	826	Q6ZVL6
LRELKQLKVLSLRSN	LRRC8E	531	Q6NSJ5
IKRKNIGLTELVQII	EXOC6B	546	Q9Y2D4
NIKQIVKLLASVRAL	PAXBP1	881	Q9Y5B6
RQAVRKKKNVLISVL	CYFIP2	496	Q96F07
ELKQIIKLLPTRRQT	DDX18	346	Q9NVP1
RKFLLSQLQKTRPVI	OAS2	621	P29728
LRKIRAAQNISKTIA	PHB2	251	Q99623
VAVALVVRKVKLRNL	HIDE1	136	A8MVS5
KIGLLVKNRITLQEV	IQGAP3	901	Q86VI3
VVIAVKLQGSKRILR	PACS1	141	Q6VY07
RTLKILIEQNRKIIA	PLOD2	401	O00469
QLRISLIALTRKNQL	FANCB	251	Q8NB91
VRINRTLKKIILEAQ	GPRC6A	256	Q5T6X5
CSRKQKRIFQTLLLL	GOLIM4	6	O00461
VAQKRFALILALTKV	GPR149	306	Q86SP6
INRILLKSKDLLRQL	ARHGAP29	796	Q52LW3
LAAREGNVKVLRKLL	ASB3	16	Q9Y575
VIQRQKKALSELRAR	FHAD1	1146	B1AJZ9
RVQKDILTQLKILRP	BLM	836	P54132
RVVIKQIITSRNKVL	CTNNAL1	161	Q9UBT7
IEKLLSNRSKALVRL	CACNA2D1	86	P54289
EQVTRLTLKLLGQKL	C21orf58	91	P58505
KINNEIRSVKRLQLL	FBXO7	266	Q9Y3I1
ARLKNVLLALQTRLQ	FSTL4	146	Q6MZW2
RQATLVRKLQAKVLQ	CEP250	51	Q9BV73
IGQTLKLLVKRNVSL	LINC01387	116	J3KSC0
LVIVVLFVTLRRQKK	CDH11	631	P55287
RNKLAVITRLLQNLI	ABCG5	381	Q9H222
RAIKTILRSKLEQVQ	ANGPT4	106	Q9Y264
QQIDRRLRKNLKSLI	BNIP2	231	Q12982
KRIVQRIKDFLRNLV	CAMP	151	P49913
KNLTELLRAALKIRI	LYST	351	Q99698
VRLLRSLVNLKQVII	MAN2A2	586	P49641
LTLKQFVRRQQVLLL	LYRM2	11	Q9NU23
LRANSLKKAIRQIIE	DGKD	611	Q16760
VNVREKAKQLVALLR	EPN1	121	Q9Y6I3
ILKRERSLNLKSLLQ	FNTB	261	P49356
ILSKLRGLKAVLERQ	IP6K1	311	Q92551
KRVIIKDLQLLGLVA	GPR156	156	Q8NFN8
AVLLVLIFVLRKRIK	SLC44A3	296	Q8N4M1
LAKALQINTKLRTVI	CARMIL1	591	Q5VZK9
LRFVLTKLRVIQKGA	FSHR	51	P23945
LTVIILSQLVARRQK	GPR139	46	Q6DWJ6
IAKRLALRINAQKNL	DDX46	851	Q7L014
QITALVRKLILLKRE	GPX7	171	Q96SL4
LVVKALQRQLKDRSV	CAND2	436	O75155
RKVKLLNQVRLLRVQ	RUBCN	801	Q92622
SQLNVLKKRRVGDLL	SCNM1	11	Q9BWG6
TIIKLVALAKSLRQR	SCNN1B	551	P51168
LLILVVLFAALKRQR	CDH9	626	Q9ULB4
TQELFRKVRSILNKL	EIF4G3	751	O43432
NENVKKSRRLIIILV	IL1R1	441	P14778
LLRIRKSLNTQKELG	CFAP74	221	Q9C0B2
LRIVVAIRNKLLLIT	GARNL3	601	Q5VVW2
TLLLTLKIDIQRNRV	DNAH5	3896	Q8TE73
INTLTRQKELLLQKL	ODF2	246	Q5BJF6
SLRNKDVQLAIRKVL	OR10R2	311	Q8NGX6
QLVCLARALLRKTKI	ABCC1	1436	P33527
KLSLLIRERQQLRKT	FES	101	P07332
AKLREQLVKANTLVR	KIF13A	676	Q9H1H9
VQNLLLIRRFKKTII	MAP3K15	486	Q6ZN16
KVERLQLLLQQKRLR	MIDN	391	Q504T8
VALQTLRKLVELTQK	PNPLA8	456	Q9NP80
RSKALLKRQLEQSIR	GOLGA8A	221	A7E2F4
ANLKVSQIKKVRLLI	SARS1	96	P49591
EKILRAGKILRNAIL	RAPGEF4	201	Q8WZA2
TNILLKNLVTIARKA	TRIM43	66	Q96BQ3
QVITLLNELKRRGKR	ACAA1	386	P09110
LTRLLDLKNNRIKQL	RPGRIP1	561	Q96KN7
ERKVLSILSRLKQQN	SPATA21	376	Q7Z572
LLATKRRKQQLVLRG	RSAD2	41	Q8WXG1
ITRQKKRLQELALAL	TMEM120A	51	Q9BXJ8
RKLLRTNSRFVKVVL	TDRD9	271	Q8NDG6
ALQTQRVLLEKRRKA	LMBR1L	276	Q6UX01
QKQLLCLARALLRKT	ABCC6	1406	O95255
TLRKSLLVQTKRRAL	RPL3	346	P39023
LVQRTIARLRLKKIF	RPL7L1	111	Q6DKI1
QRKSRKTLCIIILIL	STX7	231	O15400
RRAVILKFSLQGLKI	SH2D5	61	Q6ZV89
LQKAKTREEILQLLR	HOATZ	111	Q6PI97
ITRLKLLVQNILKRV	NGEF	416	Q8N5V2
SVLKRRLVKLVVNFL	PLEKHJ1	31	Q9NW61
NSRQQIRKLIKDGLI	RPL19	36	P84098
NLATIRVLEAIQKKL	SIN3A	626	Q96ST3
TLSLRIRKQILKFLD	ST8SIA2	91	Q92186
IIKLLRLQAAKQLSQ	TFB1M	21	Q8WVM0
QKRLRASRVLLVGLK	SAE1	31	Q9UBE0
VEKLRKLQRALVRNA	NOM1	571	Q5C9Z4
SNTILAVKLNRQRLI	WIPI2	116	Q9Y4P8
KQLSSTVLLQRLRAK	PIAS1	286	O75925
TLNSLIKLNAVKLNR	PIK3CB	721	P42338
NIKRRQGLKRLSVEI	SWT1	66	Q5T5J6
RLLQTLETITNKLKR	SVEP1	941	Q4LDE5
LLNVVSQLAKRNLRL	PRORP	426	O15091
KNNVLAIRREIVALK	OLFM4	206	Q6UX06
LVIKLQELIRNGTKL	RANBP6	501	O60518
NITRIKLLVRKFLQT	SGSH	151	P51688
LRQKQQLVERLKLQL	MRTFA	541	Q969V6
ARLTALRIKKTLSQL	TGFBR1	481	P36897
QLLEGRIKLQKALLT	AATF	236	Q9NY61
SVRKLRRAKQLVLEL	ALK	131	Q9UM73
VVNLRLQLSVSKVKL	BPIFB2	361	Q8N4F0
VKRREQLLALKNLAQ	CCDC134	41	Q9H6E4
NVRKSALQVLVSILK	NCAPD3	556	P42695
VSRNRLAQVKRKILV	CTDNEP1	51	O95476
RVNALKKIRSLLLAG	CLASP1	341	Q7Z460
LKNQRTLSRVELKRL	CLASP2	681	O75122
VNCVVRKLLVQLRRL	TMEM270	171	Q6UE05
LKQRREPLILQSQVK	ZNF610	76	Q8N9Z0
LIKKGLALRERRINN	RNF17	1096	Q9BXT8
RNRLRTVLKNLSLLK	TP53TG5	36	Q9Y2B4
LSLLKLLKSSNRRIQ	TP53TG5	46	Q9Y2B4
RIEAIRGQILSKLKL	TGFB2	36	P61812
QRKRQLLIGLLKSLR	VPS50	161	Q96JG6
RLRINSLRKNTILPK	MRPS14	51	O60783
NRRLLRKVIKAAALE	TSC1	716	Q92574
RVKVKLLQRSISSLL	SPIDR	846	Q14159
LKKQLVLRIISGQQL	PLCH2	756	O75038
LQRLFVLLQTSKKRA	USP47	236	Q96K76
KLLLELNKIRTIRTF	PREX2	131	Q70Z35
AKQLRRRNIQALKSI	PRPF40B	406	Q6NWY9
TVTIRALLQNLKEKI	STX8	41	Q9UNK0
ISASRKLQLKTLLLQ	TNNI3	41	P19429
LISIKRLTLQQKAKV	SNRNP200	2076	O75643
QVTLRLKNTALKSII	ZACN	221	Q401N2
KQRKVKARLTIAAVL	SLC30A4	106	O14863
IRKLRDVLQQRLIKF	TRAP1	411	Q12931
LLRSVKKLVNVIILT	SCN11A	246	Q9UI33
QKKLEQANRRLLLRI	TFEC	206	O14948
TNILLKNLVTIARKA	TRIM43B	66	A6NCK2
LIQKNRRVVLASFLL	TMEM134	116	Q9H6X4
VRLNLRGLLSKAKQL	TTC27	791	Q6P3X3
LKELVTLRAQKSRLL	THOP1	256	P52888
QLRALLVVVNALLRK	PXMP4	6	Q9Y6I8
EARKRVNQLRGILKL	PKP2	386	Q99959
KKTAISLLRNLSRNL	PKP2	746	Q99959
VKRGVLLNALKLLNI	TTLL7	366	Q6ZT98
KRLLKISRALQARSV	TXNRD3NB	66	Q6F5E7
SVRSVLQGLLKKRLL	ZMIZ1	686	Q9ULJ6
RLISLVFGLLKQRKL	VPS54	381	Q9P1Q0
IQRKLQAALISRKEA	GOLGB1	1481	Q14789
LATKNKNRLRRILEV	KEL	121	P23276
LVVVAAKKLVNRLQV	KIAA2013	261	Q8IYS2
LLLQKLLRAKNVQLS	KMT2D	4461	O14686
LRLKQLQARAVKVLT	EXD3	101	Q8N9H8