Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	SAM	SAMD11 PPFIBP1 LRSAM1 SAMD4B ANKS3	5.65e-05	88	87	5	SM00454
Domain	SAM_DOMAIN	SAMD11 PPFIBP1 LRSAM1 SAMD4B ANKS3	8.14e-05	95	87	5	PS50105
Domain	SAM	SAMD11 PPFIBP1 LRSAM1 SAMD4B ANKS3	8.99e-05	97	87	5	IPR001660
Domain	-	SAMD11 PPFIBP1 LRSAM1 SAMD4B ANKS3	1.37e-04	106	87	5	1.10.150.50
Domain	SAM/pointed	SAMD11 PPFIBP1 LRSAM1 SAMD4B ANKS3	2.17e-04	117	87	5	IPR013761
Domain	-	SND1 TDRD6	3.18e-04	6	87	2	2.40.50.90
Domain	Staphylococal_nuclease_OB-fold	SND1 TDRD6	3.18e-04	6	87	2	IPR016071
Domain	Cadherin_tail	PCDHA9 PCDHA7 PCDHA4	6.76e-04	37	87	3	PF15974
Domain	Cadherin_CBD	PCDHA9 PCDHA7 PCDHA4	6.76e-04	37	87	3	IPR031904
Domain	SAM_2	SAMD11 PPFIBP1 LRSAM1	1.05e-03	43	87	3	PF07647
Domain	Cadherin_CS	PCDHA9 DCHS1 PCDHA7 PCDHA4	1.68e-03	109	87	4	IPR020894
Domain	TUDOR	SND1 TDRD6	1.88e-03	14	87	2	PF00567
Domain	CADHERIN_1	PCDHA9 DCHS1 PCDHA7 PCDHA4	1.92e-03	113	87	4	PS00232
Domain	Cadherin	PCDHA9 DCHS1 PCDHA7 PCDHA4	1.92e-03	113	87	4	PF00028
Domain	HMG_box	KMT2D TCF7L2 SOX18	1.93e-03	53	87	3	PF00505
Domain	Ion_trans_dom	CACNA1F SCN11A CNGA2 KCNH4	1.99e-03	114	87	4	IPR005821
Domain	Ion_trans	CACNA1F SCN11A CNGA2 KCNH4	1.99e-03	114	87	4	PF00520
Domain	CADHERIN_2	PCDHA9 DCHS1 PCDHA7 PCDHA4	1.99e-03	114	87	4	PS50268
Domain	-	PCDHA9 DCHS1 PCDHA7 PCDHA4	1.99e-03	114	87	4	2.60.40.60
Domain	HMG	KMT2D TCF7L2 SOX18	2.04e-03	54	87	3	SM00398
Domain	CA	PCDHA9 DCHS1 PCDHA7 PCDHA4	2.05e-03	115	87	4	SM00112
Domain	Cadherin-like	PCDHA9 DCHS1 PCDHA7 PCDHA4	2.12e-03	116	87	4	IPR015919
Domain	-	KMT2D TCF7L2 SOX18	2.15e-03	55	87	3	1.10.30.10
Domain	Cadherin	PCDHA9 DCHS1 PCDHA7 PCDHA4	2.25e-03	118	87	4	IPR002126
Domain	PBD	CDC42BPA CDC42EP1	2.47e-03	16	87	2	SM00285
Domain	UIM	ANKIB1 EPN1	3.13e-03	18	87	2	PF02809
Domain	HMG_box_dom	KMT2D TCF7L2 SOX18	3.46e-03	65	87	3	IPR009071
Domain	Cadherin_2	PCDHA9 PCDHA7 PCDHA4	3.46e-03	65	87	3	PF08266
Domain	Cadherin_N	PCDHA9 PCDHA7 PCDHA4	3.46e-03	65	87	3	IPR013164
Domain	CRIB	CDC42BPA CDC42EP1	3.86e-03	20	87	2	PS50108
Domain	SAM_1	PPFIBP1 SAMD4B ANKS3	3.93e-03	68	87	3	PF00536
Domain	UIM	ANKIB1 EPN1	4.25e-03	21	87	2	SM00726
Domain	CRIB_dom	CDC42BPA CDC42EP1	4.25e-03	21	87	2	IPR000095
Domain	AAA+_ATPase	CHTF18 TOR4A ATAD2 ABCA7	4.60e-03	144	87	4	IPR003593
Domain	AAA	CHTF18 TOR4A ATAD2 ABCA7	4.60e-03	144	87	4	SM00382
Domain	TUDOR	SND1 TDRD6	5.09e-03	23	87	2	PS50304
Domain	UIM	ANKIB1 EPN1	5.54e-03	24	87	2	PS50330
Domain	UIM_dom	ANKIB1 EPN1	6.00e-03	25	87	2	IPR003903
Domain	HR1_rho-bd	TBC1D4 CDC42BPA	6.00e-03	25	87	2	IPR011072
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	NELFE DHX16 KMT2D TBC1D4 ARGLU1 CHTF18 SAMD4B ZBTB40 RBM6 SCRIB KAT6B ATAD2	6.72e-07	774	89	12	15302935
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	DHX16 UPF2 C12orf56 PPFIBP1 CHTF18 SAMD4B ANKIB1 SCRIB EDEM1 EPN1 PTK7	8.72e-07	650	89	11	38777146
Pubmed	Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex.	PCDHA9 PCDHA7 PCDHA4	2.63e-06	11	89	3	9655502
Pubmed	Proteins of the CNR family are multiple receptors for Reelin.	PCDHA9 PCDHA7 PCDHA4	3.50e-06	12	89	3	10612399
Pubmed	Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly.	SCYL1 AGFG1 EPN1	5.78e-06	14	89	3	16903783
Pubmed	Dual role of ERK5 in the regulation of T cell receptor expression at the T cell surface.	MAPK7 FOXP3	6.48e-06	2	89	2	26302753
Pubmed	Dissecting genetic heterogeneity in autoimmune thyroid diseases by subset analysis.	TG FOXP3	6.48e-06	2	89	2	17644307
Pubmed	Correlation between TCF7L2 and CAPN10 gene polymorphisms and gestational diabetes mellitus in different geographical regions: a meta-analysis.	TCF7L2 CAPN10	6.48e-06	2	89	2	38166877
Pubmed	Human lung cancer antigens recognized by autologous antibodies: definition of a novel cDNA derived from the tumor suppressor gene locus on chromosome 3p21.3.	AGFG1 RBM6	6.48e-06	2	89	2	9500467
Pubmed	TCF7L2, CAPN10 polymorphisms are associated with gestational diabetes mellitus (GDM) risks: a meta-analysis.	TCF7L2 CAPN10	6.48e-06	2	89	2	28277135
Pubmed	MLL4 prepares the enhancer landscape for Foxp3 induction via chromatin looping.	KMT2D FOXP3	6.48e-06	2	89	2	28759003
Pubmed	Monoallelic yet combinatorial expression of variable exons of the protocadherin-alpha gene cluster in single neurons.	PCDHA9 PCDHA7 PCDHA4	7.21e-06	15	89	3	15640798
Pubmed	Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice.	PCDHA9 PCDHA7 PCDHA4	1.07e-05	17	89	3	29911975
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	NELFE JCAD TBC1D4 CDC42BPA SAMD11 PPFIBP1 SAMD4B DNAJB6 AGFG1 SCRIB CDC42EP1	1.27e-05	861	89	11	36931259
Pubmed	CNR/Pcdhalpha family in subplate neurons, and developing cortical connectivity.	PCDHA9 PCDHA7 PCDHA4	1.29e-05	18	89	3	15570159
Pubmed	Genomic organization of the family of CNR cadherin genes in mice and humans.	PCDHA9 PCDHA7 PCDHA4	1.29e-05	18	89	3	10662547
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	SND1 RBM45 ARL6IP5 LRSAM1 ANKIB1 MAPK7 DCTPP1 CCDC88B ANKS3	1.38e-05	560	89	9	21653829
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	CDC42BPA PHLDA1 PPFIBP1 LRSAM1 SCRIB ATAD2 STT3B PTK7 CDC42EP1	1.57e-05	569	89	9	30639242
Pubmed	Chromatoid Body Protein TDRD6 Supports Long 3' UTR Triggered Nonsense Mediated mRNA Decay.	UPF2 TDRD6	1.94e-05	3	89	2	27149095
Pubmed	Genetic risk factors for type 2 diabetes with pharmacologic intervention in African-American patients with schizophrenia or schizoaffective disorder.	TCF7L2 CAPN10	1.94e-05	3	89	2	19643578
Pubmed	Protein tyrosine kinase 7 has a conserved role in Wnt/β-catenin canonical signalling.	SCRIB PTK7	1.94e-05	3	89	2	21132015
Pubmed	Structural Basis of Diverse Homophilic Recognition by Clustered α- and β-Protocadherins.	PCDHA9 PCDHA7	1.94e-05	3	89	2	27161523
Pubmed	Nonsense in the testis: multiple roles for nonsense-mediated decay revealed in male reproduction.	UPF2 TDRD6	1.94e-05	3	89	2	28444146
Pubmed	Developmental epigenetic modification regulates stochastic expression of clustered protocadherin genes, generating single neuron diversity.	PCDHA9 PCDHA7 PCDHA4	3.15e-05	24	89	3	24698270
Pubmed	Cdx mediates neural tube closure through transcriptional regulation of the planar cell polarity gene Ptk7.	SCRIB PTK7	3.87e-05	4	89	2	21350009
Pubmed	Ethnic difference in patients with type 2 diabetes mellitus in inter-East Asian populations: a systematic review and meta-analysis focusing on gene polymorphism.	TCF7L2 CAPN10	3.87e-05	4	89	2	20923526
Pubmed	Genetic variants harbored in the forkhead box protein 3 locus increase hay fever risk.	CACNA1F FOXP3	3.87e-05	4	89	2	20398921
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	DHX16 TBC1D4 UPF2 SND1 CHTF18 LRSAM1 DNAJB6 ANKIB1 TOR4A PRR14L SCRIB ATAD2 PCK2	3.97e-05	1353	89	13	29467282
Pubmed	Interaction with protocadherin-gamma regulates the cell surface expression of protocadherin-alpha.	PCDHA9 PCDHA7 PCDHA4	5.07e-05	28	89	3	15347688
Pubmed	Clathrin-mediated endocytosis of the epithelial sodium channel. Role of epsin.	AP1M2 EPN1	6.44e-05	5	89	2	16574660
Pubmed	Intersectin, a novel adaptor protein with two Eps15 homology and five Src homology 3 domains.	AGFG1 EPN1	6.44e-05	5	89	2	9813051
Pubmed	Diabetes genes and prostate cancer in the Atherosclerosis Risk in Communities study.	TCF7L2 CAPN10	6.44e-05	5	89	2	20142250
Pubmed	Common deletion variants causing protocadherin-α deficiency contribute to the complex genetics of BAV and left-sided congenital heart disease.	PCDHA9 PCDHA7	6.44e-05	5	89	2	34888534
Pubmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.	JCAD CDC42BPA SND1 SCYL1 RBM6 SCRIB	7.61e-05	274	89	6	34244482
Pubmed	Epidermal wound repair is regulated by the planar cell polarity signaling pathway.	SCRIB PTK7	9.65e-05	6	89	2	20643356
Pubmed	Variants of the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in an African-American population enriched for nephropathy.	TCF7L2 CAPN10	9.65e-05	6	89	2	17601994
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	JCAD SND1 ARGLU1 PPFIBP1 SCYL1 AGFG1 SCRIB CDC42EP1	1.03e-04	565	89	8	25468996
Pubmed	An expression profile analysis of ES cell-derived definitive endodermal cells and Pdx1-expressing cells.	TCF7L2 BARHL2 CHI3L1	1.18e-04	37	89	3	21362171
Pubmed	Comparative analysis of structure, expression and PSD95-binding capacity of Lrfn, a novel family of neuronal transmembrane proteins.	LRFN4 ZIC2	1.35e-04	7	89	2	16828986
Pubmed	Roles for laminin in embryogenesis: exencephaly, syndactyly, and placentopathy in mice lacking the laminin alpha5 chain.	LAMA3 SOX18	1.79e-04	8	89	2	9852162
Pubmed	Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability.	CDC42BPA STX18 PPFIBP1 ARL6IP5 STT3B PTK7 CDC42EP1	2.01e-04	467	89	7	30194290
Pubmed	Histone deacetylase 6 (HDAC6) promotes the pro-survival activity of 14-3-3ζ via deacetylation of lysines within the 14-3-3ζ binding pocket.	TBC1D4 PPFIBP1	2.30e-04	9	89	2	25770209
Pubmed	Prevalence of common disease-associated variants in Asian Indians.	TCF7L2 CAPN10	2.30e-04	9	89	2	18248681
Pubmed	The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell polarity in the ear.	SCRIB PTK7	2.30e-04	9	89	2	20704721
Pubmed	The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.	NELFE DHX16 ARL6IP5 SCYL1 AGFG1 RBM6 TMEM131 EPN1 STT3B CDC42EP1	2.55e-04	1007	89	10	34597346
Pubmed	Analysis of recently identified osteoporosis susceptibility genes in Han Chinese women.	ZBTB40 TNFRSF11A	2.88e-04	10	89	2	20554715
Pubmed	Characterization of Opr deficiency in mouse brain: subtle defects in dorsomedial telencephalon and medioventral forebrain.	TCF7L2 ZIC2	2.88e-04	10	89	2	15736266
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	NELFE TBC1D4 SAMD4B RBM6 TMEM131 SCRIB ANKS3	3.15e-04	503	89	7	16964243
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	DHX16 UPF2 SAMD4B DNAJB6 SCYL1 AGFG1 MAPK7 EPN1 ANKS3 CDC42EP1	3.24e-04	1038	89	10	26673895
Pubmed	Atypical Cadherin Fat1 Is Required for Lens Epithelial Cell Polarity and Proliferation but Not for Fiber Differentiation.	DCHS1 SCRIB	3.51e-04	11	89	2	26114487
Pubmed	Metabolic-stress-induced rearrangement of the 14-3-3ζ interactome promotes autophagy via a ULK1- and AMPK-regulated 14-3-3ζ interaction with phosphorylated Atg9.	TBC1D4 PPFIBP1	3.51e-04	11	89	2	25266655
Pubmed	Multiple genetic loci for bone mineral density and fractures.	ZBTB40 TNFRSF11A	3.51e-04	11	89	2	18445777
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	DHX16 PNKP KMT2D TBC1D4 ZBTB40 SCRIB FOXD4 ZIC2 FOXP3	3.52e-04	857	89	9	25609649
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	CDC42BPA STX18 SND1 ARGLU1 PPFIBP1 ARL6IP5 DNAJB6 TMEM131 SCRIB STT3B PTK7 CDC42EP1	4.04e-04	1487	89	12	33957083
Pubmed	Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane.	STX18 SND1 ARL6IP5 TMEM131 TNFRSF11A STT3B	4.13e-04	375	89	6	32788342
Pubmed	Planar cell polarity defects and defective Vangl2 trafficking in mutants for the COPII gene Sec24b.	SCRIB PTK7	4.20e-04	12	89	2	20215345
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	PNKP CDC42BPA STX18 SND1 ARGLU1 PPFIBP1 SAMD4B RBM6 ATAD2 EPN1 THAP12 STT3B	4.29e-04	1497	89	12	31527615
Pubmed	Clustered gamma-protocadherins regulate cortical interneuron programmed cell death.	PCDHA9 PCDHA7 PCDHA4	4.29e-04	57	89	3	32633719
Pubmed	SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation.	DPP7 LRFN4 PPFIBP1 DNAJB6 RBM6 ABCA7	4.31e-04	378	89	6	34315543
Pubmed	CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons.	PCDHA9 PCDHA7 PCDHA4	4.51e-04	58	89	3	30377227
Pubmed	Progesterone induced Warburg effect in HEK293 cells is associated with post-translational modifications and proteasomal degradation of progesterone receptor membrane component 1.	PNKP STYXL2 PCK2	4.51e-04	58	89	3	31067491
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	CDC42BPA SND1 PPFIBP1 ARL6IP5 DNAJB6 SCRIB STT3B CDC42EP1	4.70e-04	708	89	8	39231216
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	TBC1D4 STX18 SND1 PPFIBP1 ARL6IP5 SCYL1 STYXL2 DCTPP1 ANKS3 PCK2 STT3B	5.52e-04	1321	89	11	27173435
Pubmed	Origin of a Non-Clarke's Column Division of the Dorsal Spinocerebellar Tract and the Role of Caudal Proprioceptive Neurons in Motor Function.	BARHL2 GDNF	5.78e-04	14	89	2	26527010
Pubmed	Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse.	CACNA1F FOXP3	5.78e-04	14	89	2	11138001
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	STX18 PPFIBP1 ARL6IP5 SCYL1 TMEM131 PRR14L STT3B	6.48e-04	568	89	7	37774976
Pubmed	Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neurons.	TCF7L2 RBM45	6.65e-04	15	89	2	19515692
Pubmed	Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.	PCDHA9 PCDHA7 PCDHA4	7.20e-04	68	89	3	11230163
Pubmed	Expression of the winged helix genes fkh-4 and fkh-5 defines domains in the central nervous system.	SCYL1 FOXD4	7.59e-04	16	89	2	8861101
Pubmed	Beta-catenin is necessary to keep cells of ureteric bud/Wolffian duct epithelium in a precursor state.	SCRIB GDNF	7.59e-04	16	89	2	18177851
Pubmed	Wnt/β-catenin signalling regulates Sox17 expression and is essential for organizer and endoderm formation in the mouse.	TCF7L2 PYY	7.59e-04	16	89	2	23824574
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	JCAD TCF7L2 TULP4 SCYL1 AGFG1 EPN1	8.45e-04	430	89	6	35044719
Pubmed	A striking organization of a large family of human neural cadherin-like cell adhesion genes.	PCDHA9 PCDHA7 PCDHA4	8.50e-04	72	89	3	10380929
Pubmed	TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.	LAMA3 TMEM131 EDEM1 STT3B	8.52e-04	164	89	4	32409323
Pubmed	Selective translational repression of truncated proteins from frameshift mutation-derived mRNAs in tumors.	TCF7L2 UPF2	8.59e-04	17	89	2	17456004
Pubmed	Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.	PCDHA9 PCDHA7 PCDHA4	9.21e-04	74	89	3	10817752
Pubmed	The DNA sequence and comparative analysis of human chromosome 5.	PCDHA9 PCDHA7 PCDHA4	9.57e-04	75	89	3	15372022
Pubmed	Several loci in the HLA class III region are associated with T1D risk after adjusting for DRB1-DQB1.	NELFE NCR3	9.65e-04	18	89	2	19143814
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	JCAD TBC1D4 PPFIBP1 SAMD4B THAP12 CDC42EP1	1.02e-03	446	89	6	24255178
Pubmed	Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.	PCDHA9 PCDHA7 PCDHA4	1.03e-03	77	89	3	10835267
Pubmed	Tlx3 and Runx1 act in combination to coordinate the development of a cohort of nociceptors, thermoceptors, and pruriceptors.	SCN11A ASIC3	1.08e-03	19	89	2	22787056
Pubmed	Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.	SCYL1 ZBTB40 TNFRSF11A	1.11e-03	79	89	3	22504420
Pubmed	Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.	PCDHA9 PCDHA7 PCDHA4	1.15e-03	80	89	3	10716726
Pubmed	Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study.	TCF7L2 CAPN10	1.19e-03	20	89	2	20075150
Pubmed	The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines.	LRSAM1 DNAJB6 EPN1	1.24e-03	82	89	3	25260751
Pubmed	NotI flanking sequences: a tool for gene discovery and verification of the human genome.	MED30 LAMA3	1.32e-03	21	89	2	12136098
Pubmed	Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair.	PNKP TCF7L2 DNAJB6 ATAD2 CDC42EP1	1.43e-03	321	89	5	32098917
Pubmed	Impairment of Wnt11 function leads to kidney tubular abnormalities and secondary glomerular cystogenesis.	SCRIB GDNF	1.45e-03	22	89	2	27582005
Pubmed	Renal developmental defects resulting from in utero hypoxia are associated with suppression of ureteric β-catenin signaling.	TCF7L2 GDNF	1.45e-03	22	89	2	25587709
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	NELFE DHX16 SND1 CHTF18 SCYL1 SCRIB STT3B	1.45e-03	653	89	7	33742100
Pubmed	Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.	PCDHA9 PCDHA7 PCDHA4 RASAL1	1.55e-03	193	89	4	22589738
Pubmed	A human MAP kinase interactome.	CDC42BPA AGFG1 LAMA3 MAPK7 CCDC88B CDC42EP1	1.58e-03	486	89	6	20936779
Pubmed	Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation.	SCN11A ASIC3	1.58e-03	23	89	2	20096094
Pubmed	Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain.	SCN11A ASIC3	1.58e-03	23	89	2	16446141
Pubmed	Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma.	DHX16 ARGLU1 DNAJB6 RBM6 SCRIB	1.59e-03	329	89	5	34316702
Pubmed	Quantitative trait loci for obesity- and diabetes-related traits and their dietary responses to high-fat feeding in LGXSM recombinant inbred mouse strains.	TNFRSF11A CAPN10	1.72e-03	24	89	2	15561968
Pubmed	A Requirement for Zic2 in the Regulation of Nodal Expression Underlies the Establishment of Left-Sided Identity.	FOXD4 ZIC2	1.72e-03	24	89	2	29992973
Pubmed	PTPRA Phosphatase Regulates GDNF-Dependent RET Signaling and Inhibits the RET Mutant MEN2A Oncogenic Potential.	EPN1 GDNF PTK7	1.84e-03	94	89	3	32062451
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	NELFE KMT2D UPF2 SCYL1 KAT6B	1.86e-03	341	89	5	32971831
Pubmed	Holoprosencephaly Overview	KMT2D ZIC2	1.87e-03	25	89	2	20301702
GeneFamily	Sterile alpha motif domain containing	SAMD11 PPFIBP1 LRSAM1 SAMD4B ANKS3	1.60e-05	88	65	5	760
ToppCell	390C-Epithelial_cells-Epithelial-I_(AT1)\|390C / Donor, Lineage, Cell class and subclass (all cells)	PIGQ CDC42BPA RBM6 LAMA3 KAT6B CAPN10	2.57e-06	194	89	6	88db9f9e80c20ff3474f1f6459dcbdc25aec0b6d
ToppCell	390C-Epithelial_cells-Epithelial-I_(AT1)-\|390C / Donor, Lineage, Cell class and subclass (all cells)	PIGQ CDC42BPA RBM6 LAMA3 KAT6B CAPN10	2.57e-06	194	89	6	a71728202493d4858342ea2756ea281cd0d99a3a
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PNKP TBC1D4 PHLDA1 CHI3L1 CCDC88B	7.12e-06	133	89	5	f6e9a1301a3379847b215303a9b0c028841e2cc0
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PNKP TBC1D4 PHLDA1 CHI3L1 CCDC88B	7.12e-06	133	89	5	292ecfcadbaf15e0d34a3ab9bf511ab1065888bd
ToppCell	Globus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Nefm\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	SCN11A ASIC3 CNGA2 GDNF	7.31e-06	62	89	4	3eec7f31de7cc24762c5b180475650676437dc76
ToppCell	Globus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Nefm-Inhibitory_Neuron.Chat-Gad1Gad2-Slc17a8.Nefm_(Globus_Pallidus/Nucleus_Basalis_(GP/NB),_cholinergic)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	SCN11A ASIC3 CNGA2 GDNF	7.31e-06	62	89	4	f5f5441f5be00ab80a7827c4af1afbe45c552c2e
ToppCell	Globus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Nefm-Inhibitory_Neuron.Chat-Gad1Gad2-Slc17a8.Nefm_(Globus_Pallidus/Nucleus_Basalis_(GP/NB),_cholinergic)-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	SCN11A ASIC3 CNGA2 GDNF	7.31e-06	62	89	4	6e81a37b9defa96528654bee1b23152108d9c0b7
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_2-AT1_Progenitor\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NELFE PHLDA1 AP1M2 DPP3 MAPK7	1.08e-05	145	89	5	186b8bd8ac2d5c66cc29fdc2dd6751eddce3e8b8
ToppCell	PND07-Endothelial-Endothelial_lymphatic\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SCN11A TBC1D4 PPFIBP1 SOX18 TNFRSF11A	1.80e-05	161	89	5	133b4fadb499e842c19f573f9cf09ce08c1d4813
ToppCell	PND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SCN11A TBC1D4 PPFIBP1 SOX18 TNFRSF11A	1.80e-05	161	89	5	9466b8658244116f8d21f2f88fb8c2d184b1bdf2
ToppCell	PND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SCN11A TBC1D4 PPFIBP1 SOX18 TNFRSF11A	1.80e-05	161	89	5	cb177ca10d848d0e25399ab5ebfcde1071fb94c2
ToppCell	CD8+_Memory_T_cell-FLU-5\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	TBC1D4 TNFRSF11A NCR3 TG FOXP3	2.99e-05	179	89	5	7f18dffa85285599662edbcd3f32ab42672bffb8
ToppCell	facs-Lung-nan-3m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	JCAD CDC42BPA LAMA3 ZSCAN25 KCNH4	3.32e-05	183	89	5	12e876d6205af8aad74265c668b5e95b9e7487f3
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CACNA1F PPFIBP1 SOX18 TNFRSF11A ZIC2	3.49e-05	185	89	5	241ea1e178fffef9e7df971de739e794332d5173
ToppCell	metastatic_Lymph_Node-Myeloid_cells-CD207+CD1a+_LCs\|Myeloid_cells / Location, Cell class and cell subclass	TBC1D4 PPFIBP1 ARL6IP5 DCTPP1 RASAL1	4.17e-05	192	89	5	f18da8db573e584c8b90df0814afcf020360108e
ToppCell	metastatic_Brain-Endothelial_cells\|metastatic_Brain / Location, Cell class and cell subclass	JCAD PPFIBP1 DCHS1 SOX18 EXOC3L2	4.83e-05	198	89	5	97ef7946ef11ac93318c1dd46b548dc01e5a6aba
ToppCell	metastatic_Brain-Endothelial_cells-Tumor_ECs\|metastatic_Brain / Location, Cell class and cell subclass	JCAD PPFIBP1 DCHS1 SOX18 EXOC3L2	4.83e-05	198	89	5	5e274f29cc796dae7d64d6035e904816c25f9914
ToppCell	Transverse-(3)_ILC-(30)_ILC\|Transverse / shred on region, Cell_type, and subtype	PHLDA1 SAMD11 PPFIBP1 DNAJB6 NCR3	5.06e-05	200	89	5	528520dc98775aca6cc7568fedf5906ea55e0bea
ToppCell	Transverse-(3)_ILC\|Transverse / shred on region, Cell_type, and subtype	PHLDA1 SAMD11 PPFIBP1 DNAJB6 NCR3	5.06e-05	200	89	5	c1ad7cb012e1c8911e417f7d64ca662c4f5010e0
ToppCell	Transverse-ILC\|Transverse / Region, Cell class and subclass	PHLDA1 SAMD11 PPFIBP1 DNAJB6 NCR3	5.06e-05	200	89	5	eb04d6ad2270d3d9ac3d1fae1bb9bedc6fca38fe
ToppCell	Transverse-ILC-ILC\|Transverse / Region, Cell class and subclass	PHLDA1 SAMD11 PPFIBP1 DNAJB6 NCR3	5.06e-05	200	89	5	60ec185df2f1989bf8febf75b11c46a576829be3
Disease	1,5 anhydroglucitol measurement	PCDHA9 PCDHA7 PCDHA4	7.99e-05	29	85	3	EFO_0008009
Disease	probable ATP-dependent RNA helicase DHX58 measurement	DNAJB6 KCNH4	8.15e-05	5	85	2	EFO_0802901
Disease	Neural Tube Defects	PYY PTK7 ZIC2	8.85e-05	30	85	3	C0027794
Disease	neutrophil count, basophil count	PCDHA9 PCDHA7 PCDHA4 EXOC3L2 ABCA7	4.83e-04	224	85	5	EFO_0004833, EFO_0005090
Disease	Abnormality of refraction	JCAD TCF7L2 PCDHA9 FER1L4 BARHL2 PCDHA7 PCDHA4 TKTL1	7.23e-04	673	85	8	HP_0000539
Disease	reticulocyte count	PIGQ TCF7L2 DNAH17 TMC8 ZBTB40 LAMA3 TMEM131 TKTL1 EXOC3L2 NCR3	8.40e-04	1045	85	10	EFO_0007986
Disease	neutrophil collagenase measurement	NELFE NCR3	9.59e-04	16	85	2	EFO_0008248
Disease	Early infantile epileptic encephalopathy with suppression bursts	PIGQ PNKP	9.59e-04	16	85	2	C0393706
Disease	psoriasis, type 2 diabetes mellitus	TCF7L2 MED30 CCDC88B	1.34e-03	75	85	3	EFO_0000676, MONDO_0005148
Disease	post-traumatic stress disorder symptom measurement	TCF7L2 PCDHA7 PCDHA4	1.73e-03	82	85	3	EFO_0008535
Disease	Mechanical Allodynia	SCN11A MAPK7 GDNF	1.86e-03	84	85	3	C2936719
Disease	Allodynia	SCN11A MAPK7 GDNF	1.86e-03	84	85	3	C0458247
Disease	Hyperalgesia, Secondary	SCN11A MAPK7 GDNF	1.86e-03	84	85	3	C0751212
Disease	Hyperalgesia, Primary	SCN11A MAPK7 GDNF	1.86e-03	84	85	3	C0751211
Disease	Hyperalgesia, Thermal	SCN11A MAPK7 GDNF	1.86e-03	84	85	3	C0751214
Disease	Tactile Allodynia	SCN11A MAPK7 GDNF	1.86e-03	84	85	3	C0751213
Disease	Hyperalgesia	SCN11A MAPK7 GDNF	1.86e-03	84	85	3	C0020429
Disease	total blood protein measurement	KMT2D TCF7L2 SND1 SOX18 TMEM131 EXOC3L2	1.91e-03	449	85	6	EFO_0004536
Disease	Hereditary Paraganglioma-Pheochromocytoma Syndrome	KMT2D GDNF	1.99e-03	23	85	2	C1708353
Disease	visceral adipose tissue measurement, body mass index	PCDHA9 PCDHA7 PCDHA4	2.05e-03	87	85	3	EFO_0004340, EFO_0004765
Disease	mean reticulocyte volume	PIGQ TBC1D4 CHTF18 ZBTB40 RBM6 AP1M2 EXOC3L2 ABCA7	2.14e-03	799	85	8	EFO_0010701
Disease	refractive error	JCAD TCF7L2 RBM45 FER1L4 BARHL2	2.55e-03	326	85	5	MONDO_0004892
Disease	glucose tolerance test	TCF7L2 TBC1D4	2.75e-03	27	85	2	EFO_0004307
Disease	indole-3-propionate measurement	MED30 SND1	2.75e-03	27	85	2	EFO_0010501
Disease	post-traumatic stress disorder	BTN2A2 TCF7L2 PCDHA7 PCDHA4	2.80e-03	202	85	4	EFO_0001358

Protein segments in the cluster

Peptide	Gene	Start	Entry
SEEGALSPPRDRAFF	EXOC3L2	346	Q2M3D2
GRPPRTFEEALARGD	CHTF18	46	Q8WVB6
RFDNDRTISFIPPDG	AP1M2	246	Q9Y6Q5
SESFSPGDTPRQRFR	CCDC88B	1406	A6NC98
DRERASSPPDRIDIF	ARGLU1	71	Q9NWB6
PRLARPTEDDFRRAD	ANKIB1	101	Q9P2G1
GATPARELFRDAAFP	CAPN10	6	Q9HC96
RPGRFDREFLFSLPD	ATAD2	586	Q6PL18
STFFDDAPVFRIPGR	DHX16	561	O60231
SFFSEDAPGDPGRAR	ABCA7	1281	Q8IZY2
FRLLPFPRAEEDSGG	RASAL1	231	O95294
KTFFPDGEDRPVRSR	PYY	76	P10082
TPESVLRERFSPFGD	RBM45	36	Q8IUH3
RPLDSRFPLEGASDA	PCDHA9	146	Q9Y5H5
FFTPSPDGRRSRGEI	KAT6B	441	Q8WYB5
RPLDSRFPLEGASDA	PCDHA7	146	Q9UN72
RLPDSLSFGPSDDDR	CACNA1F	1686	O60840
PPFDFAFDREALTRE	MAPK7	361	Q13164
EAERGPRFPRASSEA	DCHS1	2061	Q96JQ0
GRDLRFGFDPLAFPE	LAMA3	741	Q16787
PEFRGRLAPLASSRF	NCR3	71	O14931
DREGPFRRSDSFPER	NELFE	241	P18615
SGPREAPDSLFAVRR	FOXP3	296	Q9BZS1
SEDRAPAESRPFGTL	PPFIBP1	486	Q86W92
SRDSPDGPTDRFSRE	LRSAM1	231	Q6UWE0
SPLFVGDRDSARRAP	JCAD	1156	Q9P266
RSGPFALEEAEFRQP	FER1L4	1571	A9Z1Z3
PLFRGQEDASPDRFS	CHI3L1	221	P36222
SPADFQRAVDERFPG	PCK2	136	Q16822
STAEAPSFRFSRRPE	KCNH4	836	Q9UQ05
LIRSFSERFPEDGPE	DPP3	696	Q9NY33
APAEDRSLGRRRAPF	GDNF	31	P39905
GPEEARRPASDIRVF	ASIC3	6	Q9UHC3
EFGTEFRAPPRSAAA	FOXD4	81	Q12950
FRAPPRSAAASEDAR	FOXD4	86	Q12950
DDRAGPPRFASEERR	MED30	126	Q96HR3
QSDLAFFRFPRDPAR	THAP12	16	O43422
RPLDSRFPLEGASDA	PCDHA4	146	Q9UN74
FRGAPSLDAFLASPR	GAL3ST2	161	Q9H3Q3
RDPGERFPLSFASAE	GALNS	446	P34059
EDPFEDFFGNRRGPR	DNAJB6	116	O75190
GSVLRDPRFFSNPRD	CYP2A13	396	Q16696
ERFRREAPFSFSDPN	DNAH17	1216	Q9UFH2
DRDGSFPSEPGLRRS	CDC42EP1	176	Q00587
DFRPLGEARTADFRS	BARHL2	31	Q9NY43
RFPLSFGFQRLRSPD	EDEM1	36	Q92611
PPRAATDREGFLAES	ANKS3	401	Q6ZW76
PDEFSDFDRLRTALP	EPN1	401	Q9Y6I3
GTESPRFLDRPDFFD	FIMP	56	Q96LL3
GRFSFSPEPTLEDIR	DCTPP1	21	Q9H773
RPFFRLGSDDSPIFI	BTN2A2	481	Q8WVV5
AGARRAPDPGFQERF	DPP7	21	Q9UHL4
RSERGGPFLFNAREP	PRR14L	406	Q5THK1
APDSRPEENFFSRLD	UPF2	151	Q9HAU5
HAVDFRGRDAPPSDF	RBM6	161	P78332
SLAPGRREFFNLPSE	TDRD6	111	O60522
AFSRATRDPFAPSRV	SCYL1	471	Q96KG9
PGSDRFARPDFRDIS	ARL6IP5	16	O75915
RSEVLFRSDRFDEGP	PIGQ	171	Q9BRB3
FRREADGSETPEPFA	SND1	231	Q7KZF4
REGAAPAAAPSFSER	SAMD11	276	Q96NU1
FELPAFDPRTVSRSG	PNKP	336	Q96T60
SPGRLSPDFAEELRS	SCRIB	1561	Q14160
APARDFDGEDSDSPR	CDC42BPA	1681	Q5VT25
LFDDRSSAIPDFRDP	AGFG1	96	P52594
PSGFPARRNSRLDVF	C12orf56	6	Q8IXR9
EEEPRPDSFLERFRG	CNGA2	86	Q16280
GSPSLTRREFPFEDI	TULP4	576	Q9NRJ4
APASARRFRFPSGAE	TMC8	711	Q8IU68
DARAPPSRQGSVRFD	RNF225	136	M0QZC1
EERLASGFRSRPEPS	SAMD4B	151	Q5PRF9
ARPVPFSERSQEDGR	PHLDA1	46	Q8WV24
DFRTPPGFDRTRNAE	STT3B	731	Q8TCJ2
VDGSRDELFRRSPRP	STX18	31	Q9P2W9
DELFRRSPRPKGDFS	STX18	36	Q9P2W9
FFRRTPESSEREESP	STYXL2	1041	Q5VZP5
RGREDPSPETFRLRF	ZSCAN25	31	Q6NSZ9
RRRLSFEASNPPFDV	TMEM131	1151	Q92545
DSEAERRPPPRSESF	TCF7L2	61	Q9NQB0
SPSSIPRRDDFFRHE	FSBP	206	O95073
FPEEDSDSPQFRRRA	TBC1D4	626	O60343
SRALPLRPDGFRSAE	TOR4A	316	Q9NXH8
PDERNFRPFTSDSLA	SCN11A	11	Q9UI33
PFPAASGSARAFREL	SOX18	186	P35713
RAAGPQPRFTDRETE	nan	126	Q8N1Y9
PLFEPRVFTAGSEER	PTK7	326	Q13308
FPPREAFAEQFLRGS	TG	976	P01266
FARPSRGDLAFRDDS	TDGF1P3	36	P51864
ARAEFPEEARPDRGT	TKTL1	6	P51854
REPGADAFFRAVTTP	ZBTB40	556	Q9NUA8
ARRDSFAGNGPRFPD	TNFRSF11A	576	Q9Y6Q6
PPFNSTRDFLFRSRG	ZIC2	111	O95409
PFLDSRERGGFFSPE	KMT2D	1951	O14686
ATLAPDPLFSRGRDA	LRFN4	206	Q6PJG9
DPLFSRGRDAEASPA	LRFN4	211	Q6PJG9