Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC24A5 SCN11A SLC52A1 CHRNA9 ATP6V0E1 ABCA12 SLC44A2 TMC4 SLC7A7 SLC9C2 KCNH4 SLC46A3 PIEZO2 SLC11A1 ABCB9 ABCB11 KCNN4 KCNQ3 CACNA1G CNGA2 SLC27A4	1.02e-05	1180	123	21	GO:0022857
GeneOntologyMolecularFunction	transporter activity	SLC24A5 SCN11A SLC52A1 CHRNA9 ATP6V0E1 ABCA12 SLC44A2 TMC4 SLC7A7 SLC9C2 KCNH4 SLC46A3 PIEZO2 SLC11A1 ABCB9 NPC1L1 ABCB11 KCNN4 KCNQ3 CACNA1G CNGA2 SLC27A4	1.17e-05	1289	123	22	GO:0005215
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	SLC24A5 SCN11A CHRNA9 SLC9C2 KCNH4 SLC46A3 SLC11A1 KCNN4 KCNQ3 CACNA1G CNGA2	1.44e-04	465	123	11	GO:0046873
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	SLC24A5 SCN11A CHRNA9 ATP6V0E1 SLC9C2 KCNH4 SLC46A3 PIEZO2 SLC11A1 KCNN4 KCNQ3 CACNA1G CNGA2	2.32e-04	664	123	13	GO:0008324
GeneOntologyMolecularFunction	monoatomic cation channel activity	SLC24A5 SCN11A CHRNA9 KCNH4 PIEZO2 KCNN4 KCNQ3 CACNA1G CNGA2	2.77e-04	343	123	9	GO:0005261
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	SLC24A5 SCN11A CHRNA9 ATP6V0E1 TMC4 SLC9C2 KCNH4 SLC46A3 PIEZO2 SLC11A1 KCNN4 KCNQ3 CACNA1G CNGA2	3.79e-04	793	123	14	GO:0015075
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	SLC24A5 SCN11A CHRNA9 ATP6V0E1 SLC9C2 KCNH4 SLC46A3 SLC11A1 KCNN4 KCNQ3 CACNA1G CNGA2	4.98e-04	627	123	12	GO:0022890
GeneOntologyMolecularFunction	monoatomic ion channel activity	SLC24A5 SCN11A CHRNA9 TMC4 KCNH4 PIEZO2 KCNN4 KCNQ3 CACNA1G CNGA2	5.54e-04	459	123	10	GO:0005216
GeneOntologyMolecularFunction	potassium ion transmembrane transporter activity	SLC24A5 SLC9C2 KCNH4 KCNN4 KCNQ3 CNGA2	5.93e-04	167	123	6	GO:0015079
GeneOntologyMolecularFunction	coreceptor activity	IL10RB GPR15 ITGA4 IGSF1	1.02e-03	72	123	4	GO:0015026
GeneOntologyMolecularFunction	gated channel activity	CHRNA9 TMC4 KCNH4 PIEZO2 KCNN4 KCNQ3 CACNA1G CNGA2	1.10e-03	334	123	8	GO:0022836
GeneOntologyCellularComponent	cullin-RING ubiquitin ligase complex	LZTR1 KCTD13 FBXL17 CUL9 FZR1 FBXW8 FBXL16 DAW1 KCTD10	5.30e-06	212	125	9	GO:0031461
GeneOntologyCellularComponent	ubiquitin ligase complex	LZTR1 KCTD13 MARCHF6 FBXL17 CUL9 FZR1 FBXW8 FBXL16 DAW1 KCTD10 USP33	8.85e-06	352	125	11	GO:0000151
GeneOntologyCellularComponent	monoatomic ion channel complex	SCN11A CHRNA9 CNIH2 CNIH3 KCNH4 KCNN4 KCNQ3 CACNA1G CNGA2	4.55e-04	378	125	9	GO:0034702
Domain	RmlC-like_jellyroll	RAPGEF6 RIOX1 SLC9C2 KCNH4 CNGA2	2.10e-05	51	123	5	IPR014710
Domain	cNMP	RAPGEF6 SLC9C2 KCNH4 CNGA2	7.13e-05	34	123	4	SM00100
Domain	cNMP_binding	RAPGEF6 SLC9C2 KCNH4 CNGA2	7.13e-05	34	123	4	PF00027
Domain	cNMP-bd_dom	RAPGEF6 SLC9C2 KCNH4 CNGA2	8.01e-05	35	123	4	IPR000595
Domain	CNMP_BINDING_3	RAPGEF6 SLC9C2 KCNH4 CNGA2	8.01e-05	35	123	4	PS50042
Domain	cNMP-bd-like	RAPGEF6 SLC9C2 KCNH4 CNGA2	1.11e-04	38	123	4	IPR018490
Domain	Cornichon_conserved	CNIH2 CNIH3	1.29e-04	3	123	2	IPR033466
Domain	CORNICHON	CNIH2 CNIH3	1.29e-04	3	123	2	PS01340
Domain	Cornichon	CNIH2 CNIH3	2.56e-04	4	123	2	PF03311
Domain	Cornichon	CNIH2 CNIH3	2.56e-04	4	123	2	IPR003377
Domain	Cornichon	CNIH2 CNIH3	2.56e-04	4	123	2	SM01398
Domain	-	RAPGEF6 SLC9C2 KCNH4 CNGA2	2.79e-04	48	123	4	2.60.120.10
Domain	DUSP	USP20 USP33	6.34e-04	6	123	2	SM00695
Domain	DUSP	USP20 USP33	6.34e-04	6	123	2	PF06337
Domain	-	USP20 USP33	8.84e-04	7	123	2	3.30.2230.10
Domain	DUSP	USP20 USP33	8.84e-04	7	123	2	PS51283
Domain	Pept_C19_DUSP	USP20 USP33	8.84e-04	7	123	2	IPR006615
Domain	Ion_trans_dom	SCN11A KCNH4 KCNQ3 CACNA1G CNGA2	9.46e-04	114	123	5	IPR005821
Domain	Ion_trans	SCN11A KCNH4 KCNQ3 CACNA1G CNGA2	9.46e-04	114	123	5	PF00520
Domain	CNMP_BINDING_1	SLC9C2 KCNH4 CNGA2	1.20e-03	32	123	3	PS00888
Domain	CNMP_BINDING_2	SLC9C2 KCNH4 CNGA2	1.20e-03	32	123	3	PS00889
Domain	FBOX	FBXL17 FBXW8 FBXL16 FBXO41	1.30e-03	72	123	4	PS50181
Domain	F-box_dom	FBXL17 FBXW8 FBXL16 FBXO41	1.52e-03	75	123	4	IPR001810
Domain	WD40	RFWD3 SHKBP1 FZR1 FBXW8 DAW1 TLE3 ELP2	1.65e-03	259	123	7	PF00400
Domain	WD40	RFWD3 SHKBP1 FZR1 FBXW8 DAW1 TLE3 ELP2	2.00e-03	268	123	7	SM00320
Domain	WD40_repeat	RFWD3 SHKBP1 FZR1 FBXW8 DAW1 TLE3 ELP2	2.18e-03	272	123	7	IPR001680
Domain	ZnF_UBP	USP20 USP33	2.28e-03	11	123	2	SM00290
Domain	WD_REPEATS_1	RFWD3 SHKBP1 FZR1 FBXW8 DAW1 TLE3 ELP2	2.46e-03	278	123	7	PS00678
Domain	WD_REPEATS_2	RFWD3 SHKBP1 FZR1 FBXW8 DAW1 TLE3 ELP2	2.51e-03	279	123	7	PS50082
Domain	WD_REPEATS_REGION	RFWD3 SHKBP1 FZR1 FBXW8 DAW1 TLE3 ELP2	2.51e-03	279	123	7	PS50294
Domain	ABC_transporter_CS	ABCA12 ABCB9 ABCB11	2.65e-03	42	123	3	IPR017871
Domain	F-box-like	FBXL17 FBXW8 FBXO41	3.03e-03	44	123	3	PF12937
Domain	WD40_repeat_dom	RFWD3 SHKBP1 FZR1 FBXW8 DAW1 TLE3 ELP2	3.54e-03	297	123	7	IPR017986
Domain	Znf_UBP	USP20 USP33	3.72e-03	14	123	2	IPR001607
Domain	zf-UBP	USP20 USP33	3.72e-03	14	123	2	PF02148
Domain	ZF_UBP	USP20 USP33	3.72e-03	14	123	2	PS50271
Domain	ABC_tran	ABCA12 ABCB9 ABCB11	3.88e-03	48	123	3	PF00005
Domain	ABC_TRANSPORTER_2	ABCA12 ABCB9 ABCB11	3.88e-03	48	123	3	PS50893
Domain	ABC_TRANSPORTER_1	ABCA12 ABCB9 ABCB11	4.12e-03	49	123	3	PS00211
Domain	ABC_transporter-like	ABCA12 ABCB9 ABCB11	4.36e-03	50	123	3	IPR003439
Domain	BTB_2	KCTD13 SHKBP1 KCTD10	5.14e-03	53	123	3	PF02214
Domain	T1-type_BTB	KCTD13 SHKBP1 KCTD10	5.14e-03	53	123	3	IPR003131
Domain	LRR_6	CARMIL2 FBXL17 FBXL16	5.70e-03	55	123	3	PF13516
Domain	Channel_four-helix_dom	SCN11A SLC9C2 CACNA1G	6.30e-03	57	123	3	IPR027359
Domain	-	SCN11A SLC9C2 CACNA1G	6.30e-03	57	123	3	1.20.120.350
Domain	-	RFWD3 SHKBP1 FZR1 FBXW8 DAW1 TLE3 ELP2	6.56e-03	333	123	7	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	RFWD3 SHKBP1 FZR1 FBXW8 DAW1 TLE3 ELP2	6.77e-03	335	123	7	IPR015943
Pubmed	Expression of the NEK family in normal and cancer tissue: an immunohistochemical study.	NEK2 NEK3 NEK5	1.81e-07	4	125	3	31906878
Pubmed	Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases.	KCTD13 SHKBP1 KCTD10	8.99e-07	6	125	3	28963344
Pubmed	Autosomal Recessive Congenital Ichthyosis	ABCA12 ALOXE3 SLC27A4	1.26e-05	13	125	3	20301593
Pubmed	Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans.	NEK2 NEK3	1.28e-05	2	125	2	7522034
Pubmed	Deubiquitinases USP20/33 promote the biogenesis of tail-anchored membrane proteins.	USP20 USP33	1.28e-05	2	125	2	33792613
Pubmed	Tumor-associated antigen Prame targets tumor suppressor p14/ARF for degradation as the receptor protein of CRL2Prame complex.	FBXL17 CUL9 FBXW8 KCTD10	2.74e-05	48	125	4	33504946
Pubmed	Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation.	USP20 USP33	3.84e-05	3	125	2	12865408
Pubmed	Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor.	USP20 USP33	3.84e-05	3	125	2	12056827
Pubmed	Nek5, a novel substrate for caspase-3, promotes skeletal muscle differentiation by up-regulating caspase activity.	NEK2 NEK5	3.84e-05	3	125	2	23727203
Pubmed	Upregulation of cornichon transcripts in the dorsolateral prefrontal cortex in schizophrenia.	CNIH2 CNIH3	3.84e-05	3	125	2	23103966
Pubmed	PNPLA1 defects in patients with autosomal recessive congenital ichthyosis and KO mice sustain PNPLA1 irreplaceable function in epidermal omega-O-acylceramide synthesis and skin permeability barrier.	ABCA12 ALOXE3 SLC27A4	4.21e-05	19	125	3	28369476
Pubmed	Systematic analysis and nomenclature of mammalian F-box proteins.	FBXL17 FBXW8 FBXL16 FBXO41	7.08e-05	61	125	4	15520277
Pubmed	Ubiquitin-specific peptidase 20 targets TRAF6 and human T cell leukemia virus type 1 tax to negatively regulate NF-kappaB signaling.	USP20 USP33	7.65e-05	4	125	2	21525354
Pubmed	Variant mapping and mutation discovery in inbred mice using next-generation sequencing.	PCSK5 ABCA12	7.65e-05	4	125	2	26552429
Pubmed	The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization.	USP20 USP33	7.65e-05	4	125	2	19424180
Pubmed	Discovery and refinement of loci associated with lipid levels.	PDXDC1 CYP26A1 SBNO1 NYNRIN NPC1L1 ABCB11	1.20e-04	211	125	6	24097068
Pubmed	Cullin-3-KCTD10-mediated CEP97 degradation promotes primary cilium formation.	KCTD13 SHKBP1 KCTD10	1.24e-04	27	125	3	30404837
Pubmed	Deficiency of ataxia telangiectasia mutated kinase modulates cardiac remodeling following myocardial infarction: involvement in fibrosis and apoptosis.	TIMP2 ATM	1.27e-04	5	125	2	24358288
Pubmed	Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population.	ABCB9 ABCB11	1.27e-04	5	125	2	11829140
Pubmed	The CRL3BTBD9 E3 ubiquitin ligase complex targets TNFAIP1 for degradation to suppress cancer cell migration.	KCTD13 KCTD10	1.27e-04	5	125	2	32327643
Pubmed	PARC and CUL7 form atypical cullin RING ligase complexes.	CUL9 FBXW8	1.27e-04	5	125	2	17332328
Pubmed	Identification of Myc-associated protein with JmjC domain as a novel therapeutic target oncogene for lung cancer.	RIOX1 SBNO1	1.27e-04	5	125	2	17308053
Pubmed	Degradation of FBXO31 by APC/C is regulated by AKT- and ATM-mediated phosphorylation.	FZR1 ATM	1.27e-04	5	125	2	29343641
Pubmed	NIMA-related kinases: isolation and characterization of murine nek3 and nek4 cDNAs, and chromosomal localization of nek1, nek2 and nek3.	NEK2 NEK3	1.90e-04	6	125	2	10393247
Pubmed	Cornichon proteins determine the subunit composition of synaptic AMPA receptors.	CNIH2 CNIH3	1.90e-04	6	125	2	23522044
Pubmed	The cysteine-rich domain of the secreted proprotein convertases PC5A and PACE4 functions as a cell surface anchor and interacts with tissue inhibitors of metalloproteinases.	PCSK5 TIMP2	1.90e-04	6	125	2	16135528
Pubmed	Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating.	CNIH2 CNIH3	1.90e-04	6	125	2	20805473
Pubmed	USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110.	USP20 USP33	1.90e-04	6	125	2	23486064
Pubmed	A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity.	KCTD13 CUL9 SHKBP1 KCTD10	2.46e-04	84	125	4	34591642
Pubmed	MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound β(2)-adrenergic receptors.	USP20 USP33	2.66e-04	7	125	2	23166351
Pubmed	GPR15-mediated homing controls immune homeostasis in the large intestine mucosa.	GPR15 ITGA4	2.66e-04	7	125	2	23661644
Pubmed	Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes.	USP20 ST6GALNAC4	2.66e-04	7	125	2	10369878
Pubmed	A role for Piezo2 in EPAC1-dependent mechanical allodynia.	SCN11A PIEZO2	2.66e-04	7	125	2	23575686
Pubmed	ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis.	PRDM9 ATM	3.54e-04	8	125	2	32051414
Pubmed	The trafficking protein Tmed2/p24beta(1) is required for morphogenesis of the mouse embryo and placenta.	ITGA4 ABCB9 SBNO1	5.39e-04	44	125	3	20178780
Pubmed	KCTD10 regulates brain development by destabilizing brain disorder-associated protein KCTD13.	KCTD13 KCTD10	5.66e-04	10	125	2	38489388
Pubmed	Exome sequencing identifies breast cancer susceptibility genes and defines the contribution of coding variants to breast cancer risk.	LZTR1 ATM	5.66e-04	10	125	2	37592023
Pubmed	Nek2A destruction marks APC/C activation at the prophase-to-prometaphase transition by spindle-checkpoint-restricted Cdc20.	NEK2 FZR1	5.66e-04	10	125	2	25673878
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	PCSK5 RAPGEF6 DNAJC16 TUT7 RFWD3 LPIN3 ELP2 SLC27A4 USP33	5.89e-04	650	125	9	38777146
Pubmed	Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	SANBR ZNF594 MROH1 MEGF11	6.17e-04	107	125	4	11347906
Pubmed	FBXL17/spastin axis as a novel therapeutic target of hereditary spastic paraplegia.	FBXL17 USP20	6.90e-04	11	125	2	35869491
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DNAJC16 CUL9 MROH1 ACOT11 TLE3 MEGF11 USP33	6.97e-04	407	125	7	12693553
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	SCN11A ADAP1 ZNF789 TAF1B SANBR SLC44A2 NEK2 ABCB9 SACS SBNO1 DKC1 ATM KIAA2012 SLC27A4	6.98e-04	1442	125	14	35575683
Pubmed	The nuclear localization pattern and interaction partners of GTF2IRD1 demonstrate a role in chromatin regulation.	TAF1B USP20 USP33	7.85e-04	50	125	3	26275350
Pubmed	Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1.	NEK2 FZR1	8.26e-04	12	125	2	26387737
Pubmed	Severe Skin Permeability Barrier Dysfunction in Knockout Mice Deficient in a Fatty Acid ω-Hydroxylase Crucial to Acylceramide Production.	ABCA12 ALOXE3	8.26e-04	12	125	2	31356814
Pubmed	Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation.	KCTD13 FBXL17 SHKBP1 KCTD10	9.47e-04	120	125	4	27565346
Pubmed	Novel CUL3 Variant Causing Familial Hyperkalemic Hypertension Impairs Regulation and Function of Ubiquitin Ligase Activity.	LZTR1 KCTD13 KCTD10	1.15e-03	57	125	3	34878901
Pubmed	Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans.	NEK2 NEK3	1.49e-03	16	125	2	8274451
Pubmed	FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.	PDXDC1 UFSP2 DNAJC16 USP20 LPCAT3 SLC27A4 USP33	1.56e-03	468	125	7	31056421
Pubmed	Mapping the interactome of HPV E6 and E7 oncoproteins with the ubiquitin-proteasome system.	KCTD13 SHKBP1 TLE3 USP33	1.59e-03	138	125	4	28786561
Pubmed	Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.	SCN11A KCNN4 KCNQ3 CACNA1G	1.63e-03	139	125	4	16985003
Pubmed	Transcriptional intermediary factor 1γ binds to the anaphase-promoting complex/cyclosome and promotes mitosis.	NEK2 FZR1	1.68e-03	17	125	2	23160376
Pubmed	Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.	LZTR1 CUL9 USP20 MEGF11	1.76e-03	142	125	4	19851296
Pubmed	L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.	IL10RB ADGRG3 SLC11A1 SLC27A4	1.81e-03	143	125	4	20424473
Pubmed	Association of genetic variants with hemorrhagic stroke in Japanese individuals.	LZTR1 CUL9 USP20 MEGF11	1.81e-03	143	125	4	20198315
Pubmed	An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo.	SCN11A VILL	1.89e-03	18	125	2	31666509
Pubmed	M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP.	FBXW8 FBXO41	1.89e-03	18	125	2	15070733
Pubmed	Genome-wide meta-analysis of systolic blood pressure in children with sickle cell disease.	ABCB11 CLEC12B	1.89e-03	18	125	2	24058526
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	RAPGEF6 SANBR PRDM4 SHKBP1 RASGRP1 FZR1 ABCB9 TAMM41 TLE3 DKC1	1.91e-03	925	125	10	28986522
Pubmed	Biological, clinical and population relevance of 95 loci for blood lipids.	CYP26A1 SBNO1 NYNRIN NPC1L1	1.95e-03	146	125	4	20686565
Pubmed	The finished DNA sequence of human chromosome 12.	CFAP54 LPCAT3 MANSC4	2.00e-03	69	125	3	16541075
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	TAF1B TMC4 VILL LPCAT3 CACNA1G USP33	2.05e-03	363	125	6	14691545
Pubmed	Appearance of new tetraspanin genes during vertebrate evolution.	TSPAN12 TSPAN11	2.33e-03	20	125	2	18291621
Pubmed	Engagement of the G3BP2-TRIM25 Interaction by Nucleocapsid Protein Suppresses the Type I Interferon Response in SARS-CoV-2-Infected Cells.	KCNQ3 ATM EPHX4	2.63e-03	76	125	3	36560452
Pubmed	Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database.	ABCA12 ABCB9	2.82e-03	22	125	2	8894702
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	MARCHF6 SANBR FBXO41 CACNA1G IGSF1 CARNS1 ZFP82	3.09e-03	529	125	7	14621295
Cytoband	Ensembl 112 genes in cytogenetic band chr3p22	SCN11A LYZL4 ZNF621 POMGNT2 VILL	1.68e-04	184	127	5	chr3p22
Cytoband	3p22.1	LYZL4 ZNF621 POMGNT2	1.90e-04	40	127	3	3p22.1
Cytoband	2q24	ABCB11 LY75	4.11e-04	11	127	2	2q24
GeneFamily	WD repeat domain containing	RFWD3 SHKBP1 FZR1 FBXW8 DAW1 TLE3 ELP2	3.10e-04	262	89	7	362
GeneFamily	Solute carriers	SLC24A5 SLC52A1 SLC44A2 SLC7A7 SLC9C2 SLC46A3 SLC11A1 SLC27A4	7.31e-04	395	89	8	752
GeneFamily	ATP binding cassette subfamily B	ABCB9 ABCB11	1.28e-03	11	89	2	806
Coexpression	GSE6259_33D1_POS_DC_VS_BCELL_DN	ATP6V0E1 GDPD5 SINHCAF SLC46A3 NCAPG KCTD10 LY75	7.52e-06	150	124	7	M6755
ToppCell	390C-Lymphocytic-CD4_T-cell-Treg_cell_3\|390C / Donor, Lineage, Cell class and subclass (all cells)	TAF1B ITGA4 RASGRP1 NCAPG MROH1 TAMM41 SBNO1 KCNN4	5.70e-08	183	127	8	228092290dbb08785c4eda224e3ad03e99e10fab
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LINC02901 RASGRP1 DAW1 KCNQ3 ZNF518B MEGF11	4.43e-06	149	127	6	7e295b2b82dea0754e98f8cef788e2781e5d641f
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LINC02901 RASGRP1 DAW1 KCNQ3 ZNF518B MEGF11	4.43e-06	149	127	6	b4f77dc5f9d08b249fe5cd9a0acf86308c528ef4
Computational	Neighborhood of SMO	PRDM4 FZR1 POMGNT2 KCTD10 ST6GALNAC4	1.67e-05	60	58	5	GCM_SMO
Disease	Ichthyosis Congenita II	ABCA12 ALOXE3	9.95e-05	4	121	2	C3536797
Disease	Ichthyosis Congenita I	ABCA12 ALOXE3	9.95e-05	4	121	2	C4551630
Disease	Harlequin Fetus	ABCA12 ALOXE3	9.95e-05	4	121	2	C0239849
Disease	autosomal recessive congenital ichthyosis 1 (is_implicated_in)	ABCA12 ALOXE3	9.95e-05	4	121	2	DOID:0060656 (is_implicated_in)
Disease	Collodion Fetus	ABCA12 ALOXE3	9.95e-05	4	121	2	C3543867
Disease	Congenital ichthyosis	ABCA12 ALOXE3	1.65e-04	5	121	2	C0020758
Disease	disease of cellular proliferation (implicated_via_orthology)	FZR1 ATM	3.46e-04	7	121	2	DOID:14566 (implicated_via_orthology)
Disease	vanillylmandelate (VMA) measurement	UGT2B10 CARNS1	3.46e-04	7	121	2	EFO_0800119
Disease	Inflammatory Bowel Diseases	IL10RB ITGA4 SLC11A1	4.00e-04	35	121	3	C0021390
Disease	low density lipoprotein cholesterol measurement, alcohol consumption measurement	PCSK5 CYP26A1 NYNRIN ABCB11	7.50e-04	99	121	4	EFO_0004611, EFO_0007878
Disease	low density lipoprotein cholesterol measurement, alcohol drinking	PCSK5 CYP26A1 NYNRIN ABCB11	8.39e-04	102	121	4	EFO_0004329, EFO_0004611
Disease	Congenital ichthyosis of skin	ABCA12 ALOXE3	8.95e-04	11	121	2	cv:C0020758
Disease	Congenital Nonbullous Ichthyosiform Erythroderma	ABCA12 ALOXE3	8.95e-04	11	121	2	C0079154
Disease	level of Phosphatidylinositol (16:0_18:1) in blood serum	PDXDC1 TMC4	1.07e-03	12	121	2	OBA_2045152
Disease	5alpha-pregnan-3beta,20beta-diol monosulfate (1) measurement	ZNF789 CARNS1	1.26e-03	13	121	2	EFO_0800284
Disease	1-stearoyl-2-dihomo-linolenoyl-GPI (18:0/20:3n3 or 6) measurement	PDXDC1 TMC4	1.47e-03	14	121	2	EFO_0022085
Disease	metabolite measurement	SLC24A5 PDXDC1 ZNF789 PHF23 DNAJC16 CYP26A1 CERS6 UGT2B10	2.21e-03	560	121	8	EFO_0004725
Disease	venous thromboembolism, fibrinogen measurement	RAPGEF6 SLC44A2 SBNO1	2.66e-03	67	121	3	EFO_0004286, EFO_0004623
Disease	primary ciliary dyskinesia (implicated_via_orthology)	PCSK5 DAW1	2.72e-03	19	121	2	DOID:9562 (implicated_via_orthology)
Disease	non-high density lipoprotein cholesterol measurement	PCSK5 CYP26A1 GK5 CNIH3 TAMM41 SBNO1 NYNRIN NPC1L1 ABCB11	2.73e-03	713	121	9	EFO_0005689
Disease	venous thromboembolism	SLC44A2 PIEZO2 ABCB9 SBNO1 TLE3 AGBL1 GSG1L2	2.94e-03	460	121	7	EFO_0004286
Disease	Immunologic Deficiency Syndromes	RASGRP1 ATM	3.99e-03	23	121	2	C0021051

Protein segments in the cluster

Peptide	Gene	Start	Entry
AGFDLNSYRDCLTKW	TPST1	201	O60507
ICCWSFYGQGRKIAE	KCTD13	221	Q8WZ19
ICCWSFYGQGRKIAE	KCTD10	211	Q9H3F6
CCIFYITKILRSWRE	CFAP54	1206	Q96N23
GWLCCLILADSFIYF	ABCA12	1251	Q86UK0
AALSYNLWFRCLSCV	CARMIL2	211	Q6F5E8
VLYLCDTCTTLWAFL	ASCC2	246	Q9H1I8
LCLKICYFVRYWITE	RASGRP1	121	O95267
YVVCASIWFISCLLG	GPR15	151	P49685
KLDGCFSYWDDCLVL	CARNS1	466	A5YM72
FSYWDDCLVLTALLC	CARNS1	471	A5YM72
TGFVWCLIFLCYALA	ABCB11	326	O95342
EYRRGETLCSGFCLW	ACOT11	521	Q8WXI4
SLQGVFICCWFTILY	ADGRG3	511	Q86Y34
SCISFCWIYFAASRL	CHRNA9	6	Q9UGM1
WASYTLGVFICLSCS	ADAP1	31	O75689
LYGCSIKETLWQAAC	AGBL1	911	Q96MI9
AGCAGSVCYRRKDLW	ANTKMT	121	Q9BQD7
RCGHLFGYRCISTWL	RFWD3	306	Q6PCD5
SYCLAWGSFALCLAV	GSG1L2	206	A8MUP6
YQGTCRCKATIYLWK	LPIN3	621	Q9BQK8
YTRCTDILNWFKCTR	MEGF11	51	A6BM72
LAWLSCIGSCYNKYI	PAQR7	181	Q86WK9
CQYSDTLARWLDGCK	LYZL4	131	Q96KX0
LRFDVKDCSWCRAFT	LZTR1	96	Q8N653
GCSWALYLFLVKCTI	KCNN4	51	O15554
KSDIWSLGCLLYELC	NEK2	196	P51955
LLLLCWGSFLCYATR	GPR179	551	Q6PRD1
RSLLFWSLVYCYCGL	EPHX4	16	Q8IUS5
FFRKDSWYCSRICVT	ALOXE3	76	Q9BYJ1
FALRIWAAGCCCRYK	KCNQ3	171	O43525
WACRLRSCEKIGDSY	CARF	206	Q8N187
RLSLLVCEQFWCYSA	LINC02901	176	Q4VX62
ISDYSCWKLIFQECR	FBXW8	171	Q8N3Y1
CELCLESSWVLYDGL	PCSK5	1386	Q92824
TTLWLCRIFRYENGC	PDXDC1	121	Q6P996
TTLWLCRIFRYENGC	PDXDC2P	121	Q6P474
DIWSLGCVLYELCTL	NEK5	186	Q6P3R8
CFITGSYDRTCKLWD	DAW1	106	Q8N136
PYLIKITSDWCFSCI	DNAJC16	161	Q9Y2G8
YRLWCAGYIKDSVLL	KIAA2012	171	Q0VF49
EICFYRKDGSAFWCL	KCNH4	96	Q9UQ05
YLDTCIRCGELTWQK	LANCL3	316	Q6ZV70
ILTFKGYLISCVWNC	LAPTM4B	256	Q86VI4
YLRPFACDTKLEWVC	LY75	776	O60449
LYKYVTCWLVTEGVC	LPCAT3	281	Q6P1A2
YTAACGLYVCWLTIR	MARCHF6	676	O60337
DSLCSPTIFYRDCWI	MANSC4	21	A6NHS7
AYLGLSTYLVWTCCL	SLC11A1	506	P49279
LSCLTGIYGCRWKRY	GDPD5	16	Q8WTR4
DRICRFKWLCYSNEA	POMGNT2	76	Q8NAT1
GRLLTTCLFYFKSSW	MROH1	1566	Q8NDA8
WSLGCILYELCTLKH	NEK3	186	P51956
LIAVLITGFVWYCCA	PTTG1IP2	106	P0DTF9
WGLIVLLCCFCSFLR	PRR7	21	Q8TB68
LYVCRECGRGFSWKS	PRDM9	551	Q9NQV7
DFIDWLTPSSCCRLY	NPC1L1	956	Q9UHC9
IYLGFERSELLCKSW	NPAS4	236	Q8IUM7
LSVGLGTCVYLWSAC	FZR1	201	Q9UM11
KLTYTECLRVCGNWL	ATM	2331	Q13315
LTESNAGLYRCCYWK	IGSF1	96	Q8N6C5
ACCLERDSWSAYIFP	CACNA1G	1246	O43497
RCLSASLVCKYWRDL	FBXL17	341	Q9UF56
SLVCKYWRDLCLDFQ	FBXL17	346	Q9UF56
CFWSYLIVKIACKAV	CERS6	316	Q6ZMG9
LALLGCFALLWCVYK	IL10RB	236	Q08334
LTDRSLWLASCYCRA	FBXO41	671	Q8TF61
WPSVCIDLTLCFSYK	ITGA4	491	P13612
CCFGTIDTWLLYKLT	GK5	191	Q6ZS86
YCCKSCWNEYLTTRI	CUL9	2091	Q8IWT3
LLRGYVESCSNLTWC	CUL9	2146	Q8IWT3
VTFFLLCLCIAYWAS	SLC44A2	366	Q8IWA5
LCLCIAYWASTAVFL	SLC44A2	371	Q8IWA5
KLWDLYCVSGRDRSC	CYP26A1	26	O43174
SCSQDCLIRIWKLYI	ELP2	226	Q6IA86
LTCYWGCSVQKLYEA	CGRRF1	96	Q99675
FWVSCEAGTYIRTLC	DKC1	216	O60832
RVPAWACLLCFTTYS	SPACA6	21	W5XKT8
EWVCFKCYLSTKLAL	SACS	4471	Q9NZJ4
CRTYYVLCGSVLSVW	SBNO1	1301	A3KN83
GCTLYIVWATLYRCA	BVES	76	Q8NE79
TLFTIWCTLCDRAYP	PRDM4	371	Q9UKN5
GLFLDCLCWSTLAYL	NYNRIN	96	Q9P2P1
ILNGLFWYFSACEKC	FBXL16	101	Q8N461
LVTCSVCCYLFWLIA	ATP6V0E1	41	O15342
CSETIARCWYILLSG	RAPGEF6	66	Q8TEU7
SIWLATCLGVLYCLK	TAS2R3	96	Q9NYW6
RLYGCLDRLFVCASW	MMP23B	251	O75900
LYWLSTQKFCRCYCT	TAF1B	511	Q53T94
ALATSVWLCLLCYFA	SLC46A3	111	Q7Z3Q1
CYRLKEASGWQLVFS	SHKBP1	216	Q8TBC3
FSCWVQLCSGYICRK	PDGFRL	141	Q15198
WLTCSRCYQAFLCIE	SANBR	396	Q6NSI8
AWSLYQAGCSLRLLC	RIOX1	286	Q9H6W3
SVLDLWAACLYRSCL	ABCB9	46	Q9NP78
WAACLYRSCLLLGAT	ABCB9	51	Q9NP78
ALYWCALCEYLKSKG	NCAPG	336	Q9BPX3
YISRCSAEIFWICEK	CLEC12B	251	Q2HXU8
VLYNWCLLVARACFS	CNGA2	151	Q16280
CQKESWCKLAFYLLS	CNIH2	131	Q6PI25
CQKEAWCKLAFYLLS	CNIH3	131	Q8TBE1
GCAYRSLQTICSWFK	UFSP2	301	Q9NUQ7
FLDLTYWKRQKICCG	SINHCAF	161	Q9NP50
VFSAVYILLCCWAGL	ST6GALNAC4	16	Q9H4F1
SFWEKDCKIIYLCRN	SULT1E1	116	P49888
SWVLCLCVFSYVKVA	SLC52A1	381	Q9NWF4
ASRFWDDCIKYNCTI	SLC27A4	316	Q6P1M0
AVTYLCWAFAVGLIC	TMC4	251	Q7Z404
ICLLTFINCAYVKWG	SLC7A7	166	Q9UM01
FACIKRSDGSCAWYR	TIMP2	191	P16035
AIAEIWPKYCCFLAC	PIEZO2	1161	Q9H5I5
TLSCWPLFRDCAAYT	SLC24A5	166	Q71RS6
CTVWLAAYGLFTLCE	PIGH	46	Q14442
AILWERKGCLSTYFC	TSPAN11	81	A1L157
LVIFCVELACGVWTY	TSPAN12	101	O95859
SWDLITCYCRKPFAG	PHF23	336	Q9BUL5
CCWKLYCPSEFSETL	TAMM41	381	Q96BW9
LTTFRLWCYACEKEV	USP20	76	Q9Y2K6
SCVLSLKFAYCGKWF	TLE3	701	Q04726
LVTASVCYLWFGKGC	VILL	541	O15195
KECWKAFGCRSLFIV	ZNF621	266	Q6ZSS3
CKECWKAFSRYSQLI	ZFP82	396	Q8N141
IITKCCLFCFWKFAR	UGT2B10	506	P36537
YECKECGKLFIWRTA	ZNF594	516	Q96JF6
KYFTSAWCCLDFIIV	SCN11A	1116	Q9UI33
FGYWCAKIIQCILAD	SLC9C2	231	Q5TAH2
LWKLAGDACTCLYAV	TTC37	716	Q6PGP7
LTTWYCSFKDCCPRG	TOR3A	101	Q9H497
LVIAFRYWAKLCSID	TUT7	436	Q5VYS8
ILTLWNIYACGFSCR	TMEM14EP	81	Q6UXP3
RVWCYACSKEVFLDR	USP33	111	Q8TEY7
GCYVCGKSFAWRSTL	ZNF764	176	Q96H86
YECSECGKVIRRKAW	ZNF789	201	Q5FWF6
SSQCVFKCWFCGRLY	ZNF518B	1031	Q9C0D4