Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ankyrin binding	SPTBN4 SCN5A	1.50e-03	23	50	2	GO:0030506
GeneOntologyMolecularFunction	histone reader activity	MPHOSPH8 ZZEF1	1.92e-03	26	50	2	GO:0140566
GeneOntologyMolecularFunction	actin filament binding	SPTBN4 VILL SPTBN2 ACTN3	2.49e-03	227	50	4	GO:0051015
GeneOntologyBiologicalProcess	biphenyl catabolic process	UGT2B28 UGT2B11	1.53e-04	8	49	2	GO:0070980
GeneOntologyBiologicalProcess	actin filament capping	SPTBN4 VILL SPTBN2	1.78e-04	46	49	3	GO:0051693
GeneOntologyBiologicalProcess	response to denervation involved in regulation of muscle adaptation	SCN5A ACTN3	1.97e-04	9	49	2	GO:0014894
GeneOntologyBiologicalProcess	response to muscle inactivity involved in regulation of muscle adaptation	SCN5A ACTN3	1.97e-04	9	49	2	GO:0014877
GeneOntologyBiologicalProcess	biphenyl metabolic process	UGT2B28 UGT2B11	2.46e-04	10	49	2	GO:0018879
GeneOntologyBiologicalProcess	response to muscle inactivity	SCN5A ACTN3	2.46e-04	10	49	2	GO:0014870
GeneOntologyBiologicalProcess	negative regulation of actin filament depolymerization	SPTBN4 VILL SPTBN2	2.57e-04	52	49	3	GO:0030835
GeneOntologyCellularComponent	spectrin	SPTBN4 SPTBN2	2.00e-04	9	50	2	GO:0008091
Domain	Actinin_actin-bd_CS	SPTBN4 SPTBN2 ACTN3	3.08e-05	23	50	3	IPR001589
Domain	Spectrin	SPTBN4 SPTBN2 ACTN3	3.08e-05	23	50	3	PF00435
Domain	ACTININ_2	SPTBN4 SPTBN2 ACTN3	3.08e-05	23	50	3	PS00020
Domain	ACTININ_1	SPTBN4 SPTBN2 ACTN3	3.08e-05	23	50	3	PS00019
Domain	Spectrin_bsu	SPTBN4 SPTBN2	4.20e-05	4	50	2	IPR016343
Domain	Spectrin_repeat	SPTBN4 SPTBN2 ACTN3	6.28e-05	29	50	3	IPR002017
Domain	Spectrin/alpha-actinin	SPTBN4 SPTBN2 ACTN3	8.48e-05	32	50	3	IPR018159
Domain	SPEC	SPTBN4 SPTBN2 ACTN3	8.48e-05	32	50	3	SM00150
Domain	PH_dom-spectrin-type	SPTBN4 SPTBN2	2.50e-04	9	50	2	IPR001605
Domain	CH	SPTBN4 SPTBN2 ACTN3	7.02e-04	65	50	3	SM00033
Domain	CH	SPTBN4 SPTBN2 ACTN3	8.71e-04	70	50	3	PF00307
Domain	-	SPTBN4 SPTBN2 ACTN3	9.08e-04	71	50	3	1.10.418.10
Domain	CH	SPTBN4 SPTBN2 ACTN3	9.84e-04	73	50	3	PS50021
Domain	CH-domain	SPTBN4 SPTBN2 ACTN3	1.06e-03	75	50	3	IPR001715
Domain	UDPGT	UGT2B28 UGT2B11	1.43e-03	21	50	2	PF00201
Domain	UDPGT	UGT2B28 UGT2B11	1.43e-03	21	50	2	PS00375
Domain	UDP_glucos_trans	UGT2B28 UGT2B11	1.43e-03	21	50	2	IPR002213
Domain	Ubiquitin-rel_dom	ISG15 RAPGEF5 PIK3CD RASSF7	1.47e-03	184	50	4	IPR029071
Domain	P_typ_ATPase	ATP2C1 ATP9B	4.18e-03	36	50	2	IPR001757
Domain	ATPase_P-typ_P_site	ATP2C1 ATP9B	4.18e-03	36	50	2	IPR018303
Domain	ATPASE_E1_E2	ATP2C1 ATP9B	4.18e-03	36	50	2	PS00154
Domain	ATPase_P-typ_transduc_dom_A	ATP2C1 ATP9B	4.41e-03	37	50	2	IPR008250
Domain	E1-E2_ATPase	ATP2C1 ATP9B	4.41e-03	37	50	2	PF00122
Domain	Glycoside_hydrolase_SF	MGAM CHI3L2	8.87e-03	53	50	2	IPR017853
Pathway	REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS	SPTBN4 SPTBN2 SCN5A	7.71e-05	31	38	3	M877
Pathway	REACTOME_COPI_MEDIATED_ANTEROGRADE_TRANSPORT	SPTBN4 GBF1 COG1 SPTBN2	1.58e-04	102	38	4	M27648
Pathway	REACTOME_COPI_MEDIATED_ANTEROGRADE_TRANSPORT	SPTBN4 GBF1 COG1 SPTBN2	2.11e-04	110	38	4	MM15350
Pathway	REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS	SPTBN4 SPTBN2	3.14e-04	10	38	2	MM15112
Pathway	KEGG_STARCH_AND_SUCROSE_METABOLISM	MGAM UGT2B28 UGT2B11	3.65e-04	52	38	3	M14171
Pubmed	Quantitative analysis of UGT2B28 mRNA expression by real-time RT-PCR and application to human tissue distribution study.	UGT2B28 UGT2B11	2.03e-06	2	50	2	21679149
Pubmed	Voltage-Gated Sodium Channel Phosphorylation at Ser571 Regulates Late Current, Arrhythmia, and Cardiac Function In Vivo.	SPTBN4 SCN5A	1.21e-05	4	50	2	26187182
Pubmed	Cell membrane expression of cardiac sodium channel Na(v)1.5 is modulated by alpha-actinin-2 interaction.	SCN5A ACTN3	2.02e-05	5	50	2	19943616
Pubmed	In vivo assembly of the axon initial segment in motor neurons.	SPTBN4 SPTBN2	3.03e-05	6	50	2	23728480
Pubmed	A β(IV)-spectrin/CaMKII signaling complex is essential for membrane excitability in mice.	SPTBN4 SCN5A	3.03e-05	6	50	2	20877009
Pubmed	Spectrins and ankyrinB constitute a specialized paranodal cytoskeleton.	SPTBN4 SPTBN2	3.03e-05	6	50	2	16687515
Pubmed	Weak activity of UDP-glucuronosyltransferase toward Bisphenol analogs in mouse perinatal development.	UGT2B28 UGT2B11	4.23e-05	7	50	2	26074487
Pubmed	Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT.	UGT2B28 UGT2B11	5.64e-05	8	50	2	32093886
Pubmed	Brain proteins interacting with the tetramerization region of non-erythroid alpha spectrin.	SPTBN4 SPTBN2	1.10e-04	11	50	2	17607528
Pubmed	alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells.	SPTBN4 SPTBN2	1.56e-04	13	50	2	18796539
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FOCAD GBF1 SUGP2 PIK3CD SCN5A HUWE1 ZZEF1 RASSF7	1.66e-04	1105	50	8	35748872
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	GBF1 NUP107 SUGP2 HUWE1 CHI3L2 QARS1 HELLS	2.14e-04	857	50	7	25609649
Pubmed	Characterization of 16 novel human genes showing high similarity to yeast sequences.	ATP2C1 ATP9B	2.72e-04	17	50	2	11124703
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	GBF1 NUP107 SUGP2 HUWE1 QARS1 HELLS	2.98e-04	638	50	6	33239621
Pubmed	USP53 plays an antitumor role in hepatocellular carcinoma through deubiquitination of cytochrome c.	SUGP2 SPTBN2 HELLS	3.01e-04	90	50	3	35654790
Pubmed	Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease.	SPTBN4 SPTBN2	3.05e-04	18	50	2	12119179
Pubmed	An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo.	VILL SCN5A	3.05e-04	18	50	2	31666509
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	GBF1 NUP107 UFD1 HUWE1 QARS1 ZZEF1	3.48e-04	657	50	6	36180527
Pubmed	Ubiquitination regulates ER-phagy and remodelling of endoplasmic reticulum.	ARL6IP1 HUWE1	4.59e-04	22	50	2	37225996
Pubmed	DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.	SPTBN4 RASSF7	4.59e-04	22	50	2	12812986
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	SUGP2 SPTBN2 HUWE1	4.60e-04	104	50	3	9205841
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	DRG2 NUP107 SUGP2 KIF21A SPTBN2	7.35e-04	498	50	5	36634849
Pubmed	VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.	GBF1 NUP107 HUWE1 HELLS	7.86e-04	288	50	4	23383273
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	SPTBN4 SPTBN2 CARNS1	8.80e-04	130	50	3	12421765
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	GBF1 DRG2 KIF21A UFD1 HUWE1 QARS1 ZZEF1 DDB2	1.03e-03	1455	50	8	22863883
Pubmed	Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation.	SUGP2 HUWE1	1.24e-03	36	50	2	35379950
Pubmed	Downregulation of HERC5 E3 ligase attenuates the ubiquitination of CtBP1 to inhibit apoptosis in colorectal cancer cells.	UFD1 DDB2	1.31e-03	37	50	2	34147029
Pubmed	Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3 of Structural, Metabolic, and Contractile Related Genes.	SCN5A MLYCD	1.38e-03	38	50	2	38196272
Pubmed	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.	ATP2C1 COG1 CARNS1	1.41e-03	153	50	3	10718198
Cytoband	4q13.2	UGT2B28 UGT2B11	5.30e-04	31	50	2	4q13.2
Cytoband	7q22	FBXO24 MUC3A	7.97e-04	38	50	2	7q22
GeneFamily	EF-hand domain containing\|Spectrins	SPTBN4 SPTBN2	5.56e-05	7	30	2	1113
GeneFamily	UDP glucuronosyltransferases	UGT2B28 UGT2B11	1.28e-03	32	30	2	363
ToppCell	droplet-Lung-nan-18m-Lymphocytic-plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAPGEF5 PAPOLB KCNN4 DNASE1	3.36e-05	163	50	4	5efecdd8a069a822bc9d35b407092925a865e629
ToppCell	droplet-Lung-nan-18m-Lymphocytic-Plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAPGEF5 PAPOLB KCNN4 DNASE1	3.36e-05	163	50	4	0d94a427f86e62aba12c397c6d7b8cd297f3a0e5
ToppCell	356C-Fibroblasts-Fibroblast-D-\|356C / Donor, Lineage, Cell class and subclass (all cells)	FBXO24 SWT1 BHMT2 MSMP	3.61e-05	166	50	4	7c2eee0a4f45795a956acf936b85bdb35f1b1624
ToppCell	356C-Fibroblasts-Fibroblast-D\|356C / Donor, Lineage, Cell class and subclass (all cells)	FBXO24 SWT1 BHMT2 MSMP	3.61e-05	166	50	4	7286a37b2827f3747469ffd0d76cbe81116db7ee
ToppCell	droplet-Kidney-nan-18m-Epithelial-Epcam____proximal_tube_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GALNS VILL BHMT2 DNASE1	3.61e-05	166	50	4	8ab18c9d911eb3a9970bba7a769294b0927538f7
ToppCell	droplet-Kidney-nan-3m-Epithelial-epithelial_cell_of_proximal_tubule\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GALNS VILL BHMT2 DNASE1	4.05e-05	171	50	4	05fcc72df50a380a913821b5781d9621df37d328
ToppCell	droplet-Kidney-nan-3m-Epithelial-Epcam____proximal_tube_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GALNS VILL BHMT2 DNASE1	4.05e-05	171	50	4	48fc4eca18b102b5ec5050f758281292ee8e10c6
ToppCell	AT1-AT2_cells-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	SCN5A CAPN6 PTCHD4 MUC3A	4.94e-05	180	50	4	3c7b2033821f9e34e2924bd8655f566edcbcc7d3
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B0\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	ATP2C1 NUP107 ZZEF1 DDB2	5.73e-05	187	50	4	816d37a70f7ec382a268fe828b3dfe737a36a4bf
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TMEM144 PIK3CD FPR3 ACTN3	6.22e-05	191	50	4	51f5af610983aa73b9f4ece6f27d281ebff89a04
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TMEM144 PIK3CD FPR3 ACTN3	6.22e-05	191	50	4	8fd6bdc9d2b1c8d364221d7bc68d03921b668ab5
ToppCell	TCGA-Thryoid-Primary_Tumor\|TCGA-Thryoid / Sample_Type by Project: Shred V9	RAPGEF5 SPTBN2 PTCHD4 DDB2	6.74e-05	195	50	4	7cdee2ae90edf15e4cbcf70797b8caf1f037b0ef
ToppCell	TCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma\|TCGA-Thryoid / Sample_Type by Project: Shred V9	RAPGEF5 SPTBN2 PTCHD4 DDB2	6.74e-05	195	50	4	b61b8c931bd0ca3678486653ae1d7e9915c696c7
ToppCell	Enterocyte\|World / shred on cell type and cluster	MGAM ISG15 MUC3A DNASE1	7.01e-05	197	50	4	1dd980fd066aef21694395a4b69df938501d9631
ToppCell	C_01\|World / shred on cell type and cluster	MGAM ISG15 MUC3A DNASE1	7.15e-05	198	50	4	71d38084d09a96331877384ce6346f0de4bdcef9
ToppCell	Biopsy_Other_PF-Epithelial-KRT5-/KRT17+\|Biopsy_Other_PF / Sample group, Lineage and Cell type	SPTBN2 CAPN6 PTCHD4 MUC3A	7.44e-05	200	50	4	077e6b9340686de9d0f11b035a8954e1f6a1b790
ToppCell	Skin-Keratinocytes\|Skin / Skin and Kidney Cells in Lupus Nephritis Patients.	ARL6IP1 SPTBN2 HUWE1 QARS1	7.44e-05	200	50	4	59d72395199bc30df0e811fbc99149694e208860
Disease	spinocerebellar ataxia type 5 (implicated_via_orthology)	SPTBN4 SPTBN2	1.62e-05	4	49	2	DOID:0050882 (implicated_via_orthology)
Disease	5alpha-pregnan-3beta,20beta-diol monosulfate (1) measurement	MEMO1 CARNS1	2.08e-04	13	49	2	EFO_0800284
Disease	phosphatidylcholine 36:4 measurement	UGT2B28 UGT2B11	4.06e-04	18	49	2	EFO_0010382
Disease	progression free survival, ovarian serous carcinoma	MGAM PTCHD4	6.11e-04	22	49	2	EFO_0004920, EFO_1001516
Disease	hearing threshold measurement	DRG2 SUGP2	9.93e-04	28	49	2	EFO_0007618
Disease	frontotemporal dementia	ATP9B ACTN3	1.30e-03	32	49	2	MONDO_0017276

Protein segments in the cluster

Peptide	Gene	Start	Entry
GLVEMALDMLQFIWE	CFAP46	1876	Q8IYW2
IGLGWGNAMLLMEFV	CARNS1	591	A5YM72
EQLQGWGEVMLMADK	ARL6IP1	21	Q15041
NLNLGGAMIWSIDMD	CHI3L2	351	Q15782
MENWGLMIFDESGLL	LVRN	381	Q6Q4G3
MLVGWLLGKDILEMF	ATP2C1	281	P98194
MLLGLAAMELKVWVD	RASSF7	1	Q02833
KMYNVLLFVDGGWMV	NUP107	816	P57740
MEEFRTMWVIGLGLK	PAPOLB	431	Q9NRJ5
MLWENGINGILADEM	HELLS	236	Q9NRZ9
GIGLMVLHAEMLWFG	KCNN4	36	O15554
TLMFWKGIADVGLME	GMEB1	256	Q9Y692
TLEMLRNAGIKIWML	ATP9B	751	O43861
AWDQLKKSIIGMMEF	MGAM	2426	O43451
MGWDLTVKMLAGNEF	ISG15	1	P05161
GILMAVWLKEMLLNG	FPR3	261	P25089
REMNGVLKGMLSEWF	MLYCD	176	O95822
MEWLLEDLLGAKGDM	C9orf131	1	Q5VYM1
MQLLGLLGLLWMLKA	MUC3A	1	Q02505
ILLNMDGKELWNLRM	DDB2	226	Q92466
GEFLDAWLMLVEKMV	HUWE1	1196	Q7Z6Z7
PNILLLLMDDMGWGD	GALNS	31	P34059
LKTMELMKEGLEWAG	BHMT2	216	Q9H2M3
MKGLAGIRDAMWELL	COG1	376	Q8WTW3
VQEKWGLEDVMLMGD	DNASE1	176	P24855
EIVGWMPLMAAQKDF	FBXO24	541	O75426
DILREGWKNIMEAML	GBF1	1021	Q92538
GWKNIMEAMLQLFRA	GBF1	1026	Q92538
KNLGLVMSDDGEFWM	CAPN6	311	Q9Y6Q1
GVLKRMEWLLELMGY	FOCAD	1636	Q5VW36
ILSLGMDLQLEWMKL	MPHOSPH8	531	Q99549
GELWKTGMFERMSLQ	MEMO1	111	Q9Y316
MGLLMGEARAVLKWA	QARS1	146	P47897
ELGVLGLMTLWNVDM	PTCHD4	696	Q6ZW05
ALLQVATFKGWMDIM	SCN5A	1411	Q14524
ILGMNTWDLALELMN	RAPGEF5	341	Q92565
GMKLNLDYLLEMLWE	DRG2	271	P55039
ILETEMKIAFGNLWM	SWT1	596	Q5T5J6
DGNLKMTLGMIWTII	ACTN3	131	Q08043
MALRMLWAGQAKGIL	MSMP	1	Q1L6U9
WMEEMKGRLQSQDLG	SPTBN2	546	O15020
AAMWGIFMFKEIKGL	TMEM144	306	Q7Z5S9
GILKVWNMDTFMPVG	KIF21A	1606	Q7Z4S6
FQMLQKMGWKEGHGL	SUGP2	1016	Q8IX01
LMDVLWKQEGLDLRM	PIK3CD	796	O00329
WLGEQELLMMSEDKG	SPTBN4	1636	Q9H254
LFETMGKADIWLMRN	UGT2B11	246	O75310
GDIFLLDLGKMMIQW	VILL	161	O15195
HWMMQNLLLEEGGLV	UFD1	96	Q92890
SLADGIRIWMLEMKQ	ZZEF1	1376	O43149
LFETMGKADIWLMRN	UGT2B28	246	Q9BY64
WSLGIILLEMFSGMK	UHMK1	226	Q8TAS1