Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionolfactory receptor activity

OR8A1 OR2B11 OR7D4 OR7A5 OR1B1 OR10A4 OR7C1 OR11H7 OR7D2 OR10Q1 OR2C3 OR1F12P OR1F2P OR1C1 OR4B1 OR7A17 OR2T4 OR7A10 OR2W6P

1.40e-164316719GO:0004984
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

OR8A1 MST1R OR2B11 OR7D4 ERBB2 ERBB4 OR7A5 OR1B1 OR10A4 OR7C1 GPR33 OR11H7 OR7D2 OR10Q1 OR2C3 OR1F12P OR1F2P OR1C1 OR4B1 OR7A17 OR2T4 OR7A10 PALLD OR2W6P

4.12e-1213536724GO:0004888
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR8A1 OR2B11 OR7D4 OR7A5 OR1B1 OR10A4 OR7C1 GPR33 OR11H7 OR7D2 OR10Q1 OR2C3 OR1F12P OR1F2P OR1C1 OR4B1 OR7A17 OR2T4 OR7A10 OR2W6P

5.46e-128846720GO:0004930
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of smell

OR8A1 OR2B11 OR7D4 OR7A5 OR1B1 OR10A4 OR7C1 OR11H7 OR7D2 OR10Q1 OR2C3 OR1F12P OR1F2P OR1C1 OR4B1 OR7A17 OR2T4 OR7A10 OR2W6P

5.96e-174326619GO:0050911
GeneOntologyBiologicalProcesssensory perception of smell

OR8A1 OR2B11 OR7D4 OR7A5 OR1B1 OR10A4 OR7C1 OR11H7 OR7D2 OR10Q1 OR2C3 OR1F12P OR1F2P OR1C1 OR4B1 OR7A17 OR2T4 OR7A10 OR2W6P

2.31e-164656619GO:0007608
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception

OR8A1 OR2B11 OR7D4 OR7A5 OR1B1 OR10A4 OR7C1 OR11H7 OR7D2 OR10Q1 OR2C3 OR1F12P OR1F2P OR1C1 OR4B1 OR7A17 OR2T4 OR7A10 OR2W6P

5.00e-164856619GO:0050907
GeneOntologyBiologicalProcessdetection of chemical stimulus

OR8A1 OR2B11 OR7D4 OR7A5 OR1B1 OR10A4 OR7C1 OR11H7 OR7D2 OR10Q1 OR2C3 OR1F12P OR1F2P OR1C1 OR4B1 OR7A17 OR2T4 OR7A10 OR2W6P

2.05e-155246619GO:0009593
GeneOntologyBiologicalProcesssensory perception of chemical stimulus

OR8A1 OR2B11 OR7D4 OR7A5 OR1B1 OR10A4 OR7C1 OR11H7 OR7D2 OR10Q1 OR2C3 OR1F12P OR1F2P OR1C1 OR4B1 OR7A17 OR2T4 OR7A10 OR2W6P

4.46e-155476619GO:0007606
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

OR8A1 OR2B11 OR7D4 OR7A5 OR1B1 OR10A4 OR7C1 OR11H7 OR7D2 OR10Q1 OR2C3 OR1F12P OR1F2P OR1C1 OR4B1 OR7A17 OR2T4 OR7A10 OR2W6P

1.37e-145826619GO:0050906
GeneOntologyBiologicalProcessdetection of stimulus

OR8A1 OR2B11 OR7D4 OR7A5 OR1B1 OR10A4 OR7C1 OR11H7 OR7D2 OR10Q1 OR2C3 OR1F12P OR1F2P OR1C1 OR4B1 OR7A17 OR2T4 OR7A10 OR2W6P

6.37e-137226619GO:0051606
GeneOntologyBiologicalProcesssensory perception

OR8A1 OR2B11 OR7D4 OR7A5 OR1B1 OR10A4 OR7C1 OR11H7 OR7D2 OR10Q1 OR2C3 OR1F12P OR1F2P OR1C1 OR4B1 OR7A17 OR2T4 OR7A10 OR2W6P

5.73e-1010726619GO:0007600
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

OR8A1 OR2B11 OR7D4 OR7A5 OR1B1 OR10A4 OR7C1 GPR33 OR11H7 OR7D2 OR10Q1 RAPGEF4 OR2C3 OR1F12P OR1F2P OR1C1 OR4B1 OR7A17 OR2T4 OR7A10 OR2W6P

1.10e-0913956621GO:0007186
GeneOntologyBiologicalProcessERBB2-ERBB4 signaling pathway

ERBB2 ERBB4

1.00e-045662GO:0038135
GeneOntologyBiologicalProcessregulation of cilium movement

RNASE9 CFAP206 DNAH11

5.19e-0449663GO:0003352
GeneOntologyBiologicalProcessneurotransmitter receptor localization to postsynaptic specialization membrane

ERBB2 ERBB4 RAPGEF4

5.19e-0449663GO:0099645
GeneOntologyBiologicalProcessprotein localization to postsynaptic specialization membrane

ERBB2 ERBB4 RAPGEF4

5.19e-0449663GO:0099633
GeneOntologyBiologicalProcessERBB4 signaling pathway

ERBB2 ERBB4

5.44e-0411662GO:0038130
MousePhenoabnormal sensory neuron innervation pattern

OR8A1 ERBB2 ERBB4 OR10A4

7.87e-0592354MP:0000968
MousePhenoabnormal motor neuron innervation pattern

ERBB2 ERBB4 CHN1

1.05e-0437353MP:0000940
MousePhenoabnormal innervation

OR8A1 ERBB2 ERBB4 OR10A4 CHN1

1.10e-04193355MP:0002184
MousePhenoabnormal nervous system development

OR8A1 DNAI1 STK36 ERBB2 ERBB4 OR10A4 CFAP206 BTAF1 CHN1 PALLD ITGB8

1.63e-0412573511MP:0003861
MousePhenoabdominal situs inversus

DNAI1 DNAH11

2.17e-049352MP:0011249
DomainOlfact_rcpt

OR8A1 OR2B11 OR7D4 OR7A5 OR1B1 OR10A4 OR7C1 OR7D2 OR10Q1 OR2C3 OR1F12P OR1F2P OR1C1 OR4B1 OR7A17 OR2T4 OR7A10

1.23e-143936417IPR000725
Domain7tm_1

OR8A1 OR2B11 OR7D4 OR7A5 OR1B1 OR10A4 OR7C1 GPR33 OR7D2 OR10Q1 OR2C3 OR1F12P OR1F2P OR1C1 OR4B1 OR7A17 OR2T4 OR7A10

7.06e-126776418PF00001
DomainG_PROTEIN_RECEP_F1_1

OR8A1 OR2B11 OR7D4 OR7A5 OR1B1 OR10A4 OR7C1 GPR33 OR7D2 OR10Q1 OR2C3 OR1F12P OR1F2P OR1C1 OR4B1 OR7A17 OR2T4 OR7A10

8.58e-126856418PS00237
DomainG_PROTEIN_RECEP_F1_2

OR8A1 OR2B11 OR7D4 OR7A5 OR1B1 OR10A4 OR7C1 GPR33 OR7D2 OR10Q1 OR2C3 OR1F12P OR1F2P OR1C1 OR4B1 OR7A17 OR2T4 OR7A10

9.92e-126916418PS50262
DomainGPCR_Rhodpsn

OR8A1 OR2B11 OR7D4 OR7A5 OR1B1 OR10A4 OR7C1 GPR33 OR7D2 OR10Q1 OR2C3 OR1F12P OR1F2P OR1C1 OR4B1 OR7A17 OR2T4 OR7A10

1.02e-116926418IPR000276
DomainGPCR_Rhodpsn_7TM

OR8A1 OR2B11 OR7D4 OR7A5 OR1B1 OR10A4 OR7C1 GPR33 OR7D2 OR10Q1 OR2C3 OR1C1 OR4B1 OR7A17 OR2T4 OR7A10

6.19e-106706416IPR017452
DomainTyr_kinase_EGF/ERB/XmrK_rcpt

ERBB2 ERBB4

6.90e-054642IPR016245
DomainGF_recep_IV

ERBB2 ERBB4

1.72e-046642PF14843
DomainGF_recep_IV

ERBB2 ERBB4

1.72e-046642IPR032778
DomainFurin-like

ERBB2 ERBB4

2.40e-047642PF00757
DomainRcpt_L-dom

ERBB2 ERBB4

2.40e-047642IPR000494
DomainFurin-like_Cys-rich_dom

ERBB2 ERBB4

2.40e-047642IPR006211
DomainRecep_L_domain

ERBB2 ERBB4

2.40e-047642PF01030
Domain-

ERBB2 ERBB4

2.40e-0476423.80.20.20
DomainFurin_repeat

ERBB2 ERBB4

1.71e-0318642IPR006212
DomainFU

ERBB2 ERBB4

1.71e-0318642SM00261
DomainTyrKc

MST1R ERBB2 ERBB4

3.42e-0388643SM00219
DomainTyr_kinase_cat_dom

MST1R ERBB2 ERBB4

3.42e-0388643IPR020635
DomainPROTEIN_KINASE_TYR

MST1R ERBB2 ERBB4

4.50e-0397643PS00109
DomainTyr_kinase_AS

MST1R ERBB2 ERBB4

4.50e-0397643IPR008266
DomainGlyco_hydro_catalytic_dom

GBE1 HECA

7.51e-0338642IPR013781
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR8A1 OR2B11 OR7D4 OR7A5 OR1B1 OR10A4 OR7C1 OR11H7 OR7D2 OR10Q1 OR2C3 OR1F12P OR1C1 OR4B1 OR7A17 OR2T4 OR7A10

6.25e-144175217M4072
PathwayKEGG_OLFACTORY_TRANSDUCTION

OR8A1 OR2B11 OR7D4 OR7A5 OR1B1 OR10A4 OR7C1 OR7D2 OR10Q1 OR2C3 OR1C1 OR4B1 OR7A17 OR2T4 OR7A10

5.54e-123895215M14091
PathwayREACTOME_SENSORY_PERCEPTION

OR8A1 OR2B11 OR7D4 OR7A5 OR1B1 OR10A4 OR7C1 OR11H7 OR7D2 OR10Q1 OR2C3 OR1F12P OR1C1 OR4B1 OR7A17 OR2T4 OR7A10

5.39e-116365217M41834
PathwayWP_GPCRS_ODORANT

OR8A1 OR7D4 OR7A5 GPR33 OR4B1 OR7A17 OR7A10

1.63e-06157527MM15872
PathwayWP_GPCRS_OTHER

OR7A5 OR1F2P OR4B1 OR7A17 OR7A10

2.66e-0596525MM15939
PathwayWP_GPCRS_CLASS_A_RHODOPSINLIKE

OR8A1 OR7A5 OR10A4 GPR33 OR7A17 OR7A10

5.99e-05186526MM15994
PathwayWP_GPCRS_CLASS_A_RHODOPSINLIKE

OR7A5 OR10A4 OR7C1 OR1C1 OR7A17 OR7A10

3.72e-04260526M39397
PathwayREACTOME_ERBB2_ACTIVATES_PTK6_SIGNALING

ERBB2 ERBB4

7.19e-0411522MM15478
PathwayREACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING

ERBB2 ERBB4

7.19e-0411522MM14760
PathwayREACTOME_ERBB2_ACTIVATES_PTK6_SIGNALING

ERBB2 ERBB4

1.01e-0313522M27729
PathwayREACTOME_ERBB2_REGULATES_CELL_MOTILITY

ERBB2 ERBB4

1.01e-0313522MM15320
PathwayKEGG_MEDICUS_REFERENCE_RTK_PLCG_ITPR_SIGNALING_PATHWAY

MST1R ERBB2 ERBB4

1.08e-0355523M47952
PathwayREACTOME_PI3K_EVENTS_IN_ERBB2_SIGNALING

ERBB2 ERBB4

1.18e-0314522MM14761
PathwayREACTOME_SHC1_EVENTS_IN_ERBB2_SIGNALING

ERBB2 ERBB4

1.18e-0314522MM14531
PathwayPID_ERBB_NETWORK_PATHWAY

ERBB2 ERBB4

1.36e-0315522M201
PathwayREACTOME_ERBB2_REGULATES_CELL_MOTILITY

ERBB2 ERBB4

1.36e-0315522M27608
PathwayREACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING

ERBB2 ERBB4

1.55e-0316522M562
PathwayREACTOME_PI3K_EVENTS_IN_ERBB2_SIGNALING

ERBB2 ERBB4

1.55e-0316522M570
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR2B11 OR7D4 OR2T4

2.18e-0370523MM14984
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR8A1 OR2B11 OR7D4 OR7A5 OR1B1 OR10A4 OR7C1 OR11H7 OR10Q1 OR1F12P OR1F2P OR4B1 OR7A17 OR2T4 OR7A10 OR2W6P

3.50e-18340671611875048
Pubmed

The olfactory receptor gene superfamily of the mouse.

OR8A1 OR2B11 OR7D4 OR7A5 OR1B1 OR10A4 OR7C1 OR11H7 OR10Q1 OR1F12P OR1F2P OR4B1 OR7A17 OR2T4 OR7A10 OR2W6P

3.50e-18340671611802173
Pubmed

A unified nomenclature for vertebrate olfactory receptors.

OR8A1 OR2B11 OR7D4 OR7A5 OR1B1 OR10A4 OR7C1 OR11H7 OR10Q1 OR1F12P OR1F2P OR4B1 OR7A17 OR2T4 OR7A10 OR2W6P

4.02e-18343671632295537
Pubmed

Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.

OR8A1 OR2B11 OR7D4 OR7A5 OR1B1 OR10A4 OR7C1 OR11H7 OR10Q1 OR1F12P OR1F2P OR4B1 OR7A17 OR2T4 OR7A10 OR2W6P

4.62e-18346671614611657
Pubmed

The human olfactory receptor gene family.

OR8A1 OR7D4 OR7A5 OR1B1 OR10A4 OR7C1 OR11H7 OR7D2 OR10Q1 OR2C3 OR1F12P OR1F2P OR1C1 OR4B1 OR7A17 OR2T4 OR7A10 OR2W6P

9.95e-18541671814983052
Pubmed

DEFOG: a practical scheme for deciphering families of genes.

OR8A1 OR7D4 OR7A5 OR10A4 OR7C1 OR11H7 OR7D2 OR2C3 OR1F2P OR1C1 OR4B1 OR7A17 OR7A10

3.21e-16219671312213199
Pubmed

Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species.

OR7A5 OR7C1 OR1C1 OR4B1 OR7A17 OR7A10

5.32e-12246769119360
Pubmed

Chromosomal location-dependent nonstochastic onset of odor receptor expression.

OR7D4 OR7A5 OR10A4 OR7A17 OR7A10

1.38e-101767520668191
Pubmed

Visualizing an olfactory sensory map.

OR7A5 OR10A4 OR7A17 OR7A10

1.88e-1066748929536
Pubmed

The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates.

OR7A5 OR7C1 OR1F2P OR7A17 OR7A10

7.46e-102367510706615
Pubmed

Evolution of odorant receptors expressed in mammalian testes.

OR7A5 OR4B1 OR7A17 OR7A10

8.87e-091367411014824
Pubmed

Expression of members of the putative olfactory receptor gene family in mammalian germ cells.

OR7A5 OR7D2 OR1F2P OR7A17

1.54e-07256741370859
Pubmed

Odorant and vomeronasal receptor genes in two mouse genome assemblies.

OR7C1 OR4B1 OR7A17 OR2T4 OR7A10

3.31e-077467515081110
Pubmed

Differential impact of Lhx2 deficiency on expression of class I and class II odorant receptor genes in mouse.

OR8A1 OR10A4 OR7A17 OR7A10

4.93e-073367417350283
Pubmed

Information coding in the olfactory system: evidence for a stereotyped and highly organized epitope map in the olfactory bulb.

OR8A1 OR7A17 OR7A10

2.45e-06146737528109
Pubmed

Regulation of energy metabolism during early mammalian development: TEAD4 controls mitochondrial transcription.

NDOR1 TEAD4

3.66e-06267230201685
Pubmed

The structure of the human betaII-tryptase tetramer: fo(u)r better or worse.

TPSAB1 TPSB2

3.66e-06267210500112
Pubmed

Characterization of a tryptase mRNA expressed in the human basophil cell line KU812.

TPSAB1 TPSB2

3.66e-0626728434231
Pubmed

Her4 and Her2/neu tyrosine kinase domains dimerize and activate in a reconstituted in vitro system.

ERBB2 ERBB4

3.66e-06267220022944
Pubmed

Cloning and characterization of a second complementary DNA for human tryptase.

TPSAB1 TPSB2

3.66e-0626722203827
Pubmed

Neuregulin receptors erbB2 and erbB4 in failing human myocardium -- depressed expression and attenuated activation.

ERBB2 ERBB4

3.66e-06267215685397
Pubmed

Characterization of two highly polymorphic human tryptase loci and comparison with a newly discovered monkey tryptase ortholog.

TPSAB1 TPSB2

3.66e-06267210898108
Pubmed

Characterization of EGFR family gene aberrations in cholangiocarcinoma.

ERBB2 ERBB4

3.66e-06267224927194
Pubmed

Neuregulin signaling is dispensable for NMDA- and GABA(A)-receptor expression in the cerebellum in vivo.

ERBB2 ERBB4

3.66e-06267219244516
Pubmed

A single ligand is sufficient to activate EGFR dimers.

ERBB2 ERBB4

3.66e-06267222699492
Pubmed

Human beta-tryptase is a ring-like tetramer with active sites facing a central pore.

TPSAB1 TPSB2

3.66e-0626729521329
Pubmed

The carbohydrate CT1 is expressed in topographically fixed glomeruli in the mouse olfactory bulb.

OR8A1 OR10A4

3.66e-06267221699983
Pubmed

Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family.

TPSAB1 TPSB2

3.66e-0626722187193
Pubmed

Structural requirements and mechanism for heparin-dependent activation and tetramerization of human betaI- and betaII-tryptase.

TPSAB1 TPSB2

3.66e-06267215567416
Pubmed

Human tryptases alpha and beta/II are functionally distinct due, in part, to a single amino acid difference in one of the surface loops that forms the substrate-binding cleft.

TPSAB1 TPSB2

3.66e-06267210391906
Pubmed

The human mast cell tryptase tetramer: a fascinating riddle solved by structure.

TPSAB1 TPSB2

3.66e-06267210708850
Pubmed

CDKL2 Is Associated with HER2 Status and Overall Survival in Gastric Cancer: Comparative Analysis of CDKL2 Protein Expression and Gene Copy Number.

ERBB2 CDKL2

3.66e-06267233178818
Pubmed

Tryptase haplotype in mastocytosis: relationship to disease variant and diagnostic utility of total tryptase levels.

TPSAB1 TPSB2

3.66e-06267217449330
Pubmed

Impact of naturally forming human α/β-tryptase heterotetramers in the pathogenesis of hereditary α-tryptasemia.

TPSAB1 TPSB2

3.66e-06267231337736
Pubmed

The chromosomal distribution of mouse odorant receptor genes.

OR8A1 OR4B1 OR7A17 OR7A10

3.70e-06546748570653
Pubmed

Specific antibodies and sensitive immunoassays for the human epidermal growth factor receptors (HER2, HER3, and HER4).

ERBB2 ERBB4

1.10e-05367228653892
Pubmed

Axonal Odorant Receptors Mediate Axon Targeting.

OR8A1 OR10A4

1.10e-05367231875544
Pubmed

Neuregulin/ErbB regulate neuromuscular junction development by phosphorylation of α-dystrobrevin.

ERBB2 ERBB4

1.10e-05367222184199
Pubmed

Spontaneous activation and signaling by overexpressed epidermal growth factor receptors in glioblastoma cells.

ERBB2 ERBB4

1.10e-05367212532415
Pubmed

State-dependent sculpting of olfactory sensory neurons is attributed to sensory enrichment, odor deprivation, and aging.

OR8A1 OR10A4

1.10e-05367220691762
Pubmed

erbB genes in the mouse uterus: cell-specific signaling by epidermal growth factor (EGF) family of growth factors during implantation.

ERBB2 ERBB4

1.10e-0536729851845
Pubmed

Involvement of the neuregulins and their receptors in cardiac and neural development.

ERBB2 ERBB4

1.10e-0536728967893
Pubmed

ErbB receptor tyrosine kinase family expression levels in urothelial bladder carcinoma.

ERBB2 ERBB4

1.10e-05367223333248
Pubmed

Expression and potential role of ErbB receptors in type II endometrial cancer.

ERBB2 ERBB4

1.10e-05367223395558
Pubmed

Neuregulin 1-ErbB module in C-bouton synapses on somatic motor neurons: molecular compartmentation and response to peripheral nerve injury.

ERBB2 ERBB4

1.10e-05367228065942
Pubmed

Synapses form in skeletal muscles lacking neuregulin receptors.

ERBB2 ERBB4

1.10e-05367215976301
Pubmed

Absence of EGFR, ERBB2 and ERBB4 mutation homologous to the oncogenic ERBB3 Val-104 mutation in colorectal cancers.

ERBB2 ERBB4

1.10e-05367224862237
Pubmed

Cell surface expression of epidermal growth factor receptor and Her-2 with nuclear expression of Her-4 in primary osteosarcoma.

ERBB2 ERBB4

1.10e-05367215026342
Pubmed

Olfactory marker protein (OMP) regulates formation and refinement of the olfactory glomerular map.

OR8A1 OR10A4

1.10e-05367230498219
Pubmed

Characterization of genes encoding known and novel human mast cell tryptases on chromosome 16p13.3.

TPSAB1 TPSB2

1.10e-0536729920877
Pubmed

Unique carboxyl-terminal sequences of wild type and alternatively spliced variant forms of transforming growth factor-alpha precursors mediate specific interactions with ErbB4 and ErbB2.

ERBB2 ERBB4

1.10e-05367210918572
Pubmed

Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses.

ERBB2 ERBB4

1.10e-05367210839362
Pubmed

Peripheral olfactory projections are differentially affected in mice deficient in a cyclic nucleotide-gated channel subunit.

OR8A1 OR10A4

1.10e-05367210798394
Pubmed

ErbB receptors protect the perfused heart against injury induced by epinephrine combined with low-flow ischemia.

ERBB2 ERBB4

1.10e-05367219370475
Pubmed

Expression and significance of HER family receptors in neuroblastic tumors.

ERBB2 ERBB4

1.10e-05367221203803
Pubmed

Protein expression of HER2, 3, 4 in gastric cancer: correlation with clinical features and survival.

ERBB2 ERBB4

1.10e-05367225731189
Pubmed

Association of ErbB1-4 expression in invasive breast cancer with clinicopathological characteristics and prognosis.

ERBB2 ERBB4

1.10e-05367223100016
Pubmed

Kinase activator-receiver preference in ErbB heterodimers is determined by intracellular regions and is not coupled to extracellular asymmetry.

ERBB2 ERBB4

1.10e-05367225468910
Pubmed

Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations.

TPSAB1 TPSB2

1.10e-05367219748655
Pubmed

High-resolution melting curve analysis of polymorphisms within CD58, CD226, HLA-G genes and association with multiple sclerosis susceptibility in a subset of Iranian population: a case-control study.

HLA-G CD58

1.10e-05367230128676
Pubmed

Circuit formation and function in the olfactory bulb of mice with reduced spontaneous afferent activity.

OR8A1 OR10A4

1.10e-05367225568110
Pubmed

Deletion of voltage-gated channel affects glomerular refinement and odorant receptor expression in the mouse olfactory system.

OR8A1 OR10A4

1.10e-05367218022950
Pubmed

Modulation of the combinatorial code of odorant receptor response patterns in odorant mixtures.

OR7A5 OR7A17 OR7A10

1.93e-052767332061665
Pubmed

Olfactory functions scale with circuit restoration in a rapidly reversible Alzheimer's disease model.

OR8A1 OR10A4

2.19e-05467223884929
Pubmed

The relation between survival and expression of HER1 and HER2 depends on the expression of HER3 and HER4: a study in bladder cancer patients.

ERBB2 ERBB4

2.19e-05467216685269
Pubmed

Characterisation of HER heterodimers in breast cancer using in situ proximity ligation assay.

ERBB2 ERBB4

2.19e-05467224557338
Pubmed

Absence of adenylyl cyclase 3 perturbs peripheral olfactory projections in mice.

OR8A1 OR10A4

2.19e-05467217581954
Pubmed

Analysis of ErbB receptors in pulmonary carcinoid tumors.

ERBB2 ERBB4

2.19e-05467219447869
Pubmed

Aβ alters the connectivity of olfactory neurons in the absence of amyloid plaques in vivo.

OR8A1 OR10A4

2.19e-05467222910355
Pubmed

Inverse regulation of EGFR/HER1 and HER2-4 in normal and malignant human breast tissue.

ERBB2 ERBB4

2.19e-05467223991224
Pubmed

Evaluation of the prognostic and predictive value of HER family mRNA expression in high-risk early breast cancer: a Hellenic Cooperative Oncology Group (HeCOG) study.

ERBB2 ERBB4

2.19e-05467218985033
Pubmed

Neuregulin signaling regulates neural precursor growth and the generation of oligodendrocytes in vitro.

ERBB2 ERBB4

2.19e-05467211425901
Pubmed

[Neuregulin-1 promotes proliferation and migration of human coronary artery smooth muscle cells by enhancing its receptor phosphorylation].

ERBB2 ERBB4

2.19e-05467226648299
Pubmed

Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function.

ERBB2 ERBB4

2.19e-05467212621152
Pubmed

Activation of ErbB4 by the bifunctional epidermal growth factor family hormone epiregulin is regulated by ErbB2.

ERBB2 ERBB4

2.19e-0546729556621
Pubmed

Molecular cloning and chromosomal mapping of olfactory receptor genes expressed in the male germ line: evidence for their wide distribution in the human genome.

OR7A5 OR7C1

2.19e-0546729268701
Pubmed

Expression of heregulin, phosphorylated HER-2, HER-3 and HER-4 in HER-2 negative breast cancers.

ERBB2 ERBB4

2.19e-05467219148499
Pubmed

Odor-evoked gene regulation and visualization in olfactory receptor neurons.

OR8A1 OR10A4

2.19e-05467220080187
Pubmed

Expression of epidermal growth factors, erbBs, in the nasal mucosa of patients with chronic hypertrophic rhinitis.

ERBB2 ERBB4

2.19e-05467222327010
Pubmed

Activated HER-receptors in predicting outcome of ER-positive breast cancer patients treated with adjuvant endocrine therapy.

ERBB2 ERBB4

2.19e-05467222854050
Pubmed

Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain.

ERBB2 ERBB4

2.19e-05467217177598
Pubmed

The relevance of EGFR, ErbB receptors and neuregulins in human adipocytes and adipose tissue in obesity.

ERBB2 ERBB4

2.19e-05467236411648
Pubmed

The erbB/HER type 1 tyrosine kinase receptor family.

ERBB2 ERBB4

2.19e-0546729771475
Pubmed

Expression of the HER-1-4 family of receptor tyrosine kinases in neuroendocrine tumours.

ERBB2 ERBB4

2.19e-05467220204273
Pubmed

HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 herceptin in breast cancer.

ERBB2 ERBB4

2.19e-05467221203579
Pubmed

Interaction between HLA-G and NK cell receptor KIR2DL4 orchestrates HER2-positive breast cancer resistance to trastuzumab.

ERBB2 HLA-G

2.19e-05467234158475
Pubmed

Laminin-1 and epidermal growth factor family members co-stimulate fetal pancreas cell proliferation and colony formation.

ERBB2 ERBB4

2.19e-05467215733067
Pubmed

WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus.

ERBB2 ERBB4

2.19e-05467212807903
Pubmed

ErbB2 and ErbB4 Cbl binding sites can functionally replace the ErbB1 Cbl binding site.

ERBB2 ERBB4

2.19e-05467219263517
Pubmed

Mutations in dynein genes in patients affected by isolated non-syndromic asthenozoospermia.

DNAI1 DNAH11

2.19e-05467218492703
Pubmed

HER Family Protein Expression in a Greek Population with Gastric Cancer. A Retrospective Hellenic Cooperative Oncology Group Study.

ERBB2 ERBB4

2.19e-05467227069134
Pubmed

Role of neuregulin-1/ErbB signaling in cardiovascular physiology and disease: implications for therapy of heart failure.

ERBB2 ERBB4

2.19e-05467217709650
Pubmed

A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor.

ERBB2 ERBB4

2.19e-0546728816440
Pubmed

The leucine-rich repeat protein LRIG1 is a negative regulator of ErbB family receptor tyrosine kinases.

ERBB2 ERBB4

2.19e-05467215345710
Pubmed

Up-regulation of acetyl-CoA carboxylase alpha and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells.

ERBB2 ACACA

2.19e-05467217631500
Pubmed

Evaluation of the prognostic significance of HER family mRNA expression in high-risk early breast cancer: a Hellenic Cooperative Oncology Group (HeCOG) validation study.

ERBB2 ERBB4

2.19e-05467226021752
Pubmed

Heregulin (HRG)-induced mitogenic signaling and cytotoxic activity of a HRG/PE40 ligand toxin in human breast cancer cells.

ERBB2 ERBB4

3.64e-0556729019162
Pubmed

Tissue interaction mediated by neuregulin-1 and ErbB receptors regulates epithelial morphogenesis of mouse embryonic submandibular gland.

ERBB2 ERBB4

3.64e-05567215254894
Pubmed

Leucine-rich repeat and immunoglobulin domain-containing protein-1 (Lrig1) negative regulatory action toward ErbB receptor tyrosine kinases is opposed by leucine-rich repeat and immunoglobulin domain-containing protein 3 (Lrig3).

ERBB2 ERBB4

3.64e-05567223723069
Pubmed

Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury.

ERBB2 ERBB4

3.64e-05567219632177
Cytoband1q44

OR2B11 OR2C3 OR1C1 OR2T4

2.13e-051106741q44
CytobandEnsembl 112 genes in cytogenetic band chr1q44

OR2B11 OR2C3 OR1C1 OR2T4

3.86e-05128674chr1q44
Cytoband7p21.1

AGR3 ITGB8

4.76e-04226727p21.1
CytobandEnsembl 112 genes in cytogenetic band chr19p13

OR7D4 OR7A5 OR7C1 OR7D2 OR7A17 OR7A10

1.09e-03797676chr19p13
Cytoband19p13.1

OR7A5 OR7C1

2.27e-034867219p13.1
Cytoband19p13.12

OR7A17 OR7A10

2.46e-035067219p13.12
GeneFamilyOlfactory receptors, family 7

OR7D4 OR7A5 OR7C1 OR7D2 OR7A17 OR7A10

3.03e-07113446154
GeneFamilyOlfactory receptors, family 1

OR1B1 OR1F12P OR1F2P OR1C1

2.62e-0640444147
GeneFamilyErb-b2 receptor tyrosine kinases

ERBB2 ERBB4

3.46e-0544421096
GeneFamilyOlfactory receptors, family 2

OR2B11 OR2C3 OR2T4 OR2W6P

1.62e-04113444149
GeneFamilyDyneins, axonemal

DNAI1 DNAH11

7.69e-0417442536
GeneFamilyOlfactory receptors, family 10

OR10A4 OR10Q1

1.12e-0266442157
ToppCellIPF-Multiplet-Multiplet|IPF / Disease state, Lineage and Cell class

DNAI1 ERBB4 LMO7 SYNE2 AGR3 DNAH11

4.92e-07195676fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCellIPF-Multiplet|IPF / Disease state, Lineage and Cell class

DNAI1 ERBB4 LMO7 SYNE2 AGR3 DNAH11

4.92e-07195676eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCellCOPD-Multiplet-Multiplet|COPD / Disease state, Lineage and Cell class

DNAI1 LMO7 SYNE2 AGR3 TPSB2 DNAH11

5.06e-07196676af4cdc61830685a888a1209826c23bcf54a43084
ToppCellCOPD-Multiplet|COPD / Disease state, Lineage and Cell class

DNAI1 LMO7 SYNE2 AGR3 TPSB2 DNAH11

5.06e-071966766d02d494196e3f857d53eea46d9419690d43beca
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D231|Adult / Lineage, Cell type, age group and donor

ERBB4 ACACA LMO7 SYNE2 AGR3

5.80e-06170675269dee5abca9f6aa079f116f0d8f1d198604d9d4
ToppCellsevere-Myeloid-Eosinophils|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

TMEM156 SYNE2 TMEM164 ITGB8 TPSB2

7.66e-06180675ac03812b1409435c55d323a7516deeac82bd3509
ToppCellCOVID-19-Epithelial_cells-Airway_club|COVID-19 / group, cell type (main and fine annotations)

ERBB2 ERBB4 ACACA LMO7 DOCK9

8.75e-06185675cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCellCOVID-19-lung-AT2|COVID-19 / Disease (COVID-19 only), tissue and cell type

ERBB4 ACACA CDKL2 LMO7 AGR3

9.95e-0619067527a1a86620fe9b5ee930d388b32352206485e6d0
ToppCellControl-Multiplet-Multiplet|World / Disease state, Lineage and Cell class

ERBB4 LMO7 DOCK9 SYNE2 AGR3

1.05e-051926751bfd022d5b87cf8a5d5069f559339a553a52a0a2
ToppCellEpithelial-alveolar_epithelial_cell_type_2|World / Lineage, Cell type, age group and donor

ERBB4 ACACA CDKL2 DOCK9 TMEM164

1.05e-0519267558c3737be7acce39fd2b91d70d6d7b2bbaa4f710
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT2-AT2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ERBB4 ACACA CDKL2 AGR3 TMEM164

1.07e-05193675fd4d3c0d7caf8a2fff5b3d901fc28d19a8163cdf
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2|Adult / Lineage, Cell type, age group and donor

ERBB4 ACACA CDKL2 DOCK9 TMEM164

1.07e-05193675738f4f0a9ddde2432b429ab46838e353b1790589
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ERBB4 ACACA CDKL2 AGR3 TMEM164

1.07e-05193675f3cc7cfdbc164a4ed42f87647111522b7d393bcb
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ERBB4 CDKL2 LMO7 SYNE2 ITGB8

1.10e-05194675e577d9e88390b36b5a09b97fe1026089892275a3
ToppCellControl-Multiplet|Control / Disease state, Lineage and Cell class

ERBB4 LMO7 DOCK9 SYNE2 AGR3

1.13e-05195675618900c80bea09d46dad3f741bd1bff8bf0a64ee
ToppCellControl-Multiplet-Multiplet|Control / Disease state, Lineage and Cell class

ERBB4 LMO7 DOCK9 SYNE2 AGR3

1.13e-0519567506ac685855e14e4dd2cbe6d0e73f894f2eeff91f
ToppCellIPF-Epithelial|IPF / Disease state, Lineage and Cell class

DNAI1 ERBB4 LMO7 AGR3 DNAH11

1.16e-0519667587d9881cfec461a5d89b688a83749b618c519485
ToppCellParenchymal-NucSeq-Epithelial-Epi_alveolar-AT2|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ERBB4 ACACA CDKL2 DOCK9 TMEM164

1.21e-051986752e2a4e1756bba6f4fbe529559a97d2993c890b4b
ToppCellParenchymal-NucSeq-Epithelial-Epi_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ERBB4 ACACA CDKL2 LMO7 TMEM164

1.24e-051996758587bd98de7767a575088afbea07a1feb4516b9b
ToppCellcontrol|World / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

ERBB2 LMO7 SYNE2 PALLD ITGB8

1.27e-0520067597f36d2c197e03d93a1fc59949d77ae90f6e6a9a
ToppCellNS-control|NS / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ERBB2 LMO7 SYNE2 PALLD ITGB8

1.27e-05200675ecbe89ff95d046155b984c8c150e0b9e7278f839
ToppCellmetastatic_Brain-Myeloid_cells-CD1c+_DCs|Myeloid_cells / Location, Cell class and cell subclass

DNAI1 NDOR1 ACY3 RAPGEF4

6.25e-051426741eecbec805a873fa3539df0574670cf73c18c7b1
ToppCell10x5'-bone_marrow-Mast|bone_marrow / Manually curated celltypes from each tissue

TPSAB1 CFAP206 ITGB8 TPSB2

9.68e-05159674c3d3570e83c5d25cc92fa3a7a8f0dc2f89a72913
ToppCell10x5'-bone_marrow-Mast-Mast_cells|bone_marrow / Manually curated celltypes from each tissue

TPSAB1 CFAP206 ITGB8 TPSB2

1.02e-0416167415ba7e69699558353cfeecdcf1dbc2e147379ed6
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|Adult / Lineage, Cell type, age group and donor

ERBB4 LMO7 AGR3 TMEM164

1.07e-04163674e819a1d6d28290854aa0672b3a18fa9e293d8f23
ToppCell15-Distal-Epithelial-Multiciliated_precursor|Distal / Age, Tissue, Lineage and Cell class

DNAI1 CFAP206 AGR3 DNAH11

1.17e-04167674442ea71a581ed5a547a214132b9f1b0243fd0895
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

TMEM156 LMO7 FHIP2A HECA

1.17e-04167674ced6ed9b412739c6ced622523347c10295edbf53
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

ERBB4 ACACA LMO7 SYNE2

1.25e-04170674a2c738e441ced90eeeb1fcc6ca3269b918aaa298
ToppCellcontrol-Myeloid-Eosinophils|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

TPSAB1 TMEM164 ITGB8 TPSB2

1.28e-0417167482f736c33ed96c0865618e8f8eb82a5487126bdc
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-4_VIP_DSEL|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 OR7A5 OR7C1 ASB12

1.28e-041716742c7d73f1386ddd172839734c68ed3859a90f80f8
ToppCellmild-Myeloid-Eosinophils|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

TPSAB1 SYNE2 ITGB8 TPSB2

1.28e-041716745c8198182495bda7a826e9d80aa467f4eb1094ec
ToppCelllymphoid-B_cell-pro-B|B_cell / Lineage, cell class and subclass

TPSAB1 SFRP4 PALLD TPSB2

1.31e-04172674da1e2e54f442f5c2032c857c4812e9060f2053cd
ToppCellImmune-mast_cell|World / Lineage, Cell type, age group and donor

OR8A1 TPSAB1 ACY3 TPSB2

1.31e-041726746e8e0aac5a20dbc789bf8c6916833bb8709a411a
ToppCell10x3'2.3-week_17-19-Myeloid_neutrophil-granulo-eo/baso/mast-eosinophil|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

TPSAB1 TMEM164 ITGB8 TPSB2

1.31e-041726743a76cfb2832790144a6da6406469ead0767916b5
ToppCell3'_v3-blood-Mast|blood / Manually curated celltypes from each tissue

TPSAB1 TMEM164 ITGB8 TPSB2

1.31e-04172674e7a46bbeff749ca59b9f1357409ce1ad59dd22dd
ToppCellFetal_29-31_weeks-Epithelial-club_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ERBB4 ACACA AGR3 CHN1

1.43e-041766743bbac5c2397535631fce8fa98f6ddb4fe0260351
ToppCell368C-Epithelial_cells-Epithelial-B_(AT2)-|368C / Donor, Lineage, Cell class and subclass (all cells)

MST1R LMO7 AGR3 TMEM164

1.46e-04177674ac8f774596068e66c0a9ea8a318be0ce5f5df834
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Granulocytic-Mast_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TPSAB1 STAMBPL1 TPSB2 DNAH11

1.46e-0417767486c41d262142eeaa95ea7fa6668169eb1bb2953f
ToppCell368C-Epithelial_cells-Epithelial-B_(AT2)|368C / Donor, Lineage, Cell class and subclass (all cells)

MST1R LMO7 AGR3 TMEM164

1.46e-04177674d9c4a93b0e04a13bf39992dd1c1ec8df2c5f89fe
ToppCellBAL-Severe-Epithelial-Epithelial-undefined_Epi-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

LMO7 OR7D2 RAPGEF4 ITGB8

1.49e-041786749a3ef66814dfca7b37024e7f79e86ea8c72ae10f
ToppCellBAL-Severe-Epithelial-Epithelial-undefined_Epi-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

LMO7 OR7D2 RAPGEF4 ITGB8

1.49e-04178674b413a634283550fa224db7d0d05956e3f64694a1
ToppCellBAL-Severe-Epithelial-Epithelial-undefined_Epi|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

LMO7 OR7D2 RAPGEF4 ITGB8

1.49e-0417867449a2271718637522f74334068d252963ee13b1ce
ToppCellBAL-Severe-Epithelial-Epithelial-undefined_Epi|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

LMO7 OR7D2 RAPGEF4 ITGB8

1.49e-0417867419b5432aa1d7f616d58a106543c18cf2d7ca840c
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAI1 STK36 CFAP206 DNAH11

1.49e-041786743b12db04006db6e94fc45649a4b3a63b92f21a61
ToppCellfacs-Trachea-18m-Epithelial-airway_epithelial-tracheobronchial_ciliated_cell-ciliated_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DNAI1 STK36 AGR3 DNAH11

1.53e-04179674d4efbc34f52136039b96451fd0b0a0ad164197c6
ToppCellfacs-Trachea-18m-Epithelial-airway_epithelial-tracheobronchial_ciliated_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DNAI1 STK36 AGR3 DNAH11

1.53e-041796748a66d197a2f55d763ff7ef0bec89ee96f59c3937
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ERBB4 LMO7 AGR3 CHN1

1.53e-04179674815b959ce8721c5ded70c0ca6e318dafc691746e
ToppCellTransplant_Alveoli_and_parenchyma-Epithelial-Type_1_alveolar|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X

MST1R ERBB2 LMO7 AGR3

1.53e-04179674d5763912a4ce7188535675e338799b856edb9dda
ToppCellfacs-Trachea-nan-3m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAI1 STK36 CFAP206 AGR3

1.56e-04180674cf6e9f757afeb342c5023f6e6152a1b4d0d164b4
ToppCellControl-Epithelial_cells-AT2|Control / group, cell type (main and fine annotations)

ERBB4 ACACA CDKL2 TMEM164

1.56e-04180674198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCellChildren_(3_yrs)-Epithelial-club_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

ERBB2 ERBB4 LMO7 AGR3

1.63e-04182674215c303df42f13597b2c7a95cb157c6bc7aca9a1
ToppCell367C-Epithelial_cells-Epithelial-F_(Ciliated)-|367C / Donor, Lineage, Cell class and subclass (all cells)

DNAI1 CFAP206 AGR3 DNAH11

1.66e-04183674b1336eac5adbffade4cef3e0ce3de75a781ae365
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

ERBB4 ACACA CDKL2 TMEM164

1.66e-041836746847c1252d6bb105524f812658112517fd351eab
ToppCell367C-Epithelial_cells-Epithelial-F_(Ciliated)|367C / Donor, Lineage, Cell class and subclass (all cells)

DNAI1 CFAP206 AGR3 DNAH11

1.66e-04183674cc57dcb59c68d68a546dc108dd9e009b2aab8da5
ToppCellLPS-IL1RA|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK9 CD58 GBE1 STAMBPL1

1.70e-04184674c066c2ec4f0f1d6eb183fca5c7bb0cd45c9950dc
ToppCellCOVID-19-Epithelial_cells-AT2|COVID-19 / group, cell type (main and fine annotations)

ERBB4 ACACA CDKL2 LMO7

1.70e-04184674369b82f793deab672204558ae4e112cfa5aa9ccc
ToppCellCTRL-Lymphoid|CTRL / Disease state, Lineage and Cell class

TMEM156 ACY3 SYNE2 STAMBPL1

1.70e-0418467426fb2c4e6cb9950c27eb15428e7e74e5abb4397d
ToppCell10x5'v1-week_14-16-Myeloid_neutrophil-granulo-eo/baso/mast-eosinophil|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

TPSAB1 TMEM164 ITGB8 TPSB2

1.70e-04184674ce31684772e47a294155f368e50b49753f7c8e87
ToppCellcontrol-Myeloid-Eosinophils|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

TPSAB1 TMEM164 ITGB8 TPSB2

1.70e-04184674fad517d047e8eaeaa5bd4f311d770880568dd13c
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Adult / Lineage, Cell type, age group and donor

ERBB4 ACACA LMO7 AGR3

1.73e-04185674673f0c688ae6984bc8027df2da335787924f4137
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Children_(3_yrs) / Lineage, Cell type, age group and donor

ERBB4 ACACA LMO7 AGR3

1.73e-0418567498b8ee42b89d97e4c9db01740e0c193503c68f2c
ToppCellNS-moderate-d_16-33-Epithelial-Ciliated|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAI1 ERBB4 CFAP206 DNAH11

1.73e-041856745e689c2fb36ce3ac2adc8d15f67107f21cf68868
ToppCellCOVID-19-Endothelial_cells-Systemic_venous_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

DOCK9 SYNE2 RAPGEF4 CHN1

1.73e-04185674f5e14181f45c37d13ee9e017a4c8bc248c353676
ToppCell10x5'-GI_small-bowel-Myeloid_Dendritic-DC2|GI_small-bowel / Manually curated celltypes from each tissue

GPR33 RAPGEF4 PALLD CDH17

1.73e-04185674f78be85dd6e443abb7af20f98ff351c1131ece4d
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ERBB4 LMO7 AGR3 TMEM164

1.77e-041866742ea5ff14861e5f91d0e6a5767c403a24045d715c
ToppCellEpithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|World / Lineage, Cell type, age group and donor

ERBB4 ACACA LMO7 AGR3

1.81e-0418767481cc8435b2704a9a8287b3f54acaae0f11dd4ac7
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ERBB4 CDKL2 LMO7 TMEM164

1.81e-041876745df9e1f5ca32217af255e76e6fb5afa346337811
ToppCellCOVID-19-Epithelial_cells|COVID-19 / group, cell type (main and fine annotations)

ERBB4 LMO7 AGR3 DNAH11

1.84e-04188674c9cdee6f8d42ee69f5fb335f25084603c511bd29
ToppCellPCW_13-14-Endothelial-Endothelial_mature-endo_bronchial_(8)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

TMEM156 DOCK9 RAPGEF4 TEAD4

1.84e-04188674986aaf31161ec3d1e6c76ee2dd17f44848a21f7e
ToppCellCOPD-Multiplet-Multiplet|World / Disease state, Lineage and Cell class

TPSAB1 LMO7 SYNE2 TPSB2

1.84e-04188674186fe1ea328c942910190a4240262c0d8642ea3b
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D231|Adult / Lineage, Cell type, age group and donor

ERBB4 CDKL2 DOCK9 TMEM164

1.88e-04189674dab54a52358f66a8a9460cd6089a06c5fa7e7a5d
ToppCellSevere_COVID-19-Epithelial-undefined_Epi|Severe_COVID-19 / Disease group,lineage and cell class (2021.01.30)

MST1R LMO7 OR7D2 ITGB8

1.88e-041896748cbd35320c7e7ff013ef0c0f13f8d875db1c53cd
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ERBB4 SYNE2 CD58 ITGB8

1.88e-041896748c8ca3b30d9be6c854615459a7bfba82b427c8bc
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ERBB4 SYNE2 CD58 ITGB8

1.88e-041896745d902a4660a27548764bf04c6de152b565da835c
ToppCellPCW_10-12-Endothelial-Endothelial_mature-endo_bronchial_(8)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

TMEM156 DOCK9 RAPGEF4 TEAD4

1.88e-04189674033a2be8bbb7bfb437e6f1657b6ca02070c74aa8
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

TMEM156 XRN2 SYNE2 FHIP2A

1.92e-0419067491ba66d4b56c59523485b17738e93f14bb00afa4
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ERBB4 CDKL2 LMO7 ITGB8

1.92e-041906743fc9e18c7441c0ae8cda65753cc42d0520f4e116
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2|Children_(3_yrs) / Lineage, Cell type, age group and donor

ERBB4 ACACA CDKL2 TMEM164

1.96e-04191674a0332a4ef629510fb313ec119195c44a3f704a80
ToppCellCOVID-19-lung-AT2|lung / Disease (COVID-19 only), tissue and cell type

ERBB4 ACACA CDKL2 LMO7

1.96e-04191674276455a64c2c3503d5048615762eb2ee37f0ac70
ToppCellLPS-antiTNF-Endothelial-Endothelial-Artery|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SFRP4 DOCK9 ANGEL1 CHN1

1.96e-041916744b3d5157344dbfbf4fab518611cd9fa37fac7bd9
ToppCellCOVID-19-kidney-AQP1+PLVAP+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

DOCK9 SYNE2 RAPGEF4 CHN1

2.00e-0419267427ff3621e177e7932dd44dd6baa81551ea75a874
ToppCellCOPD-Epithelial|COPD / Disease state, Lineage and Cell class

DNAI1 ERBB4 LMO7 AGR3

2.00e-041926740644fad5df18f0021f6f49cca996d8cf47f972ff
ToppCellLPS-antiTNF-Endothelial-Endothelial-Activated_Gen_Cap|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK9 RAPGEF4 ANGEL1 CHN1

2.00e-041926740aeb5351275c0a91151ea2d52b2cdde172da6731
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D122|Adult / Lineage, Cell type, age group and donor

ERBB4 ACACA DOCK9 TMEM164

2.00e-0419267406013a07e3a873b1d1c0451643c528593ac32a9c
ToppCellAdult-Epithelial|Adult / Lineage, Cell type, age group and donor

ERBB4 ACACA LMO7 DOCK9

2.00e-04192674efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CDKL2 LMO7 DOCK9 TMEM164

2.00e-04192674fb2f0e897228f808d9ff734ad05e9b49dc38fa50
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CDKL2 SYNE2 ITGB8 DNAH11

2.04e-04193674ffa1932da2979d7b63dbac32eb5788346a3f5b2a
ToppCellCOVID-19-Heart-CM_+_EC_+_Pericyte|Heart / Disease (COVID-19 only), tissue and cell type

ERBB4 LMO7 GBE1 PALLD

2.04e-04193674dd5378a1ef8eb0eda9a3aae62f3c2f3a1402bda0
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ERBB4 LMO7 SYNE2 ITGB8

2.04e-04193674f42a0f02ed00fe1bb833ff0a0640d9131bca89bd
ToppCellsevere-low-quality_cells|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SYNE2 BTAF1 STAMBPL1 ITGB8

2.04e-041936749337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCellCOVID-19-Endothelial_cells-Inflamed_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

DOCK9 RAPGEF4 GBE1 TEAD4

2.04e-04193674979ebefa527f86bebeea5d94e626ee6c1cc7d53b
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.4.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ACACA CDKL2 AGR3 TPSB2

2.04e-04193674043dd0fc2f93e0bd1ca34ac3e196622b3e91df0f
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ERBB4 LMO7 SYNE2 ITGB8

2.04e-0419367442df7ed37d11fb542b4d1d714b6f87ae8e1396a6
ToppCellnucseq-Epithelial-Epithelial_Alveolar|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ERBB4 ACACA LMO7 AGR3

2.08e-0419467453f3e49e91b1096f3226010e2de767efb490dfe4
ToppCellChildren_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

DOCK9 RAPGEF4 TEAD4 CHN1

2.08e-0419467440842a7160f337bfc191ee15fbda3e3d38a04c57
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAI1 CFAP206 AGR3 DNAH11

2.08e-04194674a46238514bca920c3e3713d23c18ba24a09e2a29
ToppCellIPF-Multiplet-Multiplet|World / Disease state, Lineage and Cell class

DNAI1 SYNE2 AGR3 DNAH11

2.12e-0419567421dbdc803c6947024dc2416e9e21c2ef0af9bc31
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK9 RAPGEF4 TEAD4 CHN1

2.12e-04195674818bc18c5834238e5f733cac6fe928ed0788f57d
ToppCellChildren_(3_yrs)-Epithelial-club_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

ERBB4 LMO7 SYNE2 AGR3

2.12e-04195674dccc32fcf772e2504de7f663ef0a5bd8e23e92fc
ToppCellnucseq-Epithelial|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ERBB4 ACACA LMO7 AGR3

2.12e-041956749406866f99555198a9be311fbd65751b70f35446
ComputationalGenes in the cancer module 85.

MST1R ERBB2 ERBB4

5.92e-0451353MODULE_85
ComputationalGenes in the cancer module 199.

MST1R ERBB2 ERBB4

8.20e-0457353MODULE_199
ComputationalGenes in the cancer module 27.

MST1R ERBB2 ERBB4 SFRP4 HLA-G ITGB8

8.97e-04355356MODULE_27
ComputationalImmune (defense) response.

MST1R TPSAB1 ERBB2 HLA-G

1.11e-03142354MODULE_223
DiseaseKartagener syndrome (is_implicated_in)

DNAI1 DNAH11

2.04e-054552DOID:0050144 (is_implicated_in)
DiseasePrimary Ciliary Dyskinesia

DNAI1 STK36 DNAH11

9.38e-0547553C4551720
Diseasehead and neck squamous cell carcinoma (is_marker_for)

ERBB2 ERBB4

9.48e-058552DOID:5520 (is_marker_for)
Diseasetryptase beta-2 measurement

TPSAB1 TPSB2

1.22e-049552EFO_0008306
Diseasegallbladder neoplasm

ERBB2 ERBB4

1.86e-0411552C0016978
DiseaseMalignant neoplasm of gallbladder

ERBB2 ERBB4

1.86e-0411552C0153452
Diseasebasophil measurement

TPSAB1 HECA TPSB2

1.94e-0460553EFO_0803539
DiseaseKartagener syndrome (implicated_via_orthology)

DNAI1 DNAH11

3.06e-0414552DOID:0050144 (implicated_via_orthology)
Diseasemedian neuropathy (biomarker_via_orthology)

ERBB2 ERBB4

3.06e-0414552DOID:571 (biomarker_via_orthology)
Diseaselaryngeal squamous cell carcinoma (is_marker_for)

ERBB2 ERBB4

5.72e-0419552DOID:2876 (is_marker_for)
Diseaseurticaria

TPSAB1 TPSB2

6.34e-0420552EFO_0005531
DiseaseBronchiectasis

DNAI1 DNAH11

7.69e-0422552C0006267
DiseaseNasopharyngeal carcinoma

MST1R ERBB2

7.69e-0422552C2931822
Diseasestomach carcinoma (is_marker_for)

ERBB2 ERBB4

9.17e-0424552DOID:5517 (is_marker_for)
DiseaseMental deterioration

ERBB4 DNAH11

1.34e-0329552HP_0001268
Diseaseintestinal cancer (implicated_via_orthology)

ERBB2 ERBB4

1.63e-0332552DOID:10155 (implicated_via_orthology)
DiseaseKartagener Syndrome

DNAI1 STK36

1.95e-0335552C0022521
DiseasePolynesian Bronchiectasis

DNAI1 STK36

1.95e-0335552C4317124
DiseaseCiliary Dyskinesia, Primary, 1, With Or Without Situs Inversus

DNAI1 STK36

1.95e-0335552C4551906
DiseasePrimary ciliary dyskinesia

DNAI1 DNAH11

2.06e-0336552cv:C0008780
Diseasevisceral heterotaxy (implicated_via_orthology)

DNAI1 DNAH11

2.18e-0337552DOID:0050545 (implicated_via_orthology)
Diseaseductal carcinoma in situ (is_marker_for)

ERBB2 ERBB4

2.42e-0339552DOID:0060074 (is_marker_for)
Diseasekynurenine measurement

GBE1 DNAH11

2.42e-0339552EFO_0008529
DiseaseMoyamoya disease

DOCK9 RAPGEF4

2.54e-0340552MONDO_0016820

Protein segments in the cluster

PeptideGeneStartEntry
THLDMLRHLYQGCQV

ERBB2

41

P04626
TQLMPHGCLLEYVHE

ERBB4

796

Q15303
PLQYASHMEPQVCLH

CCDC115

56

Q96NT0
AMHLCRHLQLQYPEL

ACY3

136

Q96HD9
PLMVIHHLEDCQYSQ

AGR3

61

Q8TD06
VCWMPYHIHQGLLLT

GPR33

256

Q49SQ1
SHMLLQQPLIYCHFA

DNAH11

2776

Q96DT5
LTAIPCANHKMHLYL

ACACA

1391

Q13085
VMCLDIHVDHPYLVA

DNAI1

386

Q9UI46
QRLLKYTPQHMHCGA

BMS1

966

Q14692
AHELYFPERVMQCHL

CFAP206

356

Q8IYR0
ICHPLHYMVIMNPHL

OR7A5

126

Q15622
HYMVIMNPHLCGLLV

OR7A5

131

Q15622
YTCHVQHEGLPEPLM

HLA-G

281

P17693
VAICDPLHYALVMNH

OR1B1

126

Q8NGR6
PLHYALVMNHQRCAC

OR1B1

131

Q8NGR6
LLAIGSDHCLHTPMY

OR1F12P

46

Q8NHA8
QCMIPEHYNSHRGLI

CD58

141

P19256
DVPCHLQGRLMHLYA

HECA

431

Q9UBI9
CLHHNCEPEYIQLLI

ASB12

221

Q8WXK4
VAICHPLRYPVLMNH

OR2T4

156

Q8NH00
LHYTIIMHPRLCGQL

OR2W6P

136

Q8NHA6
LICCLLHQMYIADPN

INTS2

996

Q9H0H0
AMIIESLGLCYHLHC

LMO7

1626

Q8WWI1
LHYTVIMHPQLCLGL

OR2C3

131

Q8N628
DKLVVHLYHLCQMFP

NOP14

496

P78316
QPCSMRHLVSHYLDI

NDOR1

291

Q9UHB4
CRPLHYTAKMIHQLC

OR1F2P

126

Q96R84
AICDPLHYPVIMGHI

OR10A4

126

Q9H209
LHYPVIMGHISCAQL

OR10A4

131

Q9H209
CKPLHYAVLMHRALC

OR2B11

131

Q5JQS5
VSMHQDNHGYICLLI

PALLD

1281

Q8WX93
ICHPLHYTVIMNPCL

OR7D4

126

Q8NG98
LDCMPPHGYIHVLSL

ITGB8

216

P26012
VCHPLHYTVIMNPQL

OR7C1

126

O76099
LYHIMMCLGNLIPRH

CDKL2

211

Q92772
TYLMLANHLVHTLCP

GBE1

391

Q04446
VVCNHEHYIPLNLPM

DOCK9

1071

Q9BZ29
HPLLVQHLPHLYMCL

BTAF1

1101

O14981
GYLCLPYMALQQHHL

AVL9

406

Q8NBF6
PCDYHQEVSLRVHLM

KCTD6

181

Q8NC69
GPCMEYLLHHKILET

FHIP2A

76

Q5W0V3
LPPAHCETLRYLMAH

CHN1

386

P15882
HLHSLCLLMLYLATG

CDH17

6

Q12864
VAICHPLLYNIIMSH

OR8A1

141

Q8NGG7
PLLYNIIMSHHTCLL

OR8A1

146

Q8NGG7
ICHPLHYTARMNLCL

OR1C1

126

Q15619
VCRPLHYTVVMHPCL

OR2B8P

126

P59922
ICHPLHYPSIMTGQL

OR11H7

126

Q8NGC8
CHPLHYTLIMTRELC

OR10Q1

131

Q8NGQ4
KPLHYMNIISRQLCH

OR4B1

126

Q8NGF8
MPNTQLCPALVAHYH

RAPGEF4

541

Q8WZA2
PIMENHICDAKYHLG

TPSAB1

181

Q15661
PIMENHICDAKYHLG

TPSB2

181

P20231
LLEQSLPYLHGMHLC

TCAIM

456

Q8N3R3
EGCLYQLNHHMEVLR

SYNE2

986

Q8WXH0
ICHPLHYMVIMNPQL

OR7A10

126

O76100
MIHEDTRHLLCPYCL

POGZ

611

Q7Z3K3
ICHPLHYTVIMNPRL

OR7A17

126

O14581
VCHPLHYMIIMNPHL

OR7D2

126

Q96RA2
HYMIIMNPHLCGLLV

OR7D2

131

Q96RA2
IEPGMPLNHIEYCNH

RNASE9

71

P60153
PLNHIEYCNHEIMGK

RNASE9

76

P60153
HLLQVCCYHLPLMQV

STK36

1016

Q9NRP7
DLMQQSSELYLHCHP

ANGEL1

256

Q9UNK9
IQHLRMHTGEKPYQC

ZNF572

176

Q7Z3I7
RIMEYPNDCIHISLH

TMEM156

186

Q8N614
VIYLLNPCHLVTMMH

TMEM164

116

Q5U3C3
PHILPHQDVLIMCYE

SFRP4

246

Q6FHJ7
LHTHCSYQLMLPEAI

STAMBPL1

361

Q96FJ0
LYLDMNGIIHPCTHP

XRN2

51

Q9H0D6
IHRSPLCEYMINFIH

TEAD4

361

Q15561
LPHVLLPYMCHGDLL

MST1R

1156

Q04912
CLMQHQRIHSGEKPY

ZNF501

176

Q96CX3