Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	SCN2A SCN4A SCN9A	8.88e-05	26	67	3	GO:0005248
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	STIM1 SLC39A2 KCNH2 SCN2A SCN4A SCN9A SLC9A7 ITPR3	1.59e-04	465	67	8	GO:0046873
GeneOntologyMolecularFunction	sodium channel activity	SCN2A SCN4A SCN9A	7.09e-04	52	67	3	GO:0005272
GeneOntologyMolecularFunction	calcium ion binding	STIM1 PCDHGC5 PCDHGB7 PCDHGB3 ITLN2 ZZEF1 PCDHGC3 CDH13 ITPR3	8.55e-04	749	67	9	GO:0005509
GeneOntologyMolecularFunction	sodium ion binding	SCN2A SCN9A	9.83e-04	14	67	2	GO:0031402
GeneOntologyMolecularFunction	monoatomic cation channel activity	STIM1 KCNH2 SCN2A SCN4A SCN9A ITPR3	1.02e-03	343	67	6	GO:0005261
GeneOntologyMolecularFunction	calmodulin binding	MYH6 MYO1A SCN2A MBP CAMSAP2	1.05e-03	230	67	5	GO:0005516
GeneOntologyMolecularFunction	ABC-type xenobiotic transporter activity	ABCB11 ABCB1	1.13e-03	15	67	2	GO:0008559
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	STIM1 SLC39A2 KCNH2 SCN2A SCN4A SCN9A SLC9A7 ITPR3	1.15e-03	627	67	8	GO:0022890
GeneOntologyBiologicalProcess	membrane depolarization during action potential	KCNH2 SCN2A SCN4A SCN9A	5.54e-06	36	67	4	GO:0086010
GeneOntologyBiologicalProcess	actin filament-based movement	MYH6 MYO1A KCNH2 SCN2A SCN4A SCN9A	1.04e-05	153	67	6	GO:0030048
GeneOntologyBiologicalProcess	establishment of cell polarity involved in ameboidal cell migration	AMOTL1 AMOTL2	3.11e-05	3	67	2	GO:0003365
GeneOntologyBiologicalProcess	transmission of nerve impulse	COL6A1 SCN2A SCN4A CNTNAP2 SCN9A	3.19e-05	112	67	5	GO:0019226
GeneOntologyBiologicalProcess	membrane depolarization	COL6A1 KCNH2 SCN2A SCN4A SCN9A	4.62e-05	121	67	5	GO:0051899
GeneOntologyBiologicalProcess	cardiac muscle cell action potential involved in contraction	KCNH2 SCN2A SCN4A SCN9A	4.92e-05	62	67	4	GO:0086002
GeneOntologyBiologicalProcess	neuronal action potential	SCN2A SCN4A CNTNAP2 SCN9A	5.24e-05	63	67	4	GO:0019228
GeneOntologyBiologicalProcess	actin-mediated cell contraction	MYH6 KCNH2 SCN2A SCN4A SCN9A	5.82e-05	127	67	5	GO:0070252
GeneOntologyBiologicalProcess	cardiac muscle cell action potential	KCNH2 SCN2A SCN4A SCN9A	1.85e-04	87	67	4	GO:0086001
GeneOntologyBiologicalProcess	cardiac muscle contraction	MYH6 KCNH2 SCN2A SCN4A SCN9A	2.11e-04	167	67	5	GO:0060048
GeneOntologyBiologicalProcess	vocal learning	CNTNAP2 HTT	2.16e-04	7	67	2	GO:0042297
GeneOntologyBiologicalProcess	imitative learning	CNTNAP2 HTT	2.16e-04	7	67	2	GO:0098596
GeneOntologyBiologicalProcess	cardiac muscle cell contraction	KCNH2 SCN2A SCN4A SCN9A	2.39e-04	93	67	4	GO:0086003
GeneOntologyBiologicalProcess	homophilic cell adhesion via plasma membrane adhesion molecules	PCDHGC5 PCDHGB7 PCDHGB3 PCDHGC3 CDH13	3.56e-04	187	67	5	GO:0007156
GeneOntologyBiologicalProcess	observational learning	CNTNAP2 HTT	3.69e-04	9	67	2	GO:0098597
GeneOntologyCellularComponent	cell-cell junction	UBN1 CSK SCN2A AMOTL1 CNTNAP2 ABCB11 AMOTL2 PCDHGC3 CDH13 ABCB1	1.76e-05	591	67	10	GO:0005911
GeneOntologyCellularComponent	voltage-gated sodium channel complex	SCN2A SCN4A SCN9A	2.07e-05	17	67	3	GO:0001518
GeneOntologyCellularComponent	sodium channel complex	SCN2A SCN4A SCN9A	1.08e-04	29	67	3	GO:0034706
GeneOntologyCellularComponent	anchoring junction	UBN1 CSK SCN2A AMOTL1 CNTNAP2 ABCB11 AMOTL2 PCDHGC3 CDH13 TNS3 ABCB1	2.53e-04	976	67	11	GO:0070161
GeneOntologyCellularComponent	intercellular canaliculus	ABCB11 ABCB1	3.59e-04	9	67	2	GO:0046581
GeneOntologyCellularComponent	cation channel complex	KCNH2 SCN2A SCN4A CNTNAP2 SCN9A	9.43e-04	235	67	5	GO:0034703
GeneOntologyCellularComponent	plasma membrane raft	STIM1 MYO1A CNTNAP2 CDH13	1.28e-03	147	67	4	GO:0044853
GeneOntologyCellularComponent	paranode region of axon	SCN2A CNTNAP2	1.33e-03	17	67	2	GO:0033270
Domain	Na_channel_asu	SCN2A SCN4A SCN9A	4.53e-06	10	64	3	IPR001696
Domain	Na_trans_assoc	SCN2A SCN4A SCN9A	4.53e-06	10	64	3	IPR010526
Domain	Na_trans_assoc	SCN2A SCN4A SCN9A	4.53e-06	10	64	3	PF06512
Domain	Cadherin_tail	PCDHGC5 PCDHGB7 PCDHGB3 PCDHGC3	7.61e-06	37	64	4	PF15974
Domain	Cadherin_CBD	PCDHGC5 PCDHGB7 PCDHGB3 PCDHGC3	7.61e-06	37	64	4	IPR031904
Domain	IQ	MYH6 MYO1A SCN2A SCN4A SCN9A	8.45e-06	81	64	5	SM00015
Domain	Cadherin_C	PCDHGC5 PCDHGB7 PCDHGB3 PCDHGC3	1.27e-05	42	64	4	IPR032455
Domain	Cadherin_C_2	PCDHGC5 PCDHGB7 PCDHGB3 PCDHGC3	1.27e-05	42	64	4	PF16492
Domain	IQ_motif_EF-hand-BS	MYH6 MYO1A SCN2A SCN4A SCN9A	1.42e-05	90	64	5	IPR000048
Domain	IQ	MYH6 MYO1A SCN2A SCN4A SCN9A	1.66e-05	93	64	5	PS50096
Domain	Angiomotin_C	AMOTL1 AMOTL2	3.46e-05	3	64	2	IPR024646
Domain	Angiomotin	AMOTL1 AMOTL2	3.46e-05	3	64	2	IPR009114
Domain	Angiomotin_C	AMOTL1 AMOTL2	3.46e-05	3	64	2	PF12240
Domain	Cadherin_CS	PCDHGC5 PCDHGB7 PCDHGB3 PCDHGC3 CDH13	3.58e-05	109	64	5	IPR020894
Domain	CADHERIN_1	PCDHGC5 PCDHGB7 PCDHGB3 PCDHGC3 CDH13	4.25e-05	113	64	5	PS00232
Domain	Cadherin	PCDHGC5 PCDHGB7 PCDHGB3 PCDHGC3 CDH13	4.25e-05	113	64	5	PF00028
Domain	Ion_trans_dom	KCNH2 SCN2A SCN4A SCN9A ITPR3	4.44e-05	114	64	5	IPR005821
Domain	Ion_trans	KCNH2 SCN2A SCN4A SCN9A ITPR3	4.44e-05	114	64	5	PF00520
Domain	CADHERIN_2	PCDHGC5 PCDHGB7 PCDHGB3 PCDHGC3 CDH13	4.44e-05	114	64	5	PS50268
Domain	-	PCDHGC5 PCDHGB7 PCDHGB3 PCDHGC3 CDH13	4.44e-05	114	64	5	2.60.40.60
Domain	CA	PCDHGC5 PCDHGB7 PCDHGB3 PCDHGC3 CDH13	4.63e-05	115	64	5	SM00112
Domain	Cadherin-like	PCDHGC5 PCDHGB7 PCDHGB3 PCDHGC3 CDH13	4.82e-05	116	64	5	IPR015919
Domain	Cadherin	PCDHGC5 PCDHGB7 PCDHGB3 PCDHGC3 CDH13	5.23e-05	118	64	5	IPR002126
Domain	Cadherin_2	PCDHGC5 PCDHGB7 PCDHGB3 PCDHGC3	7.26e-05	65	64	4	PF08266
Domain	Cadherin_N	PCDHGC5 PCDHGB7 PCDHGB3 PCDHGC3	7.26e-05	65	64	4	IPR013164
Domain	IQ	MYH6 MYO1A SCN4A SCN9A	1.03e-04	71	64	4	PF00612
Domain	Na_trans_cytopl	SCN2A SCN9A	1.72e-04	6	64	2	PF11933
Domain	Na_trans_cytopl	SCN2A SCN9A	1.72e-04	6	64	2	IPR024583
Domain	Channel_four-helix_dom	SCN2A SCN4A SCN9A	9.84e-04	57	64	3	IPR027359
Domain	-	SCN2A SCN4A SCN9A	9.84e-04	57	64	3	1.20.120.350
Domain	-	COL6A1 SEC24A PSMD4	2.09e-03	74	64	3	3.40.50.410
Domain	ABC_membrane	ABCB11 ABCB1	3.04e-03	24	64	2	PF00664
Domain	ABC_TM1F	ABCB11 ABCB1	4.13e-03	28	64	2	PS50929
Domain	ABC1_TM_dom	ABCB11 ABCB1	4.13e-03	28	64	2	IPR011527
Domain	VWF_A	COL6A1 SEC24A PSMD4	4.76e-03	99	64	3	IPR002035
Domain	SH2	CSK SOCS4 TNS3	5.04e-03	101	64	3	PF00017
Domain	FIBRINOGEN_C_1	CNTNAP2 ITLN2	5.37e-03	32	64	2	PS00514
Domain	Fibrinogen_a/b/g_C_dom	CNTNAP2 ITLN2	5.37e-03	32	64	2	IPR002181
Domain	FIBRINOGEN_C_2	CNTNAP2 ITLN2	5.37e-03	32	64	2	PS51406
Domain	SH2	CSK SOCS4 TNS3	6.38e-03	110	64	3	SM00252
Domain	SH2	CSK SOCS4 TNS3	6.54e-03	111	64	3	PS50001
Domain	SH2	CSK SOCS4 TNS3	6.71e-03	112	64	3	IPR000980
Domain	-	CSK SOCS4 TNS3	6.71e-03	112	64	3	3.30.505.10
Pathway	REACTOME_CARDIAC_CONDUCTION	STIM1 KCNH2 SCN2A SCN4A SCN9A ITPR3	4.31e-06	130	47	6	M27454
Pathway	REACTOME_MUSCLE_CONTRACTION	STIM1 MYH6 KCNH2 SCN2A SCN4A SCN9A ITPR3	4.47e-06	203	47	7	M5485
Pathway	BIOCARTA_MRP_PATHWAY	ABCB11 ABCB1	1.08e-04	5	47	2	MM1586
Pathway	REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS	SCN2A SCN4A SCN9A	1.46e-04	31	47	3	M877
Pathway	REACTOME_PHASE_0_RAPID_DEPOLARISATION	SCN2A SCN4A SCN9A	1.61e-04	32	47	3	M27455
Pathway	BIOCARTA_MRP_PATHWAY	ABCB11 ABCB1	1.62e-04	6	47	2	M22078
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	AATK UBN1 NUAK1 KCNH2 CASKIN1 HECTD4 C19orf44 ZZEF1 MED13 HTT NSD3 ITPR3 GGT7	1.62e-07	1105	67	13	35748872
Pubmed	International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.	SCN2A SCN4A SCN9A	5.69e-07	9	67	3	16382098
Pubmed	State- and use-dependent block of muscle Nav1.4 and neuronal Nav1.7 voltage-gated Na+ channel isoforms by ranolazine.	SCN4A SCN9A	3.66e-06	2	67	2	18079277
Pubmed	ABCB11 and ABCB1 gene polymorphisms impact on telaprevir pharmacokinetic at one month of therapy.	ABCB11 ABCB1	3.66e-06	2	67	2	25661339
Pubmed	Compensatory role of P-glycoproteins in knockout mice lacking the bile salt export pump.	ABCB11 ABCB1	3.66e-06	2	67	2	19650158
Pubmed	Evidence for an interaction between Golli and STIM1 in store-operated calcium entry.	STIM1 MBP	3.66e-06	2	67	2	20629634
Pubmed	STIM1 Deficiency Leads to Specific Down-Regulation of ITPR3 in SH-SY5Y Cells.	STIM1 ITPR3	3.66e-06	2	67	2	32916960
Pubmed	Multidrug resistance protein 1 reduces the aggregation of mutant huntingtin in neuronal cells derived from the Huntington's disease R6/2 model.	HTT ABCB1	3.66e-06	2	67	2	26586297
Pubmed	Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.	SGSM1 CNTNAP2 SCN9A ELAPOR1 TEF NSD3 ITPR3	7.45e-06	371	67	7	15747579
Pubmed	Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.	PCDHGC5 PCDHGB7 PCDHGB3 PCDHGC3	9.33e-06	68	67	4	11230163
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	MRE11 NOP58 TCOF1 AMOTL1 TAF1 AMOTL2 HTT NSD3	1.06e-05	549	67	8	38280479
Pubmed	Voltage-gated sodium channels in taste bud cells.	SCN2A SCN9A	1.10e-05	3	67	2	19284629
Pubmed	Differential expression of the motin family in the peri-implantation mouse uterus and their hormonal regulation.	AMOTL1 AMOTL2	1.10e-05	3	67	2	22813598
Pubmed	Human ABCB1 with an ABCB11-like degenerate nucleotide binding site maintains transport activity by avoiding nucleotide occlusion.	ABCB11 ABCB1	1.10e-05	3	67	2	33031417
Pubmed	Identification and characterization of a novel tight junction-associated family of proteins that interacts with a WW domain of MAGI-1.	AMOTL1 AMOTL2	1.10e-05	3	67	2	16019084
Pubmed	[Association of SCN2A, ABCB1 and CYP2C19*3 with genetic susceptibility to major depressive disorder].	SCN2A ABCB1	1.10e-05	3	67	2	35381649
Pubmed	Omentin-1 drives cardiomyocyte cell cycle arrest and metabolic maturation by interacting with BMP7.	BMP7 ITLN2	1.10e-05	3	67	2	37344704
Pubmed	Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains.	AMOTL1 AMOTL2	1.10e-05	3	67	2	12406577
Pubmed	Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents.	SCN4A SCN9A	1.10e-05	3	67	2	20038812
Pubmed	A striking organization of a large family of human neural cadherin-like cell adhesion genes.	PCDHGC5 PCDHGB7 PCDHGB3 PCDHGC3	1.17e-05	72	67	4	10380929
Pubmed	Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.	PCDHGC5 PCDHGB7 PCDHGB3 PCDHGC3	1.31e-05	74	67	4	10817752
Pubmed	Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.	PCDHGC5 PCDHGB7 PCDHGB3 PCDHGC3	1.53e-05	77	67	4	10835267
Pubmed	Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.	PCDHGC5 PCDHGB7 PCDHGB3 PCDHGC3	1.78e-05	80	67	4	10716726
Pubmed	Angiomotin-like proteins associate with and negatively regulate YAP1.	AMOTL1 AMOTL2	2.19e-05	4	67	2	21187284
Pubmed	Angiomotin'g YAP into the nucleus for cell proliferation and cancer development.	AMOTL1 AMOTL2	2.19e-05	4	67	2	24003252
Pubmed	The endothelial E3 ligase HECW2 promotes endothelial cell junctions by increasing AMOTL1 protein stability via K63-linked ubiquitination.	AMOTL1 AMOTL2	2.19e-05	4	67	2	27498087
Pubmed	Angiomotin regulates endothelial cell migration during embryonic angiogenesis.	AMOTL1 AMOTL2	2.19e-05	4	67	2	17699752
Pubmed	Comparison of oxcarbazepine efficacy and MHD concentrations relative to age and BMI: Associations among ABCB1, ABCC2, UGT2B7, and SCN2A polymorphisms.	SCN2A ABCB1	2.19e-05	4	67	2	30896644
Pubmed	TMEM203 Is a Novel Regulator of Intracellular Calcium Homeostasis and Is Required for Spermatogenesis.	STIM1 ITPR3	2.19e-05	4	67	2	25996873
Pubmed	ERK8, a new member of the mitogen-activated protein kinase family.	CSK MBP	2.19e-05	4	67	2	11875070
Pubmed	A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.	SCN2A SCN9A	3.64e-05	5	67	2	8812438
Pubmed	Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein.	AMOTL1 AMOTL2	3.64e-05	5	67	2	21205866
Pubmed	Do candidate genes discriminate patients with an autism spectrum disorder from those with attention deficit/hyperactivity disorder and is there an effect of lifetime substance use disorders?	CNTNAP2 CDH13	3.64e-05	5	67	2	20446882
Pubmed	Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population.	ABCB11 ABCB1	3.64e-05	5	67	2	11829140
Pubmed	Identification of HAX-1 as a protein that binds bile salt export protein and regulates its abundance in the apical membrane of Madin-Darby canine kidney cells.	ABCB11 ABCB1	3.64e-05	5	67	2	15159385
Pubmed	Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.	SCN2A SCN4A	3.64e-05	5	67	2	17724025
Pubmed	A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.	SCN2A SCN9A	5.46e-05	6	67	2	23652591
Pubmed	Angiomotin functions in HIV-1 assembly and budding.	AMOTL1 AMOTL2	5.46e-05	6	67	2	25633977
Pubmed	Molecular characterization of angiomotin/JEAP family proteins: interaction with MUPP1/Patj and their endogenous properties.	AMOTL1 AMOTL2	5.46e-05	6	67	2	17397395
Pubmed	AATYK is a Novel Regulator of Oligodendrocyte Differentiation and Myelination.	AATK MBP	5.46e-05	6	67	2	29556912
Pubmed	Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation.	MRE11 TCOF1 AMOTL2	6.42e-05	40	67	3	28805822
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	NUAK1 CASKIN1 HECTD4 CNTNAP2 AMOTL2 ZZEF1 MED13	7.16e-05	529	67	7	14621295
Pubmed	Differential expression of individual gamma-protocadherins during mouse brain development.	PCDHGC5 PCDHGC3	7.63e-05	7	67	2	15964765
Pubmed	Gene-environment interaction in the etiology of mathematical ability using SNP sets.	NUAK1 DNAH5	7.63e-05	7	67	2	20978832
Pubmed	Arhgap28 is a RhoGAP that inactivates RhoA and downregulates stress fibers.	ARHGAP6 ARHGAP28	7.63e-05	7	67	2	25211221
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	MYH6 MYO1A PCDHGC5 PCDHGB7 PCDHGB3 SCN4A SCN9A CAMSAP2 PCDHGC3 MED13 ABCB1	9.10e-05	1442	67	11	35575683
Pubmed	Functions of the MRE11 complex in the development and maintenance of oocytes.	MRE11 RAD21L1	1.02e-04	8	67	2	26232174
Pubmed	Mapping of unconventional myosins in mouse and human.	MYO1A CSK MBP	1.11e-04	48	67	3	8884266
Pubmed	Evolution of the mammalian G protein alpha subunit multigene family.	COL6A1 MBP ABCB1	1.18e-04	49	67	3	1302014
Pubmed	Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU.	STIM1 ITPR3	1.30e-04	9	67	2	25737585
Pubmed	Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.	SCN2A SCN4A	1.30e-04	9	67	2	15746173
Pubmed	Domperidone treatment for gastroparesis: demographic and pharmacogenetic characterization of clinical efficacy and side-effects.	KCNH2 ABCB1	1.63e-04	10	67	2	21063774
Pubmed	Genetic profile of patients with epilepsy on first-line antiepileptic drugs and potential directions for personalized treatment.	SCN2A ABCB1	1.63e-04	10	67	2	20602612
Pubmed	NEDD4L-mediated Merlin ubiquitination facilitates Hippo pathway activation.	AMOTL1 AMOTL2	1.63e-04	10	67	2	33058421
Pubmed	Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes.	ABCB11 ABCB1	1.63e-04	10	67	2	12068294
Pubmed	Removal of RTF2 from Stalled Replisomes Promotes Maintenance of Genome Integrity.	MRE11 PSMD4	1.63e-04	10	67	2	29290612
Pubmed	Genome-wide association scan for five major dimensions of personality.	CNTNAP2 CDH13	1.63e-04	10	67	2	18957941
Pubmed	Identification and genetic mapping of 151 dispersed members of 16 ribosomal protein multigene families in the mouse.	COL6A1 MBP ABCB1	1.67e-04	55	67	3	7873877
Pubmed	Chromatin accessibility complex subunit 1 enhances tumor growth by regulating the oncogenic transcription of YAP in breast and cervical cancer.	MRE11 AMOTL1 AMOTL2	1.86e-04	57	67	3	38223760
Pubmed	Mutations in C1orf194, encoding a calcium regulator, cause dominant Charcot-Marie-Tooth disease.	COL6A1 MBP	1.99e-04	11	67	2	31199454
Pubmed	Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth.	AMOTL1 AMOTL2	1.99e-04	11	67	2	28239148
Pubmed	Differential impacts of Cntnap2 heterozygosity and Cntnap2 null homozygosity on axon and myelinated fiber development in mouse.	MBP CNTNAP2	2.81e-04	13	67	2	36793543
Pubmed	Blood pressure and hypertension are associated with 7 loci in the Japanese population.	CSK ABCB1	2.81e-04	13	67	2	20479155
Pubmed	Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.	SCN2A SCN9A	2.81e-04	13	67	2	15123669
Pubmed	WAVE1 is required for oligodendrocyte morphogenesis and normal CNS myelination.	SCN2A MBP	2.81e-04	13	67	2	16723544
Pubmed	Cell-fate determination by ubiquitin-dependent regulation of translation.	NOP58 TCOF1	3.28e-04	14	67	2	26399832
Pubmed	Functional suppression of Kcnq1 leads to early sodium channel remodelling and cardiac conduction system dysmorphogenesis.	MYH6 KCNH2	3.28e-04	14	67	2	23542581
Pubmed	Several common variants modulate heart rate, PR interval and QRS duration.	MYH6 KCNH2	3.28e-04	14	67	2	20062063
Pubmed	Maturation of postnatally generated olfactory bulb granule cells depends on functional γ-protocadherin expression.	PCDHGC5 PCDHGC3	3.78e-04	15	67	2	23515096
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	ARHGAP28 AMOTL2 CDH13 ITPR3 GGT7	3.98e-04	322	67	5	26514267
Pubmed	The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells.	AMOTL1 AMOTL2	4.31e-04	16	67	2	18824598
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	UBN1 AMOTL1 AMOTL2 DNAH5 TNS3	4.58e-04	332	67	5	37433992
Pubmed	Lhx2 is required for patterning and expansion of a distinct progenitor cell population committed to eye development.	BMP7 NUAK1	4.88e-04	17	67	2	21886788
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	MRE11 TCOF1 CSK PSMD4 PIPSL TNS3 ITPR3 GGT7	5.56e-04	974	67	8	28675297
Pubmed	Huntingtin interacting proteins are genetic modifiers of neurodegeneration.	MRE11 PSMD4 CDH13 HTT	5.79e-04	197	67	4	17500595
Pubmed	Transcriptome analysis of the murine forelimb and hindlimb autopod.	BMP7 MBP	6.12e-04	19	67	2	16059910
Pubmed	Impact of ancestry and common genetic variants on QT interval in African Americans.	KCNH2 MBP	6.12e-04	19	67	2	23166209
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	NOP58 PAPOLA TCOF1 PSMD4 AMOTL2 CAMSAP2 MED13 TNS3 ITPR3	6.27e-04	1247	67	9	27684187
Pubmed	STAGA recruits Mediator to the MYC oncoprotein to stimulate transcription and cell proliferation.	TAF1 MED13	6.79e-04	20	67	2	17967894
Pubmed	A distinct response to endogenous DNA damage in the development of Nbs1-deficient cortical neurons.	MRE11 MBP	6.79e-04	20	67	2	22212482
Pubmed	A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients.	ZNF462 CDH13	7.50e-04	21	67	2	24025145
Pubmed	The RNF146 and tankyrase pathway maintains the junctional Crumbs complex through regulation of angiomotin.	AMOTL1 AMOTL2	8.24e-04	22	67	2	27521426
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	STIM1 CSK SEC24A RALGAPB PSMD4 TNS3 NSD3 ITPR3	9.01e-04	1049	67	8	27880917
Pubmed	Cytokinesis involves a nontranscriptional function of the Hippo pathway effector YAP.	AMOTL1 AMOTL2	9.01e-04	23	67	2	26933062
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	ZNF462 MRE11 NOP58 UBN1	9.04e-04	222	67	4	37071664
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	MRE11 NOP58 UBN1 NUAK1 CSK RALGAPB PSMD4 MED13 HTT	9.74e-04	1327	67	9	32694731
Pubmed	FGF signaling regulates the number of posterior taste papillae by controlling progenitor field size.	BMP7 ITPR3	9.82e-04	24	67	2	21655085
Pubmed	MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice.	MYH6 MED13	9.82e-04	24	67	2	19726871
Pubmed	NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.	ZNF462 NOP58 TCOF1	1.05e-03	103	67	3	32744500
Pubmed	The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function.	TAF1 MED13	1.07e-03	25	67	2	19240132
Pubmed	The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway.	AMOTL1 AMOTL2	1.07e-03	25	67	2	21145499
Pubmed	Deubiquitinating Enzyme USP9X Suppresses Tumor Growth via LATS Kinase and Core Components of the Hippo Pathway.	AMOTL1 AMOTL2	1.15e-03	26	67	2	28720576
Pubmed	Myocardial Tbx20 regulates early atrioventricular canal formation and endocardial epithelial-mesenchymal transition via Bmp2.	BMP7 MYH6	1.24e-03	27	67	2	21983003
Pubmed	Same but different - Molecular comparison of human KTI12 and PSTK.	TDRKH AMOTL1	1.24e-03	27	67	2	33417976
Pubmed	Interaction with protocadherin-gamma regulates the cell surface expression of protocadherin-alpha.	PCDHGC5 PCDHGC3	1.34e-03	28	67	2	15347688
Pubmed	Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8.	ZNF462 HTT	1.34e-03	28	67	2	25752541
Pubmed	Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis.	COL6A1 SGSM1 MBP PSMD4	1.38e-03	249	67	4	9371744
Pubmed	Atm deficiency in the DNA polymerase β null cerebellum results in cerebellar ataxia and Itpr1 reduction associated with alteration of cytosine methylation.	MBP ITPR3	1.44e-03	29	67	2	32123907
Pubmed	Genome-wide association study of periodontal pathogen colonization.	GLDC EVX2	1.64e-03	31	67	2	22699663
Pubmed	miR-218 Promotes Dopaminergic Differentiation and Controls Neuron Excitability and Neurotransmitter Release through the Regulation of a Synaptic-Related Genes Network.	CASKIN1 CNTNAP2	1.64e-03	31	67	2	37816598
Cytoband	5q31	PCDHGC5 PCDHGB7 PCDHGB3 PCDHGC3	2.54e-05	115	67	4	5q31
Cytoband	Ensembl 112 genes in cytogenetic band chr5q31	PCDHGC5 PCDHGB7 PCDHGB3 SEC24A PCDHGC3	7.74e-05	298	67	5	chr5q31
Cytoband	2q24	SCN9A ABCB11	1.14e-04	11	67	2	2q24
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN2A SCN4A SCN9A	1.37e-06	9	47	3	1203
GeneFamily	Clustered protocadherins	PCDHGC5 PCDHGB7 PCDHGB3 PCDHGC3	2.27e-05	64	47	4	20
GeneFamily	ATP binding cassette subfamily B	ABCB11 ABCB1	3.58e-04	11	47	2	806
GeneFamily	SH2 domain containing	CSK SOCS4 TNS3	2.30e-03	101	47	3	741
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	ARHGAP6 ARHGAP28	7.48e-03	50	47	2	721
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	AATK UBN1 ITPR3	1.16e-02	181	47	3	694
ToppCell	droplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP7 SGSM1 PCDHGC5 PCDHGB7 CDH13	1.34e-06	126	67	5	4eeea015efe17e0aae5bd76b71fa70b5149dfada
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell-D175\|Adult / Lineage, Cell type, age group and donor	ARHGAP6 COL6A1 NUAK1 ARHGAP28 CDH13	9.21e-06	187	67	5	e15d2967aac248da3517bc2c7d1beaa1d5a0aa7f
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ARHGAP6 COL6A1 NUAK1 ARHGAP28 CDH13	1.02e-05	191	67	5	6688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ARHGAP6 COL6A1 NUAK1 ARHGAP28 CDH13	1.05e-05	192	67	5	99ce9e3c4c50cf64ebb62145f2b5420efa0db309
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell-D231\|Adult / Lineage, Cell type, age group and donor	ARHGAP6 COL6A1 NUAK1 ARHGAP28 CDH13	1.07e-05	193	67	5	ef2f456c094e6e3c6ee81e0668c953cb8d0e1c0a
ToppCell	Mesenchymal-matrix_fibroblast_1_cell\|World / Lineage, Cell type, age group and donor	ARHGAP6 COL6A1 NUAK1 CNTNAP2 ARHGAP28	1.07e-05	193	67	5	acad568621ed677031797b8c2e34dafea798d681
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell\|Adult / Lineage, Cell type, age group and donor	ARHGAP6 COL6A1 NUAK1 ARHGAP28 CDH13	1.13e-05	195	67	5	61c9e09fc84d1012e472185d70ad0a06cee30d6e
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell-D122\|Adult / Lineage, Cell type, age group and donor	ARHGAP6 COL6A1 NUAK1 ARHGAP28 CDH13	1.13e-05	195	67	5	aa0add081881d349099d12efca5cdee098038d4e
ToppCell	Adult-Mesenchymal\|Adult / Lineage, Cell type, age group and donor	ARHGAP6 COL6A1 NUAK1 ARHGAP28 CDH13	1.21e-05	198	67	5	26e55b409db2a1637c95fae7c54b0abea1ef550c
ToppCell	COVID-19-lung-Fibroblast\|lung / Disease (COVID-19 only), tissue and cell type	ARHGAP6 COL6A1 NUAK1 ARHGAP28 CDH13	1.21e-05	198	67	5	df3de77216f5c5d6141ec44d01c56b942f611838
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic-Fibro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGAP6 COL6A1 NUAK1 ARHGAP28 CDH13	1.27e-05	200	67	5	e8462395fee0a532d1e7ec7f1795f28c42af6541
ToppCell	Parenchyma_Control_(B.)-Stromal-TX-Fibroblasts-1\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	COL6A1 ARHGAP28 AMOTL2 PCDHGC3 CDH13	1.27e-05	200	67	5	aa1a35dcca3b799241eef4237f6eb94660e019f0
ToppCell	Lung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-1\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	COL6A1 ARHGAP28 AMOTL2 PCDHGC3 CDH13	1.27e-05	200	67	5	a510deaada669e690329183e18df02870bd204b3
ToppCell	Parenchymal-NucSeq-Stromal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGAP6 COL6A1 NUAK1 ARHGAP28 CDH13	1.27e-05	200	67	5	cf433f9b43d7db07acaf70e060f8f77c974e72f3
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGAP6 COL6A1 NUAK1 ARHGAP28 CDH13	1.27e-05	200	67	5	311fab076f2ceb258e3970eb21e39344b894042a
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGAP6 COL6A1 NUAK1 ARHGAP28 CDH13	1.27e-05	200	67	5	34f52003988ce6329d8deeee1ab875fa77e01e9d
ToppCell	Lung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-1-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	COL6A1 ARHGAP28 AMOTL2 PCDHGC3 CDH13	1.27e-05	200	67	5	dd4228cbed8a4395166a6332e08d44d88bebe3b9
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GLDC CASKIN1 HTT ABCB1	3.57e-05	123	67	4	a45d6907c041ad3f3218cd46dccfc25d4bd961cb
ToppCell	droplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Endothelial-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP7 PCDHGC5 PCDHGB7 CDH13	3.80e-05	125	67	4	35042ed43045dddc341b76cc5f9fe31b5ba0abb8
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Drd1-Excitatory_Neuron.Gad1Gad2.Drd1-Fos_(dSPN,_IEG+)-\|Striatum / BrainAtlas - Mouse McCarroll V32	MYO1A SCN4A RAD21L1	4.28e-05	45	67	3	cce61a18a2d2ac9c3113ef7d9fe8adf70bad773c
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Drd1-Excitatory_Neuron.Gad1Gad2.Drd1-Fos_(dSPN,_IEG+)\|Striatum / BrainAtlas - Mouse McCarroll V32	MYO1A SCN4A RAD21L1	4.28e-05	45	67	3	08e956e0a428432382ecc13f293f20154fac042c
ToppCell	droplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Endothelial-endothelial_cell_of_coronary_artery\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP7 PCDHGC5 PCDHGB7 CDH13	4.56e-05	131	67	4	419a0a83b38eaea890d065c3f252ef83c2d37b5b
ToppCell	Substantia_nigra-Endothelial-ENDOTHELIAL_TIP-Dcn_1\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	COL6A1 BMP7 SCN4A ABCB11	4.70e-05	132	67	4	893b7ec2a2d8a140cc98575d1beca1189f053e9a
ToppCell	droplet-Kidney-nan-3m-Lymphocytic-nan\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TDRKH NOP58 CSK SLC9A7	6.25e-05	142	67	4	a88bf4bcc80206b16dcc504cc19a3380d01e34a4
ToppCell	Club_cells-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	GARIN4 ELAPOR1 ARHGAP28 DNAH5	7.14e-05	147	67	4	5a824c89e4d045af465d7333275f8191fb29b041
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SGSM1 SCN2A ADGRG4 GGT7	9.45e-05	158	67	4	7960337d87afecf2692ab65e5991f052ceddfacc
ToppCell	Substantia_nigra-Endothelial-ENDOTHELIAL_TIP\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	COL6A1 BMP7 SCN4A ABCB11	9.68e-05	159	67	4	cb2470b288c13e454a2a80115b0d5613b3f718e6
ToppCell	normal-na-Lymphocytic_NK-NK_bright-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	GARIN4 MBP CDH13 ABCB1	1.09e-04	164	67	4	b5a91f2cbfad9a2bc38aea576085a37865df955d
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells-CD8_T_cells_L.1.1.2.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TCOF1 CASKIN1 ARHGAP28 ABCB1	1.09e-04	164	67	4	30c3c25b05a403a509b2e755c2f0878fecb10a02
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c09-SLC4A10\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	BMP7 AATK KCNH2 ABCB1	1.12e-04	165	67	4	5e7ee76f3dcddbd1b560bacd043f9001b0c18b5f
ToppCell	Mild-Myeloid-Mast\|Mild / Condition, Lineage, Cell class and cell subclass	ZNF462 BMP7 KCNH2 SCN9A	1.12e-04	165	67	4	5fa9552c37890c5cc7e672a47038aebba2413cb4
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Epithelial-neuronal_stem_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C19orf44 DNAH5 PCDHGC3 CDH13	1.12e-04	165	67	4	1703d3eb644b3c743ad3c5532b1d29ea010c79c8
ToppCell	Mild-Myeloid-Mast-\|Mild / Condition, Lineage, Cell class and cell subclass	ZNF462 BMP7 KCNH2 SCN9A	1.12e-04	165	67	4	93d3909a0f5f43d473d5005c842d7d73e25eceed
ToppCell	368C-Myeloid-Macrophage-FABP4+_Macrophage_2\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	KCNH2 AMOTL2 TEF CDH13	1.12e-04	165	67	4	3d2acdae0dd2b79a15f74158e8e566ce22b4218e
ToppCell	Nasal_Brush-Epithelial-Basal_1\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	COL6A1 BMP7 AMOTL1 CNTNAP2	1.31e-04	172	67	4	58eaadf12366701103a0d1f133462c9495fedc30
ToppCell	Nasal_Brush-Epithelial-Basal_1\|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	COL6A1 BMP7 AMOTL1 CNTNAP2	1.31e-04	172	67	4	4483073469001770015526303772fd54906c5d68
ToppCell	368C-Myeloid-Mast_cell\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	ZNF462 BMP7 KCNH2 NMT2	1.34e-04	173	67	4	8cffb4a37d30b6626188309b868ac4a62e91262f
ToppCell	368C-Myeloid-Mast_cell-\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	ZNF462 BMP7 KCNH2 NMT2	1.34e-04	173	67	4	fb87ea74bf70aa83b458edf728c81857c8b8eb96
ToppCell	NS-moderate-d_07-13-Lymphoid-NK\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	COL6A1 AMOTL1 PCDHGC3 CDH13	1.40e-04	175	67	4	f6cd24d22f62469319f9d244e3e5de527d3d4d94
ToppCell	Thalamus-Neuronal-Excitatory\|Thalamus / BrainAtlas - Mouse McCarroll V32	DBNDD1 SCN2A AMOTL1 ELAPOR1	1.43e-04	176	67	4	d2bbf13d21fb7582d7e5f90cd61a4ebe1cfccd66
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Rectal_Adenocarcinoma-7\|TCGA-Colorectal / Sample_Type by Project: Shred V9	TDRKH RALGAPB AMOTL2 TNS3	1.49e-04	178	67	4	edc76b8f15056ec1c9a1c61a048b6331a92592d6
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.2.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	AATK SCN9A AMOTL2 ITPR3	1.49e-04	178	67	4	f3b5eeca6081d65d48824b5d13e3b8eb5fdeb2dd
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP6 SCN2A MBP ABCB1	1.59e-04	181	67	4	aa233b652921848af2257cc3687a7a09c3acfb67
ToppCell	critical-Myeloid-Mast_cell\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ZNF462 ARHGAP6 KCNH2 NMT2	1.59e-04	181	67	4	f0d81ae74d3f32979624a94b2ef93774831a7970
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF462 BMP7 TNS3 ABCB1	1.63e-04	182	67	4	5e1b316599436740f1b30875f0ebd33c3edfb2b6
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_PP_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP6 KCNH2 ELAPOR1 PCDHGC3	1.63e-04	182	67	4	eb4be1c02b8b033d025e57b8b4cdbfaec4698054
ToppCell	(4)_B_cells-(4)_B_mantle\|(4)_B_cells / Spleen cell shreds - cell class (v1) and cell subclass (v1)	DBNDD1 CNTNAP2 NSD3 ABCB1	1.66e-04	183	67	4	21b7fb6482eb1d5d31a4029e47e0992e8ddc8e2c
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-myocytic-myofibroblast\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ARHGAP6 COL6A1 KCNH2 ARHGAP28	1.66e-04	183	67	4	af8d86f15a549064530d94bd47081daf59d58ecd
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Epcam____podocyte-2\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GARIN4 ARHGAP28 CDH13 TNS3	1.70e-04	184	67	4	e123ad8ee46a032825a0bd4b3586ddcb3eda03d4
ToppCell	Transplant_Alveoli_and_parenchyma-Immune-Mast_cells\|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X	ZNF462 BMP7 KCNH2 NMT2	1.70e-04	184	67	4	bc394eaa441fcaffcc4ace062741bca1da229324
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNH2 NMT2 SCN2A CNTNAP2	1.73e-04	185	67	4	70de48988c1f8e0809afc8092b663aa439d8e528
ToppCell	droplet-Heart-nan-18m-Neuronal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP7 AATK MBP DNAH5	1.73e-04	185	67	4	c61267cfadea018794f7964904445787629a40d1
ToppCell	droplet-Heart-nan-18m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP7 AATK MBP DNAH5	1.73e-04	185	67	4	3a592719d5643011954f89d5bb61a5e94682b68e
ToppCell	Substantia_nigra-Neuronal-Inhibitory\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	DBNDD1 KCNH2 CNTNAP2 SCN9A	1.77e-04	186	67	4	9d3efe2a4feea2bc205a7e45b9b9f9ed9b3609ce
ToppCell	Substantia_nigra-Neuronal\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	DBNDD1 SCN2A CNTNAP2 ELAPOR1	1.77e-04	186	67	4	3f889083fcffe516388e9b03a5e23af2010ced33
ToppCell	Control-Fibroblasts-Alveolar_FB\|Control / group, cell type (main and fine annotations)	ARHGAP6 NUAK1 ARHGAP28 CDH13	1.81e-04	187	67	4	92d468dde81125d51daf7abd4703741abe1ab91c
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GLDC SCN2A MBP ABCB1	1.81e-04	187	67	4	2d17408b3b5f09d135084fd7ccce98e6b5ca632b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GLDC SCN2A MBP ABCB1	1.81e-04	187	67	4	e3095455d2f255854f339f6b05fa87852af0700f
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	DBNDD1 SCN2A CNTNAP2 SCN9A	1.84e-04	188	67	4	b73e8a40393c3f656e2fcfe395a761b1f985c254
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GLDC SCN2A MBP ABCB1	1.88e-04	189	67	4	3a295c215b5c18e7c673f92b7af5be523421682c
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_3\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	SEC24A SOCS4 ITPR3 ENOX2	1.88e-04	189	67	4	99b01893da9f9f7c9528afaffad178285211738b
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GLDC SCN2A MBP ABCB1	1.88e-04	189	67	4	fc88c51ace7d883c01617f3f9b5fab70cc91cc09
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal-bronchial_smooth_muscle_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF462 GARIN4 KCNH2 SCN2A	1.88e-04	189	67	4	4dc32b463546bbe7250dddd281b92ad17ec22da1
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal-Airway_Smooth_Muscle\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF462 GARIN4 KCNH2 SCN2A	1.88e-04	189	67	4	0d06bf0d7191d13a1c4f30a7881e7ea1093bfd6f
ToppCell	facs-Lung-EPCAM-24m-Epithelial-Neuroendocrine\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SGSM1 SCN9A CDH13 GGT7	1.96e-04	191	67	4	501d4f6ad389d9ac5051d4247b9bd3da96f713f9
ToppCell	facs-Lung-EPCAM-24m-Epithelial-lung_neuroendocrine_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SGSM1 SCN9A CDH13 GGT7	1.96e-04	191	67	4	8e06cc61eaff1796c2ce014074029408ba88d561
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GLDC SCN2A MBP ABCB1	2.00e-04	192	67	4	0bb06738e1c3ec0c044a7ee61f6cf1d4781fb53c
ToppCell	PBMC-Control-Lymphocyte-B-B_cell-B_naive-B_naive-2\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TCOF1 CNTNAP2 SLC9A7 NSD3	2.00e-04	192	67	4	ef86d82e4f04f9f54e821ef496d70fc81072d773
ToppCell	COPD-Stromal-Myofibroblast\|Stromal / Disease state, Lineage and Cell class	ARHGAP6 ARHGAP28 CDH13 TNS3	2.00e-04	192	67	4	62904f94dfce430456f05066522cbf9bd29f4d7e
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-myocytic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ARHGAP6 COL6A1 KCNH2 ARHGAP28	2.04e-04	193	67	4	146e8c148478ab61b1c1dbaf1ee98a8cd4a0ff8a
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF462 AMOTL1 AMOTL2 PCDHGC3	2.04e-04	193	67	4	826b8dd801298b3e0cd76232feae5a14026b8806
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL6A1 MBP CNTNAP2 CDH13	2.04e-04	193	67	4	164cc8d51a67c2df3112338acbb1f93c5f838376
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF462 AMOTL1 AMOTL2 PCDHGC3	2.04e-04	193	67	4	87d3a577d37fb0cb4b6313c596310de452bc3872
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ARHGAP6 COL6A1 NUAK1 ARHGAP28	2.04e-04	193	67	4	99525545552b371c86b18b6ea6f4897dc6e9a9ec
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ARHGAP6 COL6A1 NUAK1 ARHGAP28	2.04e-04	193	67	4	b3ad5ff480d99217f36cc7471e5a96a519ddb409
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARHGAP6 COL6A1 NUAK1 ARHGAP28	2.04e-04	193	67	4	fb28717fadd06c3840636d25409ce80c9254bd34
ToppCell	Thalamus-Neuronal\|Thalamus / BrainAtlas - Mouse McCarroll V32	KCNH2 SCN2A CNTNAP2 ELAPOR1	2.04e-04	193	67	4	712a4acd1167e43543950bc819ff11984e6f718d
ToppCell	severe_influenza-B_naive\|World / disease group, cell group and cell class (v2)	DBNDD1 TCOF1 CNTNAP2 SLC9A7	2.04e-04	193	67	4	c52ba94782ad57b93d20f853a89344dffa8351f9
ToppCell	Control-Stromal-Myofibroblast\|Stromal / Disease state, Lineage and Cell class	ARHGAP6 NUAK1 CDH13 TNS3	2.04e-04	193	67	4	5896242f713ae5fd1a4ebb63827f15d7279dced2
ToppCell	severe_influenza-B_naive\|severe_influenza / disease group, cell group and cell class (v2)	DBNDD1 TCOF1 CNTNAP2 SLC9A7	2.08e-04	194	67	4	7c1e9ce5de3bb1657a67010de673c8bb60129cb6
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ARHGAP6 COL6A1 NUAK1 ARHGAP28	2.08e-04	194	67	4	e93de9428c986b8943fc169258847c650cfab0e5
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_2_(ZEB2+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL6A1 MBP CNTNAP2 CDH13	2.08e-04	194	67	4	88a2dfba7d16cf52ecbc3d8c28ff82450c1bb13a
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCDHGC5 SCN2A CNTNAP2 ELAPOR1	2.12e-04	195	67	4	ffbab350e67d9c4b66c0ab84550daec8b8139a27
ToppCell	COVID-19-Fibroblasts-Alveolar_FB\|COVID-19 / group, cell type (main and fine annotations)	ARHGAP6 NUAK1 ARHGAP28 CDH13	2.12e-04	195	67	4	603050beeb33c331d4b2e3fa46cae3f3e0e4bdc7
ToppCell	Influenza_Severe-B_naive\|Influenza_Severe / Disease group and Cell class	DBNDD1 TCOF1 CNTNAP2 SLC9A7	2.12e-04	195	67	4	a25516ed670c7738670ffbaa6f7cd167946f3825
ToppCell	Healthy/Control-B_naive\|Healthy/Control / Disease group and Cell class	DBNDD1 TCOF1 CNTNAP2 SLC9A7	2.16e-04	196	67	4	e92d2c814d2dcb049f3e455fe66fd40898b3524d
ToppCell	Healthy_donor-B_naive\|Healthy_donor / disease group, cell group and cell class (v2)	DBNDD1 TCOF1 CNTNAP2 SLC9A7	2.16e-04	196	67	4	cf254b1466357984201595fa32408d659eb741ef
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_neuro-secretory-Ionocyte_n_Brush\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	KCNH2 CNTNAP2 SCN9A SLC9A7	2.16e-04	196	67	4	50aaca81b593ff71790bb75403b2e4c3ab03a6d2
ToppCell	Healthy/Control-B_naive\|World / Disease group and Cell class	DBNDD1 TCOF1 CNTNAP2 SLC9A7	2.16e-04	196	67	4	ec935a4e16495c87b17070eb13c1e28bdb64e7ee
ToppCell	Children_(3_yrs)-Mesenchymal\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ARHGAP6 COL6A1 NUAK1 ARHGAP28	2.16e-04	196	67	4	bc94909f9b2dc08a59eef1914148b69720569c8f
ToppCell	nucseq-Mesenchymal-Fibroblastic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ARHGAP6 COL6A1 ARHGAP28 CDH13	2.16e-04	196	67	4	7d8505dac15fa59935ccf592afc54b04c4c6554f
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL6A1 ARHGAP28 DNAH5 CDH13	2.20e-04	197	67	4	1da8ba5bbab232add6e43ad78b15c2339d0c2bc3
ToppCell	PCW_13-14-Mesenchymal\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ARHGAP6 COL6A1 CNTNAP2 ARHGAP28	2.20e-04	197	67	4	73a2085d2682d636726a5432d572ae2a3fbe1c3f
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL6A1 ARHGAP28 DNAH5 CDH13	2.20e-04	197	67	4	d9e196c8b4a6ede4733946dbdba3331534954beb
ToppCell	Bronchial-10x5prime-Stromal-Peri/Epineurial_-NAF_epineurial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CASKIN1 AMOTL1 SCN9A CAMSAP2	2.29e-04	199	67	4	a13f4b8a039304e685464cc8879659824cad5a3e
ToppCell	PCW_10-12-Mesenchymal\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ARHGAP6 COL6A1 CNTNAP2 ARHGAP28	2.29e-04	199	67	4	a09292de4c4447b8eee55d401808e43b817321cc
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ZNF462 SCN2A SCN9A CDH13	2.29e-04	199	67	4	19a97e27a4758e794ce7246d295e112b47931a48
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-ADGRG6-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ARHGAP6 AMOTL1 CNTNAP2 CDH13	2.33e-04	200	67	4	a9cdddc4e985dae59521e557479c24fcc2ac727d
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-ADGRG6--L3-5\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ARHGAP6 AMOTL1 CNTNAP2 CDH13	2.33e-04	200	67	4	33b9199e0dfc267e2cea20b82d1c167f8adcc635
ToppCell	Influenza-Influenza_Severe-Lymphocyte-B-B_naive\|Influenza_Severe / Disease, condition lineage and cell class	DBNDD1 TCOF1 CNTNAP2 SLC9A7	2.33e-04	200	67	4	0e05600d725dc5cc9afccc11eedc60efa41e4e46
Drug	APETx1, Anthopleura elegantissima	KCNH2 SCN2A SCN4A	4.62e-07	6	66	3	ctd:C475726
Drug	lamotrigine	KCNH2 SCN2A SCN4A SCN9A ABCB1 ITPR3	1.09e-06	116	66	6	CID000003878
Drug	Mexiletine	KCNH2 SCN9A ABCB1	1.93e-06	9	66	3	ctd:D008801
Drug	azelastine	COL6A1 KCNH2 ABCB1	1.93e-06	9	66	3	ctd:C020976
Drug	5-hydroxypropafenone	KCNH2 SCN4A SCN9A ABCB1	2.80e-06	34	66	4	CID000107927
Drug	phenytoin	COL6A1 KCNH2 SCN2A SCN4A SCN9A ABCB1 ITPR3	3.33e-06	219	66	7	CID000001775
Drug	aprindine	KCNH2 SCN4A SCN9A PSMD4	4.41e-06	38	66	4	CID000002218
Drug	ranolazine	KCNH2 SCN4A SCN9A ABCB1	4.91e-06	39	66	4	CID000056959
Drug	mu-conotoxin KIIIA, Conus kinoshitai	SCN2A SCN4A	8.28e-06	2	66	2	ctd:C502265
Drug	rescinnamine	KCNH2 ABCB1	8.28e-06	2	66	2	ctd:C084826
Drug	cepharanthine	KCNH2 ABCB1	8.28e-06	2	66	2	ctd:C006947
Drug	Quetiapine Fumarate	KCNH2 MBP ABCB1	1.27e-05	16	66	3	ctd:D000069348
Drug	valproate	PCDHGC5 PCDHGB7 KCNH2 SCN4A SCN9A PCDHGC3 ABCB1 ITPR3	1.41e-05	381	66	8	CID000003121
Drug	Zonisamide	SCN2A SCN4A SCN9A	1.54e-05	17	66	3	DB00909
Drug	Scorpion Venoms	SCN2A SCN4A SCN9A	1.84e-05	18	66	3	ctd:D012604
Drug	Fluvoxamine	KCNH2 ABCB11 ABCB1	1.84e-05	18	66	3	ctd:D016666
Drug	2-phenylglycine	CNTNAP2 ABCB11 TAF1 ABCB1	1.97e-05	55	66	4	CID000003866
Drug	Cetirizine dihydrochloride [83881-52-1]; Down 200; 8.6uM; PC3; HT_HG-U133A	ARHGAP6 TDRKH CNTNAP2 TAF1 ZZEF1 NSD3	2.29e-05	197	66	6	4231_DN
Drug	Elacridar	ABCB11 ABCB1	2.48e-05	3	66	2	ctd:C083501
Drug	Clofazimine	KCNH2 ABCB11	2.48e-05	3	66	2	ctd:D002991
Drug	N-(2-methyl-3-(4-(4-(4-(trifluoromethoxy)benzyloxy)piperidin-1-yl)-1,3,5-triazin-2-ylamino)phenyl)acetamide	SCN4A SCN9A	2.48e-05	3	66	2	ctd:C561228
Drug	3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester	ABCB11 ABCB1	2.48e-05	3	66	2	ctd:C541506
Drug	2-Chloropyrazine [14508-49-7]; Down 200; 35uM; PC3; HT_HG-U133A	COL6A1 TDRKH DBNDD1 KCNH2 SCN9A ENOX2	2.50e-05	200	66	6	5750_DN
Drug	bepridil	KCNH2 SCN4A SCN9A PSMD4 ITPR3	3.27e-05	126	66	5	CID000002351
Drug	Quinine	KCNH2 SLC9A7 ABCB1	3.44e-05	22	66	3	ctd:D011803
Drug	saxitoxin	MYH6 SCN2A SCN4A SCN9A	3.82e-05	65	66	4	CID000037165
Drug	AC1L1CQC	KCNH2 SCN4A SCN9A ABCB1	3.82e-05	65	66	4	CID000002012
Drug	disopyramide	KCNH2 SCN4A SCN9A PSMD4	4.05e-05	66	66	4	CID000003114
Drug	quindine	KCNH2 SCN4A SCN9A SLC9A7 ABCB11 ABCB1	4.15e-05	219	66	6	CID000001065
Drug	1-chloro-1,2,2-trifluorocyclobutane	KCNH2 SCN2A SCN4A	4.51e-05	24	66	3	CID000079091
Drug	Fospropofol	SCN2A SCN4A	4.95e-05	4	66	2	DB06716
Drug	2-methoxy-N-(3-(4-((3-methyl-4-((6-methyl-3-pyridinyl)oxy)phenyl)amino)-6-quinazolinyl)-2-propenyl)acetamide	ABCB11 ABCB1	4.95e-05	4	66	2	ctd:C521104
Drug	cinchonine	KCNH2 ABCB1	4.95e-05	4	66	2	ctd:C010086
Drug	Propofol	SCN2A SCN4A	4.95e-05	4	66	2	DB00818
Drug	lamotrigine	KCNH2 SCN2A ABCB1	5.11e-05	25	66	3	ctd:C047781
Drug	Multicide	SCN2A SCN4A SCN9A	5.11e-05	25	66	3	CID000024365
Drug	Pirmenolum	KCNH2 SCN4A SCN9A	5.77e-05	26	66	3	CID000004853
Drug	Flupenthixol	KCNH2 ABCB1	8.23e-05	5	66	2	ctd:D005475
Drug	davidigenin	ABCB11 PSMD4 ABCB1	8.93e-05	30	66	3	CID000442342
Drug	Loratadine	KCNH2 ABCB11 ABCB1	8.93e-05	30	66	3	ctd:D017336
Drug	amiodarone	MYH6 KCNH2 SCN4A SCN9A ABCB1	1.02e-04	160	66	5	CID000002156
Drug	Sodium	KCNH2 SCN2A SCN9A SLC9A7	1.04e-04	84	66	4	ctd:D012964
Drug	fexofenadine	KCNH2 ABCB11 ABCB1	1.09e-04	32	66	3	ctd:C093230
Drug	bisbenzimide ethoxide trihydrochloride	ABCB11 ABCB1	1.23e-04	6	66	2	ctd:C017807
Drug	domiphen	KCNH2 CDH13	1.23e-04	6	66	2	ctd:C007556
Drug	Mefloquine	KCNH2 ABCB1	1.23e-04	6	66	2	ctd:D015767
Drug	NSC15627	KCNH2 SCN4A SCN9A	1.31e-04	34	66	3	CID000002073
Drug	gabapentin	KCNH2 SCN4A SCN9A ABCB1 ITPR3	1.32e-04	169	66	5	CID000003446
Drug	Terfenadine	KCNH2 ABCB11 ABCB1	1.42e-04	35	66	3	ctd:D016593
Drug	Syrosingopine [84-36-6]; Up 200; 6uM; MCF7; HT_HG-U133A	TDRKH KCNH2 AMOTL2 ZZEF1 NSD3	1.68e-04	178	66	5	2753_UP
Drug	benzocaine	SCN2A SCN4A SCN9A	1.68e-04	37	66	3	CID000002337
Drug	1,2-dichlorohexafluorocyclobutane	KCNH2 SCN2A SCN4A	1.68e-04	37	66	3	CID000009643
Drug	sipatrigine	SCN2A SCN4A SCN9A	1.68e-04	37	66	3	CID000060803
Drug	fluorocyclobutane	SCN2A SCN4A	1.72e-04	7	66	2	CID011051569
Drug	amprenavir	ABCB11 ABCB1	1.72e-04	7	66	2	ctd:C095108
Drug	Ranolazine	KCNH2 ABCB11	1.72e-04	7	66	2	ctd:D000069458
Drug	propafenone	KCNH2 SCN4A SCN9A ABCB1	1.90e-04	98	66	4	CID000004932
Drug	CID9959010	PCDHGC5 PCDHGB7 PCDHGC3	1.97e-04	39	66	3	CID009959010
Drug	TiNi	MYH6 SLC39A2 PSMD4 DNAH5	2.05e-04	100	66	4	CID000159408
Drug	Thonzonium bromide [553-08-2]; Up 200; 6.8uM; MCF7; HT_HG-U133A	COL6A1 TDRKH CNTNAP2 ZZEF1 NSD3	2.11e-04	187	66	5	5678_UP
Drug	montmorillonite	PCDHGC5 PCDHGB7 PCDHGC3	2.13e-04	40	66	3	CID000517273
Drug	S-ropivacaine	KCNH2 SCN4A SCN9A	2.13e-04	40	66	3	CID000071273
Drug	Primaquine diphosphate [63-45-6]; Down 200; 8.8uM; MCF7; HT_HG-U133A	PAPOLA TCOF1 MBP HECTD4 ITPR3	2.16e-04	188	66	5	4845_DN
Drug	Ampyrone [83-07-8]; Down 200; 19.6uM; PC3; HT_HG-U133A	COL6A1 DBNDD1 CNTNAP2 ARHGAP28 TAF1	2.27e-04	190	66	5	4507_DN
Drug	calcein AM	ABCB11 ABCB1	2.29e-04	8	66	2	ctd:C085925
Drug	Fusidic Acid	ABCB11 ABCB1	2.29e-04	8	66	2	ctd:D005672
Drug	T beta-MC	ABCB11 ABCB1	2.29e-04	8	66	2	CID000168408
Drug	Cisapride	KCNH2 ABCB11	2.29e-04	8	66	2	ctd:D020117
Drug	F2 g	BMP7 ITPR3	2.29e-04	8	66	2	CID006857713
Drug	methanethiosulfonate	KCNH2 SCN4A SCN9A ABCB1	2.30e-04	103	66	4	CID004188587
Drug	Butylparaben [94-26-8]; Down 200; 20.6uM; PC3; HT_HG-U133A	ZKSCAN3 CNTNAP2 ARHGAP28 TAF1 ITPR3	2.33e-04	191	66	5	4647_DN
Drug	Novobiocin sodium salt [1476-53-5]; Up 200; 6.4uM; PC3; HT_HG-U133A	CNTNAP2 ARHGAP28 TEF NSD3 ENOX2	2.44e-04	193	66	5	4569_UP
Drug	Racecadotril [81110-73-8]; Down 200; 10.4uM; PC3; HT_HG-U133A	COL6A1 TDRKH DBNDD1 KCNH2 ENOX2	2.50e-04	194	66	5	5755_DN
Drug	butein; Down 200; 10uM; PC3; HG-U133A	AATK DBNDD1 MYO1A MBP ENOX2	2.50e-04	194	66	5	582_DN
Drug	pyraclofos	KCNH2 SCN2A SCN4A SCN9A	2.56e-04	106	66	4	CID000093460
Drug	PF-00562151-00 [351320-12-2]; Down 200; 10uM; PC3; HT_HG-U133A	ARHGAP6 TDRKH PAPOLA ELAPOR1 NSD3	2.62e-04	196	66	5	6863_DN
Drug	prostaglandin E2; Down 200; 10uM; MCF7; HT_HG-U133A	STIM1 PAPOLA SEC24A NMT2 ITPR3	2.62e-04	196	66	5	6590_DN
Drug	Quipazine dimaleate salt [4774-24-7]; Up 200; 9uM; HL60; HG-U133A	TDRKH AATK NMT2 RALGAPB ENOX2	2.69e-04	197	66	5	1789_UP
Drug	Deoxycorticosterone [64-85-7]; Down 200; 12.2uM; PC3; HT_HG-U133A	COL6A1 PAPOLA TCOF1 TAF1 ZZEF1	2.69e-04	197	66	5	6758_DN
Drug	S(-)-terguride hydrogen maleate [37686-85-4]; Down 200; 8.8uM; MCF7; HT_HG-U133A	COL6A1 KCNH2 CNTNAP2 ZZEF1 ITPR3	2.75e-04	198	66	5	6473_DN
Drug	AG-028671 [847803-03-6]; Down 200; 10uM; MCF7; HT_HG-U133A	STIM1 BMP7 SEC24A NMT2 NSD3	2.75e-04	198	66	5	6587_DN
Drug	Meclocycline sulfosalicylate [73816-42-9]; Up 200; 5.8uM; PC3; HT_HG-U133A	COL6A1 BMP7 CNTNAP2 SLC9A7 ZZEF1	2.75e-04	198	66	5	6637_UP
Drug	Metronidazole [443-48-1]; Down 200; 23.4uM; PC3; HT_HG-U133A	TDRKH AATK CNTNAP2 ZZEF1 ENOX2	2.75e-04	198	66	5	4023_DN
Drug	Mevalonic-D, L acid lactone [674-26-0]; Down 200; 30.8uM; PC3; HT_HG-U133A	COL6A1 TDRKH KCNH2 NMT2 ENOX2	2.75e-04	198	66	5	5738_DN
Drug	Tetramisole hydrochloride [16595-80-5]; Up 200; 16.6uM; MCF7; HT_HG-U133A	COL6A1 TDRKH PAPOLA ELAPOR1 TAF1	2.75e-04	198	66	5	2849_UP
Drug	Moricizine hydrochloride [31883-05-3]; Down 200; 8.6uM; MCF7; HT_HG-U133A	STIM1 TDRKH KCNH2 NMT2 ZKSCAN3	2.75e-04	198	66	5	3520_DN
Drug	Aspartic acid, N-acetyl (R,S) [997-55-7]; Down 200; 22.8uM; HL60; HT_HG-U133A	RALGAPB CAMSAP2 HTT NSD3 ENOX2	2.75e-04	198	66	5	1329_DN
Drug	Serotonin hydrochloride [153-98-0]; Up 200; 18.8uM; HL60; HT_HG-U133A	BMP7 DBNDD1 KCNH2 MBP CAMSAP2	2.81e-04	199	66	5	2449_UP
Drug	Butacaine [149-16-6]; Down 200; 13uM; PC3; HT_HG-U133A	COL6A1 TDRKH PAPOLA KCNH2 ENOX2	2.81e-04	199	66	5	5748_DN
Drug	Amethopterin (R,S) [59-05-2]; Up 200; 8.8uM; PC3; HT_HG-U133A	TDRKH SCN2A CNTNAP2 ARHGAP28 ZZEF1	2.81e-04	199	66	5	6654_UP
Drug	Rose Bengal	KCNH2 ABCB1	2.94e-04	9	66	2	ctd:D012395
Drug	AC1L1JPZ	KCNH2 ABCB1	2.94e-04	9	66	2	CID000055756
Drug	desloratadine	KCNH2 ABCB1	2.94e-04	9	66	2	ctd:C121345
Drug	Maprotiline	KCNH2 ABCB11	2.94e-04	9	66	2	ctd:D008376
Drug	pilsicainide	KCNH2 SCN4A SCN9A	3.23e-04	46	66	3	CID000004820
Drug	epinastine	KCNH2 ABCB1	3.67e-04	10	66	2	ctd:C053090
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN2A SCN4A SCN9A	1.33e-06	10	67	3	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN2A SCN4A SCN9A	1.33e-06	10	67	3	DOID:0080422 (implicated_via_orthology)
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN2A SCN4A SCN9A	2.43e-06	12	67	3	DOID:0060170 (implicated_via_orthology)
Disease	childhood trauma measurement, alcohol consumption measurement	PCDHGC5 PCDHGB7 PCDHGB3 PCDHGC3	2.10e-05	71	67	4	EFO_0007878, EFO_0007979
Disease	epilepsy (implicated_via_orthology)	KCNH2 SCN2A SCN4A SCN9A ABCB1	3.54e-05	163	67	5	DOID:1826 (implicated_via_orthology)
Disease	orofacial cleft, sex interaction measurement	AMOTL1 MBP CDH13 TNS3	4.48e-05	86	67	4	EFO_0008343, MONDO_0000358
Disease	Epilepsy	SCN2A CNTNAP2 SCN9A ABCB1	1.13e-04	109	67	4	C0014544
Disease	chemotherapy-induced alopecia, methylcobalamin deficiency type cblE	DNAH5 CDH13	1.41e-04	8	67	2	EFO_0005400, MONDO_0009354
Disease	Autistic behavior	ZNF462 MED13	1.41e-04	8	67	2	C0856975
Disease	Pruritus	SCN9A ABCB11	1.41e-04	8	67	2	C0033774
Disease	encephalitis (biomarker_via_orthology)	MBP ABCB1	1.81e-04	9	67	2	DOID:9588 (biomarker_via_orthology)
Disease	cystic fibrosis (implicated_via_orthology)	ABCB11 ABCB1	1.81e-04	9	67	2	DOID:1485 (implicated_via_orthology)
Disease	Generalized Epilepsy with Febrile Seizures Plus	SCN2A SCN9A	1.81e-04	9	67	2	C3502809
Disease	Malignant Neoplasms	MRE11 KCNH2 ABCB1 ENOX2	2.10e-04	128	67	4	C0006826
Disease	long QT syndrome (implicated_via_orthology)	ARHGAP6 KCNH2	2.26e-04	10	67	2	DOID:2843 (implicated_via_orthology)
Disease	Infantile Severe Myoclonic Epilepsy	SCN2A SCN9A	3.90e-04	13	67	2	C0751122
Disease	Benign Neoplasm	KCNH2 ABCB1 ENOX2	5.05e-04	68	67	3	C0086692
Disease	Neoplasms	KCNH2 ABCB1 ENOX2	5.05e-04	68	67	3	C0027651
Disease	body surface area	ZNF462 COL6A1 AATK UBN1 KCNH2 SCN4A CDH13	6.33e-04	643	67	7	EFO_0022196
Disease	Epilepsy, Cryptogenic	SCN2A CNTNAP2 ABCB1	8.72e-04	82	67	3	C0086237
Disease	Awakening Epilepsy	SCN2A CNTNAP2 ABCB1	8.72e-04	82	67	3	C0751111
Disease	Aura	SCN2A CNTNAP2 ABCB1	8.72e-04	82	67	3	C0236018
Disease	anxiety disorder (implicated_via_orthology)	SCN2A SCN9A	1.14e-03	22	67	2	DOID:2030 (implicated_via_orthology)
Disease	myocardial infarction	TDRKH CSK HECTD4 CDH13 HTT	1.21e-03	350	67	5	EFO_0000612
Disease	complement factor D measurement	AATK CNTNAP2 CDH13	1.25e-03	93	67	3	EFO_0020283
Disease	obesity (implicated_via_orthology)	STIM1 BMP7 MED13 ITPR3	1.47e-03	215	67	4	DOID:9970 (implicated_via_orthology)
Disease	breast carcinoma (is_implicated_in)	MRE11 CDH13	1.47e-03	25	67	2	DOID:3459 (is_implicated_in)
Disease	intestinal permeability measurement	COL6A1 AATK	1.59e-03	26	67	2	EFO_0011031
Disease	waist-hip ratio	UBN1 CSK SCN2A SCN4A HECTD4 PIPSL ZZEF1 CDH13 HTT	1.75e-03	1226	67	9	EFO_0004343
Disease	hearing threshold measurement	SGSM1 CDH13	1.85e-03	28	67	2	EFO_0007618
Disease	temporal lobe epilepsy (biomarker_via_orthology)	MBP ABCB1	2.26e-03	31	67	2	DOID:3328 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
QFAMDAAATAAAQRD	AMOTL2	581	Q9Y2J4
SASISDDMFIQNLAD	ADGRG4	2651	Q8IZF6
SEAAAEADMSSDVEV	EVX2	106	Q03828
LLDMATSALDNESEA	ABCB11	581	O95342
AMNAAATAAAERDTT	AMOTL1	701	Q8IY63
NDATAQAFLAEASVM	CSK	226	P41240
RMTAFDADDPATDNA	CDH13	266	P55290
EALRMANVAENSSSD	BMP7	311	P18075
AAEESSLMNDLFAQE	RAD21L1	446	Q9H4I0
MSAEAADREAATSSR	INTS8	1	Q75QN2
DLDFANDASSMLASA	ITPR3	441	Q14573
QAMILASASEAADGS	PCDHGB7	846	Q9Y5F8
SEIDALEMSSNDSRS	ABCB1	646	P08183
QDTAEALAAFTALME	NOP58	51	Q9Y2X3
TFQDSELSDELQAAM	CASKIN1	651	Q8WXD9
MAEDSESAASQQSLE	NMT2	1	O60551
DGMDDASSFRAVQSA	MYO1A	236	Q9UBC5
VLTSRTAAEADMDAA	GARIN4	376	Q8IYT1
SLSANMELDDSAAES	ELAPOR1	136	Q6UXG2
AADNSRTLNVDSTAM	ENOX2	16	Q16206
SSESLALDEVTAMDN	KCNH2	206	Q12809
MAAENEASQESALGA	GGT7	1	Q9UJ14
QAMILASASEAADGS	PCDHGC5	861	Q9Y5F6
QAMILASASEAADGS	PCDHGB3	846	Q9Y5G1
QAMILASASEAADGS	PCDHGC3	851	Q9UN70
EALPFAMASDSDNDA	HECTD4	2161	Q9Y4D8
GLAESADIDASSAMD	PIPSL	786	A2A3N6
TALNDSSLDLSMDSD	PAPOLA	516	P51003
AMSVDSITDLDDNQS	ARHGAP6	361	O43182
DEASEAFRNSSMALQ	HTT	611	P42858
ASAVDAMDFINDATD	COL6A1	901	P12109
TDMSDQELAEVFADS	DBNDD1	81	Q9H9R9
RNLSDTESDSMTADA	C19orf44	111	Q9H6X5
QEDSAATSESLDVMA	MBP	121	P02686
AAAASSLEMLSREFE	ITLN2	26	Q8WWU7
AESAESADAAIMNND	CNTNAP2	1301	Q9UHC6
GQAESADIDASSAMD	PSMD4	301	P55036
SLDSDMDDASKFLQD	CAMSAP2	646	Q08AD1
MAALQSNEDSDSDVE	DNAH5	1066	Q8TE73
SADSLAASDEDGEMN	SCN4A	806	P35499
DSADSEEAPAAMTAA	TCOF1	616	Q13428
DDDSDGSTAASLAME	AATK	561	Q6ZMQ8
MTASLSDARDALVNA	SEC24A	856	O95486
DASVFQDESNMSVLD	TAF1	1661	P21675
SDLENMNAEELSSDS	SCN9A	1096	Q15858
NLVSNNSIEDSDMDS	SOCS4	216	Q8WXH5
LEEDEAAAASTMAVS	TEF	61	Q10587
RLADSSFSLLTDMDD	NUAK1	631	O60285
SVSDDVGMDADSASQ	MED13	481	Q9UHV7
NVSASADQALDRFAM	TNS3	126	Q68CZ2
AEQMANDSDDSISAA	MRE11	551	P49959
DSEELMATDSAFDVL	MYH6	326	P13533
SRAADEALNAMTSNG	STIM1	541	Q13586
ASERNSSGDADSAHM	SLC39A2	86	Q9NP94
LSLSEAASMSGDDNL	TDRKH	541	Q9Y2W6
RSNSEASVDSASMED	ARHGAP28	66	Q9P2N2
FSSDNLAATDDDNEM	SCN2A	986	Q99250
SLESDLLANESMDEF	SGSM1	836	Q2NKQ1
VMDLTEGDNEASASA	nan	51	A6NLC8
LESNISDQDSDSNMD	RALGAPB	1276	Q86X10
ADADVSDVQSMDSSL	NSD3	676	Q9BZ95
ADLSNMERVSLSTAD	VSTM1	186	Q6UX27
TSDNDLLQAATAMDS	UBN1	296	Q9NPG3
MARELSESTALDAQS	ZKSCAN3	1	Q9BRR0
DELAMSSSSDFQQDR	ZZEF1	2741	O43149
DLETNSMLNDSSSDE	ZNF462	376	Q96JM2
AAAEDSSAMEELATE	SLC9A7	46	Q96T83
MANASLLDEGTAAAE	GLDC	191	P23378