Immunoglobulin lambda variable 8-61
1_MSVPT 6_ MAWMM 11_ LLLGL 16_ LAYGS 21_ GVDSQ 26_ TVVTQ 31_ EPSFS 36_ VSPGG 41_ TVTLT 46_ CGLSS 51_ GSVST 56_ SYYPS 61_ WYQQT 66_ PGQAP 71_ RTLIY 76_ STNTR 81_ SSGVP 86_ DRFSG 91_ SILGN 96_ KAALT 101_ ITGAQ 106_ ADDES 111_ DYYCV 116_LYMGS
1: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)