Immunoglobulin lambda variable 4-60
1_MAWTP 6_ LLLLF 11_ PLLLH 16_ CTGSL 21_ SQPVL 26_ TQSSS 31_ ASASL 36_ GSSVK 41_ LTCTL 46_ SSGHS 51_ SYIIA 56_ WHQQQ 61_ PGKAP 66_ RYLMK 71_ LEGSG 76_ SYNKG 81_ SGVPD 86_ RFSGS 91_ SSGAD 96_ RYLTI 101_ SNLQF 106_ EDEAD 111_YYCET
1: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)