Immunoglobulin lambda variable 3-22
1_MAWAT 6_ LLLPL 11_ LNLYT 16_ GSVAS 21_ YELTQ 26_ LPSVS 31_ VSPGQ 36_ TARIT 41_ CSGDV 46_ LGENY 51_ ADWYQ 56_ QKPGQ 61_ APELV 66_ IYEDS 71_ ERYPG 76_ IPERF 81_ SGSTS 86_ GNTTT 91_ LTISR 96_ VLTED 101_ EADYY 106_CLSGD
1: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)