Immunoglobulin lambda variable 3-16
1_MAWIP 6_ LLLPL 11_ LTLCT 16_ GSEAS 21_ YELTQ 26_ PPSVS 31_ VSLGQ 36_ MARIT 41_ CSGEA 46_ LPKKY 51_ AYWYQ 56_ QKPGQ 61_ FPVLV 66_ IYKDS 71_ ERPSG 76_ IPERF 81_ SGSSS 86_ GTIVT 91_ LTISG 96_ VQAED 101_ EADYY 106_CLSAD
1: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)