Immunoglobulin lambda variable 3-10
1_MAWTP 6_ LLLPL 11_ LTFCT 16_ VSEAS 21_ YELTQ 26_ PPSVS 31_ VSPGQ 36_ TARIT 41_ CSGDA 46_ LPKKY 51_ AYWYQ 56_ QKSGQ 61_ APVLV 66_ IYEDS 71_ KRPSG 76_ IPERF 81_ SGSSS 86_ GTMAT 91_ LTISG 96_ AQVED 101_ EADYY 106_CYSTD
1: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)