Meiosis-specific kinetochore protein
1_MWPLR 6_ VYTRK 11_ KREGQ 16_ RLNLT 21_ PTPDL 26_ GSPAK 31_ AEAPP 36_ GSKRK 41_ GKVHG 46_ LSKIA 51_ EKAER 56_ SRQGG 61_ SGSGP 66_ FSPRL 71_ GVTGE 76_ KSLQE 81_ NRSSE 86_ DTQDE 91_ KIASL 96_ RESVT 101_ DDLQV 106_ DSSSS 111_ NSELV 116_ SGLSL 121_ HHGMA 126_ SSLLS 131_ YSVTD 136_ SYAEY 141_ KSFEE 146_ SFPSP 151_ ELFRK 156_ SDYLD 161_ WECPN 166_ LEEHM 171_ QWKNS 176_ TLLDT 181_ SKAVA 186_ IEKAP 191_ QFSNV 196_ SAIFS 201_ TSSED 206_ YQKCH 211_ RKTVM 216_ TVADQ 221_ NVSPK 226_ AKCAS 231_ NSESD 236_ NAACE 241_ ILLAE 246_ KTCPS 251_ TPEKT 256_ KKKKT 261_ NSSTP 266_ GKKNR 271_ GLLTS 276_ TPSSE 281_ TAGFV 286_ IDLSS 291_ VQKAS 296_ FEELF 301_ PNVSN 306_ YVNSN 311_ EIVPV 316_ SSLQE 321_ NSSNE 326_ FPANA 331_ SEICC 336_ IIRTS 341_ PGTRQ 346_ VKNKG 351_ VIVKK 356_ KKYSL 361_ PKDTP 366_QDIII
1: Key regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage. Acts by facilitating kinetochore mono-orientation during meiosis I, when kinetochores on sister chromosomes face the same direction and are thus captured and pulled by spindle fibers from the same pole. Also required to prevent cleavage of cohesin at centromeres during meiosis I, possibly by acting as a regulator of the shugoshin-dependent protection pathway. Acts in collaboration with PLK1: required for PLK1 enrichment to kinetochores. Not required during meiosis II or mitosis