Immunoglobulin lambda variable 5-52
1_MAWTL 6_ LLLVL 11_ LSHCT 16_ GSLSQ 21_ PVLTQ 26_ PSSHS 31_ ASSGA 36_ SVRLT 41_ CMLSS 46_ GFSVG 51_ DFWIR 56_ WYQQK 61_ PGNPP 66_ RYLLY 71_ YHSDS 76_ NKGQG 81_ SGVPS 86_ RFSGS 91_ NDASA 96_ NAGIL 101_ RISGL 106_ QPEDE 111_ ADYYC 116_GTWHS
1: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)