Immunoglobulin lambda variable 9-49
1_MAWAP 6_ LLLTL 11_ LSLLT 16_ GSLSQ 21_ PVLTQ 26_ PPSAS 31_ ASLGA 36_ SVTLT 41_ CTLSS 46_ GYSNY 51_ KVDWY 56_ QQRPG 61_ KGPRF 66_ VMRVG 71_ TGGIV 76_ GSKGD 81_ GIPDR 86_ FSVLG 91_ SGLNR 96_ YLTIK 101_ NIQEE 106_ DESDY 111_ HCGAD 116_HGSGS
1: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)