Small regulatory polypeptide of amino acid response
1_MGAKA 6_ PRGPK 11_ VAQWA 16_ METAV 21_ IGVVV 26_ VLFVV 31_ TVAIT 36_ CVLCC 41_ FSCDS 46_ RAQDP 51_ QGGPG 56_ RSFTV 61_ ATFRQ 66_ EASLF 71_ TGPVR 76_ HAQPV 81_PSAQD
1: Negative regulator of amino acid sensing and mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels and amino acids (PubMed:28024296). Negatively regulates mTORC1 activation by inhibiting recruitment of mTORC1 to lysosomes upon stimulation with amino acids: acts by promoting the formation of a tightly bound supercomplex composed of the lysosomal V-ATPase, Ragulator and Rag GTPases, preventing recruitment of mTORC1 (PubMed:28024296). Acts as a regulator of muscle regeneration following injury by regulating mTORC1 activation (By similarity)