Histone H2B type 2-K1 (Histone H2B type 2-E1)
1_MSAEY 6_ GQRQQ 11_ PGGRG 16_ GRSSG 21_ NKKSK 26_ KRCRR 31_ KESYS 36_ MYIYK 41_ VLKQV 46_ HPDIG 51_ ISAKA 56_ MSIMN 61_ SFVND 66_ VFEQL 71_ ACEAA 76_ RLAQY 81_ SGRTT 86_ LTSRE 91_ VQTAV 96_ RLLLP 101_ GELAK 106_ HAVSE 111_ GTKAV 116_TKYTS
1: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling