Transcription factor E2F8 (E2F-8)
1_MENEK 6_ ENLFC 11_ EPHKR 16_ GLMKT 21_ PLKES 26_ TTANI 31_ VLAEI 36_ QPDFG 41_ PLTTP 46_ TKPKE 51_ GSQGE 56_ PWTPT 61_ ANLKM 66_ LISAV 71_ SPEIR 76_ NRDQK 81_ RGLFD 86_ NRSGL 91_ PEAKD 96_ CIHEH 101_ LSGDE 106_ FEKSQ 111_ PSRKE 116_ KSLGL 121_ LCHKF 126_ LARYP 131_ NYPNP 136_ AVNND 141_ ICLDE 146_ VAEEL 151_ NVERR 156_ RIYDI 161_ VNVLE 166_ SLHMV 171_ SRLAK 176_ NRYTW 181_ HGRHN 186_ LNKTL 191_ GTLKS 196_ IGEEN 201_ KYAEQ 206_ IMMIK 211_ KKEYE 216_ QEFDF 221_ IKSYS 226_ IEDHI 231_ IKSNT 236_ GPNGH 241_ PDMCF 246_ VELPG 251_ VEFRA 256_ ASVNS 261_ RKDKS 266_ LRVMS 271_ QKFVM 276_ LFLVS 281_ TPQIV 286_ SLEVA 291_ AKILI 296_ GEDHV 301_ EDLDK 306_ SKFKT 311_ KIRRL 316_ YDIAN 321_ VLSSL 326_ DLIKK 331_ VHVTE 336_ ERGRK 341_ PAFKW 346_ TGPEI 351_ SPNTS 356_ GSSPV 361_ IHFTP 366_ SDLEV 371_ RRSSK 376_ ENCAK 381_ NLFST 386_ RGKPN 391_ FTRHP 396_ SLIKL 401_ VKSIE 406_ SDRRK 411_ INSAP 416_ SSPIK 421_ TNKAE 426_ SSQNS 431_ APFPS 436_ KMAQL 441_ AAICK 446_ MQLEE 451_ QSSES 456_ RQKVK 461_ VQLAR 466_ SGPCK 471_ PVAPL 476_ DPPVN 481_ AEMEL 486_ TAPSL 491_ IQPLG 496_ MVPLI 501_ PSPLS 506_ SAVPL 511_ ILPQA 516_ PSGPS 521_ YAIYL 526_ QPTQA 531_ HQSVT 536_ PPQGL 541_ SPTVC 546_ TTHSS 551_ KATGS 556_ KDSTD 561_ ATTEK 566_ AANDT 571_ SKASA 576_ STRPG 581_ SLLPA 586_ PERQG 591_ AKSRT 596_ REPAG 601_ ERGSK 606_ RASML 611_ EDSGS 616_ KKKFK 621_ EDLKG 626_ LENVS 631_ ATLFP 636_ SGYLI 641_ PLTQC 646_ SSLGA 651_ ESILS 656_ GKENS 661_ SALSP 666_ NHRIY 671_ SSPIA 676_ GVIPV 681_ TSSEL 686_ TAVNF 691_ PSFHV 696_ TPLKL 701_ MVSPT 706_ SVAAV 711_ PVGNS 716_ PALAS 721_ SHPVP 726_ IQNPS 731_ SAIVN 736_ FTLQH 741_ LGLIS 746_ PNVQL 751_ SASPG 756_ SGIVP 761_ VSPRI 766_ ESVNV 771_ APENA 776_ GTQQG 781_ RATNY 786_ DSPVP 791_ GQSQP 796_ NGQSV 801_ AVTGA 806_ QQPVP 811_ VTPKG 816_ SQLVA 821_ ESFFR 826_ TPGGP 831_ TKPTS 836_ SSCMD 841_ FEGAN 846_ KTSLG 851_ TLFVP 856_ QRKLE 861_VSTED
1: Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene