Mediator of RNA polymerase II transcription subunit 19 (Lung cancer metastasis-related protein 1) (Mediator complex subunit 19)
1_MENFT 6_ ALFGA 11_ QADPP 16_ PPPTA 21_ LGFGP 26_ GKPPP 31_ PPPPP 36_ AGGGP 41_ GTAPP 46_ PTAAT 51_ APPGA 56_ DKSGA 61_ GCGPF 66_ YLMRE 71_ LPGST 76_ ELTGS 81_ TNLIT 86_ HYNLE 91_ QAYNK 96_ FCGKK 101_ VKEKL 106_ SNFLP 111_ DLPGM 116_ IDLPG 121_ SHDNS 126_ SLRSL 131_ IEKPP 136_ ILSSS 141_ FNPIT 146_ GTMLA 151_ GFRLH 156_ TGPLP 161_ EQCRL 166_ MHIQP 171_ PKKKN 176_ KHKHK 181_ QSRTQ 186_ DPVPP 191_ ETPSD 196_ SDHKK 201_ KKKKK 206_ EEDPD 211_ RKRKK 216_ KEKKK 221_ KKNRH 226_ SPDHP 231_ GMGSS 236_QASSS
1: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors