Shootin-1 (Shootin1)
1_MNSSD 6_ EEKQL 11_ QLITS 16_ LKEQA 21_ IGEYE 26_ DLRAE 31_ NQKTK 36_ EKCDK 41_ IRQER 46_ DEAVK 51_ KLEEF 56_ QKISH 61_ MVIEE 66_ VNFMQ 71_ NHLEI 76_ EKTCR 81_ ESAEA 86_ LATKL 91_ NKENK 96_ TLKRI 101_ SMLYM 106_ AKLGP 111_ DVITE 116_ EINID 121_ DEDST 126_ TDTDG 131_ AAETC 136_ VSVQC 141_ QKQIK 146_ ELRDQ 151_ IVSVQ 156_ EEKKI 161_ LAIEL 166_ ENLKS 171_ KLVEV 176_ IEEVN 181_ KVKQE 186_ KTVLN 191_ SEVLE 196_ QRKVL 201_ EKCNR 206_ VSMLA 211_ VEEYE 216_ EMQVN 221_ LELEK 226_ DLRKK 231_ AESFA 236_ QEMFI 241_ EQNKL 246_ KRQSH 251_ LLLQS 256_ SIPDQ 261_ QLLKA 266_ LDENA 271_ KLTQQ 276_ LEEER 281_ IQHQQ 286_ KVKEL 291_ EEQLE 296_ NETLH 301_ KEIHN 306_ LKQQL 311_ ELLEE 316_ DKKEL 321_ ELKYQ 326_ NSEEK 331_ ARNLK 336_ HSVDE 341_ LQKRV 346_ NQSEN 351_ SVPPP 356_ PPPPP 361_ PLPPP 366_ PPNPI 371_ RSLMS 376_ MIRKR 381_ SHPSG 386_ SGAKK 391_ EKATQ 396_ PETTE 401_ EVTDL 406_ KRQAV 411_ EEMMD 416_ RIKKG 421_ VHLRP 426_ VNQTA 431_ RPKTK 436_ PESSK 441_ GCESA 446_ VDELK 451_ GILGT 456_ LNKST 461_ SSRSL 466_ KSLDP 471_ ENSET 476_ ELERI 481_ LRRRK 486_ VTAEA 491_ DSSSP 496_ TGILA 501_ TSESK 506_ SMPVL 511_ GSVSS 516_ VTKTA 521_ LNKKT 526_ LEAEF 531_ NSPSP 536_ PTPEP 541_ GEGPR 546_ KLEGC 551_ TSSKV 556_ TFQPP 561_ SSIGC 566_ RKKYI 571_ DGEKQ 576_ AEPVV 581_ VLDPV 586_ STHEP 591_ QTKDQ 596_ VAEKD 601_ PTQHK 606_ EDEGE 611_ IQPEN 616_ KEDSI 621_ ENVRE 626_TDSSN
1: Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Also plays a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons