Sodium/glucose cotransporter 5 (Na(+)/glucose cotransporter 5) (Solute carrier family 5 member 10)
1_MAANS 6_ TSDLH 11_ TPGTQ 16_ LSVAD 21_ IIVIT 26_ VYFAL 31_ NVAVG 36_ IWSSC 41_ RASRN 46_ TVNGY 51_ FLAGR 56_ DMTWW 61_ PIGAS 66_ LFASS 71_ EGSGL 76_ FIGLA 81_ GSGAA 86_ GGLAV 91_ AGFEW 96_ NATYV 101_ LLALA 106_ WVFVP 111_ IYISS 116_ EIVTL 121_ PEYIQ 126_ KRYGG 131_ QRIRM 136_ YLSVL 141_ SLLLS 146_ VFTKI 151_ SLDLY 156_ AGALF 161_ VHICL 166_ GWNFY 171_ LSTIL 176_ TLGIT 181_ ALYTI 186_ AGGLA 191_ AVIYT 196_ DALQT 201_ LIMVV 206_ GAVIL 211_ TIKAF 216_ DQIGG 221_ YGQLE 226_ AAYAQ 231_ AIPSR 236_ TIANT 241_ TCHLP 246_ RTDAM 251_ HMFRD 256_ PHTGD 261_ LPWTG 266_ MTFGL 271_ TIMAT 276_ WYWCT 281_ DQVIV 286_ QRSLS 291_ ARDLN 296_ HAKAG 301_ SILAS 306_ YLKML 311_ PMGLI 316_ IMPGM 321_ ISRAL 326_ FPDDV 331_ GCVVP 336_ SECLR 341_ ACGAE 346_ VGCSN 351_ IAYPK 356_ LVMEL 361_ MPIGL 366_ RGLMI 371_ AVMLA 376_ ALMSS 381_ LTSIF 386_ NSSST 391_ LFTMD 396_ IWRRL 401_ RPRSG 406_ ERELL 411_ LVGRL 416_ VIVAL 421_ IGVSV 426_ AWIPV 431_ LQDSN 436_ SGQLF 441_ IYMQS 446_ VTSSL 451_ APPVT 456_ AVFVL 461_ GVFWR 466_ RANEQ 471_ GAFWG 476_ LIAGL 481_ VVGAT 486_ RLVLE 491_ FLNPA 496_ PPCGE 501_ PDTRP 506_ AVLGS 511_ IHYLH 516_ FAVAL 521_ FALSG 526_ AVVVA 531_ GSLLT 536_ PPPQS 541_ VQIEN 546_ LTWWT 551_ LAQDV 556_ PLGTK 561_ AGDGQ 566_ TPQKH 571_ AFWAR 576_ VCGFN 581_ AILLM 586_ CVNIF 591_FYAYF
1: Electrogenic Na+-coupled sugar symporter that actively transports D-mannose or D-fructose at the plasma membrane, with a Na+ to sugar coupling ratio of 1:1. Transporter activity is driven by a transmembrane Na+ electrochemical gradient set by the Na+/K+ pump. Exclusively recognizes sugar substrates having a pyranose ring with an axial hydroxyl group on carbon 2 (PubMed:22212718, PubMed:23451068, PubMed:24573086). Has likely evolved to enable renal reabsorption of D-mannose, an important constituent of oligosaccharide chains of glycoproteins. Contributes to dietary D-fructose reabsorption from glomerular filtrate across the brush border of the kidney (PubMed:22212718, PubMed:23451068)
2: Appears to have no transporter activity