Rho GTPase-activating protein 10 (GTPase regulator associated with focal adhesion kinase 2) (Graf-related protein 2) (Rho-type GTPase-activating protein 10)
1_MGLQP 6_ LEFSD 11_ CYLDS 16_ PWFRE 21_ RIRAH 26_ EAELE 31_ RTNKF 36_ IKELI 41_ KDGKN 46_ LIAAT 51_ KSLSV 56_ AQRKF 61_ AHSLR 66_ DFKFE 71_ FIGDA 76_ VTDDE 81_ RCIDA 86_ SLREF 91_ SNFLK 96_ NLEEQ 101_ REIMA 106_ LSVTE 111_ TLIKP 116_ LEKFR 121_ KEQLG 126_ AVKEE 131_ KKKFD 136_ KETEK 141_ NYSLI 146_ DKHLN 151_ LSAKK 156_ KDSHL 161_ QEADI 166_ QVEQN 171_ RQHFY 176_ ELSLE 181_ YVCKL 186_ QEIQE 191_ RKKFE 196_ FVEPM 201_ LSFFQ 206_ GMFTF 211_ YHQGH 216_ ELAKD 221_ FNHYK 226_ MELQI 231_ NIQNT 236_ RNRFE 241_ GTRSE 246_ VEELM 251_ NKIRQ 256_ NPKDH 261_ KRASQ 266_ FTAEG 271_ YLYVQ 276_ EKRPA 281_ PFGSS 286_ WVKHY 291_ CMYRK 296_ AAKKF 301_ NMIPF 306_ EHRSG 311_ GKLGD 316_ GEVFF 321_ LKECT 326_ KRHTD 331_ SIDRR 336_ FCFDI 341_ EAADR 346_ PGVSL 351_ TMQAF 356_ SEEER 361_ KQWLE 366_ ALGGK 371_ EALSH 376_ SFNTA 381_ IIPRP 386_ EGNAQ 391_ LDKMG 396_ FTIIR 401_ KCISA 406_ VETRG 411_ INDQG 416_ LYRVV 421_ GVSSK 426_ VQRLL 431_ SMLMD 436_ VKTCN 441_ EVDLE 446_ NSADW 451_ EVKTI 456_ TSALK 461_ QYLRS 466_ LPEPL 471_ MTYEL 476_ HGDFI 481_ VPAKS 486_ GSPES 491_ RVNAI 496_ HFLVH 501_ KLPEK 506_ NKEML 511_ DILVK 516_ HLTNV 521_ SNHSK 526_ QNLMT 531_ VANLG 536_ VVFGP 541_ TLMRP 546_ QEETV 551_ AALMD 556_ LKFQN 561_ IVVEI 566_ LIENH 571_ EKIFR 576_ TPPDT 581_ TFPEP 586_ TCLSA 591_ SPPNA 596_ PPRQS 601_ KRQGQ 606_ RTKRP 611_ VAVYN 616_ LCLEL 621_ EDGDN 626_ PYPSK 631_ EDTPT 636_ SSLDS 641_ LSSPS 646_ PVTTA 651_ VPGPP 656_ GPDKN 661_ HLLAD 666_ GGSFG 671_ DWAST 676_ IPGQT 681_ RSSMV 686_ QWLNP 691_ QSPTT 696_ TSSNS 701_ AVTPL 706_ SPGSS 711_ PFPFS 716_ PPATV 721_ ADKPP 726_ ESIRS 731_ RKARA 736_ VYPCE 741_ AEHSS 746_ ELSFE 751_ IGAIF 756_ EDVQT 761_ SREPG 766_ WLEGT 771_ LNGKR 776_ GLIPQ 781_NYVKL
1: GTPase-activating protein that catalyzes the conversion of active GTP-bound Rho GTPases to their inactive GDP-bound form, thus suppressing various Rho GTPase-mediated cellular processes (PubMed:11432776). Also converts Cdc42 to an inactive GDP-bound state (PubMed:11432776). Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity). Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation with MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins (PubMed:32344433)