Anoctamin-9 (Transmembrane protein 16J) (Tumor protein p53-inducible protein 5) (p53-induced gene 5 protein)
1_MQGEE 6_ SLRIL 11_ VEPEG 16_ DSFPL 21_ MEIST 26_ CETEA 31_ SEQWD 36_ YVLVA 41_ QRHTQ 46_ RDPRQ 51_ ARQQQ 56_ FLEEL 61_ RRKGF 66_ HIKVI 71_ RDQKQ 76_ VFFGI 81_ RADNS 86_ VFGLY 91_ RTLLL 96_ EPEGP 101_ APHAE 106_ LAAPT 111_ TIPVT 116_ TSLRI 121_ RIVNF 126_ VVMNN 131_ KTSAG 136_ ETFED 141_ LMKDG 146_ VFEAR 151_ FPLHK 156_ GEGRL 161_ KKTWA 166_ RWRHM 171_ FREQP 176_ VDEIR 181_ NYFGE 186_ KVALY 191_ FVWLG 196_ WYTYM 201_ LVPAA 206_ LTGLL 211_ VFLSG 216_ FSLFE 221_ ASQIS 226_ KEICE 231_ AHDIL 236_ MCPLG 241_ DHSRR 246_ YQRLS 251_ ETCTF 256_ AKLTH 261_ LFDND 266_ GTVVF 271_ AIFMA 276_ LWATV 281_ FLEIW 286_ KRQRA 291_ RVVLH 296_ WDLYV 301_ WDEEQ 306_ EEMAL 311_ QLINC 316_ PDYKL 321_ RPYQH 326_ SYLRS 331_ TVILV 336_ LTLLM 341_ ICLMI 346_ GMAHV 351_ LVVYR 356_ VLASA 361_ LFSSS 366_ AVPFL 371_ EEQVT 376_ TAVVV 381_ TGALV 386_ HYVTI 391_ IIMTK 396_ INRCV 401_ ALKLC 406_ DFEMP 411_ RTFSE 416_ RESRF 421_ TIRFF 426_ TLQFF 431_ THFSS 436_ LIYIA 441_ FILGR 446_ INGHP 451_ GKSTR 456_ LAGLW 461_ KLEEC 466_ HASGC 471_ MMDLF 476_ VQMAI 481_ IMGLK 486_ QTLSN 491_ CVEYL 496_ VPWVT 501_ HKCRS 506_ LRASE 511_ SGHLP 516_ RDPEL 521_ RDWRR 526_ NYLLN 531_ PVNTF 536_ SLFDE 541_ FMEMM 546_ IQYGF 551_ TTIFV 556_ AAFPL 561_ APLLA 566_ LFSNL 571_ VEIRL 576_ DAIKM 581_ VWLQR 586_ RLVPR 591_ KAKDI 596_ GTWLQ 601_ VLETI 606_ GVLAV 611_ IANGM 616_ VIAFT 621_ SEFIP 626_ RVVYK 631_ YRYSP 636_ CLKEG 641_ NSTVD 646_ CLKGY 651_ VNHSL 656_ SVFHT 661_ KDFQD 666_ PDGIE 671_ GSENV 676_ TLCRY 681_ RDYRN 686_ PPDYN 691_ FSEQF 696_ WFLLA 701_ IRLAF 706_ VILFE 711_ HVALC 716_ IKLIA 721_ AWFVP 726_ DIPQS 731_ VKNKV 736_ LEVKY 741_ QRLRE 746_ KMWHG 751_ RQRLG 756_ GVGAG 761_ SRPPM 766_ PAHPT 771_ PASIF 776_SARST
1: PKA-activated nonselective cation channel (PubMed:29604966). Discriminates poorly among cations but is more permeable to Ca(2+) ions than to monovalent cations (By similarity). Acts as a calcium-activated calcium permeable channel which may operate as a endoplasmic reticulum (ER) Ca(2+)-leak channel, reducing the loading of the ER Ca(2+) store (PubMed:36520003). Regulates intracellular Ca2+ signals, ion channel activity, and cytokine release in the renal tissue (PubMed:36520003). Plays an important role in olfaction, amplifying cAMP-evoked cyclic nucleotide-gated (CNG) channel currents in the olfactory sensory neurons (By similarity). Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity (PubMed:22178883). Can inhibit the activity of ANO1 (PubMed:20056604, PubMed:22946059)