Synaptonemal complex central element protein 3 (Testis highly expressed gene 2 protein) (THEG-2)
1_MDDAD 6_ PEERN 11_ YDNML 16_ KMLSD 21_ LNKDL 26_ EKLLE 31_ EMEKI 36_ SVQAT 41_ WMAYD 46_ MVVMR 51_ TNPTL 56_ AESMR 61_ RLEDA 66_ FVNCK 71_ EEMEK 76_ NWQEL 81_LHETK
1: Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase (PubMed:36635604). Required for the assembly of the central element of the synaptonemal complex during meiosis, via remodeling of SYCP1 lattice structures and promoting recruitment of SYCE2-TEX12 and SYCE1-SIX60S1 complexes (PubMed:36635604). Required for chromosome loading of the central element-specific SCS proteins, and for initiating synapsis between homologous chromosomes (By similarity). Chromosome loading appears to require SYCP1 (By similarity). Required for fertility and normal testis development (By similarity)