Elongation of very long chain fatty acids protein 7 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL7) (ELOVL fatty acid elongase 7) (ELOVL FA elongase 7) (Very long chain 3-ketoacyl-CoA synthase 7) (Very long chain 3-oxoacyl-CoA synthase 7)
1_MAFSD 6_ LTSRT 11_ VHLYD 16_ NWIKD 21_ ADPRV 26_ EDWLL 31_ MSSPL 36_ PQTIL 41_ LGFYV 46_ YFVTS 51_ LGPKL 56_ MENRK 61_ PFELK 66_ KAMIT 71_ YNFFI 76_ VLFSV 81_ YMCYE 86_ FVMSG 91_ WGIGY 96_ SFRCD 101_ IVDYS 106_ RSPTA 111_ LRMAR 116_ TCWLY 121_ YFSKF 126_ IELLD 131_ TIFFV 136_ LRKKN 141_ SQVTF 146_ LHVFH 151_ HTIMP 156_ WTWWF 161_ GVKFA 166_ AGGLG 171_ TFHAL 176_ LNTAV 181_ HVVMY 186_ SYYGL 191_ SALGP 196_ AYQKY 201_ LWWKK 206_ YLTSL 211_ QLVQF 216_ VIVAI 221_ HISQF 226_ FFMED 231_ CKYQF 236_ PVFAC 241_ IIMSY 246_ SFMFL 251_ LLFLH 256_ FWYRA 261_ YTKGQ 266_ RLPKT 271_ VKNGT 276_CKNKD
1: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate in the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators