SH3 and PX domain-containing protein 2B (Adapter protein HOFI) (Factor for adipocyte differentiation 49) (Tyrosine kinase substrate with four SH3 domains)
1_MPPRR 6_ SIVEV 11_ KVLDV 16_ QKRRV 21_ PNKHY 26_ VYIIR 31_ VTWSS 36_ GSTEA 41_ IYRRY 46_ SKFFD 51_ LQMQM 56_ LDKFP 61_ MEGGQ 66_ KDPKQ 71_ RIIPF 76_ LPGKI 81_ LFRRS 86_ HIRDV 91_ AVKRL 96_ IPIDE 101_ YCKAL 106_ IQLPP 111_ YISQC 116_ DEVLQ 121_ FFETR 126_ PEDLN 131_ PPKEE 136_ HIGKK 141_ KSGGD 146_ QTSVD 151_ PMVLE 156_ QYVVV 161_ ANYQK 166_ QESSE 171_ ISLSV 176_ GQVVD 181_ IIEKN 186_ ESGWW 191_ FVSTA 196_ EEQGW 201_ VPATC 206_ LEGQD 211_ GVQDE 216_ FSLQP 221_ EEEEK 226_ YTVIY 231_ PYTAR 236_ DQDEM 241_ NLERG 246_ AVVEV 251_ IQKNL 256_ EGWWK 261_ IRYQG 266_ KEGWA 271_ PASYL 276_ KKNSG 281_ EPLPP 286_ KPGPG 291_ SPSHP 296_ GALDL 301_ DGVSR 306_ QQNAV 311_ GREKE 316_ LLSSQ 321_ RDGRF 326_ EGRPV 331_ PDGDA 336_ KQRSP 341_ KMRQR 346_ PPPRR 351_ DMTIP 356_ RGLNL 361_ PKPPI 366_ PPQVE 371_ EEYYT 376_ IAEFQ 381_ TTIPD 386_ GISFQ 391_ AGLKV 396_ EVIEK 401_ NLSGW 406_ WYIQI 411_ EDKEG 416_ WAPAT 421_ FIDKY 426_ KKTSN 431_ ASRPN 436_ FLAPL 441_ PHEVT 446_ QLRLG 451_ EAAAL 456_ ENNTG 461_ SEATG 466_ PSRPL 471_ PDAPH 476_ GVMDS 481_ GLPWS 486_ KDWKG 491_ SKDVL 496_ RKASS 501_ DMSAS 506_ AGYEE 511_ ISDPD 516_ MEEKP 521_ SLPPR 526_ KESII 531_ KSEGE 536_ LLERE 541_ RERQR 546_ TEQLR 551_ GPTPK 556_ PPGVI 561_ LPMMP 566_ AKHIP 571_ PARDS 576_ RRPEP 581_ KPDKS 586_ RLFQL 591_ KNDMG 596_ LECGH 601_ KVLAK 606_ EVKKP 611_ NLRPI 616_ SKSKT 621_ DLPEE 626_ KPDAT 631_ PQNPF 636_ LKSRP 641_ QVRPK 646_ PAPSP 651_ KTEPP 656_ QGEDQ 661_ VDICN 666_ LRSKL 671_ RPAKS 676_ QDKSL 681_ LDGEG 686_ PQAVG 691_ GQDVA 696_ FSRSF 701_ LPGEG 706_ PGRAQ 711_ DRTGK 716_ QDGLS 721_ PKEIS 726_ CRAPP 731_ RPAKT 736_ TDPVS 741_ KSVPV 746_ PLQEA 751_ PQQRP 756_ VVPPR 761_ RPPPP 766_ KKTSS 771_ SSRPL 776_ PEVRG 781_ PQCEG 786_ HESRA 791_ APTPG 796_ RALLV 801_ PPKAK 806_ PFLSN 811_ SLGGQ 816_ DDTRG 821_ KGSLG 826_ PWGTG 831_ KIGEN 836_ REKAA 841_ AASVP 846_ NADGL 851_ KDSLY 856_ VAVAD 861_ FEGDK 866_ DTSSF 871_ QEGTV 876_ FEVRE 881_ KNSSG 886_ WWFCQ 891_ VLSGA 896_ PSWEG 901_ WIPSN 906_YLRKK
1: Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity)