CBY1-interacting BAR domain-containing protein 1
1_MMRRT 6_ LENRN 11_ AQTKQ 16_ LQTAV 21_ SNVEK 26_ HFGEL 31_ CQIFA 36_ AYVRK 41_ TARLR 46_ DKADL 51_ LVNEI 56_ NAYAA 61_ TETPH 66_ LKLGL 71_ MNFAD 76_ EFAKL 81_ QDYRQ 86_ AEVER 91_ LEAKV 96_ VEPLK 101_ TYGTI 106_ VKMKR 111_ DDLKA 116_ TLTAR 121_ NREAK 126_ QLTQL 131_ ERTRQ 136_ RNPSD 141_ RHVIS 146_ QAETE 151_ LQRAA 156_ MDASR 161_ TSRHL 166_ EETIN 171_ NFERQ 176_ KMKDI 181_ KTIFS 186_ EFITI 191_ EMLFH 196_ GKALE 201_ VYTAA 206_ YQNIQ 211_ NIDED 216_ EDLEV 221_ FRNSL 226_ YAPDY 231_ SSRLD 236_ IVRAN 241_ SKSPL 246_ QRSLS 251_ AKCVS 256_ GTGQV 261_ STCRL 266_ RKDQQ 271_ AEDDE 276_ DDELD 281_VTEEE
1: Plays a critical role in regulating mitochondrial ultrastructure and function by maintaining the integrity of mitochondrial morphology, particularly the organization of cristae (PubMed:30404948). Preferentially binds to negatively charged phospholipids like cardiolipin and phosphatidylinositol 4,5-bisphosphate enhancing its interaction with mitochondrial membranes (PubMed:30404948). Induces membrane curvature and tubulation, which are critical for maintaining mitochondrial ultrastructure and the organization of cristae (PubMed:30404948). Plays a crucial role in ciliogenesis (PubMed:27528616, PubMed:30395363). May play a role in limb development through its role in ciliogenesis (PubMed:30395363). Plays a key role in the correct positioning of the annulus, a septin-based ring structure in the sperm flagellum, serving both as a physical barrier and a membrane diffusion barrier that separates the midpiece (MP) from the principal piece (PP) (By similarity). This positioning is essential for proper sperm motility and function (By similarity). Interacts with CBY3 to form a complex which localizes to the curved membrane region of the flagellar pocket (By similarity). By doing so, may provide stability and rigidity to the periannular membrane to prevent membrane deformation (By similarity). This function is crucial for halting annulus migration at the proximal end of the fibrous sheath-containing PP (By similarity)