ADP-ribose glycohydrolase MACROD2 (MACRO domain-containing protein 2) (O-acetyl-ADP-ribose deacetylase MACROD2) (EC 3.5.1.-) ([Protein ADP-ribosylaspartate] hydrolase MACROD2) (EC 3.2.2.-) ([Protein ADP-ribosylglutamate] hydrolase MACROD2) (EC 3.2.2.-)
1_MYPSN 6_ KKKKV 11_ WREEK 16_ ERLLK 21_ MTLEE 26_ RRKEY 31_ LRDYI 36_ PLNSI 41_ LSWKE 46_ EMKGK 51_ GQNDE 56_ ENTQE 61_ TSQVK 66_ KSLTE 71_ KVSLY 76_ RGDIT 81_ LLEVD 86_ AIVNA 91_ ANASL 96_ LGGGG 101_ VDGCI 106_ HRAAG 111_ PCLLA 116_ ECRNL 121_ NGCDT 126_ GHAKI 131_ TCGYD 136_ LPAKY 141_ VIHTV 146_ GPIAR 151_ GHING 156_ SHKED 161_ LANCY 166_ KSSLK 171_ LVKEN 176_ NIRSV 181_ AFPCI 186_ STGIY 191_ GFPNE 196_ PAAVI 201_ ALNTI 206_ KEWLA 211_ KNHHE 216_ VDRII 221_ FCVFL 226_ EVDFK 231_ IYKKK 236_ MNEFF 241_ SVDDN 246_ NEEEE 251_ DVEMK 256_ EDSDE 261_ NGPEE 266_ KQSVE 271_ EMEEQ 276_ SQDAD 281_ GVNTV 286_ TVPGP 291_ ASEEA 296_ VEDCK 301_ DEDFA 306_ KDENI 311_ TKGGE 316_ VTDHS 321_ VRDQD 326_ HPDGQ 331_ ENDST 336_ KNEIK 341_ IETES 346_ QSSYM 351_ ETEEL 356_ SSNQE 361_ DAVIV 366_ EQPEV 371_ IPLTE 376_ DQEEK 381_ EGEKA 386_ PGEDT 391_ PRMPG 396_ KSEGS 401_ SDLEN 406_ TPGPD 411_ AGAQD 416_EAKEQ
1: Removes ADP-ribose from aspartate and glutamate residues in proteins bearing a single ADP-ribose moiety (PubMed:23474712, PubMed:23474714). Inactive towards proteins bearing poly-ADP-ribose (PubMed:23474712, PubMed:23474714). Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (PubMed:21257746)