Probable ribonuclease ZC3H12D (EC 3.1.-.-) (MCP-induced protein 4) (Transformed follicular lymphoma) (Zinc finger CCCH domain-containing protein 12D) (p34)
1_MEHPS 6_ KMEFF 11_ QKLGY 16_ DREDV 21_ LRVLG 26_ KLGEG 31_ ALVND 36_ VLQEL 41_ IRTGS 46_ RPGAL 51_ EHPAA 56_ PRLVP 61_ RGSCG 66_ VPDSA 71_ QRGPG 76_ TALEE 81_ DFRTL 86_ ASSLR 91_ PIVID 96_ GSNVA 101_ MSHGN 106_ KETFS 111_ CRGIK 116_ LAVDW 121_ FRDRG 126_ HTYIK 131_ VFVPS 136_ WRKDP 141_ PRADT 146_ PIREQ 151_ HVLAE 156_ LERQA 161_ VLVYT 166_ PSRKV 171_ HGKRL 176_ VCYDD 181_ RYIVK 186_ VAYEQ 191_ DGVIV 196_ SNDNY 201_ RDLQS 206_ ENPEW 211_ KWFIE 216_ QRLLM 221_ FSFVN 226_ DRFMP 231_ PDDPL 236_ GRHGP 241_ SLSNF 246_ LSRKP 251_ KPPEP 256_ SWQHC 261_ PYGKK 266_ CTYGI 271_ KCKFY 276_ HPERP 281_ HHAQL 286_ AVADE 291_ LRAKT 296_ GARPG 301_ AGAEE 306_ QRPPR 311_ APGGS 316_ AGARA 321_ APREP 326_ FAHSL 331_ PPARG 336_ SPDLA 341_ ALRGS 346_ FSRLA 351_ FSDDL 356_ GPLGP 361_ PLPVP 366_ ACSLT 371_ PRLGG 376_ PDWVS 381_ AGGRV 386_ PGPLS 391_ LPSPE 396_ SQFSP 401_ GDLPP 406_ PPGLQ 411_ LQPRG 416_ EHRPR 421_ DLHGD 426_ LLSPR 431_ RPPDD 436_ PWARP 441_ PRSDR 446_ FPGRS 451_ VWAEP 456_ AWGDG 461_ ATGGL 466_ SVYAT 471_ EDDEG 476_ DARAR 481_ ARIAL 486_ YSVFP 491_ RDQVD 496_ RVMAA 501_ FPELS 506_ DLARL 511_ ILLVQ 516_ RCQSA 521_GAPLG
1: May regulate cell growth likely by suppressing RB1 phosphorylation (PubMed:19531561). May function as RNase and regulate the levels of target RNA species (Potential). In association with ZC3H12A enhances the degradation of interleukin IL-6 mRNA level in activated macrophages (PubMed:26134560). Serve as a tumor suppressor in certain leukemia cells (PubMed:17210687). Overexpression inhibits the G1 to S phase progression through suppression of RB1 phosphorylation (PubMed:19531561)