Protein TESPA1 (Thymocyte-expressed positive selection-associated protein 1)
1_MEASV 6_ LSPTS 11_ WEKRR 16_ AWLRQ 21_ SRNWQ 26_ TQVLE 31_ EEAAA 36_ ALQDV 41_ PDPEP 46_ SSLDD 51_ VFQEG 56_ NPINK 61_ IEDWL 66_ QDCGY 71_ SEEGF 76_ SEEAG 81_ QFIYN 86_ GFCSH 91_ GTSFE 96_ DDLTL 101_ GAEAT 106_ LLAAN 111_ GKLFS 116_ RSFLE 121_ TARPC 126_ QLLDL 131_ GCSLA 136_ SSSMT 141_ GGTNK 146_ TSSSI 151_ SEILD 156_ KVQED 161_ AEDVL 166_ FSLGF 171_ GQEDH 176_ KDTSR 181_ IPARF 186_ FTTPS 191_ QAKGI 196_ DFQLF 201_ LKSQV 206_ RRIEM 211_ EDPCL 216_ MLASR 221_ FKQVQ 226_ TLAVT 231_ ADAFF 236_ CLYSY 241_ VSKTP 246_ VQKFT 251_ PSHMF 256_ WNCNH 261_ PTDVP 266_ SIRIL 271_ SREPE 276_ PQSPR 281_ DRLRK 286_ AISKM 291_ CLYTC 296_ PRDRP 301_ PPPHN 306_ TPKRN 311_ SLDQV 316_ VLEVM 321_ DKVKE 326_ EKQFL 331_ QQDSD 336_ LGQFS 341_ QEDPV 346_ PPAEG 351_ KKLPT 356_ SPYPC 361_ VFCCE 366_ EETQQ 371_ RMSTV 376_ LAPSQ 381_ TLDSN 386_ PKVPC 391_ CTHSL 396_ PIEDP 401_ QWSTD 406_ PAQIR 411_ RELCS 416_ LPATN 421_ TETHP 426_ AKDET 431_ FWKRK 436_ SRARK 441_ SLFQK 446_ NLMGR 451_ KVKSL 456_ DLSIT 461_ QQKWK 466_ QSVDR 471_ PELRR 476_ SLSQQ 481_ PQDTF 486_ DLEEV 491_ QSNSE 496_ EEQSQ 501_ SRWPS 506_ RPRHP 511_ HHHQT 516_FAGKD
1: Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development (By similarity). Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. May play a role in the regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release and mitochondrial Ca(2+) uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment