DENN domain-containing protein 3
1_MRSLR 6_ KKREK 11_ PRPEQ 16_ WKGLP 21_ GPPRA 26_ PEPED 31_ VAVPG 36_ GVDLL 41_ TLPQL 46_ CFPGG 51_ VCVAT 56_ EPKED 61_ CVHFL 66_ VLTDV 71_ CGNRT 76_ YGVVA 81_ QYYRP 86_ LHDEY 91_ CFYNG 96_ KTHRE 101_ CPGCF 106_ VPFAV 111_ CVVSR 116_ FPYYN 121_ SLKDC 126_ LSCLL 131_ ALLKP 136_ CKDFE 141_ VDSHI 146_ KDFAA 151_ KLSLI 156_ PSPPP 161_ GPLHL 166_ VFNMK 171_ SLQIV 176_ LPARA 181_ DPESP 186_ ILDLD 191_ LHLPL 196_ LCFRP 201_ EKVLQ 206_ ILTCI 211_ LTEQR 216_ IVFFS 221_ SDWAL 226_ LTLVT 231_ ECFMA 236_ YLYPL 241_ QWQHP 246_ FVPIL 251_ SDQML 256_ DFVMA 261_ PTSFL 266_ MGCHL 271_ DHFEE 276_ VSKEA 281_ DGLVL 286_ INIDH 291_ GSITY 296_ SKSTD 301_ DNVDI 306_ PDVPL 311_ LAAQT 316_ FIQRV 321_ QSLQL 326_ HHELH 331_ AAHLL 336_ SSTDL 341_ KEGRA 346_ HRRSW 351_ QQKLN 356_ CQIQQ 361_ TTLQL 366_ LVSIF 371_ RDVKN 376_ HLNYE 381_ HRVFN 386_ SEEFL 391_ KTRAP 396_ GDHQF 401_ YKQVL 406_ DTYMF 411_ HSFLK 416_ ARLNR 421_ RMDAF 426_ AQMDL 431_ DTQSE 436_ EDRIN 441_ GMLLS 446_ PRRPT 451_ VEKRA 456_ SRKSS 461_ HLHVT 466_ HRRMV 471_ VSMPN 476_ LQDIA 481_ MPELA 486_ PRNSS 491_ LRLTD 496_ TAGCR 501_ GSSAV 506_ LNVTP 511_ KSPYT 516_ FKIPE 521_ IHFPL 526_ ESKCV 531_ QAYHA 536_ HFVSM 541_ LSEAM 546_ CFLAP 551_ DNSLL 556_ LARYL 561_ YLRGL 566_ VYLMQ 571_ GQLLN 576_ ALLDF 581_ QNLYK 586_ TDIRI 591_ FPTDL 596_ VKRTV 601_ ESMSA 606_ PEWEG 611_ AEQAP 616_ ELMRL 621_ ISEIL 626_ DKPHE 631_ ASKLD 636_ DHVKK 641_ FKLPK 646_ KHMQL 651_ GDFMK 656_ RVQES 661_ GIVKD 666_ ASIIH 671_ RLFEA 676_ LTVGQ 681_ EKQID 686_ PETFK 691_ DFYNC 696_ WKETE 701_ AEAQE 706_ VSLPW 711_ LVMEH 716_ LDKNE 721_ CVCKL 726_ SSSVK 731_ TNLGV 736_ GKIAM 741_ TQKRL 746_ FLLTE 751_ GRPGY 756_ LEIST 761_ FRNIE 766_ EVRRT 771_ TTTFL 776_ LRRIP 781_ TLKIR 786_ VASKK 791_ EVFEA 796_ NLKTE 801_ CDLWH 806_ LMVKE 811_ MWAGK 816_ KLADD 821_ HKDPH 826_ YVQQA 831_ LTNVL 836_ LMDAV 841_ VGTLQ 846_ SPGAI 851_ YAASK 856_ LSYFD 861_ KMSNE 866_ MPMTL 871_ PETTL 876_ ETLKH 881_ KINPS 886_ AGEAF 891_ PQAVD 896_ VLLYT 901_ PGHLD 906_ PAEKV 911_ EDAHP 916_ KLWCA 921_ LSEGK 926_ VTVFN 931_ ASSWT 936_ IHQHS 941_ FKVGT 946_ AKVNC 951_ MVMAD 956_ QNQVW 961_ VGSED 966_ SVIYI 971_ INVHS 976_ MSCNK 981_ QLTAH 986_ CSSVT 991_ DLIVQ 996_ DGQEA 1001_ PSNVY 1006_ SCSMD 1011_ GMVLV 1016_ WNVST 1021_ LQVTS 1026_ RFQLP 1031_ RGGLT 1036_ SIRLH 1041_ GGRLW 1046_ CCTGN 1051_ SIMVM 1056_ KMNGS 1061_ LHQEL 1066_ KIEEN 1071_ FKDTS 1076_ TSFLA 1081_ FQLLP 1086_ EEEQL 1091_ WAACA 1096_ GRSEV 1101_ YIWSL 1106_ KDLAQ 1111_ PPQRV 1116_ PLEDC 1121_ SEINC 1126_ MIRVK 1131_ KQVWV 1136_ GSRGL 1141_ GQGTP 1146_ KGKIY 1151_ VIDAE 1156_ RKTVE 1161_ KELVA 1166_ HMDTV 1171_ RTLCS 1176_ AEDRY 1181_ VLSGS 1186_ GREEG 1191_KVAIW
1: Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form (PubMed:20937701). Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the degradation of the transferrin receptor and of the amino acid transporter PAT4 (PubMed:20937701). Starvation also induces phosphorylation at Tyr-858, which leads to up-regulated GEF activity and initiates autophagy (By similarity)