Fucose mutarotase (EC 5.1.3.29)
1_MVALK 6_ GVPAL 11_ LSPEL 16_ LYALA 21_ RMGHG 26_ DEIVL 31_ ADLNF 36_ PASSI 41_ CQCGP 46_ MEIRA 51_ DGLGI 56_ PQLLE 61_ AVLKL 66_ LPLDT 71_ YVESP 76_ AAVME 81_ LVPSD 86_ KERGL 91_ QTPVW 96_ TEYES 101_ ILRRA 106_ GCVRA 111_ LAKIE 116_ RFEFY 121_ ERAKK 126_ AFAVV 131_ ATGET 136_ ALYGN 141_ LILRK 146_GVLAL
1: Involved in the interconversion between alpha- and beta-L-fucoses. L-Fucose (6-deoxy-L-galactose) exists as alpha-L-fucose (29.5%) and beta-L-fucose (70.5%), the beta-form is metabolized through the salvage pathway. GDP-L-fucose formed either by the de novo or salvage pathways is transported into the endoplasmic reticulum, where it serves as a substrate for N- and O-glycosylations by fucosyltransferases. Fucosylated structures expressed on cell surfaces or secreted in biological fluids are believed to play a critical role in cell-cell adhesion and recognition processes