D-ribitol-5-phosphate cytidylyltransferase (EC 2.7.7.40) (2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein) (Isoprenoid synthase domain-containing protein) (hISPD)
1_MEAGP 6_ PGSAR 11_ PAEPG 16_ PCLSG 21_ QRGAD 26_ HTASA 31_ SLQSV 36_ AGTEP 41_ GRHPQ 46_ AVAAV 51_ LPAGG 56_ CGERM 61_ GVPTP 66_ KQFCP 71_ ILERP 76_ LISYT 81_ LQALE 86_ RVCWI 91_ KDIVV 96_ AVTGE 101_ NMEVM 106_ KSIIQ 111_ KYQHK 116_ RISLV 121_ EAGVT 126_ RHRSI 131_ FNGLK 136_ ALAED 141_ QINSK 146_ LSKPE 151_ VVIIH 156_ DAVRP 161_ FVEEG 166_ VLLKV 171_ VTAAK 176_ EHGAA 181_ GAIRP 186_ LVSTV 191_ VSPSA 196_ DGCLD 201_ YSLER 206_ ARHRA 211_ SEMPQ 216_ AFLFD 221_ VIYEA 226_ YQQCS 231_ DYDLE 236_ FGTEC 241_ LQLAL 246_ KYCCT 251_ KAKLV 256_ EGSPD 261_ LWKVT 266_ YKRDL 271_ YAAES 276_ IIKER 281_ ISQEI 286_ CVVMD 291_ TEEDN 296_ KHVGH 301_ LLEEV 306_ LKSEL 311_ NHVKV 316_ TSEAL 321_ GHAGR 326_ HLQQI 331_ ILDQC 336_ YNFVC 341_ VNVTT 346_ SDFQE 351_ TQKLL 356_ SMLEE 361_ SSLCI 366_ LYPVV 371_ VVSVH 376_ FLDFK 381_ LVPPS 386_ QKMEN 391_ LMQIR 396_ EFAKE 401_ VKERN 406_ ILLYG 411_ LLISY 416_ PQDDQ 421_ KLQES 426_ LRQGA 431_ IIIAS 436_ LIKER 441_ NSGLI 446_GQLLI
1: Cytidylyltransferase required for protein O-linked mannosylation (PubMed:22522420, PubMed:22522421, PubMed:26687144, PubMed:26923585, PubMed:27130732, PubMed:27601598). Catalyzes the formation of CDP-ribitol nucleotide sugar from D-ribitol 5-phosphate (PubMed:26687144, PubMed:26923585, PubMed:27130732). CDP-ribitol is a substrate of FKTN during the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:26687144, PubMed:26923585, PubMed:27130732). Shows activity toward other pentose phosphate sugars and mediates formation of CDP-ribulose or CDP-ribose using CTP and ribulose-5-phosphate or ribose-5-phosphate, respectively (PubMed:26687144). Not Involved in dolichol production (PubMed:26687144)