Gamma-secretase-activating protein (GSAP) (Protein pigeon homolog) [Cleaved into: Gamma-secretase-activating protein 16 kDa C-terminal form (GSAP-16K)]
1_MALRL 6_ VADFD 11_ LGKDV 16_ LPWLR 21_ AQRAV 26_ SEASG 31_ AGSGG 36_ ADVLE 41_ NDYES 46_ LHVLN 51_ VERNG 56_ NIIYT 61_ YKDDK 66_ GNVVF 71_ GLYDC 76_ QTRQN 81_ ELLYT 86_ FEKDL 91_ QVFSC 96_ SVNSE 101_ RTLLA 106_ ASLVQ 111_ STKEG 116_ KRNEL 121_ QPGSK 126_ CLTLL 131_ VEIHP 136_ VNNVK 141_ VLKAV 146_ DSYIW 151_ VQFLY 156_ PHIES 161_ HPLPE 166_ NHLLL 171_ ISEEK 176_ YIEQF 181_ RIHVA 186_ QEDGN 191_ RVVIK 196_ NSGHL 201_ PRDRI 206_ AEDFV 211_ WAQWD 216_ MSEQR 221_ LYYID 226_ LKKSR 231_ SILKC 236_ IQFYA 241_ DESYN 246_ LMFEV 251_ PLDIS 256_ LSNSG 261_ FKLVN 266_ FGCDY 271_ HQYRD 276_ KFSKH 281_ LTLCV 286_ FTNHT 291_ GSLCV 296_ CYSPK 301_ CASWG 306_ QITYS 311_ VFYIH 316_ KGHSK 321_ TFTTS 326_ LENVG 331_ SHMTK 336_ GITFL 341_ NLDYY 346_ VAVYL 351_ PGHFF 356_ HLLNV 361_ QHPDL 366_ ICHNL 371_ FLTGN 376_ NEMID 381_ MLPHC 386_ PLQSL 391_ SGSLV 396_ LDCCS 401_ GKLYR 406_ ALLSQ 411_ SSLLQ 416_ LLQNT 421_ CLDCE 426_ KMAAL 431_ HCALY 436_ CGQGA 441_ QFLEA 446_ QIIQW 451_ ISENV 456_ SACHS 461_ FDLIQ 466_ EFIIA 471_ SSYWS 476_ VYSET 481_ SNMDK 486_ LLPHS 491_ SVLTW 496_ NTEIP 501_ GITLV 506_ TEDIA 511_ LPLMK 516_ VLSFK 521_ GYWEK 526_ LNSNL 531_ EYVKY 536_ AKPHF 541_ HYNNS 546_ VVRRE 551_ WHNLI 556_ SEEKT 561_ GKRRS 566_ AAYVR 571_ NILDN 576_ AVKVI 581_ SNLEA 586_ RNLGP 591_ RLTPL 596_ LQEED 601_ SHQRL 606_ LMGLM 611_ VSELK 616_ DHFLR 621_ HLQGV 626_ EKKKI 631_ EQMVL 636_ DYISK 641_ LLDLI 646_ CHIVE 651_ TNWRK 656_ HNLHS 661_ WVLHF 666_ NSRGS 671_ AAEFA 676_ VFHIM 681_ TRILE 686_ ATNSL 691_ FLPLP 696_ PGFHT 701_ LHTIL 706_ GVQCL 711_ PLHNL 716_ LHCID 721_ SGVLL 726_ LTETA 731_ VIRLM 736_ KDLDN 741_ TEKNE 746_ KLKFS 751_ IIVRL 756_ PPLIG 761_ QKICR 766_ LWDHP 771_ MSSNI 776_ ISRNH 781_ VTRLL 786_ QNYKK 791_ QPRNS 796_ MINKS 801_ SFSVE 806_ FLPLN 811_ YFIEI 816_ LTDIE 821_ SSNQA 826_ LYPFE 831_ GHDNV 836_ DAEFV 841_ EEAAL 846_KHTAM
1: Regulator of gamma-secretase activity, which specifically activates the production of amyloid-beta protein (amyloid-beta protein 40 and amyloid-beta protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Specifically promotes the gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate amyloid-beta, while it reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD