Metallo-beta-lactamase domain-containing protein 1 (EC 3.1.27.-) (Endoribonuclease MBLAC1)
1_MRTEP 6_ LCGAS 11_ PLLVP 16_ GDPYS 21_ VVVLL 26_ QGYAE 31_ PEGVG 36_ DAVRA 41_ DGSVT 46_ LVLPQ 51_ TRGPA 56_ SSHRE 61_ SPRGS 66_ GGAEA 71_ ALEEA 76_ ARGPI 81_ LVDTG 86_ GPWAR 91_ EALLG 96_ ALAGQ 101_ GVAPG 106_ DVTLV 111_ VGTHG 116_ HSDHI 121_ GNLGL 126_ FPGAA 131_ LLVSH 136_ DFCLP 141_ GGRYL 146_ PHGLG 151_ EGQPL 156_ RLGPG 161_ LEVWA 166_ TPGHG 171_ GQRDV 176_ SVVVA 181_ GTALG 186_ TVVVA 191_ GDVFE 196_ RDGDE 201_ DSWQA 206_ LSEDP 211_ AAQER 216_ SRKRV 221_ LVVAD 226_ VVVPG 231_ HGPPF 236_ RVLRE 241_ ASQPE 246_ TEGGG 251_ NSQQE 256_ PVVGD 261_EEPAL
1: Endoribonuclease that catalyzes the hydrolysis of histone-coding pre-mRNA 3'-end. Involved in histone pre-mRNA processing during the S-phase of the cell cycle, which is required for entering/progressing through S-phase (PubMed:30507380). Cleaves histone pre-mRNA at a major and a minor cleavage site after the 5'-ACCCA-3' and the 5'-ACCCACA-3' sequence, respectively, and located downstream of the stem-loop (PubMed:30507380). May require the presence of the HDE element located at the histone pre-RNA 3'-end to avoid non-specific cleavage (PubMed:30507380)