Proteasome subunit beta type-11 (EC 3.4.25.1) (Proteasome subunit beta-5t)
1_MALQD 6_ VCKWQ 11_ SPDTQ 16_ GPSPH 21_ LPRAG 26_ GWAVP 31_ RGCDP 36_ QTFLQ 41_ IHGPR 46_ LAHGT 51_ TTLAF 56_ RFRHG 61_ VIAAA 66_ DTRSS 71_ CGSYV 76_ ACPAS 81_ CKVIP 86_ VHQHL 91_ LGTTS 96_ GTSAD 101_ CATWY 106_ RVLQR 111_ ELRLR 116_ ELREG 121_ QLPSV 126_ ASAAK 131_ LLSAM 136_ MSQYR 141_ GLDLC 146_ VATAL 151_ CGWDR 156_ SGPEL 161_ FYVYS 166_ DGTRL 171_ QGDIF 176_ SVGSG 181_ SPYAY 186_ GVLDR 191_ GYRYD 196_ MSTQE 201_ AYALA 206_ RCAVA 211_ HATHR 216_ DAYSG 221_ GSVDL 226_ FHVRE 231_ SGWEH 236_ VSRSD 241_ ACVLY 246_ VELQK 251_ LLEPE 256_ PEEDA 261_ SHAHP 266_ EPATA 271_ HRAAE 276_ DRELS 281_ VGPGE 286_ VTPGD 291_SRMPA
1: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome (By similarity). Plays a pivotal role in development of CD8-positive T cells (By similarity)