CCR4-NOT transcription complex subunit 1 (CCR4-associated factor 1) (Negative regulator of transcription subunit 1 homolog) (NOT1H) (hNOT1)
1_MNLDS 6_ LSLAL 11_ SQISY 16_ LVDNL 21_ TKKNY 26_ RASQQ 31_ EIQHI 36_ VNRHG 41_ PEADR 46_ HLLRC 51_ LFSHV 56_ DFSGD 61_ GKSSG 66_ KDFHQ 71_ TQFLI 76_ QECAL 81_ LITKP 86_ NFIST 91_ LSYAI 96_ DNPLH 101_ YQKSL 106_ KPAPH 111_ LFAQL 116_ SKVLK 121_ LSKVQ 126_ EVIFG 131_ LALLN 136_ SSSSD 141_ LRGFA 146_ AQFIK 151_ QKLPD 156_ LLRSY 161_ IDADV 166_ SGNQE 171_ GGFQD 176_ IAIEV 181_ LHLLL 186_ SHLLF 191_ GQKGA 196_ FGVGQ 201_ EQIDA 206_ FLKTL 211_ RRDFP 216_ QERCP 221_ VVLAP 226_ LLYPE 231_ KRDIL 236_ MDRIL 241_ PDSGG 246_ VAKTM 251_ MESSL 256_ ADFMQ 261_ EVGYG 266_ FCASI 271_ EECRN 276_ IIVQF 281_ GVREV 286_ TAAQV 291_ ARVLG 296_ MMART 301_ HSGLT 306_ DGIPL 311_ QSISA 316_ PGSGI 321_ WSDGK 326_ DKSDG 331_ AQAHT 336_ WNVEV 341_ LIDVL 346_ KELNP 351_ SLNFK 356_ EVTYE 361_ LDHPG 366_ FQIRD 371_ SKGLH 376_ NVVYG 381_ IQRGL 386_ GMEVF 391_ PVDLI 396_ YRPWK 401_ HAEGQ 406_ LSFIQ 411_ HSLIN 416_ PEIFC 421_ FADYP 426_ CHTVA 431_ TDILK 436_ APPED 441_ DNREI 446_ ATWKS 451_ LDLIE 456_ SLLRL 461_ AEVGQ 466_ YEQVK 471_ QLFSF 476_ PIKHC 481_ PDMLV 486_ LALLQ 491_ INTSW 496_ HTLRH 501_ ELIST 506_ LMPIF 511_ LGNHP 516_ NSAII 521_ LHYAW 526_ HGQGQ 531_ SPSIR 536_ QLIMH 541_ AMAEW 546_ YMRGE 551_ QYDQA 556_ KLSRI 561_ LDVAQ 566_ DLKAL 571_ SMLLN 576_ GTPFA 581_ FVIDL 586_ AALAS 591_ RREYL 596_ KLDKW 601_ LTDKI 606_ REHGE 611_ PFIQA 616_ CMTFL 621_ KRRCP 626_ SILGG 631_ LAPEK 636_ DQPKS 641_ AQLPP 646_ ETLAT 651_ MLACL 656_ QACAG 661_ SVSQE 666_ LSETI 671_ LTMVA 676_ NCSNV 681_ MNKAR 686_ QPPPG 691_ VMPKG 696_ RPPSA 701_ SSLDA 706_ ISPVQ 711_ IDPLA 716_ GMTSL 721_ SIGGS 726_ AAPHT 731_ QSMQG 736_ FPPNL 741_ GSAFS 746_ TPQSP 751_ AKAFP 756_ PLSTP 761_ NQTTA 766_ FSGIG 771_ GLSSQ 776_ LPVGG 781_ LGTGS 786_ LTGIG 791_ TGALG 796_ LPAVN 801_ NDPFV 806_ QRKLG 811_ TSGLN 816_ QPTFQ 821_ QSKMK 826_ PSDLS 831_ QVWPE 836_ ANQHF 841_ SKEID 846_ DEANS 851_ YFQRI 856_ YNHPP 861_ HPTMS 866_ VDEVL 871_ EMLQR 876_ FKDST 881_ IKRER 886_ EVFNC 891_ MLRNL 896_ FEEYR 901_ FFPQY 906_ PDKEL 911_ HITAC 916_ LFGGI 921_ IEKGL 926_ VTYMA 931_ LGLAL 936_ RYVLE 941_ ALRKP 946_ FGSKM 951_ YYFGI 956_ AALDR 961_ FKNRL 966_ KDYPQ 971_ YCQHL 976_ ASISH 981_ FMQFP 986_ HHLQE 991_ YIEYG 996_ QQSRD 1001_ PPVKM 1006_ QGSIT 1011_ TPGSI 1016_ ALAQA 1021_ QAQAQ 1026_ VPAKA 1031_ PLAGQ 1036_ VSTMV 1041_ TTSTT 1046_ TTVAK 1051_ TVTVT 1056_ RPTGV 1061_ SFKKD 1066_ VPPSI 1071_ NTTNI 1076_ DTLLV 1081_ ATDQT 1086_ ERIVE 1091_ PPENI 1096_ QEKIA 1101_ FIFNN 1106_ LSQSN 1111_ MTQKV 1116_ EELKE 1121_ TVKEE 1126_ FMPWV 1131_ SQYLV 1136_ MKRVS 1141_ IEPNF 1146_ HSLYS 1151_ NFLDT 1156_ LKNPE 1161_ FNKMV 1166_ LNETY 1171_ RNIKV 1176_ LLTSD 1181_ KAAAN 1186_ FSDRS 1191_ LLKNL 1196_ GHWLG 1201_ MITLA 1206_ KNKPI 1211_ LHTDL 1216_ DVKSL 1221_ LLEAY 1226_ VKGQQ 1231_ ELLYV 1236_ VPFVA 1241_ KVLES 1246_ SIRSV 1251_ VFRPP 1256_ NPWTM 1261_ AIMNV 1266_ LAELH 1271_ QEHDL 1276_ KLNLK 1281_ FEIEV 1286_ LCKNL 1291_ ALDIN 1296_ ELKPG 1301_ NLLKD 1306_ KDRLK 1311_ NLDEQ 1316_ LSAPK 1321_ KDVKQ 1326_ PEELP 1331_ PITTT 1336_ TTSTT 1341_ PATNT 1346_ TCTAT 1351_ VPPQP 1356_ QYSYH 1361_ DINVY 1366_ SLAGL 1371_ APHIT 1376_ LNPTI 1381_ PLFQA 1386_ HPQLK 1391_ QCVRQ 1396_ AIERA 1401_ VQELV 1406_ HPVVD 1411_ RSIKI 1416_ AMTTC 1421_ EQIVR 1426_ KDFAL 1431_ DSEES 1436_ RMRIA 1441_ AHHMM 1446_ RNLTA 1451_ GMAMI 1456_ TCREP 1461_ LLMSI 1466_ STNLK 1471_ NSFAS 1476_ ALRTA 1481_ SPQQR 1486_ EMMDQ 1491_ AAAQL 1496_ AQDNC 1501_ ELACC 1506_ FIQKT 1511_ AVEKA 1516_ GPEMD 1521_ KRLAT 1526_ EFELR 1531_ KHARQ 1536_ EGRRY 1541_ CDPVV 1546_ LTYQA 1551_ ERMPE 1556_ QIRLK 1561_ VGGVD 1566_ PKQLA 1571_ VYEEF 1576_ ARNVP 1581_ GFLPT 1586_ NDLSQ 1591_ PTGFL 1596_ AQPMK 1601_ QAWAT 1606_ DDVAQ 1611_ IYDKC 1616_ ITELE 1621_ QHLHA 1626_ IPPTL 1631_ AMNPQ 1636_ AQALR 1641_ SLLEV 1646_ VVLSR 1651_ NSRDA 1656_ IAALG 1661_ LLQKA 1666_ VEGLL 1671_ DATSG 1676_ ADADL 1681_ LLRYR 1686_ ECHLL 1691_ VLKAL 1696_ QDGRA 1701_ YGSPW 1706_ CNKQI 1711_ TRCLI 1716_ ECRDE 1721_ YKYNV 1726_ EAVEL 1731_ LIRNH 1736_ LVNMQ 1741_ QYDLH 1746_ LAQSM 1751_ ENGLN 1756_ YMAVA 1761_ FAMQL 1766_ VKILL 1771_ VDERS 1776_ VAHVT 1781_ EADLF 1786_ HTIET 1791_ LMRIN 1796_ AHSRG 1801_ NAPEG 1806_ LPQLM 1811_ EVVRS 1816_ NYEAM 1821_ IDRAH 1826_ GGPNF 1831_ MMHSG 1836_ ISQAS 1841_ EYDDP 1846_ PGLRE 1851_ KAEYL 1856_ LREWV 1861_ NLYHS 1866_ AAAGR 1871_ DSTKA 1876_ FSAFV 1881_ GQMHQ 1886_ QGILK 1891_ TDDLI 1896_ TRFFR 1901_ LCTEM 1906_ CVEIS 1911_ YRAQA 1916_ EQQHN 1921_ PAANP 1926_ TMIRA 1931_ KCYHN 1936_ LDAFV 1941_ RLIAL 1946_ LVKHS 1951_ GEATN 1956_ TVTKI 1961_ NLLNK 1966_ VLGIV 1971_ VGVLL 1976_ QDHDV 1981_ RQSEF 1986_ QQLPY 1991_ HRIFI 1996_ MLLLE 2001_ LNAPE 2006_ HVLET 2011_ INFQT 2016_ LTAFC 2021_ NTFHI 2026_ LRPTK 2031_ APGFV 2036_ YAWLE 2041_ LISHR 2046_ IFIAR 2051_ MLAHT 2056_ PQQKG 2061_ WPMYA 2066_ QLLID 2071_ LFKYL 2076_ APFLR 2081_ NVELT 2086_ KPMQI 2091_ LYKGT 2096_ LRVLL 2101_ VLLHD 2106_ FPEFL 2111_ CDYHY 2116_ GFCDV 2121_ IPPNC 2126_ IQLRN 2131_ LILSA 2136_ FPRNM 2141_ RLPDP 2146_ FTPNL 2151_ KVDML 2156_ SEINI 2161_ APRIL 2166_ TNFTG 2171_ VMPPQ 2176_ FKKDL 2181_ DSYLK 2186_ TRSPV 2191_ TFLSD 2196_ LRSNL 2201_ QVSNE 2206_ PGNRY 2211_ NLQLI 2216_ NALVL 2221_ YVGTQ 2226_ AIAHI 2231_ HNKGS 2236_ TPSMS 2241_ TITHS 2246_ AHMDI 2251_ FQNLA 2256_ VDLDT 2261_ EGRYL 2266_ FLNAI 2271_ ANQLR 2276_ YPNSH 2281_ THYFS 2286_ CTMLY 2291_ LFAEA 2296_ NTEAI 2301_ QEQIT 2306_ RVLLE 2311_ RLIVN 2316_ RPHPW 2321_ GLLIT 2326_ FIELI 2331_ KNPAF 2336_ KFWNH 2341_ EFVHC 2346_ APEIE 2351_ KLFQS 2356_ VAQCC 2361_ MGQKQ 2366_ AQQVM 2371_EGTGA
1: Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES) cell identity. Plays a role in rapid sperm motility via mediating timely mRNA turnover (By similarity)