Gene name: TMEM150B

Uniprot entry:

A6NC51

Protein names:

Modulator of macroautophagy TMEM150B (Protein DRAM-3) (Transmembrane protein 150B) (Transmembrane protein 224)

Protein sequence:

1_MWGYL 6_ SLMPV 11_ FLAVW 16_ AISGV 21_ WIVFA 26_ IAVTN 31_ RTVDL 36_ SKGFP 41_ YISIC 46_ GSFPP 51_ QSCIF 56_ SQVLN 61_ MGAAL 66_ AAWIC 71_ IVRYH 76_ QLRDW 81_ GVRRW 86_ PNQLI 91_ LWTGL 96_ LCALG 101_ TSVVG 106_ NFQEK 111_ NQRPT 116_ HLAGA 121_ FLAFI 126_ LGNVY 131_ FWLQL 136_ LLWRL 141_ KRLPQ 146_ PGAAW 151_ IGPLR 156_ LGLCS 161_ VCTIL 166_ IVAMI 171_ VLHAC 176_ SLRSV 181_ SAACE 186_ WVVAM 191_ LLFAL 196_ FGLLA 201_ VDFSA 206_ LESCT 211_ LCVQP 216_ WPSLS 221_ PPPAS 226_PISLP

Protein annotations

Protein functions:

1: Modulator of macroautophagy that causes accumulation of autophagosomes under basal conditions and enhances autophagic flux (PubMed:25929859). Represses cell death and promotes long-term clonogenic survival of cells grown in the absence of glucose in a macroautophagy-independent manner (PubMed:25929859). May have some role in extracellular matrix engulfment or growth factor receptor recycling, both of which can modulate cell survival (PubMed:25929859)