Microtubule-associated proteins 1A/1B light chain 3 beta 2 (Microtubule-associated proteins 1A/1B light chain 3B-like)
1_MPSEK 6_ TFKQR 11_ RTFEQ 16_ RVEDV 21_ RLIRE 26_ QHPTK 31_ IPVII 36_ ERYKG 41_ EKQLP 46_ VLDKT 51_ KFLVP 56_ DHVNM 61_ SELIK 66_ IIRRR 71_ LQLNA 76_ NQAFF 81_ LLVNG 86_ HSMVS 91_ VSTPI 96_ SEVYE 101_ SEKDE 106_ DGFLY 111_ MVCAS 116_QETFG
1: Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. In response to cellular stress and upon mitochondria fission, binds C-18 ceramides and anchors autophagolysosomes to outer mitochondrial membranes to eliminate damaged mitochondria. While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation