Sperm-egg fusion protein Juno (Folate receptor 4) (Folate receptor delta) (FR-delta) (IZUMO1 receptor protein JUNO)
1_MACWW 6_ PLLLE 11_ LWTVM 16_ PTWAG 21_ DELLN 26_ ICMNA 31_ KHHKR 36_ VPSPE 41_ DKLYE 46_ ECIPW 51_ KDNAC 56_ CTLTT 61_ SWEAH 66_ LDVSP 71_ LYNFS 76_ LFHCG 81_ LLMPG 86_ CRKHF 91_ IQAIC 96_ FYECS 101_ PNLGP 106_ WIQPV 111_ GSLGW 116_ EVAPS 121_ GQGER 126_ VVNVP 131_ LCQED 136_ CEEWW 141_ EDCRM 146_ SYTCK 151_ SNWRG 156_ GWDWS 161_ QGKNR 166_ CPKGA 171_ QCLPF 176_ SHYFP 181_ TPADL 186_ CEKTW 191_ SNSFK 196_ ASPER 201_ RNSGR 206_ CLQKW 211_ FEPAQ 216_ GNPNV 221_ AVARL 226_ FASSA 231_ PSWEL 236_ SYTIM 241_VCSLF
1: Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion (PubMed:30517645). The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate