RCC1 domain-containing protein 1
1_MAEER 6_ PGAWF 11_ GFGFC 16_ GFGQE 21_ LGSGR 26_ GRQVH 31_ SPSPL 36_ RAGVD 41_ ICRVS 46_ ASWSY 51_ TAFVT 56_ RGGRL 61_ ELSGS 66_ ASGAA 71_ GRCKD 76_ AWASE 81_ GLLAV 86_ LRAGP 91_ GPEAL 96_ LQVWA 101_ AESAL 106_ RGEPL 111_ WAQNV 116_ VPEAE 121_ GEDDP 126_ AGEAQ 131_ AGRLP 136_ LLPCA 141_ RAYVS 146_ PRAPF 151_ YRPLA 156_ PELRA 161_ RQLEL 166_ GAEHA 171_ LLLDA 176_ AGQVF 181_ SWGGG 186_ RHGQL 191_ GHGTL 196_ EAELE 201_ PRLLE 206_ ALQGL 211_ VMAEV 216_ AAGGW 221_ HSVCV 226_ SETGD 231_ IYIWG 236_ WNESG 241_ QLALP 246_ TRNLA 251_ EDGET 256_ VAREA 261_ TELNE 266_ DGSQV 271_ KRTGG 276_ AEDGA 281_ PAPFI 286_ AVQPF 291_ PALLD 296_ LPMGS 301_ DAVKA 306_ SCGSR 311_ HTAVV 316_ TRTGE 321_ LYTWG 326_ WGKYG 331_ QLGHE 336_ DTTSL 341_ DRPRR 346_ VEYFV 351_ DKQLQ 356_ VKAVT 361_ CGPWN 366_ TYVYA 371_VEKGK
1: Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8 (PubMed:24981860). Possibly together with KDM8, is involved in proper mitotic spindle organization and chromosome segregation (PubMed:24981860). Plays a role in regulating alpha-tubulin deacetylation and cytoskeletal microtubule stability, thereby promoting cell migration and TGF-beta-induced epithelial to mesenchymal transition (EMT), potentially through the inhibition of KDM8 (PubMed:28455245)