Metalloprotease TIKI2 (EC 3.4.-.-) (Heart, kidney and adipose-enriched transmembrane protein homolog) (TRAB domain-containing protein 2B)
1_MHAAL 6_ AGPLL 11_ AALLA 16_ TARAR 21_ PQPPD 26_ GGQCR 31_ PPGSQ 36_ RDLNS 41_ FLWTI 46_ RRDPP 51_ AYLFG 56_ TIHVP 61_ YTRVW 66_ DFIPD 71_ NSKAA 76_ FQAST 81_ RVYFE 86_ LDLTD 91_ PYTIS 96_ ALASC 101_ QLLPH 106_ GENLQ 111_ DVLPH 116_ ELYWR 121_ LKRHL 126_ DYVKL 131_ MMPSW 136_ MTPAQ 141_ RGKGL 146_ YADYL 151_ FNAIA 156_ GNWER 161_ KRPVW 166_ VMLMV 171_ NSLTE 176_ RDVRF 181_ RGVPV 186_ LDLYL 191_ AQQAE 196_ KMKKT 201_ TGAVE 206_ QVEEQ 211_ CHPLN 216_ NGLNF 221_ SQVLF 226_ ALNQT 231_ LLQQE 236_ SVRAG 241_ SLQAS 246_ YTTED 251_ LIKHY 256_ NCGDL 261_ SAVIF 266_ NHDTS 271_ QLPNF 276_ INTTL 281_ PPHEQ 286_ VTAQE 291_ IDSYF 296_ RQELI 301_ YKRNE 306_ RMGKR 311_ VMALL 316_ RENED 321_ KICFF 326_ AFGAG 331_ HFLGN 336_ NTVID 341_ ILRQA 346_ GLEVD 351_ HTPAG 356_ QAIHS 361_ PAPQS 366_ PAPSP 371_ EGTST 376_ SPAPV 381_ TPAAA 386_ VPEAP 391_ SVTPT 396_ APPED 401_ EDPAL 406_ SPHLL 411_ LPDSL 416_ SQLEE 421_ FGRQR 426_ KWHKR 431_ QSTHQ 436_ RPRQF 441_ NDLWV 446_ RIEDS 451_ TTASP 456_ PPLPL 461_ QPTHS 466_ SGTAK 471_ PPFQL 476_ SDQLQ 481_ QQDPP 486_ GPASS 491_ SAPTL 496_ GLLPA 501_ IATTI 506_ AVCFL 511_LHSLG
1: Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation